{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:28:47Z","timestamp":1791232127636,"version":"4.1.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.01564","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T12:46:47Z","timestamp":1542026807000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["The Effects of Physical Training on Quality of Life, Aerobic Capacity, and Cardiac Function in Older Patients With Heart Failure: A Meta-Analysis"],"prefix":"10.3389","volume":"9","author":[{"given":"Maamer","family":"Slimani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Ramirez-Campillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Paravlic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence D.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Luigi","family":"Bragazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Sellami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/S0735-1097(02)02342-2","article-title":"Selective low-level leg muscle training alleviates dyspnea in patients with heart failure","volume":"40","author":"Beniaminovitz","year":"2002","journal-title":"J. Am. Coll. Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1152\/japplphysiol.00793.2006","article-title":"Effect of endurance exercise training on the heart rate onset and heart rate recovery responses to submaximal exercise in animals susceptible to ventricular fibrillation","volume":"102","author":"Billman","year":"2007","journal-title":"J. Appl. Physiol"},{"key":"B3","volume-title":"Comprehensive Meta-Analysis, Version 2","author":"Borenstein","year":"2005"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1111\/j.1532-5415.2009.02499.x","article-title":"Endurance exercise training in older patients with heart failure: results from a randomized, controlled, single-blind trial","volume":"57","author":"Brubaker","year":"2009","journal-title":"J. Am. Geriatr. Soc"},{"key":"B5","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1519\/JSC.0b013e318207ed66","article-title":"Effects of strength, endurance, and concurrent training on aerobic power and dynamic neuromuscular economy in elderly men","volume":"25","author":"Cadore","year":"2011","journal-title":"J. Strength Cond. Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1836-9553(11)70036-4","article-title":"Home-based exercise improves the quality of life and physical function but not the psychological status of people with chronic heart failure: a randomised trial","volume":"57","author":"Chien","year":"2011","journal-title":"J. Physiother"},{"key":"B7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1093\/qjmed\/hct194","article-title":"High intensity, interval exercise improves quality of life of patients with chronic heart failure: a randomized controlled trial","volume":"107","author":"Chrysohoou","year":"2014","journal-title":"QJM"},{"key":"B8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1745-0179-1-19","article-title":"Heart failure and health related quality of life","volume":"1","author":"Coelho","year":"2005","journal-title":"Clin Pract. Epidemiol. Mental Health"},{"key":"B9","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1093\/eurjhf\/hfs048","article-title":"Adherence of heart failure patients to exercise: barriers and possible solutions: a position statement of the study group on exercise training in heart failure of the heart failure association of the European society of cardiology","volume":"14","author":"Conraads","year":"2012","journal-title":"Eur. J. Heart Fail"},{"key":"B10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/HJR.0b013e32801164b3","article-title":"The effect of endurance training on exercise capacity following cardiac resynchronization therapy in chronic heart failure patients: a pilot trial","volume":"14","author":"Conraads","year":"2007","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil"},{"key":"B11","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/HJR.0b013e328334ea56","article-title":"Can a heart failure-specific cardiac rehabilitation program decrease hospitalizations and improve outcomes in high-risk patients?","volume":"17","author":"Davidson","year":"2010","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil"},{"key":"B12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1177\/2040622313480382","article-title":"Exercise training in chronic heart failure","volume":"4","author":"De Maeyer","year":"2013","journal-title":"Ther. Adv. Chronic Dis"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1097\/00005768-200212000-00002","article-title":"Strength\/endurance training versus endurance training in congestive heart failure","volume":"34","author":"Delagardelle","year":"2002","journal-title":"Med. Sci. Sports Exerc"},{"key":"B14","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.ahj.2007.07.019","article-title":"Effects of a home-based exercise program on clinical outcomes in heart failure","volume":"154","author":"Dracup","year":"2007","journal-title":"Am. Heart