{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:46:39Z","timestamp":1774359999242,"version":"3.50.1"},"reference-count":107,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.01103","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T04:14:57Z","timestamp":1534220097000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Vitamin C and Helicobacter pylori Infection: Current Knowledge and Future Prospects"],"prefix":"10.3389","volume":"9","author":[{"given":"Haixin","family":"Mei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1007\/s10620-012-2203-7","article-title":"Vitamin C, gastritis, and gastric disease: a historical review and update","volume":"57","author":"Aditi","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1007\/s00277-014-2124-y","article-title":"Adding ascorbic acid to arsenic trioxide produces limited benefit in patients with acute myeloid leukemia excluding acute promyelocytic leukemia","volume":"93","author":"Aldoss","year":"2014","journal-title":"Ann. Hematol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1136\/gut.52.4.496","article-title":"Concomitant alterations in intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency anaemia","volume":"52","author":"Annibale","year":"2003","journal-title":"Gut"},{"key":"B4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/gut.35.3.317","article-title":"Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid","volume":"35","author":"Banerjee","year":"1994","journal-title":"Gut"},{"key":"B5","doi-asserted-by":"publisher","first-page":"8560871","DOI":"10.1155\/2016\/8560871","article-title":"Intravenous vitamin C administered as adjunctive therapy for recurrent acute respiratory distress syndrome","volume":"2016","author":"Bharara","year":"2016","journal-title":"Case Rep. Crit. Care"},{"key":"B6","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/ajg.2014.24","article-title":"The problem of Helicobacter pylori resistance to antibiotics: a systematic review in Latin America","volume":"109","author":"Camargo","year":"2014","journal-title":"Am. J. Gastroenterol"},{"key":"B7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0009-2797(74)90019-2","article-title":"The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer","volume":"9","author":"Cameron","year":"1974","journal-title":"Chem. Biol. Interact"},{"key":"B8","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1073\/pnas.73.10.3685","article-title":"Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer","volume":"73","author":"Cameron","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B9","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1073\/pnas.75.9.4538","article-title":"Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer","volume":"75","author":"Cameron","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B10","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/ajcn\/69.6.1086","article-title":"Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans","volume":"69","author":"Carr","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"B11","doi-asserted-by":"publisher","first-page":"13604","DOI":"10.1073\/pnas.0506390102","article-title":"Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B12","doi-asserted-by":"publisher","first-page":"8749","DOI":"10.1073\/pnas.0702854104","article-title":"Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular ?uid in vivo","volume":"104","author":"Chen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B13","doi-asserted-by":"publisher","first-page":"11105","DOI":"10.1073\/pnas.0804226105","article-title":"Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice","volume":"105","author":"Chen","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B14","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1046\/j.1523-5378.2002.00095.x","article-title":"Vitamin C and E supplements to lansoprazole-amoxicillin-metronidazole triple therapy may reduce the eradication rate of metronidazole-susceptible Helicobacter pylori infection","volume":"7","author":"Chuang","year":"2002","journal-title":"Helicobacter"},{"key":"B15","first-page":"320","article-title":"Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication","volume":"54","author":"Chuang","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"9092","DOI":"10.1074\/jbc.M112.436790","article-title":"Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8","volume":"288","author":"Corpe","year":"2013","journal-title":"J. Biol. Chem"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1172\/JCI39191","article-title":"Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice","volume":"120","author":"Corpe","year":"2010","journal-title":"J. Clin. Invest."},{"key":"B18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/jnci\/87.1.52","article-title":"Gastric juice ascorbic acid after intravenous injection: effect of ethnicity, pH, and Helicobacter pylori infection","volume":"87","author":"Correa","year":"1995","journal-title":"J. Natl. Cancer Inst"},{"key":"B19","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1056\/NEJM197909273011303","article-title":"Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial","volume":"301","author":"Creagan","year":"1979","journal-title":"N Engl J Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"456","DOI":"10.5152\/tjg.2015.0233","article-title":"Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection","volume":"26","author":"Demirci","year":"2015","journal-title":"Turk. J. Gastroenterol"},{"key":"B20","first-page":"48","article-title":"The Mystery of