{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:33:36Z","timestamp":1790778816133,"version":"4.1.0"},"reference-count":194,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["HL-74815"],"award-info":[{"award-number":["HL-74815"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["HL-107640"],"award-info":[{"award-number":["HL-107640"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["NS-084823"],"award-info":[{"award-number":["NS-084823"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["HL-139047"],"award-info":[{"award-number":["HL-139047"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AR071789"],"award-info":[{"award-number":["AR071789"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.01268","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:50:56Z","timestamp":1536108656000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":61,"title":["Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and Pyroptosis"],"prefix":"10.3389","volume":"9","author":[{"given":"Rubens P.","family":"Homme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahavir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avisek","family":"Majumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash K.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavya","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpal S.","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lominadze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh C","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.4239\/wjd.v7.i8.165","article-title":"Diabetes epidemic sweeping the Arab world.","volume":"7","author":"Abuyassin","year":"2016","journal-title":"World J. Diabetes"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1056\/nejm199412013312203","article-title":"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders.","volume":"331","author":"Aiello","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"B3","first-page":"1473","article-title":"Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor.","volume":"46","author":"Aiello","year":"1997","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.sjopt.2011.01.009","article-title":"Diabetic retinopathy - An update.","volume":"25","author":"Alghadyan","year":"2011","journal-title":"Saudi J. Ophthalmol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1083\/jcb.148.1.203","article-title":"Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow.","volume":"148","author":"Allport","year":"2000","journal-title":"J. Cell Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1136\/bjo.79.12.1120","article-title":"Diabetic retinopathy: morphometric analysis of basement membrane thickening of capillaries in different retinal layers within arterial and venous environments.","volume":"79","author":"Anderson","year":"1995","journal-title":"Br. J. Ophthalmol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4693801","article-title":"Anti-Inflammatory therapy modulates Nrf2-Keap1 in kidney from rats with diabetes.","volume":"2016","author":"Arellano-Buendia","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/432685","article-title":"The role of inflammation in the pathogenesis of macular edema secondary to retinal vascular diseases.","volume":"2014","author":"Ascaso","year":"2014","journal-title":"Mediators Inflamm."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.2337\/dc10-0132","article-title":"Homocysteinethiolactone and paraoxonase: novel markers of diabetic retinopathy.","volume":"33","author":"Barathi","year":"2010","journal-title":"Diabetes Care"},{"key":"B10","doi-asserted-by":"publisher","first-page":"4343","DOI":"10.1210\/jc.2017-01922","article-title":"Diabetic microvascular disease: an endocrine society scientific statement.","volume":"102","author":"Barrett","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B11","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome - biological and translational implications.","volume":"11","author":"Baylin","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: host cell death and inflammation.","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"B13","first-page":"268","article-title":"Proliferative vitreoretinopathy: does oral low-dose colchicine have an inhibitory effect? A controlled study in humans.","volume":"20","author":"Berman","year":"1989","journal-title":"Ophthalmic Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1002\/jbio.201600282","article-title":"Ratiometric analysis of optical coherence tomography-measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy.","volume":"10","author":"Bhaduri","year":"2017","journal-title":"J. Biophotonics"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.survophthal.2008.10.001","article-title":"Diabetic macular edema: pathogenesis and treatment.","volume":"54","author":"Bhagat","year":"2009","journal-title":"Surv. Ophthalmol."},{"key":"B16","first-page":"1660","article-title":"Signaling pathways for glycated human serum albumin-induced IL-8 and MCP-1 secretion in human RPE cells.","volume":"42","author":"Bian","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"294","DOI":"10.2174\/157339912800840479","article-title":"Corneal changes in diabetes mellitus.","volume":"8","author":"Bikbova","year":"2012","journal-title":"Curr. Diabetes Rev."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001928","article-title":"Aflibercept after ranibizumab intravitreal injections in exudative age-related macular degeneration: the ari2 study.","author":"Blanco-Garavito","year":"2017","journal-title":"Retina"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e339","DOI":"10.1016\/s2214-109x(13)70113-x","article-title":"Causes of vision loss worldwide, 1990-2010: a systematic analysis.","volume":"1","author":"Bourne","year":"2013","journal-title":"Lancet Glob. Health"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1001\/archopht.122.12.1801","article-title":"Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone.","volume":"122","author":"Brooks","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/dmrr.415","article-title":"Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives.","volume":"19","author":"Caldwell","year":"2003","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1080\/09629350020025764","article-title":"Effect of cyclosporin-A on the blood\u2013retinal barrier permeability in streptozotocin-induced diabetes.","volume":"9","author":"Carmo","year":"2000","journal-title":"Mediators Inflamm."