{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:22:47Z","timestamp":1778588567080,"version":"3.51.4"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.01433","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T03:55:54Z","timestamp":1539143754000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Intra-Renal Angiotensin Levels Are Increased in High-Fructose Fed Rats in the Extracorporeal Renal Perfusion Model"],"prefix":"10.3389","volume":"9","author":[{"given":"Rodrigo","family":"Yokota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Aparecida","family":"Ronchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Barrinha","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaira Palomino","family":"Jara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo Mattar","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula de Oliveira","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Fiorino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Farah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilberto Robson Falc\u00e3o do","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manass\u00e9s C.","family":"Fonteles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce Elena","family":"Casarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/sj.ki.5000134","article-title":"Escherichia coli lipopolysaccharide inhibits renin activity in human mesangial cells.","volume":"69","author":"Almeida","year":"2006","journal-title":"Kidney Int."},{"key":"B2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00394-014-0826-5","article-title":"Early developmental exposure to high fructose intake in rats with NaCl stimulation causes cardiac damage.","volume":"55","author":"Araujo","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"B3","first-page":"S149","article-title":"Actions of angiotensin II on the renal microvasculature.","volume":"10","author":"Arendshorst","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1263S","DOI":"10.3945\/jn.108.098020","article-title":"Dietary fructose and metabolic syndrome and diabetes.","volume":"139","author":"Bantle","year":"2009","journal-title":"J. Nutr."},{"key":"B5","doi-asserted-by":"crossref","DOI":"10.1186\/1743-7075-2-5","article-title":"Fructose, insulin resistance, and metabolic dyslipidemia.","volume":"2","author":"Basciano","year":"2005","journal-title":"Nutr. Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.metabol.2005.04.004","article-title":"Hepatic adaptations to sucrose and fructose.","volume":"54","author":"Bizeau","year":"2005","journal-title":"Metabolism"},{"key":"B7","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/S0021-9258(19)77136-1","article-title":"Gluconeogenesis in the isolated perfused rat kidney.","volume":"245","author":"Bowman","year":"1970","journal-title":"J. Biol. Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.7326\/0003-4819-140-3-200402030-00007","article-title":"The metabolic syndrome and chronic kidney disease in U.S. adults.","volume":"140","author":"Chen","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180712","article-title":"Renin inhibition improves metabolic syndrome, and reduces angiotensin II levels and oxidative stress in visceral fat tissues in fructose-fed rats.","volume":"12","author":"Chou","year":"2017","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.regpep.2006.11.023","article-title":"Relationship between renal and cardiovascular changes in a murine model of glucose intolerance.","volume":"139","author":"Cunha","year":"2007","journal-title":"Regul. Pept."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.autneu.2008.10.013","article-title":"Diabetes and cardiovascular autonomic dysfunction: application of animal models.","volume":"145","author":"De Angelis","year":"2009","journal-title":"Auton. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"R950","DOI":"10.1152\/ajpregu.00450.2011","article-title":"Sympathetic overactivity precedes metabolic dysfunction in a fructose model of glucose intolerance in mice.","volume":"302","author":"De Angelis","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1093\/ajcn\/76.5.911","article-title":"Fructose, weight gain, and the insulin resistance syndrome.","volume":"76","author":"Elliott","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"B15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.autneu.2006.05.006","article-title":"Nocturnal hypertension in mice consuming a high fructose diet.","volume":"130","author":"Farah","year":"2006","journal-title":"Auton. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"H1083","DOI":"10.1152\/ajpheart.00106.2006","article-title":"Genetic and dietary interactions: role of angiotensin AT1a receptors in response to a high-fructose diet.","volume":"293","author":"Farah","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s11906-010-0097-3","article-title":"The role of high-fructose corn syrup in metabolic syndrome and hypertension.","volume":"12","author":"Ferder","year":"2010","journal-title":"Curr. Hypertens. Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1161\/CIRCULATIONAHA.108.767202","article-title":"Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans.","volume":"117","author":"Fisher","year":"2008","journal-title":"Circulation"},{"key":"B19","first-page":"F235","article-title":"Support of kidney function by long-chain fatty acids derived from renal tissue.","volume":"244","author":"Fonteles","year":"1983","journal-title":"Am. J. Physiol."},{"key":"B20","first-page":"F191","article-title":"Natriuretic and kaliuretic activities of guanylin and uroguanylin in the isolated perfused rat kidney.","volume":"275","author":"Fonteles","year":"1998","journal-title":"Am. J. Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1056\/NEJMoa022207","article-title":"A randomized trial of a low-carbohydrate diet for obesity.","volume":"348","author":"Foster","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1097\/00004872-200018060-00006","article-title":"The tissue renin-angiotensin system in rats with fructose-induced hypertension: overexpression of type 1 angiotensin II receptor in adipose tissue.","volume":"18","author":"Giacchetti","year":"2000","journal-title":"J. Hypertens."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1097\/01.ASN.0000015762.92814.85","article-title":"Association of the insulin resistance syndrome and microalbuminuria among nondiabetic native Americans. The Inter-Tribal Heart Project.","volume":"13","author":"Hoehner","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"B24","first-page":"121","article-title":"Renal hemodynamic and tubular effects of angiotensins II and III.","volume":"34","author":"Huang","year":"1991","journal-title":"Chin. J. Physiol."},{"key":"B25","first-page":"195","article-title":"Insulin resistance and impaired endothelium-dependent renal vasodilatation in fructose-fed hypertensive rats.","volume":"103","author":"Kamata","year":"1999","journal-title":"Res. Commun. Mol. Pathol. Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1097\/HJH.0000000000000551","article-title":"The mechanisms underlying fructose-induced hypertension: a review.","volume":"33","author":"Klein","year":"2015","journal-title":"J. Hypertens."},{"key":"B27","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1600-0773.1992.tb00449.x","article-title":"The effects of Escherichia coli heat-stable enterotoxin in renal sodium tubular transport.","volume":"70","author":"Lima","year":"1992","journal-title":"Pharmacol. Toxicol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"731","DOI":"10.3892\/br.2015.498","article-title":"A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats.","volume":"3","author":"Madani","year":"2015","journal-title":"Biomed. Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1161\/CIRCULATIONAHA.109.876185","article-title":"Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk.","volume":"121","author":"Malik","year":"","journal-title":"Circulation"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.2337\/dc10-1079","article-title":"Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis.","volume":"33","author":"Malik","year":"","journal-title":"Diabetes Care"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/895961","article-title":"Fructose-drinking water induced nonalcoholic fatty liver disease and ultrastructural alteration of hepatocyte mitochondria in male wistar rat.","volume":"2015","author":"Mamikutty","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"B32","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1113\/jphysiol.1978.sp012396","article-title":"Free water clearance curves during saline, mannitol, glucose and urea diuresis in the rat.","volume":"280","author":"Martinez-Maldonado","year":"1978","journal-title":"J. Physiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.1440-1681.2011.05636.x","article-title":"Timing of fructose intake: an important regulator of adiposity.","volume":"39","author":"Morris","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1161\/HYPERTENSIONAHA.110.168708","article-title":"Role of SRC family kinase in extracellular renal cyclic guanosine 3\u2019,5\u2019-monophosphate- and pressure-induced natriuresis.","volume":"58","author":"Nascimento","year":"2011","journal-title":"Hypertension"},{"key":"B35","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1161\/01.HYP.0000024267.71656.0D","article-title":"Decrease in renal medullary endothelial nitric oxide synthase of fructose-fed, salt-sensitive hypertensive rats.","volume":"40","author":"Nishimoto","year":"2002","journal-title":"Hypertension"},{"key":"B36","first-page":"66","article-title":"Evaluation of the chronic complications of diabetes in a high fructose diet in rats.","volume":"46","author":"Patel","year":"2009","journal-title":"Indian J. Biochem. Biophys."},{"key":"B37","first-page":"S45","article-title":"Rilmenidine normalizes fructose-induced insulin resistance and hypertension in rats.","volume":"16","author":"Penicaud","year":"1998","journal-title":"J. Hypertens. Suppl."},{"key":"B38","doi-asserted-by":"publisher","first-page":"H1219","DOI":"10.1152\/ajpheart.00796.2011","article-title":"The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome.","volume":"302","author":"Putnam","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B39","first-page":"E305","article-title":"Inhibition of insulin-mediated glucose uptake in rat hindlimb by an alpha-adrenergic vascular effect.","volume":"268","author":"Rattigan","year":"1995","journal-title":"Am. J. Physiol."