Vitamin C","volume":"3","author":"De Tullio","year":"2010","journal-title":"Nat. Educ"},{"key":"B22","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/CAD.0000000000000603","article-title":"Treatment of pancreatic cancer with intravenous vitamin C: a case report","volume":"29","author":"Drisko","year":"2018","journal-title":"Anticancer Drugs"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.2147\/DDDT.S83144","article-title":"Effect of vitamin C on inflammation and metabolic markers in hypertensive and\/or diabetic obese adults: a randomized controlled trial","volume":"9","author":"Ellulu","year":"2015","journal-title":"Drug Des. Devel. Ther"},{"key":"B24","first-page":"369","article-title":"Levels of malondialdehyde-deoxyguanosine in the gastric mucosa: relationship with lipid peroxidation, ascorbic acid, and Helicobacter pylori","volume":"10","author":"Everett","year":"2001","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"B25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00004836-199606000-00007","article-title":"Gastric antioxidant, nitrites, and mucosal lipoperoxidation in chronic gastritis and Helicobacter pylori infection","volume":"22","author":"Farinati","year":"1996","journal-title":"J. Clin. Gastroenterol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1479-5876-12-32","article-title":"Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis","volume":"12","author":"Fowler","year":"2014","journal-title":"J. Transl. Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.5492\/wjccm.v6.i1.85","article-title":"Intravenous vitamin C as adjunctive therapy for enterovirus\/rhinovirus induced acute respiratory distress syndrome","volume":"6","author":"Fowler","year":"2017","journal-title":"World J. Crit. Care Med"},{"key":"B28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0891-5849(95)02022-5","article-title":"Ascorbyl radical formation in patients with sepsis: effect of ascorbate loading","volume":"20","author":"Galley","year":"1996","journal-title":"Free Radic. Biol. Med"},{"key":"B29","first-page":"154","article-title":"High dose intraveneous vitamin C and chikungunya fever: a case report","volume":"29","author":"Gonzalez","year":"2014","journal-title":"J. Orthomol. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.2741\/4160","article-title":"Effects of vitamin C on health: a review of evidence","volume":"18","author":"Grosso","year":"2013","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s00210-013-0880-1","article-title":"Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases","volume":"386","author":"Hagel","year":"2013","journal-title":"Naunyn Schmiedebergs. Arch. Pharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/j.1365-2036.2005.02568.x","article-title":"Proton pump inhibitors reduce the bioavailability of dietary vitamin C","volume":"22","author":"Henry","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1093\/annonc\/mdn377","article-title":"Phase I clinical trial of i.v. ascorbic acid in advanced malignancy","volume":"19","author":"Hoffer","year":"2008","journal-title":"Ann Oncol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e0120228","DOI":"10.1371\/journal.pone.0120228","article-title":"High-dose intravenous vitamin C combined with cytotoxic chemotherapy in patients with advanced cancer: a Phase I-II Clinical Trial","volume":"10","author":"Hoffer","year":"2015","journal-title":"PLoS ONE"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1046\/j.1365-2036.2002.01311.x","article-title":"Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis","volume":"16","author":"Ito","year":"2002","journal-title":"Aliment Pharmacol. Ther."},{"key":"B36","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00008469-199812000-00004","article-title":"Effects of high dose vitamin C treatment on Helicobacter pylori infection and total vitamin C concentration in gastric juice","volume":"7","author":"Jarosz","year":"1998","journal-title":"Eur. J. Cancer Prev"},{"key":"B37","first-page":"222","article-title":"Effect of additionof vitamin C to clarithromycin-amoxicillin-omeprazol triple regimen on Helicobacter pylori eradication","volume":"72","author":"Kaboli","year":"2009","journal-title":"Acta Gastroenterol. Belg"},{"key":"B38","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/BCR.0b013e318204b336","article-title":"Resuscitation after severe burn injury using high-dose ascorbic acid: a retrospective review","volume":"32","author":"Kahn","year":"2011","journal-title":"J. Burn Care Res"},{"key":"B39","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1590\/S0004-28032005000300008","article-title":"Effect of vitamin C administration on gastric colonization by Helicobacter pylori","volume":"42","author":"Kamiji","year":"2005","journal-title":"Arq. Gastroenterol."},{"key":"B40","first-page":"111","article-title":"Phase I clinical trial of intravenous L-ascorbic acid following salvage chemotherapy for relapsed B-cell non-Hodgkin's Lymphoma","volume":"39","author":"Kawada","year":"2014","journal-title":"Tokai J. Exp. Clin. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"677","DOI":"10.5021\/ad.2016.28.6.677","article-title":"A study of intravenous administration of vitamin C in the treatment of acute herpetic pain and postherpetic neuralgia","volume":"28","author":"Kim","year":"2016","journal-title":"Ann. Dermatol."