},{"key":"B23","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.4103\/2230-8210.94253","article-title":"Infections in patients with diabetes mellitus: a review of pathogenesis.","author":"Casqueiro","year":"2012","journal-title":"Indian J. Endocrinol. Metab."},{"key":"B24","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00109-013-0993-5","article-title":"Ocular neovascularization.","volume":"91","author":"Campochiaro","year":"2013","journal-title":"J. Mol. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.athoracsur.2003.09.128","article-title":"Overexpressed nuclear factor kappaB correlates with enhanced expression of interleukin-1beta and inducible nitric oxide synthase in aged murine lungs to endotoxic stress.","volume":"77","author":"Chang","year":"2004","journal-title":"Ann. Thorac. Surg."},{"key":"B26","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/s0140-6736(09)62124-3","article-title":"Diabetic retinopathy.","volume":"376","author":"Cheung","year":"2010","journal-title":"Lancet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1203\/01.pdr.0000141990.12375.13","article-title":"Effects of vitamin E supplementation on intracellular antioxidant enzyme production in adolescents with type 1 diabetes and early microangiopathy.","volume":"56","author":"Chiarelli","year":"2004","journal-title":"Pediatr. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.2337\/diacare.26.9.2653","article-title":"Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies.","volume":"26","author":"Ciulla","year":"2003","journal-title":"Diabetes Care"},{"key":"B29","doi-asserted-by":"publisher","first-page":"8","DOI":"10.2174\/157339909787314149","article-title":"Diabetic retinopathy and angiogenesis.","volume":"5","author":"Crawford","year":"2009","journal-title":"Curr. Diabetes Rev."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.12.003","article-title":"Diabetic retinopathy is not present in non-diabetic older overweight\/obese African Americans.","volume":"126","author":"Davidson","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-015-0176-y","article-title":"Matrix metalloproteinases in the mouse retina: a comparative study of expression patterns and MMP antibodies.","volume":"15","author":"De Groef","year":"2015","journal-title":"BMC Ophthalmol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4103\/0974-9233.154389","article-title":"Novel pharmacotherapies in diabetic retinopathy.","volume":"22","author":"Dedania","year":"2015","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/srep37819","article-title":"Purslane (Portulaca oleracea) seed consumption and aerobic training improves biomarkers associated with atherosclerosis in women with type 2 diabetes (T2D).","volume":"6","author":"Dehghan","year":"2016","journal-title":"Sci. Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1016\/j.ajpath.2016.01.023","article-title":"Adeno-associated virus overexpression of angiotensin-converting enzyme-2 reverses diabetic retinopathy in type 1 diabetes in mice.","volume":"186","author":"Dominguez","year":"2016","journal-title":"Am. J. Pathol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1007\/s00417-014-2651-1","article-title":"Association of monocyte chemoattractant protein-1 (MCP-1)2518A\/G polymorphism with proliferative diabetic retinopathy in northern Chinese type 2 diabetes.","volume":"252","author":"Dong","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.oret.2018.01.010","article-title":"The systemic safety of ranibizumab in patients 85 years and older with neovascular age-related macular degeneration.","volume":"2","author":"Dugel","year":"2018","journal-title":"Ophthalmol. Retina"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.3109\/02713689508998529","article-title":"Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy.","volume":"14","author":"Elner","year":"1995","journal-title":"Curr. Eye Res."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011234.pub2","article-title":"Laser photocoagulation for proliferative diabetic retinopathy.","volume":"24","author":"Evans","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9570.1000298","article-title":"Modes of retinal cell death in diabetic retinopathy.","volume":"4","author":"Feenstra","year":"2013","journal-title":"J. Clin. Exp. Ophthalmol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1056\/nejm199908263410907","article-title":"Treatment of diabetic retinopathy.","volume":"341","author":"Ferris","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.tibs.2008.01.003","article-title":"LSD1: oxidative chemistry for multifaceted functions in chromatin regulation.","volume":"33","author":"Forneris","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0002-9394(02)01323-5","article-title":"Angiotensin II and vascular endothelial growth factor in the vitreous fluid of patients with diabetic macular edema and other retinal disorders.","volume":"133","author":"Funatsu","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/690243","article-title":"NLRP3 inflammasome: activation and regulation in age-related macular degeneration.","volume":"2015","author":"Gao","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B44","doi-asserted-by":"publisher","first-page":"637","DOI":"10.5301\/ejo.2010.6212","article-title":"A 5-year follow-up of antioxidant supplementation in type 2 diabetic retinopathy.","volume":"21","author":"Garcia-Medina","year":"2011","journal-title":"Eur. J. Ophthalmol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"6608","DOI":"10.1093\/nar\/gkn666","article-title":"Epstein-barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway.","volume":"36","author":"Gatto","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/labinvest.3700251","article-title":"Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier.","volume":"85","author":"Giebel","year":"2005","journal-title":"Lab. Invest."