{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:36:11Z","timestamp":1781645771037,"version":"3.54.5"},"reference-count":97,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U24DC015910-01"],"award-info":[{"award-number":["1U24DC015910-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002046","name":"Hearing Health Foundation","doi-asserted-by":"publisher","award":["20180673"],"award-info":[{"award-number":["20180673"]}],"id":[{"id":"10.13039\/100002046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.01068","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T07:15:05Z","timestamp":1535958905000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Oxidative Stress in the Blood Labyrinthine Barrier in the Macula Utricle of Meniere\u2019s Disease Patients"],"prefix":"10.3389","volume":"9","author":[{"given":"Gail","family":"Ishiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Wester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan A.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Beltran-Parrazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/path.1250","article-title":"Protective role of endothelial nitric oxide synthase.","volume":"199","author":"Albrecht","year":"2003","journal-title":"J. Pathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF01642552","article-title":"Local effects of nitric oxide on vestibular blood flow in the Mongolian gerbil.","volume":"254","author":"Arenberg","year":"1997","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/ar.22622","article-title":"Immunocytochemical localization of the translocase of the outer mitochondrial membrane (Tom20) in the human cochlea.","volume":"296","author":"Balaker","year":"2013","journal-title":"Anatom. Rec."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1001\/archneur.58.7.1151","article-title":"Prosper Meniere\u2019s and his disease.","volume":"58","author":"Baloh","year":"2001","journal-title":"Arch. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3174\/ajnr.A3856","article-title":"Detection and grading of endolymphatic hydrops in Meniere\u2019s disease using MR imaging.","volume":"35","author":"Barath","year":"2014","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1152\/ajpcell.1996.271.5.C1424","article-title":"Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.","volume":"271","author":"Beckman","year":"1996","journal-title":"Am. J. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.brainres.2010.03.005","article-title":"Neuroglobin, cryoglobulin, and transcriptional profiling of hypoxia-related genes in the rat cerebellum after prenatal chronic very mild carbon monoxide exposure (25 ppm).","volume":"1330","author":"Beltran-Parrazal","year":"2010","journal-title":"Brain Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/cne.21570","article-title":"Griffonia simplicifolia isolectin B4 identifies a specific population of angiogenic blood vessels following contusive spiral cord injury in the adult mouse.","volume":"597","author":"Benton","year":"2008","journal-title":"J Comp. Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/sj.cdd.4400582","article-title":"Nitric oxide (NO): an effector of apoptosis.","volume":"6","author":"Br\u00fcne","year":"1999","journal-title":"Cell Death Differ"},{"key":"B10","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00441-012-1481-x","article-title":"Cochlin expression in vestibular endorgans obtained from patients with Meniere\u2019s disease.","volume":"350","author":"Calzada","year":"","journal-title":"Cell Tissue Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1097\/MAO.0b013e318271c48b","article-title":"Otolithic membrane damage in patients with endolymphatic hydrops and drop attacks.","volume":"33","author":"Calzada","year":"","journal-title":"Otol. Neurotol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s00405-011-1671-2","article-title":"Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss.","volume":"269","author":"Capaccio","year":"2011","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1097\/MAO.0b013e31821553ce","article-title":"Histopathology after endolymphatic sac surgery for Meniere\u2019s syndrome.","volume":"32","author":"Chung","year":"2011","journal-title":"Otol. Neurotol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"7631","DOI":"10.1073\/pnas.95.13.7631","article-title":"Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.","volume":"95","author":"Clementi","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B15","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Meniere\u2019s disease: criteria for diagnosis and evaluation of therapy for reporting.","volume":"113","year":"1995","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"B16","doi-asserted-by":"crossref","first-page":"e20656","DOI":"10.1371\/journal.pone.0020652","article-title":"Fibro-vascular coupling in the control of cochlear blood flow.","volume":"6","author":"Dai","year":"2011","journal-title":"PLoS One"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.2174\/138161208784705469","article-title":"Pericytes: pluripotent cells of the blood brain barrier.","volume":"14","author":"Dore-Duffy","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"B18","first-page":"459","article-title":"Antibodies defining rat endothelial cells. RECA-1, a pan-endothelial cell-specific monoclonal antibody.","volume":"66","author":"Duijvestijn","year":"1992","journal-title":"Lab Invest"},{"key":"B19","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00726-003-0022-z","article-title":"A review of approaches to the analysis of 3-nitrotyrosine.","volume":"25","author":"Duncan","year":"2003","journal-title":"Amino Acids."