{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:55:36Z","timestamp":1787630136398,"version":"build-2736575974"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500837"],"award-info":[{"award-number":["81500837"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.00942","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T17:35:48Z","timestamp":1531935348000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Extracellular Matrix Membrane Induces Cementoblastic\/Osteogenic Properties of Human Periodontal Ligament Stem Cells"],"prefix":"10.3389","volume":"9","author":[{"given":"Yuanyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Papagerakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denver","family":"Faulk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Badylak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Papagerakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1089\/ten.TEA.2011.0036","article-title":"Recruitment of progenitor cells by an extracellular matrix cryptic peptide in a mouse model of digit amputation.","volume":"17","author":"Agrawal","year":"2011","journal-title":"Tissue Eng. Part A"},{"key":"B2","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/j.1600-051X.1995.tb00163.x","article-title":"Clinical trial of cross-linked human type I collagen as a barrier material in surgical periodontaltreatment.","volume":"22","author":"Alarrayed","year":"1995","journal-title":"J. Clin. Periodontol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/ar.b.20081","article-title":"Regenerative medicine and developmental biology: the role of the extracellular matrix.","volume":"287","author":"Badylak","year":"2005","journal-title":"Anat. Rec. B New Anat."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1089\/ten.tea.2008.0162","article-title":"Chemoattraction of progenitor cells by remodeling extracellular matrix scaffolds.","volume":"15","author":"Beattie","year":"2009","journal-title":"Tissue Eng. Part A"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1902\/jop.2007.070102","article-title":"Effect of two different bioabsorbable collagen membranes on guided bone regeneration: a comparative histomorphometric study in the dog mandible.","volume":"78","author":"Bornstein","year":"2007","journal-title":"J. Clin. Periodontol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jss.2009.02.014","article-title":"Constructive remodeling of biologic scaffolds is dependent on early exposure to physiologic bladder filling in a canine partial cystectomy model.","volume":"161","author":"Boruch","year":"2010","journal-title":"J. Surg. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1002\/term.123","article-title":"Chemoattractant activity of degradation products of fetal and adult skin extracellular matrix for keratinocyte progenitor cells.","volume":"2","author":"Brennan","year":"2008","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1016\/j.actbio.2014.04.030","article-title":"Fabrication and characterization of bioactive and antibacterial composites for dental applications.","volume":"10","author":"Chatzistavrou","year":"2014","journal-title":"Acta Biomater."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/856470","article-title":"Innovative approaches to regenerate enamel and dentin.","volume":"2012","author":"Chatzistavrou","year":"2012","journal-title":"Int. J. Dent."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0934-8832(11)80221-0","article-title":"Structure of cDNAs encoding the triple-helical domain of murine \u03b12 (VI) collagen chain and comparison to human and chick homologues. Use of polymerase chain reaction and partially degenerate oligonucleotides for generation of novel cDNA clones.","volume":"11","author":"Constantinou","year":"1991","journal-title":"Matrix"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1097\/00006534-200111000-00045","article-title":"The use of fibrin glue in skin grafts and tissue-engineered skin replacements: a review.","volume":"108","author":"Currie","year":"2001","journal-title":"Plast. Reconstr. Surg."},{"key":"B12","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement.","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"B13","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1177\/0022034512457373","article-title":"Prevalence of periodontitis in adults in the United States: 2009 and 2010.","volume":"91","author":"Eke","year":"2012","journal-title":"J. Dent. Res."},{"key":"B14","doi-asserted-by":"crossref","first-page":"15559","DOI":"10.1016\/S0021-9258(19)49572-0","article-title":"Sea urchin collagen evolutionarily homologous to vertebrate Pro-\u03b12(I) collagen.","volume":"267","author":"Exposito","year":"1992","journal-title":"J. Biol. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.biomaterials.2007.12.014","article-title":"Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix.","volume":"29","author":"Freytes","year":"2008","journal-title":"Biomaterials"},{"key":"B16","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/j.1600-051x.2011.01738.x","article-title":"Randomized controlled trial on lateral augmentation using two collagen membranes: morphometric results on mineralized tissue compound.","volume":"38","author":"Friedmann","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005033","article-title":"Molecular architecture and function of matrix adhesions.","volume":"3","author":"Geiger","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1002\/biot.201100294","article-title":"Polymeric membranes for guided bone regeneration.","volume":"6","author":"Gentile","year":"2011","journal-title":"Biotechnol. J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1016\/j.biomaterials.2006.02.014","article-title":"Decellularization of tissues and organs.","volume":"27","author":"Gilbert","year":"2006","journal-title":"Biomaterials"},{"key":"B20","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1902\/jop.1990.61.11.680","article-title":"Guided tissue regeneration following treatment of recession-type defects in the monkey.","volume":"61","author":"Gottlow","year":"1990","journal-title":"J. Clin. Periodontol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/j.1600-051X.1986.tb00854.x","article-title":"New attachment formation in the human periodontium by guided tissue regeneration. Case reports.","volume":"13","author":"Gottlow","year":"1986","journal-title":"J. Clin. Periodontol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1600-0757.1994.tb00020.x","article-title":"Microbial etiological agents of destructive periodontal diseases.","volume":"5","author":"Haffajee","year":"1994","journal-title":"Periodontol. 2000"},{"key":"B23","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1034\/j.1600-0501.1992.030307.x","article-title":"Osseous healing of experimentally created defects in the calvaria of rabbits using guided bone regeneration. A pilot study.","volume":"3","author":"H\u00e4mmerle","year":"1992","journal-title":"Clin. Oral Implants Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3109\/10623320109063154","article-title":"Vascular endothelial growth factor in porcine-derived extracellular matrix.","volume":"8","author":"Hodde","year":"2001","journal-title":"Endothelium"},{"key":"B25","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1177\/0885328209338956","article-title":"Novel scaffolds of collagen with bioactive nanofiller for the osteogenic stimulation of bone marrow stromal cells.","volume":"24","author":"Hong","year":"2010","journal-title":"J. Biomater. Appl."},{"key":"B26","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1080\/14653240500319234","article-title":"Clarification of the nomenclature for MSC: the international society for cellular therapy position statement.","volume":"7","author":"Horwitz","year":"2005","journal-title":"Cytotherapy"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600502","article-title":"Matrix bound nano vesicles within ECM bioscaffolds.","volume":"10","author":"Huleihel","year":"2016","journal-title":"Sci. Adv."},{"key":"B28","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1600-0501.2010.02104.x","article-title":"Transcriptional profiling of \u201cguided bone regeneration\u201d in a critical-size calvarial defect.","volume":"22","author":"Ivanovski","year":"2015","journal-title":"Clin. Oral Implants Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1242\/dev.02245","article-title":"Notch 1 inhibits photoreceptor production in the developing mammalian retina.","volume":"133","author":"Jadhav","year":"2006","journal-title":"Development"},{"key":"B30","doi-asserted-by":"publisher","first-page":"4668","DOI":"10.3390\/ma8084668","article-title":"Physical properties of an ag-doped bioactive flowable composite resin.","volume":"24","author":"Kattan","year":"2015","journal-title":"Materials"},{"key":"B31","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1080\/10623320490512390","article-title":"Low-molecular-weight peptides derived from extracellular matrix as chemoattractants for primary endothelial cells.","volume":"11","author":"Li","year":"2004","journal-title":"Endothelium"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1021\/bm1001087","article-title":"Three-dimensional mineralization of dense nanofibrillar collagen-bioglass hybrid scaffolds.","volume":"11","author":"Marelli","year":"2010","journal-title":"Biomacromolecules"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20100526-24","article-title":"Clinical application of an acellular biologic scaffold for surgical repair of a large, traumatic quadriceps femoris muscle defect.","volume":"33","author":"Mase","year":"2010","journal-title":"Orthopedics"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/S0278-2391(10)80045-X","article-title":"Osseous guided tissue regeneration using a collagen barrier membrane.","volume":"51","author":"Mundell","year":"1993","journal-title":"J. Oral Maxillofac. Surg."