},{"key":"B47","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/sj.eye.6700702","article-title":"Hyperhomocysteinemia in patients with diabetes mellitus with and without diabetic retinopathy.","volume":"18","author":"Goldstein","year":"2004","journal-title":"Eye"},{"key":"B48","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/ajcn\/82.2.335","article-title":"A proinflammatory state is associated with hyperhomocysteinemia in the elderly.","volume":"82","author":"Gori","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"B49","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1001\/jamaophthalmol.2015.5079","article-title":"A novel treatment for proliferative diabetic retinopathy: anti-vascular endothelial growth factor therapy.","volume":"134","author":"Gross","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1007\/s13346-017-0429","article-title":"The environmental pollutant, polychlorinated biphenyls, and cardiovascular disease: a potential target for antioxidant nanotherapeutics.","volume":"8","author":"Gupta","year":"2017","journal-title":"Drug Deliv. Transl. Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/1753-0407.12378","article-title":"Epidemiology of microvascular complications of diabetes in South Asians and comparison with other ethnicities.","volume":"8","author":"Gupta","year":"2016","journal-title":"J. Diabetes"},{"key":"B52","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.plefa.2005.02.004","article-title":"New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy.","volume":"72","author":"Hardy","year":"2005","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"B53","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1055\/s-0043-113452","article-title":"Mortality and its causes in a german cohort with diabetes mellitus type 1 after 20 years of follow-up: the JEVIN trial.","volume":"126","author":"Heller","year":"2017","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"B54","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/aos.13638","article-title":"Diabetic macular oedema treated with intravitreal anti-vascular endothelial growth factor - 2-4 years follow-up of visual acuity and retinal thickness in 566 patients following Danish national guidelines.","volume":"96","author":"Hodzic-Hadzibegovic","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7839101","article-title":"Macrovascular complications in patients with diabetes and prediabetes.","volume":"2017","author":"Huang","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021411","article-title":"Blockade of VEGFR1 and 2 suppresses pathological angiogenesis and vascular leakage in the eye.","volume":"6","author":"Huang","year":"2011","journal-title":"PLoS One"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1001\/jamaophthalmol.2016.4272","article-title":"Visualization of 3 distinct retinal plexuses by projection-resolved optical coherence tomography angiography in diabetic retinopathy.","volume":"134","author":"Hwang","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.ophtha.2014.08.048","article-title":"Long-term effects of therapy with ranibizumab on diabetic retinopathy severity and baseline risk factors for worsening retinopathy.","volume":"122","author":"Ip","year":"2015","journal-title":"Ophthalmology"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6542689","article-title":"The association of a genetic variant in SCAF8-CNKSR3 with diabetic kidney disease and diabetic retinopathy in a Chinese population.","volume":"2017","author":"Jin","year":"2017","journal-title":"J. Diabetes Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1056\/nejm199912163412507","article-title":"Infections in patients with diabetes mellitus.","volume":"341","author":"Joshi","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/s0002-9440(10)63952-1","article-title":"Leukocyte-mediated endothelial cell injury and death in the diabetic retina.","volume":"158","author":"Joussen","year":"2001","journal-title":"Am. J. Pathol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1096\/fj.03-1476fje","article-title":"A central role for inflammation in the pathogenesis of diabetic retinopathy.","volume":"18","author":"Joussen","year":"2004","journal-title":"FASEB J."},{"key":"B63","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1096\/fj.02-0157fje","article-title":"Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes.","volume":"17","author":"Joussen","year":"2003","journal-title":"FASEB J."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000007671","article-title":"Effects of fenofibrate on inflammatory cytokines in diabetic retinopathy patients.","volume":"96","author":"Ju","year":"2017","journal-title":"Medicine"},{"key":"B65","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.diabet.2009.11.004","article-title":"Exercise ameliorates serum MMP-9 and TIMP-2 levels in patients with type 2 diabetes.","volume":"36","author":"Kadoglou","year":"2010","journal-title":"Diabetes Metab."},{"key":"B66","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nature09830","article-title":"DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.","volume":"471","author":"Kaneko","year":"2011","journal-title":"Nature"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/213130","article-title":"Inflammation and pharmacological treatment in diabetic retinopathy.","volume":"2013","author":"Kastelan","year":"2013","journal-title":"Mediators Inflamm."