},{"key":"B20","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.brainres.2010.10.056","article-title":"Immunohistochemical distribution of WARP (von Willebrand A domain-related protein) in the inner ear.","volume":"1367","author":"Duong","year":"2011","journal-title":"Brain Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jneumeth.2005.06.018","article-title":"Isolectin-IB4 as a vascular stain for the study of adult neurogenesis.","volume":"150","author":"Ernst","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"B22","doi-asserted-by":"publisher","first-page":"5779","DOI":"10.1073\/pnas.88.13.5779","article-title":"Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial luminal and abluminal membranes: an electron microscopic immunogold study.","volume":"88","author":"Farrell","year":"1991","journal-title":"Proc Natl Acad Sci. U.S.A."},{"key":"B23","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1476-5381.2010.01196.x","article-title":"Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling.","volume":"164","author":"F\u00f6rstermann","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s10456-016-9502-0","article-title":"Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1-alpha deficient mice.","volume":"19","author":"Garcia-Quintans","year":"2016","journal-title":"Angiogenesis"},{"key":"B25","first-page":"523","article-title":"Retinal capillary basement membrane thickening in a porcine model of diabetes mellitus.","volume":"52","author":"Hainsworth","year":"2002","journal-title":"Comp. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1017\/S0022215100003947","article-title":"Observations on the pathology of M\u00e9ni\u00e8re\u2019s syndrome.","volume":"53","author":"Hallpike","year":"1938","journal-title":"J. Laryngol. Otol."},{"key":"B27","first-page":"2923","article-title":"Noise-induced nitrotyrosine increase and outer hair cell death in guinea pig cochlea.","volume":"126","author":"Han","year":"2013","journal-title":"Chin. Med. J."},{"key":"B28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.brainres.2005.04.023","article-title":"Endothelial nitric oxide synthase upregulation in the guinea pig organ of Corti after acute noise trauma.","volume":"1047","author":"Heinrich","year":"2005","journal-title":"Brain Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s00405-005-0949-7","article-title":"Endothelial nitric oxide synthase upregulation in the cochlea of the guinea pig after intratympanic gentamicin injection.","volume":"263","author":"Heinrich","year":"2006","journal-title":"European Arch Oto-Rhino-Laryn."},{"key":"B30","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0006-8993(99)01433-X","article-title":"Expression of inducible nitric oxide synthase (iNOS\/NOS II) in the cochlea of guinea pigs after intratympanical endotoxin-treatment.","volume":"830","author":"Hess","year":"","journal-title":"Brain. Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0304-3940(99)00195-0","article-title":"Expression of inducible nitric oxide-synthase in the vestibular system of hydropic guinea pigs.","volume":"264","author":"Hess","year":"","journal-title":"Neurosci. Lett."},{"key":"B32","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1002\/jemt.1070270609","article-title":"Electron microscopy of the blood brain barrier in disease.","volume":"1194","author":"Hirano","year":"1994","journal-title":"Microsc. Res. Technol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s10162-014-0476-6","article-title":"Systemic lipopolysaccharide compromises the blood-labyrinthine barrier and increases entry of serum fluorescein into the perilymph.","volume":"15","author":"Hirose","year":"2014","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/S0378-5955(02)00328-3","article-title":"Effects of nitric oxide synthase inhibitor on cochlear blood flow.","volume":"171","author":"Hoshijima","year":"2002","journal-title":"Hear. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1212\/WNL.57.6.1103","article-title":"Drop attacks in older patients secondary to an otologic cause.","volume":"57","author":"Ishiyama","year":"2001","journal-title":"Neurology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00441-010-0975-7","article-title":"Immunohistochemical localization and mRNA expression of aquaporins in the macula utricle of patients with Meniere\u2019s disease and acoustic neuroma.","volume":"340","author":"Ishiyama","year":"2010","journal-title":"Cell Tissue Res."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00330-5","article-title":"The blood labyrinthine barrier in the human normal and Meniere\u2019s disease macula utricle.","volume":"7","author":"Ishiyama","year":"2017","journal-title":"Sci. Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.clinimag.2014.09.014","article-title":"Meniere\u2019s disease: histopathology, cytochemistry and imaging.","volume":"1343","author":"Ishiyama","year":"2015","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF00455891","article-title":"The blood-perilymph barrier.","volume":"228","author":"Jahnke","year":"1980","journal-title":"Arch. Otorhinolaryngol."},{"key":"B40","first-page":"72","article-title":"Blood-labyrinth barrier and fluid dynamics of the inner ear.","volume":"7","author":"Juhn","year":"2001","journal-title":"Int. Tinnitus J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1177\/000348948109000208","article-title":"Nature of blood \u2013 labyrinth barrier in experimental conditions.","volume":"90","author":"Juhn","year":"1981","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1152\/ajpregu.003227.2006","article-title":"An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.","volume":"292","author":"Kregel","year":"2007","journal-title":"Am. J. Physiol. Reg. Integr. Comp. Physiol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056419","article-title":"Blood brain barrier breakdown after embolic stroke in rats occurs without ultrastructural evidence for disrupting tight junctions.","volume":"8","author":"Krueger","year":"2013","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.heares.2004.10.002","article-title":"Activation of caspase-3 is associated with oxidative stress in the hydropic guinea pig cochlea.","volume":"202","author":"Labbe","year":"2005","journal-title":"Hear. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/jmri.24144","article-title":"Markers of cochlear inflammation.","volume":"39","author":"LeFloc\u2019h","year":"2014","journal-title":"J. Magn. Reson. Imaging"},{"key":"B46","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.coph.2013.01.006","article-title":"Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease.","volume":"13","author":"Li","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1080\/00016480801901774","article-title":"Expression of VEGF, iNOS, and eNOS is increased in cochlear of diabetic rat.","volume":"128","author":"Liu","year":"2008","journal-title":"Acta-Otolaryngol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1097\/MAO.0000000000001144","article-title":"High resolution MRI shows presence of endolymphatic hydrops in patients still symptomatic after endolymphatic shunt surgery.","volume":"37","author":"Liu","year":"2016","journal-title":"Otol. Neurotol."},{"key":"B49","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/S0002-9440(10)64677-9","article-title":"Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions.","volume":"158","author":"Liu","year":"2001","journal-title":"Am. J. Pathol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"3653","DOI":"10.2174\/138161212802002706","article-title":"The role of pericytes in blood\u2013brain barrier function and stroke.","volume":"18","author":"Liu","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"B51","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s00418-016-1471-2","article-title":"Immunohistochemical techniques for the human inner ear.","volume":"146","author":"Lopez","year":"2016","journal-title":"Histochem. Cell Biol."},{"key":"B52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Meniere\u2019s disease.","volume":"25","author":"Lopez-Escamez","year":"2015","journal-title":"J. Vestib. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1472-6815-9-4","article-title":"Histopathological and ultrastructural analysis of vestibular endorgans obtained from patients with Meniere\u2019s disease.","volume":"9","author":"McCall","year":"2009","journal-title":"BMC Ear Nose Throat. Disord."},{"key":"B54","article-title":"Sur une forme de surdit\u00e9 grave d\u00e9pendant d\u2019une l\u00e9sion de l\u2019oreille interne.","volume":"16","author":"M\u00e9ni\u00e8re\u2019s","year":"1861","journal-title":"Gaz M\u00e9d de Paris"},{"key":"B55","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neulet.2005.08.038","article-title":"Ischemic damage increases nitric oxide production via inducible nitric oxide synthase in the cochlea.","volume":"391","author":"Morizane","year":"2005","journal-title":"Neurosci. Lett."},{"key":"B56","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1385\/1-59259-419-0:97","article-title":"Pathophysiology of blood-brain barrier breakdown.","volume":"89","author":"Nag","year":"2003","journal-title":"Methods Mod Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1365-2990.2010.01138.x","article-title":"Review: molecular pathogenesis of blood-brain barrier breakdown in acute brain injury.","volume":"37","author":"Nag","year":"2011","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s11604-014-0290-4","article-title":"Visualization of endolymphatic hydrops with MR imaging in patients with Meniere\u2019s disease and related pathologies: current status of its methods and clinical significance.","volume":"32","author":"Naganawa","year":"2014","journal-title":"Jpn. J. Radiol."