},{"key":"B42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14712\/18059694.2019.92","article-title":"Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin","volume":"44","author":"Ko\u00e7kar","year":"2001","journal-title":"Acta Medica (Hradec. Kralove)"},{"key":"B43","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3109\/14756366.2010.504675","article-title":"Urease activity and L-ascorbic acid","volume":"26","author":"Krajewska","year":"2011","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.3945\/ajcn.113.061267","article-title":"Prediagnostic plasma vitamin C and risk of gastric adenocarcinoma and esophageal squamous cell carcinoma in a Chinese population","volume":"98","author":"Lam","year":"2013","journal-title":"Am. J. Clin. Nutr"},{"key":"B45","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ejogrb.2016.02.014","article-title":"Effect of intravenous ascorbic acid infusion on blood loss during laparoscopic myomectomy: a randomized, double-blind, placebo-controlled trial","volume":"199","author":"Lee","year":"2016","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol"},{"key":"B46","first-page":"892","article-title":"New concepts in the biology and biochemistry of ascorbic acid","volume":"31","author":"Levine","year":"1986","journal-title":"New Engl. J. Med"},{"key":"B47","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1073\/pnas.93.8.3704","article-title":"Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance","volume":"93","author":"Levine","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B48","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3945\/an.110.000109","article-title":"Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries","volume":"2","author":"Levine","year":"2011","journal-title":"Adv. Nutr."},{"key":"B49","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1001\/jama.281.15.1415","article-title":"Criteria and recommendations for vitamin C intake","volume":"281","author":"Levine","year":"1999","journal-title":"JAMA"},{"key":"B50","doi-asserted-by":"publisher","first-page":"9842","DOI":"10.1073\/pnas.171318198","article-title":"A new recommended dietary allowance of vitamin C for healthy young women","volume":"98","author":"Levine","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.3390\/nu5082860","article-title":"Regulation of vitamin C homeostasis during deficiency","volume":"5","author":"Lindblad","year":"2013","journal-title":"Nutrients"},{"key":"B52","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1093\/jnci\/djs003","article-title":"Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality","volume":"104","author":"Ma","year":"2012","journal-title":"J. Natl. Cancer Inst"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.chest.2016.11.036","article-title":"Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study","volume":"151","author":"Marik","year":"2017","journal-title":"Chest"},{"key":"B53","doi-asserted-by":"publisher","first-page":"222r","DOI":"10.1126\/scitranslmed.3007154","article-title":"High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy","volume":"6","author":"Ma","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1136\/gutjnl-2012-302254","article-title":"Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption","volume":"62","author":"Megraud","year":"2013","journal-title":"Gut"},{"key":"B56","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1097\/01.mcg.0000174023.73472.29","article-title":"Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial","volume":"39","author":"Melhem","year":"2005","journal-title":"J. Clin. Gastroenterol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"725","DOI":"10.12659\/MSM.890423","article-title":"Effect of high dose vitamin C on Epstein-Barr viral infection","volume":"20","author":"Mikirova","year":"2014","journal-title":"Med. Sci. Monit"},{"key":"B58","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1056\/NEJM198501173120301","article-title":"High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison","volume":"312","author":"Moertel","year":"1985","journal-title":"N. Engl. J. Med"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e29794","DOI":"10.1371\/journal.pone.0029794","article-title":"Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer","volume":"7","author":"Monti","year":"2012","journal-title":"PLoS ONE"},{"key":"B60","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1475-2891-2-7","article-title":"Vitamin C in human health and disease is still a mystery? An overview","volume":"2","author":"Naidu","year":"2003","journal-title":"Nutr. J."},{"key":"B61","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1097\/00000658-200212000-00014","article-title":"Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients","volume":"236","author":"Nathens","year":"2002","journal-title":"Ann. Surg."},{"key":"B62","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/bcpt.12323","article-title":"Elimination of ascorbic acid after high-dose infusion in prostate cancer patients: a pharmacokinetic evaluation","volume":"116","author":"Nielsen","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1203S","DOI":"10.1093\/ajcn\/54.6.1203s","article-title":"Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis","volume":"54","author":"Nishikimi","year":"1991","journal-title":"Am. J. Clin. Nutr"},{"key":"B64","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/odi.12446","article-title":"Vitamin C physiology: the known and the unknown and Goldilocks","volume":"22","author":"Padayatty","year":"2016","journal-title":"Oral Dis"},{"key":"B65","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1503\/cmaj.050346","article-title":"Intravenously administered vitamin C as cancer therapy: three cases","volume":"174","author":"Padayatty","year":"2006","journal-title":"CMAJ"},{"key":"B66","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7326\/0003-4819-140-7-200404060-00010","article-title":"Vitamin C pharmacokinetics: implications for oral and intravenous use","volume":"140","author":"Padayatty","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"624","DOI":"10.4103\/0253-7613.89814","article-title":"Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- critical review","volume":"43","author":"Pal","year":"2011","journal-title":"Indian J. Pharmacol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1089\/ars.2013.5372","article-title":"Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics","volume":"19","author":"Parrow","year":"2013","journal-title":"Antioxid. Redox Signal"},{"key":"B69","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","article-title":"Helicobacter pylori infection and the risk of gastric carcinoma","volume":"325","author":"Parsonnet","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"B70","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/bmj.1.4027.554","article-title":"Vitamin C deficiency in peptic ulceration and haematemesis","volume":"1","author":"Portnoy","year":"1938","journal-title":"Br. Med. J"},{"key":"B71","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00404-011-1897-7","article-title":"Intravenous ascorbic acid (vitamin C) administration in myomectomy: a prospective, randomized clinical trial","volume":"285","author":"Pourmatroud","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"B72","first-page":"269","article-title":"A pilot clinical study of continuous intravenous ascorbate in terminal cancer patients","volume":"24","author":"Riordan","year":"2005","journal-title":"P. R. Health Sci. J"},{"key":"B73","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12937-016-0158-9","article-title":"A simple method for plasma total vitamin C analysis suitable for routine clinical laboratory use","volume":"15","author":"Robitaille","year":"2016","journal-title":"Nutr. J"},{"key":"B74","first-page":"533","article-title":"Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment","volume":"89","author":"Ruiz","year":"1994","journal-title":"Am. J. Gastroenterol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"28246","DOI":"10.1074\/jbc.M000988200","article-title":"Dehydroascorbic acid transport by GLUT4 in Xenopus oocytes and isolated rat adipocytes","volume":"275","author":"Rumsey","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B76","doi-asserted-by":"crossref","first-page":"18982","DOI":"10.1074\/jbc.272.30.18982","article-title":"Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid","volume":"272","author":"Rumsey","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"191","DOI":"10.17305\/bjbms.2018.2306","article-title":"Analysis of oxidative stress-related markers in critically ill polytrauma patients: an observational prospective single-center study","volume":"18","author":"Sandesc","year":"2018","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"B78","first-page":"CS58","article-title":"Intravenous administration of vitamin C in the treatment of herpetic neuralgia: two case reports","volume":"16","author":"Schencking","year":"2010","journal-title":"Med Sci Monit"},{"key":"B79","doi-asserted-by":"publisher","first-page":"CR215","DOI":"10.12659\/MSM.882621","article-title":"Intravenous vitamin C in the treatment of shingles: results of a multicenter prospective cohort study","volume":"18","author":"Schencking","year":"2012","journal-title":"Med Sci Monit"},{"key":"B80","doi-asserted-by":"publisher","first-page":"487.e8","DOI":"10.1016\/j.ccell.2017.02.018","article-title":"O2\u00b7- and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological Ascorbate","volume":"31","author":"Schoenfeld","year":"2017","journal-title":"Cancer Cell"},{"key":"B81","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.clinre.2011.07.001","article-title":"Efficacy of vitamins supplementation to therapy on Helicobacter pylori eradication in patients with low antioxidant capacity","volume":"35","author":"Sezikli","year":"2011","journal-title":"Clin. Res. Hepatol. Gastroenterol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/j.1365-2710.2011.01286.x","article-title":"Supplementing vitamins C and E to standard triple therapy for the eradication of Helicobacter pylori","volume":"37","author":"Sezikli","year":"2012","journal-title":"J. Clin. Pharm. Ther."},{"key":"B83","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1523-5378.2009","article-title":"Oxidative stress in Helicobacter pylori infection: does supplementation with vitamins C and E increase the eradication rate?","volume":"14","author":"Sezikli","year":"2009","journal-title":"Helicobacter"},{"key":"B84","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/07315724.2003.10719305","article-title":"Relation of serum ascorbic acid to Helicobacter pylori serology in US adults: the Third National Health and Nutrition Examination Survey","volume":"22","author":"Simon","year":"2003","journal-title":"J. Am. Coll. Nutr"},{"key":"B85","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1136\/gut.32.11.1415","article-title":"Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations","volume":"32","author":"Sobala","year":"1991","journal-title":"Gut"},{"key":"B86","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1136\/gut.34.8.1038","article-title":"Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations","volume":"34","author":"Sobala","year":"1993","journal-title":"Gut"},{"key":"B87","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/nm0502-514","article-title":"Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival","volume":"8","author":"Sotiriou","year":"2002","journal-title":"Nat. Med."