},{"key":"B68","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrneph.2014.116","article-title":"Diabetic nephropathy\u2013emerging epigenetic mechanisms.","volume":"10","author":"Kato","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/95103","article-title":"Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy.","volume":"2007","author":"Kern","year":"2007","journal-title":"Exp. Diabetes Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","article-title":"Matrix metalloproteinases: regulators of the tumor microenvironment.","volume":"141","author":"Kessenbrock","year":"2010","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"178","DOI":"10.4103\/0974-9233.95245","article-title":"Screening and public health strategies for diabetic retinopathy in the Eastern mediterranean region.","volume":"19","author":"Khandekar","year":"2012","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/978-1-4614-3209-8_98","article-title":"Antioxidant therapy for retinal disease.","volume":"801","author":"Kiang","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"B73","first-page":"1103","article-title":"Evidence that glucose increases monocyte binding to human aortic endothelial cells.","volume":"43","author":"Kim","year":"1994","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B74","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1159\/000452789","article-title":"A case of proliferative diabetic retinopathy with HIV infection in which HAART possibly influenced the prognosis of visual function.","volume":"7","author":"Kitagaki","year":"2016","journal-title":"Case Rep. Ophthalmol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1016\/j.ophtha.2008.08.023","article-title":"The wisconsin epidemiologic study of diabetic retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes.","volume":"115","author":"Klein","year":"2008","journal-title":"Ophthalmology"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0786-7","article-title":"Fenofibrate and diabetic retinopathy.","volume":"16","author":"Knickelbein","year":"2016","journal-title":"Curr. Diab. Rep."},{"key":"B77","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00421-015-3244-3","article-title":"Avenanthramide supplementation attenuates eccentric exercise-inflicted blood inflammatory markers in women.","volume":"116","author":"Koenig","year":"2016","journal-title":"Eur. J. Appl. Physiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.1167\/iovs.10-6879","article-title":"MicroRNAs in early diabetic retinopathy in streptozotocin-induced diabetic rats.","volume":"52","author":"Kovacs","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.visres.2017.02.011","article-title":"Diabetic retinopathy, metabolic memory and epigenetic modifications.","volume":"139","author":"Kowluru","year":"2017","journal-title":"Vis. Res."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/43603","article-title":"Oxidative stress and diabetic retinopathy.","volume":"2007","author":"Kowluru","year":"2007","journal-title":"Exp. Diabetes Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1080\/1071576021000006572","article-title":"Diabetes-induced activation of caspase-3 in retina: effect of antioxidant therapy.","volume":"36","author":"Kowluru","year":"2002","journal-title":"Free Radic. Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.2337\/db11-0816","article-title":"Abrogation of MMP-9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage.","volume":"60","author":"Kowluru","year":"2011","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B83","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.1167\/iovs.04-0633","article-title":"Role of interleukin-1beta in the development of retinopathy in rats: effect of antioxidants.","volume":"45","author":"Kowluru","year":"","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1136\/bjo.2003.038133","article-title":"Role of interleukin-1beta in the pathogenesis of diabetic retinopathy.","volume":"88","author":"Kowluru","year":"","journal-title":"Br. J. Ophthalmol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1007\/s00417-017-3594-0","article-title":"Role of oxidative stress in epigenetic modification of MMP-9 promoter in the development of diabetic retinopathy.","volume":"255","author":"Kowluru","year":"2017","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"8665","DOI":"10.1167\/iovs.10-6768","article-title":"Beyond AREDS: is there a place for antioxidant therapy in the prevention\/treatment of eye disease?","volume":"52","author":"Kowluru","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1517\/13543784.2012.681043","article-title":"Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9.","volume":"21","author":"Kowluru","year":"2012","journal-title":"Expert Opin. Investig. Drugs"},{"key":"B88","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1159\/000481711","article-title":"Visual outcomes based on early response to anti-vascular endothelial growth factor treatment for diabetic macular edema.","volume":"239","author":"Koyanagi","year":"2018","journal-title":"Ophthalmologica"},{"key":"B89","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1159\/000330051","article-title":"Green tea prevents hyperglycemia-induced retinal oxidative stress and inflammation in streptozotocin-induced diabetic rats.","volume":"47","author":"Kumar","year":"2012","journal-title":"Ophthalmic Res."},{"key":"B90","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1001\/jamaophthalmol.2013.5024","article-title":"Challenges in elucidating the genetics of diabetic retinopathy.","volume":"132","author":"Kuo","year":"2014","journal-title":"JAMA Ophthalmol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.ymthe.2005.04.022","article-title":"Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys.","volume":"12","author":"Lai","year":"2005","journal-title":"Mol. Ther."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.2337\/dc15-2171","article-title":"Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 1990 to 2010.","volume":"39","author":"Leasher","year":"2016","journal-title":"Diabetes Care"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-015-0026-2","article-title":"Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss.","volume":"2","author":"Lee","year":"2015","journal-title":"Eye Vis."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20160572","article-title":"Effects of miRNA-200b on the development of diabetic retinopathy by targeting VEGFA gene.","volume":"37","author":"Li","year":"2017","journal-title":"Biosci. Rep."