J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1016\/j.jacc.2011.06.054","article-title":"Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study","volume":"58","author":"Edelmann","year":"2011","journal-title":"J. Am. Coll. Cardiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1097\/JCN.0000000000000407","article-title":"Dose-response relationship between exercise intensity, mood states, and quality of life in patients with heart failure","volume":"32","author":"Evangelista","year":"2017","journal-title":"J. Cardiovasc. Nurs"},{"key":"B17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/PHM.0000000000000312","article-title":"Aerobic interval training elicits different hemodynamic adaptations between heart failure patients with preserved and reduced ejection fraction","volume":"95","author":"Fu","year":"2016","journal-title":"Am. J. Phys. Med. Rehabil"},{"key":"B18","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.0889-7204.2007.05375.x","article-title":"Physical function and quality of life in older women with diastolic heart failure: effects of a progressive walking program on sleep patterns","volume":"22","author":"Gary","year":"2007","journal-title":"Prog. Cardiovasc. Nurs"},{"key":"B19","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.hrtlng.2004.01.004","article-title":"Home-based exercise improves functional performance and quality of life in women with diastolic heart failure","volume":"33","author":"Gary","year":"2004","journal-title":"Heart Lung."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1007\/s40279-018-0926-0","article-title":"Effects and dose-response relationship of balance training on balance performance in youth: a systematic review and meta-analysis","volume":"48","author":"Gebel","year":"2018","journal-title":"Sports Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ijcard.2016.11.023","article-title":"The effects of resistance training on muscle strength, quality of life and aerobic capacity in patients with chronic heart failure - a meta-analysis","volume":"15","author":"Giuliano","year":"2017","journal-title":"Int. J. Cardiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0195-668X(02)00822-9","article-title":"A randomised study of home-based electrical stimulation of the legs and conventional bicycle exercise training for patients with chronic heart failure","volume":"24","author":"Harris","year":"2003","journal-title":"Eur. Heart J"},{"key":"B23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1519\/00124278-200702000-00017","article-title":"Resistance training improves metabolic economy during functional tasks in older adults","volume":"21","author":"Hartman","year":"2007","journal-title":"J. Strength Cond. Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e22643","DOI":"10.5812\/asjsm.22643","article-title":"Effect of exercise training on the quality of life and echocardiography parameter of systolic function in patients with chronic heart failure: a randomized trial","volume":"6","author":"Hassanpour Dehkordi","year":"2015","journal-title":"Asian J. Sports Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1471-2261-13-69","article-title":"Predictors of physical and mental health-related quality of life outcomes among myocardial infarction patients","volume":"13","author":"Hawkes","year":"2013","journal-title":"BMC Cardiovasc. Disord"},{"key":"B26","first-page":"1277","article-title":"Supervised exercise training improves aerobic capacity and muscle strength in older women with heart failure. Can","volume":"21","author":"Haykowsky","year":"2005","journal-title":"J. Cardiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1016\/j.jacc.2007.02.055","article-title":"A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients: the benefit depends on the type of training performed","volume":"49","author":"Haykowsky","year":"2007","journal-title":"J. Am. Coll. Cardiol"},{"key":"B28","year":"1999","journal-title":"Canada's Physical Activity Guide to Health Active Living for Older Adults"},{"key":"B29","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1161\/CIRCULATIONAHA.117.028002","article-title":"Physical activity and prognosis in the TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist)","volume":"136","author":"Hegde","year":"2017","journal-title":"Circulation"},{"key":"B30","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.hrtlng.2008.04.002","article-title":"Quality of life in patients with heart failure: ask the patients","volume":"38","author":"Heo","year":"2009","journal-title":"Heart Lung"},{"key":"B31","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"Br. Med. J"},{"key":"B32","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/eurjhf\/hfn029","article-title":"A randomized trial of the addition of home-based exercise to specialist heart failure nurse care: the Birmingham Rehabilitation Uptake Maximisation study for patients with congestive heart failure (BRUM-CHF) study","volume":"11","author":"Jolly","year":"2009","journal-title":"Eur. J. Heart Fail"},{"key":"B33","first-page":"3","article-title":"How useful is the concept of quality of life in psychiatry?","volume-title":"Quality of Life in Mental Disorders.","author":"Katschnig","year":"1997"},{"key":"B34","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0002-8703(99)70106-7","article-title":"Effects