},{"key":"B88","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00280-013-2179-9","article-title":"Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer","volume":"72","author":"Stephenson","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1089\/ars.2006.8.243","article-title":"Hydrogen peroxide: a signaling messenger","volume":"8","author":"Stone","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1056\/NEJMra020542","article-title":"Helicobacter pylori infection","volume":"347","author":"Suerbaum","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"B91","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1001\/archsurg.135.3.326","article-title":"Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study","volume":"135","author":"Tanaka","year":"2000","journal-title":"Arch. Surg"},{"key":"B92","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s10620-006-9411-y","article-title":"Basis of decreased risk of gastric cancer in severe atrophic gastritis with eradication of Helicobacter pylori","volume":"52","author":"Tari","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"B93","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/oxfordjournals.epirev.a036078","article-title":"The epidemiology of Helicobacter pylori infection","volume":"13","author":"Taylor","year":"1991","journal-title":"Epidemiol. Rev."},{"key":"B94","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/apt.13497","article-title":"Review article: the global emergence of Helicobacter pylori antibiotic resistance","volume":"43","author":"Thung","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B95","first-page":"983","article-title":"Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany","volume":"25","author":"Vollbracht","year":"2011","journal-title":"In Vivo"},{"key":"B96","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/gut.38.2.171","article-title":"Ascorbic acid and total vitamin C concentrations in plasma, gastric juice, and gastrointestinal mucosa: effect of gastritis and oral supplementation","volume":"38","author":"Waring","year":"1996","journal-title":"Gut"},{"key":"B97","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","volume":"1","author":"Warren","year":"1983","journal-title":"Lancet"},{"key":"B98","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s00280-013-2070-8","article-title":"Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial","volume":"71","author":"Welsh","year":"2013","journal-title":"Cancer Chemother. Pharmacol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1089\/ars.2013.5401","article-title":"Evaluation of vitamin C for adjuvant sepsis therapy","volume":"19","author":"Wilson","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B100","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1001\/jama.291.2.187","article-title":"Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial","volume":"291","author":"Wong","year":"2004","journal-title":"JAMA"},{"key":"B101","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00042737-200103000-00003","article-title":"Helicobacter pylori infection reduces systemic availability of dietary vitamin C","volume":"13","author":"Woodward","year":"2001","journal-title":"Eur J Gastroenterol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"8018","DOI":"10.1200\/JCO.2005.02.3903","article-title":"Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication","volume":"23","author":"W\u00fcndisch","year":"2005","journal-title":"J. Clin. Oncol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1126\/science.aaa5004","article-title":"Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH","volume":"350","author":"Yun","year":"2015","journal-title":"Science"},{"key":"B104","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4103\/2279-042X.179569","article-title":"Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock","volume":"5","author":"Zabet","year":"2016","journal-title":"J. Res. Pharm. Pract"},{"key":"B105","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1136\/gut.50.2.165","article-title":"Effect of physiological concentrations of vitamin C on gastric cancer cells and Helicobacter pylori","volume":"50","author":"Zhang","year":"2002","journal-title":"Gut"},{"key":"B106","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/gut.43.3.322","article-title":"The relation between gastric vitamin C concentrations, mucosal histology, and CagA seropositivity in the human stomach","volume":"43","author":"Zhang","year":"1998","journal-title":"Gut"},{"key":"B107","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.dld.2008.09.008","article-title":"The efficacy of Helicobacter pylori eradication regimen with and without vitamin C supplementation","volume":"41","author":"Zojaji","year":"2009","journal-title":"Dig. Liver Dis."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01103\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T07:38:37Z","timestamp":1571729917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01103\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,14]]},"references-count":107,"alternative-id":["10.3389\/fphys.2018.01103"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.01103","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,14]]},"article-number":"1103"}}