},{"key":"B40","first-page":"237","article-title":"High fructose consumption combined with low dietary magnesium intake may increase the incidence of the metabolic syndrome by inducing inflammation.","volume":"19","author":"Rayssiguier","year":"2006","journal-title":"Magnes. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3317\/jraas.2007.005","article-title":"Association of somatic and N-domain angiotensin-converting enzymes from Wistar rat tissue with renal dysfunction in diabetes mellitus.","volume":"8","author":"Ronchi","year":"2007","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"B42","doi-asserted-by":"publisher","first-page":"F496","DOI":"10.1152\/ajprenal.00121.2014","article-title":"Alternative pathways for angiotensin II production as an important determinant of kidney damage in endotoxemia.","volume":"311","author":"Rosa","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"S31","DOI":"10.1097\/00004872-199715011-00004","article-title":"Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructose-fed rat.","volume":"15","author":"Rosen","year":"1997","journal-title":"J. Hypertens. Suppl."},{"key":"B44","doi-asserted-by":"publisher","first-page":"F423","DOI":"10.1152\/ajprenal.00124.2006","article-title":"Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats.","volume":"292","author":"Sanchez-Lozada","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1161\/01.HYP.0000111136.86976.26","article-title":"Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance.","volume":"43","author":"Shinozaki","year":"2004","journal-title":"Hypertension"},{"key":"B46","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1254\/jjp.74.297","article-title":"Effect of an insulin sensitizer, pioglitazone, on hypertension in fructose-drinking rats.","volume":"74","author":"Suzuki","year":"1997","journal-title":"Jpn. J. Pharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s11010-008-0023-z","article-title":"Endothelin-1 modulates angiotensin II in the development of hypertension in fructose-fed rats.","volume":"325","author":"Tran","year":"","journal-title":"Mol. Cell. Biochem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s11010-009-0184-4","article-title":"The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension.","volume":"332","author":"Tran","year":"","journal-title":"Mol. Cell. Biochem."},{"key":"B49","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/nature05487","article-title":"Mechanisms linking obesity with cardiovascular disease.","volume":"444","author":"Van Gaal","year":"2006","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"crossref","first-page":"F86","DOI":"10.1152\/ajprenal.00121.2001","article-title":"Renal microvascular actions of angiotensin II fragments.","volume":"283","author":"van Rodijnen","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"F1039","DOI":"10.1152\/ajprenal.00371.2003","article-title":"High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells.","volume":"286","author":"Vidotti","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1172\/JCI103204","article-title":"The renal clearance of alkali-stable inulin.","volume":"34","author":"Walser","year":"1955","journal-title":"J. Clin. Invest."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1046\/j.1523-1755.2001.00999.x","article-title":"Angiotensin II enhances tubuloglomerular feedback via luminal AT(1) receptors on the macula densa.","volume":"60","author":"Wang","year":"2001","journal-title":"Kidney Int."},{"key":"B54","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/jdi.12309","article-title":"Association between sugar-sweetened beverages and type 2 diabetes: a meta-analysis.","volume":"6","author":"Wang","year":"2015","journal-title":"J. Diabetes Investig."},{"key":"B55","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.peptides.2012.03.025","article-title":"Divergent pathways for the angiotensin-(1-12) metabolism in the rat circulation and kidney.","volume":"35","author":"Westwood","year":"2012","journal-title":"Peptides"},{"key":"B56","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1161\/HYPERTENSIONAHA.116.08240","article-title":"Activation of renal (Pro)renin receptor contributes to high fructose-induced salt sensitivity.","volume":"69","author":"Xu","year":"2017","journal-title":"Hypertension"},{"key":"B57","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/414782a","article-title":"Global and societal implications of the diabetes epidemic.","volume":"414","author":"Zimmet","year":"2001","journal-title":"Nature"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01433\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T14:34:11Z","timestamp":1662215651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01433\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,10]]},"references-count":57,"alternative-id":["10.3389\/fphys.2018.01433"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.01433","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734297361.793553253","asserted-by":"object"}]},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,10]]},"article-number":"1433"}}