of exercise training on chronotropic incompetence in patients with heart failure","volume":"138","author":"Keteyian","year":"1999","journal-title":"Am. Heart J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1096\/fj.99-0896rev","article-title":"Nitric oxide-mediated metabolic regulation during exercise: effects of training in health and cardiovascular disease","volume":"14","author":"Kingwell","year":"2002","journal-title":"FASEB J"},{"key":"B36","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.jacc.2013.04.033","article-title":"Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial","volume":"62","author":"Kitzman","year":"2013","journal-title":"J. Am. Coll. Cardiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1161\/CIRCHEARTFAILURE.110.958785","article-title":"Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial","volume":"3","author":"Kitzman","year":"2010","journal-title":"Circ. Heart Fail"},{"key":"B38","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1080\/11026480310015549","article-title":"Quality of life, psychological and physiological changes following exercise training in patients with chronic heart failure","volume":"36","author":"Koukouvou","year":"2004","journal-title":"J. Rehabil. Med."},{"key":"B39","first-page":"5188","volume-title":"Definition of an Older Person. Proposed Working Definition of an Older Person in Africa for the MDS Project.","author":"Kowal","year":"2001"},{"key":"B40","article-title":"Aging and the elderly","author":"Little","year":"2012","journal-title":"Introduction to Sociology-1st Canadian Edition"},{"key":"B41","doi-asserted-by":"publisher","first-page":"CD002759","DOI":"10.1002\/14651858.CD002759.pub2","article-title":"Progressive resistance strength training for improving physical function in older adults","volume":"3","author":"Liu","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"B42","first-page":"47","article-title":"Exercise training and heart failure: a systematic review of current evidence","volume":"52","author":"Lloyd-Williams","year":"2002","journal-title":"Br. J. Gen. Pract"},{"key":"B43","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.hfc.2015.07.015","article-title":"Epidemiology of Heart Failure in Europe","volume":"11","author":"Maggioni","year":"2015","journal-title":"Heart Fail Clin"},{"key":"B44","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1177\/0269215508095362","article-title":"Effects of aerobic or aerobic and resistance training on cardiorespiratory and skeletal muscle function in heart failure: a randomized controlled pilot trial","volume":"23","author":"Mandic","year":"2009","journal-title":"Clin. Rehabil"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1714\/1167.12938","article-title":"Heart failure: epidemiology, costs and healthcare programs in Italy","author":"Marangoni","year":"2012","journal-title":"G Ital. Cardiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1097\/01.hjr.0000238396.42718.61","article-title":"Effect of physical training on exercise capacity, gas exchange and N-terminal pro-brain natriuretic peptide levels in patients with chronic heart failure","volume":"13","author":"Maria Sarullo","year":"2006","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil"},{"key":"B47","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1067\/mhj.2002.123310","article-title":"Effects of exercise training in patients with heart failure: the Exercise Rehabilitation Trial (EXERT)","volume":"144","author":"McKelvie","year":"2002","journal-title":"Am. Heart J"},{"key":"B48","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S0895-4356(98)00037-7","article-title":"A population-based perspective of changes in health-related quality of life after myocardial infarction in older men and women","volume":"51","author":"Mendes de Leon","year":"1998","journal-title":"J. Clin. Epidemiol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"Br. Med. J"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1249\/mss.0b013e3180616aa2","article-title":"Physical activity and public health in olderadults: recommendation from the American College of Sports Medicine and the American Heart Association","volume":"39","author":"Nelson","year":"2007","journal-title":"Med. Sci. Sports Exerc"},{"key":"B51","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000448088","article-title":"The effect of exercise training intensity on quality of life in heart failure patients: a systematic review and meta-analysis","volume":"136","author":"Ostman","year":"2017","journal-title":"Cardiology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1161\/CIRCULATIONAHA.115.015853","article-title":"Dose response relationship between physical activity and risk of heart failure: a meta-analysis","volume":"132","author":"Pandey","year":"2015","journal-title":"Circulation"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1016\/j.jacc.2009.02.063","article-title":"Maximizing patient benefit from cardiac resynchronization therapy with the addition of structured exercise training: a randomized controlled