},{"key":"B95","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s11010-017-3256-x","article-title":"Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation.","volume":"445","author":"Liu","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"B96","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bbi.2016.01.018","article-title":"Euflammation attenuates peripheral inflammation-induced neuroinflammation and mitigates immune-to-brain signaling.","volume":"54","author":"Liu","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"B97","doi-asserted-by":"publisher","first-page":"23457","DOI":"10.1074\/jbc.M110.136168","article-title":"Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions.","volume":"285","author":"Long","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/61038","article-title":"The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient.","volume":"2007","author":"Lorenzi","year":"2007","journal-title":"Exp. Diabetes Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1111\/aos.13427","article-title":"NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.","volume":"95","author":"Loukovaara","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"B100","first-page":"637","article-title":"Multiplex bead analysis of vitreous and serum concentrations of inflammatory and proangiogenic factors in diabetic patients.","volume":"14","author":"Maier","year":"2008","journal-title":"Mol. Vis."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.7754\/Clin.Lab.2013.130622","article-title":"VEGF levels in diagnosis of vasculitic neuropathy.","volume":"60","author":"Manolov","year":"2014","journal-title":"Clin. Lab."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1038\/eye.2017.95","article-title":"Black patients sustain vision loss while White and South Asian patients gain vision following delamination or segmentation surgery for tractional complications associated with proliferative diabetic retinopathy.","volume":"31","author":"Mastropasqua","year":"2017","journal-title":"Eye"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030.","volume":"3","author":"Mathers","year":"2006","journal-title":"PLoS Med."},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1186\/s12992-015-0109-9","article-title":"Reducing the global burden of type 2 diabetes by improving the quality of staple foods: the global nutrition and epidemiologic transition initiative.","volume":"11","author":"Mattei","year":"2015","journal-title":"Glob. Health"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.2337\/db10-1557","article-title":"MicroRNA-200b regulates vascular endothelial growth factor-mediated alterations in diabetic retinopathy.","volume":"60","author":"McArthur","year":"2011","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B106","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s00702-017-1732-9","article-title":"The IL-1beta phenomena in neuroinflammatory diseases.","volume":"125","author":"Mendiola","year":"2017","journal-title":"J. Neural Transm."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.2147\/dddt.s72797","article-title":"Choosing preclinical study models of diabetic retinopathy: key problems for consideration.","volume":"8","author":"Mi","year":"2014","journal-title":"Drug Des. Devel. Ther."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-017-0332-8","article-title":"Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities.","volume":"9","author":"Micevic","year":"2017","journal-title":"Clin. Epigenetics"},{"key":"B109","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000459687","article-title":"Emerging insights into pathogenesis.","volume":"60","author":"Midena","year":"2017","journal-title":"Dev. Ophthalmol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"5748","DOI":"10.1167\/iovs.16-19759","article-title":"The role of dna methylation in the metabolic memory phenomenon associated with the continued progression of diabetic retinopathy.","volume":"57","author":"Mishra","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1016\/s0002-9440(10)63728-5","article-title":"Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes.","volume":"164","author":"Miyahara","year":"2004","journal-title":"Am. J. Pathol."},{"key":"B112","first-page":"2190","article-title":"In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats.","volume":"39","author":"Miyamoto","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B113","doi-asserted-by":"publisher","first-page":"10836","DOI":"10.1073\/pnas.96.19.10836","article-title":"Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition.","volume":"96","author":"Miyamoto","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1002\/jcp.22822","article-title":"Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9.","volume":"227","author":"Mohammad","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1172\/jci656","article-title":"Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion.","volume":"101","author":"Morigi","year":"1998","journal-title":"J. Clin. Invest."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.2337\/db11-1367","article-title":"Protein kinase cbeta phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo.","volume":"61","author":"Murakami","year":"2012","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1167\/iovs.12-10921","article-title":"MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model.","volume":"54","author":"Murray","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2337\/dc13-2112","article-title":"The diabetes control and complications trial\/epidemiology of diabetes interventions and complications study at 30 years: overview.","volume":"37","author":"Nathan","year":"2014","journal-title":"Diabetes Care"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1001\/jama.2015.9536","article-title":"Diabetes: advances in diagnosis and treatment.","volume":"314","author":"Nathan","year":"2015","journal-title":"JAMA"},{"key":"B120","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.2337\/db06-1694","article-title":"Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes.","volume":"56","author":"Navaratna","year":"2007","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B121","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.visres.2017.05.006","article-title":"OCT angiography and visible-light OCT in diabetic retinopathy.","volume":"139","author":"Nesper","year":"2017","journal-title":"Vis. Res."