},{"key":"B59","first-page":"437","article-title":"Age related thickening of retinal capillary basement membrane.","volume":"27","author":"Nagata","year":"1986","journal-title":"Investigative Ophthalmol and Visual Sci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s10162-012-0365-9","article-title":"Endothelial cell, pericytes, and perivascular macrophage-type melanocyte interactions regulate cochlear intrastrial fluid-blood barrier permeability.","volume":"14","author":"Neng","year":"2013","journal-title":"JARO"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A48822","article-title":"Blood-labyrinth barrier permeability in Meniere\u2019s disease and idiopathic sudden sensorineural hearing loss: findings on delayed contrast 3D-Flair MRI.","author":"Pakdaman","year":"2016","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.cardiores.2007.04.024","article-title":"Biochemistry of protein tyrosine nitration in cardiovascular pathology.","volume":"75","author":"Peluffo","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1080\/000164801300366570","article-title":"Localization of nitric oxide synthase isoform in the human cochlea.","volume":"121","author":"Popa","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1152\/ajplegacy.1972.223.2.323","article-title":"Testing of a hypothesis for osmotic opening of the blood-brain barrier.","volume":"223","author":"Rapoport","year":"1972","journal-title":"Am. J. Physiol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1083\/jcb.34.1.207","article-title":"Fine structural localization of a blood-brain barrier to exogenous peroxidase.","volume":"34","author":"Reese","year":"1967","journal-title":"J. Cell. Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.brainres.2015.03.018","article-title":"Targeting transporters: promoting blood-brain barrier repair in response to oxidative stress injury.","volume":"1623","author":"Ronaldson","year":"2015","journal-title":"Brain Res."},{"key":"B67","author":"Schuknecht","year":"1993","journal-title":"Pathology of the Ear"},{"key":"B68","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.clinimag.2014.09.014","article-title":"Delayed intravenous contrast-enhanced 3D FLAIR MRI in Meniere\u2019s disease: correlation of quantitative measures of endolymphatic hydrops with hearing.","volume":"39","author":"Sepahdari","year":"2015","journal-title":"Clin. Imaging"},{"key":"B69","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3174\/ajnr.A4462","article-title":"Endolymphatic hydrops reversal following acetazolamide therapy: demonstrated with delayed intravenous contrast-enhanced 3D-FLAIR MRI.","volume":"37","author":"Sepahdari","year":"2016","journal-title":"Am. J. Neuroradiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.2353\/ajpath.2009.080739","article-title":"Cochlear pericyte responses to acoustic trauma and the involvement of hypoxia-inducible factor-1-alpha and vascular endothelial growth factor.","volume":"174","author":"Shi","year":"2009","journal-title":"Am. J. Pathol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00441-010-1040-2","article-title":"Resident macrophages in the cochlear blood-labyrinth barrier and their renewal via migration of bone-marrow-derived cells.","volume":"342","author":"Shi","year":"2010","journal-title":"Cell Tissue Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.heares.2011.08.006","article-title":"Physiopathology of the cochlear microcirculation.","volume":"282","author":"Shi","year":"2011","journal-title":"Hear. Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.hearres.2016.01.010","article-title":"Pathophysiology of the cochlear intrastrial fluid-blood barrier (review) Hear.","volume":"338","author":"Shi","year":"2016","journal-title":"Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1080\/107396808002047445","article-title":"The cochlear pericytes.","volume":"15","author":"Shi","year":"2008","journal-title":"Microcirculation"},{"key":"B75","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0378-5955(02)00513-0","article-title":"The demonstration of nitric oxide in cochlear blood vessels in vivo and in vitro: the role of endothelial nitric oxide in venular permeability.","volume":"172","author":"Shi","year":"2002","journal-title":"Hear. Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0006-8993(02)04090-8","article-title":"Upregulated iNOS and oxidative damage to the cochlear stria vascularis due to noise stress.","volume":"967","author":"Shi","year":"2003","journal-title":"Brain Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1177\/0271678x15617172","article-title":"Molecular pathophysiology of cerebral edema.","volume":"36","author":"Stokum","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B78","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0378-5955(98)00214-7","article-title":"Development of blood-labyrinth barrier in the semicircular canal ampulla of the rat.","volume":"129","author":"Suzuki","year":"1999","journal-title":"Hear. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3109\/00016489.2010.534114","article-title":"Endolymphatic hydrops and blood-labyrinthine barrier in Meniere\u2019s disease.","volume":"131","author":"Tagaya","year":"2011","journal-title":"Acta Otolaryngol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/00016480701497436","article-title":"A new animal mode for Meniere\u2019s disease.","volume":"128","author":"Takumida","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/s004050050040","article-title":"Lipopolysaccharide-induced expression of nitric oxide synthase II in the guinea pig vestibular end organs.","volume":"255","author":"Takumida","year":"","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000027567","article-title":"Localization of nitric oxide synthase isoforms (NOS I,II and III) in the vestibular end organs of the guinea pig.","volume":"60","author":"Takumida","year":"","journal-title":"ORL"},{"key":"B83","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1080\/000164801300102734","article-title":"Nitric oxide in guinea pig vestibular sensory cells following Gentamicin exposure in vitro.","volume":"121","author":"Takumida","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"B84","first-page":"345","article-title":"Functional significance of nitric oxide in the inner ear.","volume":"18","author":"Takumida","year":"2004","journal-title":"In vivo"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1089\/dna.2012.1631","article-title":"Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and M\u00e9ni\u00e8re\u2019s disease in a japanese population.","volume":"31","author":"Teranishi","year":"2012","journal-title":"DNA Cell Biol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1055\/s-0032-1315723","article-title":"Vascular pathophysiology in hearing disorders.","volume":"33","author":"Trune","year":"2012","journal-title":"Semin. Hear."},{"key":"B87","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.neulet.2017.02.003","article-title":"Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice.","volume":"642","author":"Tuerdi","year":"2017","journal-title":"Neurosci. Lett."},{"key":"B88","doi-asserted-by":"publisher","first-page":"9220","DOI":"10.1073\/pnas.95.16.9220","article-title":"Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors.","volume":"95","author":"Vasquez-Vivar","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B89","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/S0194-5998(95)70307-1","article-title":"Histopathologic findings in Meniere\u2019s Disease.","volume":"112","author":"Wackym","year":"1995","journal-title":"Otol. Head & Neck Surg."},{"key":"B90","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1080\/10715760000300361","article-title":"Inhibition of inducible nitric oxide synthase lowers the cochlear damage by lipopolysaccharide in guinea pigs.","volume":"32","author":"Watanabe","year":"2000","journal-title":"Free Radical Res."},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-014-0136-0","article-title":"Noise alters guinea pig\u2019s blood labyrinth barrier ultrastructure and permeability along with a decrease of cochlear claudin-5 and occludin","volume":"15","author":"Wu","year":"2014","journal-title":"BMC Neurosci."},{"key":"B92","first-page":"2310","article-title":"Uber die pathologisch veranderung bei einem M\u00e9ni\u00e8re-kranken.","volume":"4","author":"Yamakawa","year":"1938","journal-title":"J. Otorhinolaryngol. Soc. Jpn."},{"key":"B93","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3174\/ajnr.A2821","article-title":"Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection.","volume":"33","author":"Yamazaki","year":"2012","journal-title":"AJNR"},{"key":"B94","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0076-6879(96)69022-3","article-title":"Antibodies that recognize nitrotyrosine.","volume":"269","author":"Ye","year":"1996","journal-title":"Methods Enzymol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/nm.2022","article-title":"Pericyte contraction induced by oxidative-nitrative stress impair capillary reflow despite successful opening of an occluded cerebral artery.","volume":"15","author":"Yemisci","year":"2009","journal-title":"Nat. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s10162-013-0403-2","article-title":"Characterization and inflammatory response of perivascular macrophage-resident macrophage-like melanocytes in the vestibular system.","volume":"14","author":"Zhang","year":"2013","journal-title":"JARO"},{"key":"B97","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000084024","article-title":"Communication between the perilymphatic scalae and spiral ligament visualized by in vivo MRI.","volume":"10","author":"Zou","year":"2005","journal-title":"Audiol. Neurotol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01068\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T18:44:22Z","timestamp":1604861062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01068\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,3]]},"references-count":97,"alternative-id":["10.3389\/fphys.2018.01068"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.01068","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,3]]},"article-number":"1068"}}