{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T12:26:40Z","timestamp":1784982400406,"version":"3.55.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.01735","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T01:13:04Z","timestamp":1543799584000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":73,"title":["Myokine Response to High-Intensity Interval vs. Resistance Exercise: An Individual Approach"],"prefix":"10.3389","volume":"9","author":[{"given":"Zihong","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L.","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanye","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Lucia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08889","article-title":"Irisin-a myth rather than an exercise-inducible myokine.","volume":"5","author":"Albrecht","year":"2015","journal-title":"Sci. Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1249\/MSS.0b013e3181915670","article-title":"American college of sports medicine position stand. progression models in resistance training for healthy adults.","volume":"41","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00779","article-title":"Acute and chronic effects of endurance running on inflammatory markers: a systematic review.","volume":"8","author":"Barros","year":"2017","journal-title":"Front. Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1007\/s40279-015-0385-9","article-title":"Dose\u2013response relationships of resistance training in healthy old adults: a systematic review and meta-analysis.","volume":"45","author":"Borde","year":"2015","journal-title":"Sports Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1194\/jlr.M039719","article-title":"Follistatin promotes adipocyte differentiation, browning, and energy metabolism.","volume":"55","author":"Braga","year":"2014","journal-title":"J. Lipid Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1152\/ajpregu.90706.2008","article-title":"Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males.","volume":"296","author":"Broom","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1016\/j.bbagen.2006.09.001","article-title":"Interleukin-15 increases glucose uptake in skeletal muscle. an antidiabetogenic effect of the cytokine.","volume":"1760","author":"Busquets","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"B8","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/MCO.0b013e328363bc65","article-title":"Irisin: what promise does it hold?","volume":"16","author":"Elbelt","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"B9","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev-physiol-021115-105339","article-title":"Understanding the physiology of FGF21.","volume":"78","author":"Fisher","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1152\/physiol.00019.2013","article-title":"Exercise is the real polypill.","volume":"28","author":"Fiuza-Luces","year":"2013","journal-title":"Physiology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/s41569-018-0065-1","article-title":"Exercise benefits in cardiovascular disease: beyond attenuating traditional risk factors.","volume":"15","author":"Fiuza-Luces","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/ijlh.12426","article-title":"Effect of an acute exercise bout on immediate post-exercise irisin concentration in adults: a meta-analysis.","volume":"28","author":"Fox","year":"2018","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1113\/jphysiol.2011.224725","article-title":"Physiological adaptations to low-volume, high-intensity interval training in health and disease.","volume":"590","author":"Gibala","year":"2012","journal-title":"J. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1097\/JES.0b013e318168ec1f","article-title":"Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain?","volume":"36","author":"Gibala","year":"2008","journal-title":"Exerc. Sports Sci. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.mce.2015.09.018","article-title":"Fibroblast growth factor-21, energy balance and obesity.","volume":"418","author":"Giralt","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1210\/en.2010-0868","article-title":"Exercise induces a marked increase in plasma follistatin: evidence that follistatin is a contraction-induced hepatokine.","volume":"152","author":"Hansen","year":"2011","journal-title":"Endocrinology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1249\/MSS.0b013e3181e0b9a8","article-title":"Myostatin decrease with aerobic exercise and associates with insulin resistance.","volume":"42","author":"Hittel","year":"2010","journal-title":"Med. Sci. Sports Exerc."},{"key":"B18","first-page":"36","article-title":"Spreadsheets for analysis of validity and reliability.","volume":"19","author":"Hopkins","year":"2015","journal-title":"Sportscience"},{"key":"B19","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2165\/00007256-200030050-00006","article-title":"Measures of reliability in sports medicine and science.","volume":"30","author":"Hopkins","year":"2000","journal-title":"Sports Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/j.cellsig.2011.05.003","article-title":"Myostatin: a novel insight into its role in metabolism, signal pathways, and expression regulation.","volume":"23","author":"Huang","year":"2011","journal-title":"Cell. Signal."},{"key":"B21","doi-asserted-by":"publisher","first-page":"662","DOI":"10.2337\/diacare.28.3.662","article-title":"Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes.","volume":"28","author":"Ibanez","year":"2005","journal-title":"Diabetes Care"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e3181c8664f.Exercise","article-title":"Exercise does not influence myostatin and follistatin mrna expression in young women.","volume":"24","author":"Jensky","year":"2010","journal-title":"J. Strength Cond. Res."},{"key":"B23","first-page":"904","article-title":"Plasma ghrelin is altered after maximal exercise in elite male rowers.","volume":"232","author":"J\u00fcrim\u00e4e","year":"2007","journal-title":"Exp. Biol. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1113\/jphysiol.2008.164269","article-title":"The role of peptide YY in appetite regulation and obesity.","volume":"587","author":"Karra","year":"2009","journal-title":"J. Physiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"358","DOI":"10.4093\/dmj.2013.37.5.358","article-title":"Effect of treadmill exercise on interleukin-15 expression and glucose tolerance in zucker diabetic fatty rats.","volume":"37","author":"Kim","year":"2013","journal-title":"Diabetes Metab. J."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063517","article-title":"Acute exercise induces FGF21 expression in mice and in healthy humans.","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1249\/MSS.0000000000001220","article-title":"Individual variation in hunger, energy intake, and ghrelin responses to acute exercise.","volume":"49","author":"King","year":"2017","journal-title":"Med. Sci. Sports Exerc."