},{"key":"B122","doi-asserted-by":"publisher","first-page":"373","DOI":"10.2174\/138920111794480642","article-title":"Aldose reductase \/ polyol inhibitors for diabetic retinopathy.","volume":"12","author":"Obrosova","year":"2011","journal-title":"Curr. Pharm. Biotechnol."},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/108328","article-title":"Neural degeneration in the retina of the streptozotocin-induced type 1 diabetes model.","volume":"2011","author":"Ozawa","year":"2011","journal-title":"Exp. Diabetes Res."},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057915","article-title":"Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice.","volume":"8","author":"Pang","year":"2013","journal-title":"PLoS One"},{"key":"B125","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nri1418","article-title":"Matrix metalloproteinases as modulators of inflammation and innate immunity.","volume":"4","author":"Parks","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-015-0677-3","article-title":"Epigenetics and cardiovascular disease in diabetes.","volume":"15","author":"Pasquier","year":"2015","journal-title":"Curr. Diab. Rep."},{"key":"B127","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1136\/bjo.2004.049940","article-title":"Angiopoietin concentrations in diabetic retinopathy.","volume":"89","author":"Patel","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"33988","DOI":"10.1074\/jbc.M006493200","article-title":"Cysteine array matrix metalloproteinase (CA-MMP)\/MMP-23 is a type II transmembrane matrix metalloproteinase regulated by a single cleavage for both secretion and activation.","volume":"275","author":"Pei","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B129","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3109\/09286586.2015.1119287","article-title":"Risk factors for proliferative diabetic retinopathy in African Americans with type 2 diabetes.","volume":"23","author":"Penman","year":"2016","journal-title":"Ophthalmic Epidemiol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"192","DOI":"10.15761\/nfo.1000145","article-title":"Genetic and epigenetic modifications in the pathogenesis of diabetic retinopathy: a molecular link to regulate gene expression.","volume":"2","author":"Pradhan","year":"2016","journal-title":"New Front. Ophthalmol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/441143a","article-title":"Epigenetics: unfinished symphony.","volume":"441","author":"Qiu","year":"2006","journal-title":"Nature"},{"key":"B132","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4103\/0974-9233.92116","article-title":"Diabetic retinopathy and inflammation: novel therapeutic targets.","volume":"19","author":"Rangasamy","year":"2012","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108508","article-title":"Chemokine mediated monocyte trafficking into the retina: role of inflammation in alteration of the blood-retinal barrier in diabetic retinopathy.","volume":"9","author":"Rangasamy","year":"2014","journal-title":"PLoS One"},{"key":"B134","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1167\/iovs.10-6386","article-title":"A potential role for angiopoietin 2 in the regulation of the blood-retinal barrier in diabetic retinopathy.","volume":"52","author":"Rangasamy","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B135","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00125-014-3462-y","article-title":"Epigenetic mechanisms in diabetic complications and metabolic memory.","volume":"58","author":"Reddy","year":"2015","journal-title":"Diabetologia"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-017-0617-x","article-title":"Injections frequency and health care costs in patients treated with aflibercept compared to ranibizumab: new real-life evidence from Switzerland.","volume":"17","author":"Reich","year":"2017","journal-title":"BMC Ophthalmol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: how are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.2147\/opth.s14521","article-title":"Prospective comparison of two methods of screening for diabetic retinopathy by nonmydriatic fundus camera.","volume":"4","author":"Romero-Aroca","year":"2010","journal-title":"Clin. Ophthalmol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"603","DOI":"10.2217\/epi.13.61","article-title":"Effect of exercise on DNA methylation and metabolism in human adipose tissue and skeletal muscle.","volume":"5","author":"Ronn","year":"2013","journal-title":"Epigenomics"},{"key":"B140","doi-asserted-by":"publisher","first-page":"4327","DOI":"10.1167\/iovs.09-4690","article-title":"Exogenous SOD mimetic tempol ameliorates the early retinal changes reestablishing the redox status in diabetic hypertensive rats.","volume":"51","author":"Rosales","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/801269","article-title":"Molecular mechanisms of diabetic retinopathy, general preventive strategies, and novel therapeutic targets.","volume":"2014","author":"Safi","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1136\/bjo.84.10.1091","article-title":"Matrix metalloproteinases and their natural inhibitors in fibrovascular membranes of proliferative diabetic retinopathy.","volume":"84","author":"Salzmann","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/eye.1988.106","article-title":"Evolution of geographic atrophy of the retinal pigment epithelium.","author":"Sarks","year":"1988","journal-title":"Eye"},{"key":"B144","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1006\/exer.1993.1119","article-title":"Aldose reductase in human retinal pigment epithelial cells.","volume":"57","author":"Sato","year":"1993","journal-title":"Exp. Eye Res."},{"key":"B145","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4103\/0974-9233.120007","article-title":"Epidemiological issues in diabetic retinopathy.","volume":"20","author":"Scanlon","year":"2013","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3109\/10715769209079515","article-title":"Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review).","volume":"17","author":"Schreck","year":"1992","journal-title":"Free Radic. Res. Commun."