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/nbt864","article-title":"The application of bone morphogenetic proteins to dental tissue engineering.","volume":"21","author":"Nakashima","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/812547","article-title":"Odontogenic differentiation of human dental pulp stem cells stimulated by the calcium phosphate porous granules.","volume":"2011","author":"Nam","year":"2011","journal-title":"J. Tissue Eng."},{"key":"B37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1600-0757.2005.00141.x","article-title":"Structure of periodontal tissues in health and disease.","volume":"40","author":"Nanci","year":"2006","journal-title":"Periodontol. 2000"},{"key":"B38","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1146\/annurev.cellbio.22.010305.104315","article-title":"Of extracellular matrix, scaffolds, and signaling: tissue architectureregulates development, homeostasis, and cancer.","volume":"22","author":"Nelson","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.gie.2008.04.022","article-title":"An extracellular matrix scaffold for esophageal stricture prevention after circumferential EMR.","volume":"69","author":"Nieponice","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"B40","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/j.1600-051X.1982.tb02095.x","article-title":"New attachment following surgical treatment of human periodontal disease.","volume":"9","author":"Nyman","year":"1982","journal-title":"J. Clin. Periodontol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1563\/1548-1336(2002)028<0220:CAAIMI>2.3.CO;2","article-title":"Collagen as an implantable material in medicine and dentistry.","volume":"28","author":"Patino","year":"2002","journal-title":"J. Oral Implantol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases.","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"B43","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1073\/pnas.75.2.871","article-title":"Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides.","volume":"75","author":"Postlethwaite","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B44","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1600-0501.2004.01039.x","article-title":"Biocompatibility of various collagen membranes in cultures of human PDL fibroblasts and human osteoblast-like cells.","volume":"15","author":"Rothamel","year":"2004","journal-title":"Clin. Oral Implants Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament.","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"key":"B46","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1600-0757.1999.tb00154.x","article-title":"Infectious aspects of periodontal regeneration.","volume":"19","author":"Slots","year":"1999","journal-title":"Periodontol. 2000"},{"key":"B47","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1111\/j.1600-0501.2008.01546.x","article-title":"Cross-linked and non-cross-linked collagen barrier membranes disintegrate following surgical exposure to the oral environment: a histological study in the cat.","volume":"19","author":"Tal","year":"2008","journal-title":"Clin. Oral Implants Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/S0955-0674(96)80102-5","article-title":"Macromolecular organization of basement membranes.","volume":"8","author":"Timpl","year":"1996","journal-title":"Curr. Opin. Cell Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/(SICI)1097-4644(19971215)67:4<478::AID-JCB6>3.0.CO;2-P","article-title":"Identification of extractable growth factors from small intestinal submucosa.","volume":"67","author":"Voytik-Harbin","year":"1997","journal-title":"J. Cell. Biochem."},{"key":"B50","doi-asserted-by":"publisher","first-page":"342","DOI":"10.22203\/eCM.v029a26","article-title":"Biological and bactericidal properties of Ag-doped bioactive glass in a natural extracellular matrix hydrogel with potential application in dentistry.","volume":"29","author":"Wang","year":"2015","journal-title":"Eur. Cell Mater."},{"key":"B51","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1902\/jop.2007.060055","article-title":"Ossification of a novel cross-linked porcine collagen barrier in guided bone regeneration in dogs.","volume":"78","author":"Zubery","year":"2007","journal-title":"J. Clin. Periodontol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.00942\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T20:46:24Z","timestamp":1661633184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.00942\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,18]]},"references-count":51,"alternative-id":["10.3389\/fphys.2018.00942"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.00942","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,18]]},"article-number":"942"}}