study","volume":"53","author":"Patwala","year":"2009","journal-title":"J. Am. Coll. Cardiol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1176\/appi.psy.48.4.331","article-title":"Poor health-related quality of life is a predictor of early, but not late, cardiac events after percutaneous coronary intervention","volume":"48","author":"Pedersen","year":"2007","journal-title":"Psychosom"},{"key":"B55","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1136\/bmj.328.7441.711-b","article-title":"Exercise training meta-analysis of trials in patients with chronic heart failure (ExTra- MATCH)","volume":"328","author":"Piepoli","year":"2004","journal-title":"BMJ"},{"key":"B56","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ejcnurse.2011.03.002","article-title":"Exercise in elderly patients with chronic heart failure in primary care: effects on physical capacity and health-related quality of life","volume":"10","author":"Pihl","year":"2011","journal-title":"Eur. J. Cardiovasc. Nurs"},{"key":"B57","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/01823246-201021010-00003","article-title":"Examination of the six minute walk test to determine functional capacity in people with chronic heart failure: a systematic review","volume":"21","author":"Pollentier","year":"2010","journal-title":"Cardiopulm. Phys. Ther. J"},{"key":"B58","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1249\/01.MSS.0000053727.63505.D4","article-title":"A meta-analysis to determine the dose response for strength development","volume":"35","author":"Rhea","year":"2003","journal-title":"Med. Sci. Sports Exerc"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.69151","article-title":"Quality of life and physical activity: their relationship with physical and psychological well-being","author":"Rodr\u00edguez-Fern\u00e1ndez","year":"2017","journal-title":"Quality of Life and Quality of Working Life."},{"key":"B60","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1161\/CIRCRESAHA.113.300268","article-title":"Epidemiology of Heart Failure","volume":"113","author":"Roger","year":"2013","journal-title":"Circ. Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"406","DOI":"10.7416\/ai.2015.2028","article-title":"Adapted physical activity for the promotion of health and the prevention of multifactorial chronic diseases: the Erice Charter","volume":"27","author":"Romano-Spica","year":"2015","journal-title":"Ann. Ig"},{"key":"B62","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1177\/0269215511403941","article-title":"Effects of home-based exercise training for patients with chronic heart failure and sleep apnoea: a randomized comparison of two different programmes","volume":"26","author":"Servantes","year":"2012","journal-title":"Clin. Rehabil"},{"key":"B63","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.amjmed.2003.11.033","article-title":"Exercise training for patients with heart failure: a systematic review of factors that improve mortality and morbidity","volume":"116","author":"Smart","year":"2004","journal-title":"Am. J. Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1161\/CIRCHEARTFAILURE.108.775460","article-title":"The absence of exercise capacity improvement after exercise training program: a strong prognostic factor in patients with chronic heart failure","volume":"1","author":"Tabet","year":"2008","journal-title":"Circ. Heart. Fail"},{"key":"B65","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ejheart.2003.10.005","article-title":"Does aerobic training lead to a more active lifestyle and improved quality of life in patients with chronic heart failure?","volume":"6","author":"van den Berg-Emons","year":"2004","journal-title":"Eur. J. Heart Fail"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1097\/00005768-200110000-00021","article-title":"Concurrent cardio-vascular and resistance training in healthy older adults","volume":"33","author":"Wood","year":"2001","journal-title":"Med. Sci. Sports Exerc"},{"key":"B67","volume-title":"Proposed Working Definition of an Older Person in Africa for the MDS Project.","year":"2016"},{"key":"B68","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1519\/JSC.0b013e3181c86583","article-title":"The effects of resistance training on road cycling performance among highly trained cyclists: a systematic review","volume":"24","author":"Yamamoto","year":"2010","journal-title":"J. Strength Cond. Res"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1519\/JSC.0b013e318185f2f0","article-title":"The effects of resistance training on endurance distance running performance among highly trained runners: a systematic review","volume":"22","author":"Yamamoto","year":"2008","journal-title":"J. Strength Cond. Res"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01564\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T12:46:51Z","timestamp":1542026811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01564\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":69,"alternative-id":["10.3389\/fphys.2018.01564"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.01564","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]},"article-number":"1564"}}