},{"key":"B147","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1126\/science.1184003","article-title":"The NLRP3 inflammasome: a sensor for metabolic danger?","volume":"327","author":"Schroder","year":"2010","journal-title":"Science"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/431985","article-title":"Anti-inflammatory nutrition as a pharmacological approach to treat obesity.","volume":"2011","author":"Sears","year":"2011","journal-title":"J. Obes."},{"key":"B149","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/01.icu.0000161227.21797.3d","article-title":"The impact of diabetic retinopathy on health-related quality of life.","volume":"16","author":"Sharma","year":"2005","journal-title":"Curr. Opin. Ophthalmol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/ni.1828","article-title":"Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21.","volume":"11","author":"Sheedy","year":"2010","journal-title":"Nat. Immunol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nrg2218","article-title":"Histone lysine demethylases: emerging roles in development, physiology and disease.","volume":"8","author":"Shi","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"B152","doi-asserted-by":"publisher","first-page":"362","DOI":"10.4103\/2008-322x.143378","article-title":"Diabetes and retinal vascular dysfunction.","volume":"9","author":"Shin","year":"2014","journal-title":"J. Ophthalmic Vis. Res."},{"key":"B153","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1167\/iovs.12-11103","article-title":"The effects of macular ischemia on visual acuity in diabetic retinopathy.","volume":"54","author":"Sim","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2174\/157339906775473671","article-title":"Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy.","volume":"2","author":"Simo","year":"2006","journal-title":"Curr. Diabetes Rev."},{"key":"B155","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.cbi.2014.12.028","article-title":"Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls.","volume":"234","author":"Singh","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"B156","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.cbi.2017.01.012","article-title":"Aldose reductase (AKR1B) deficiency promotes phagocytosis in bone marrow derived mouse macrophages.","volume":"265","author":"Singh","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"B157","doi-asserted-by":"publisher","first-page":"696","DOI":"10.18240\/ijo.2017.05.06","article-title":"Homocysteine mediates transcriptional changes of the inflammatory pathway signature genes in human retinal pigment epithelial cells.","volume":"10","author":"Singh","year":"","journal-title":"Int. J. Ophthalmol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.mehy.2017.06.012","article-title":"Hyperhomocysteinemia and age-related macular degeneration: role of inflammatory mediators and pyroptosis; a proposal.","volume":"105","author":"Singh","year":"","journal-title":"Med. Hypotheses"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.18240\/ijo.2017.08.20","article-title":"Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology.","volume":"10","author":"Singh","year":"","journal-title":"Int. J. Ophthalmol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/dmrr.568","article-title":"Inflammation and the etiology of type 2 diabetes.","volume":"22","author":"Sjoholm","year":"2006","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1210\/en.2011-1759","article-title":"Minireview: epigenetics of obesity and diabetes in humans.","volume":"153","author":"Slomko","year":"2012","journal-title":"Endocrinology"},{"key":"B162","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0014-4800(03)00035-2","article-title":"The role of advanced glycation in the pathogenesis of diabetic retinopathy.","volume":"75","author":"Stitt","year":"2003","journal-title":"Exp. Mol. Pathol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"4925","DOI":"10.3748\/wjg.v18.i35.4925","article-title":"Endothelial precursor cells promote angiogenesis in hepatocellular carcinoma.","volume":"18","author":"Sun","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"B164","first-page":"V","article-title":"Is Diabetes becoming the biggest epidemic of the Twenty-first Century?","volume":"1","author":"Tabish","year":"2007","journal-title":"Int. J. Health Sci."},{"key":"B165","doi-asserted-by":"publisher","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses.","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B166","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1097\/iae.0000000000000849","article-title":"Enlargement Of foveal avascular zone in diabetic eyes evaluated by en face optical coherence tomography angiography.","volume":"35","author":"Takase","year":"2015","journal-title":"Retina"},{"key":"B167","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.preteyeres.2011.05.002","article-title":"Inflammation in diabetic retinopathy.","volume":"30","author":"Tang","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"B168","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1167\/iovs.04-1120","article-title":"Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice.","volume":"46","author":"Tanito","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.cell.2012.03.036","article-title":"DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.","volume":"149","author":"Tarallo","year":"2012","journal-title":"Cell"},{"key":"B170","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.thromres.2004.08.023","article-title":"Effects of age, gender, ethnicity, diurnal variation and exercise on circulating levels of matrix metalloproteinases (MMP)-2 and -9, and their inhibitors, tissue inhibitors of matrix metalloproteinases (TIMP)-1 and -2.","volume":"115","author":"Tayebjee","year":"2005","journal-title":"Thromb. Res."},{"key":"B171","doi-asserted-by":"publisher","first-page":"4881","DOI":"10.1167\/iovs.12-9732","article-title":"Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy.","volume":"53","author":"Tewari","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B172","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1038\/eye.2014.137","article-title":"High intravitreal TGF-beta1 and MMP-9 levels in eyes with retinal vein occlusion.","volume":"28","author":"Tuuminen","year":"2014","journal-title":"Eye"},{"key":"B173","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.visres.2017.06.015","article-title":"Novel therapeutic targets in diabetic macular edema: beyond VEGF.","volume":"139","author":"Urias","year":"2017","journal-title":"Vis. Res."},{"key":"B174","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1001\/jama.293.12.1509","article-title":"Inhibitors of ocular neovascularization: promises and potential problems.","volume":"293","author":"van Wijngaarden","year":"2005","journal-title":"JAMA"},{"key":"B175","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1001\/jamaophthalmol.2016.1261","article-title":"Prevalence and causes of visual impairment and blindness in chinese american adults: the chinese american eye study.","volume":"134","author":"Varma","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3801570","article-title":"Ocular complications of diabetes and therapeutic approaches.","volume":"2016","author":"Vieira-Potter","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"B177","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2174\/1872214810666160219163314","article-title":"Inflammasome as a new therapeutic target for diabetic complications.","volume":"10","author":"Volpe","year":"2016","journal-title":"Recent Pat. Endocr. Metab. Immune Drug Discov."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1172\/jci25102","article-title":"Inflammation, stress, and diabetes.","volume":"115","author":"Wellen","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/724648","article-title":"Inflammation in retinal disease.","volume":"2013","author":"Whitcup","year":"2013","journal-title":"Int. J. Inflam."},{"key":"B180","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/s0161-6420(03)00475-5","article-title":"Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales.","volume":"110","author":"Wilkinson","year":"2003","journal-title":"Ophthalmology"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.12","article-title":"Diabetic retinopathy.","volume":"2","author":"Wong","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001986","article-title":"Efficacy and safety of intravitreal aflibercept and ranibizumab in asian patients with neovascular age-related macular degeneration: subgroup analyses from the view trials.","author":"Wong","year":"2017","journal-title":"Retina"},{"key":"B183","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000331992","article-title":"Altered microRNA expression profiles in retinas with diabetic retinopathy.","volume":"47","author":"Wu","year":"2012","journal-title":"Ophthalmic Res."},{"key":"B184","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1089\/rej.2015.1738","article-title":"Protective role of sodium-glucose co-transporter 2 inhibition against vascular complications in diabetes.","volume":"19","author":"Yamagishi","year":"2016","journal-title":"Rejuvenation Res."},{"key":"B185","doi-asserted-by":"publisher","first-page":"462","DOI":"10.12659\/AJCR.909708","article-title":"Recovery from diabetic macular edema in a diabetic patient after minimal dose of a Sodium Glucose co-transporter 2 inhibitor.","volume":"19","author":"Yoshizumi","year":"2018","journal-title":"Am. J. Case Rep."},{"key":"B186","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S1056-8727(01)00155-6","article-title":"Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy.","volume":"15","author":"Yuuki","year":"2001","journal-title":"J. Diabetes Complications"},{"key":"B187","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000357824","article-title":"Epigenetic mechanisms in the pathogenesis of diabetic retinopathy.","volume":"232","author":"Zeng","year":"2014","journal-title":"Ophthalmologica"},{"key":"B188","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.diabres.2011.12.006","article-title":"Metabolic memory: mechanisms and implications for diabetic retinopathy.","volume":"96","author":"Zhang","year":"2012","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B189","doi-asserted-by":"publisher","first-page":"96","DOI":"10.4103\/0975-3583.83035","article-title":"Inflammation and diabetic retinal microvascular complications.","volume":"2","author":"Zhang","year":"2011","journal-title":"J. Cardiovasc. Dis. Res."},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-017-0167-1","article-title":"Diabetic retinopathy: reversibility of epigenetic modifications and new therapeutic targets.","volume":"7","author":"Zhang","year":"2017","journal-title":"Cell Biosci."},{"key":"B191","doi-asserted-by":"publisher","first-page":"428","DOI":"10.4103\/0301-4738.100542","article-title":"The worldwide epidemic of diabetic retinopathy.","volume":"60","author":"Zheng","year":"2012","journal-title":"Indian J. Ophthalmol."},{"key":"B192","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/jcb.22644","article-title":"Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon.","volume":"110","author":"Zhong","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"B193","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.2337\/db10-0133","article-title":"Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy.","volume":"60","author":"Zhong","year":"2011","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B194","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1167\/iovs.12-10854","article-title":"Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: role of histone methylation.","volume":"54","author":"Zhong","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01268\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:50:59Z","timestamp":1536108659000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01268\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":194,"alternative-id":["10.3389\/fphys.2018.01268"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.01268","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,5]]},"article-number":"1268"}}