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.metabol.2012.01.012","article-title":"Fibroblast growth factor-21 protects human skeletal muscle myotubes from palmitate-induced insulin resistance by inhibiting stress kinase and NF-\u03baB.","volume":"61","author":"Lee","year":"2012","journal-title":"Metabolism"},{"key":"B29","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.cmet.2013.12.017","article-title":"Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans.","volume":"19","author":"Lee","year":"2014","journal-title":"Cell Metab."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1152\/japplphysiol.00679.2007","article-title":"Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle.","volume":"103","author":"Louis","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1249\/MSS.0b013e318256fbe8","article-title":"Aerobic exercise alters skeletal muscle molecular responses to resistance exercise.","volume":"44","author":"Lundberg","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"B32","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1210\/jc.2006-1028","article-title":"Regulation of appetite in lean and obese adolescents after exercise: role of acylated and desacyl ghrelin.","volume":"92","author":"Mackelvie","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068743","article-title":"Inhibition of myostatin signaling through notch activation following acute resistance exercise.","volume":"8","author":"MacKenzie","year":"2013","journal-title":"PLoS One"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1007\/s40279-014-0197-3","article-title":"High responders and low responders: factors associated with individual variation in response to standardized training.","volume":"44","author":"Mann","year":"2014","journal-title":"Sports Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s40279-015-0365-0","article-title":"Effectiveness of high-intensity interval training (hit) and continuous endurance training for vo2max improvements: a systematic review and meta-analysis of controlled trials.","volume":"45","author":"Milanovi\u0107","year":"2015","journal-title":"Sports Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1210\/jc.2007-2561","article-title":"Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass.","volume":"93","author":"Nielsen","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B37","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.bbi.2011.02.010","article-title":"Exercise-induced myokines and their role in chronic diseases.","volume":"25","author":"Pedersen","year":"2011","journal-title":"Brain. Behav. Immun."},{"key":"B38","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ.","volume":"8","author":"Pedersen","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nrendo.2016.221.Physiology","article-title":"Physiology and role of irisin in glucose homeostasis.","volume":"13","author":"Perakakis","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/sms.12901","article-title":"Skeletal muscle IL-15\/IL-15R\u03b1 and myofibrillar protein synthesis after resistance exercise.","volume":"28","author":"P\u00e9rez-L\u00f3pez","year":"2018","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"B41","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/MCO.0000000000000101","article-title":"The role of ghrelin in metabolic regulation.","volume":"17","author":"Pinkney","year":"2014","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"B42","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1097\/MCO.0b013e328365b9be","article-title":"Ghrelin: much more than a hunger hormone.","volume":"16","author":"Pradhan","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073680","article-title":"Evidence against a beneficial effect of irisin in humans.","volume":"8","author":"Raschke","year":"2013","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1152\/japplphysiol.00491.2004","article-title":"Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses.","volume":"97","author":"Riechman","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.trecan.2017.04.007","article-title":"Exercise and the hallmarks of Cancer.","volume":"3","author":"Ruiz-Casado","year":"2017","journal-title":"Trends Cancer"},{"key":"B46","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s40279-013-0120-3","article-title":"Acute exercise and hormones related to appetite regulation: a meta-analysis.","volume":"44","author":"Schubert","year":"2014","journal-title":"Sports Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"397","DOI":"10.2165\/11531380-000000000-00000","article-title":"Resistance training in the treatment of the metabolic syndrome: a systematic review and meta-analysis of the effect of resistance training on metabolic clustering in patients with abnormal glucose metabolism.","volume":"40","author":"Strasser","year":"2010","journal-title":"Sports Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1515\/hmbci-2017-0001","article-title":"Impact of FGF21 on glycemic control.","volume":"30","author":"Strowski","year":"2017","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12828","article-title":"Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation.","volume":"4","author":"Tanimura","year":"2016","journal-title":"Physiol. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1249\/FIT.0000000000000341","article-title":"Worldwide survey of fitness trends for 2018: the CREP Edition.","volume":"21","author":"Thompson","year":"2017","journal-title":"ACSMs Health. Fit. J."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1136\/bjsports-2013-092576","article-title":"High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis.","volume":"48","author":"Weston","year":"2014","journal-title":"Br. J. Sports Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1007\/s40279-014-0180-z","article-title":"Effects of low-volume high-intensity interval training (HIT) on fitness in adults: a meta-analysis of controlled and non-controlled trials.","volume":"44","author":"Weston","year":"2014","journal-title":"Sports Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/obr.12532","article-title":"The effects of high-intensity interval training vs. moderate-intensity continuous training on body composition in overweight and obese adults: a systematic review and meta-analysis.","volume":"18","author":"Wewege","year":"2017","journal-title":"Obes. Rev."},{"key":"B54","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1083\/jcb.201109091","article-title":"Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.","volume":"197","author":"Winbanks","year":"2012","journal-title":"J. Cell Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/cen.12095","article-title":"Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.","volume":"78","author":"Woo","year":"2013","journal-title":"Clin. Endocrinol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01735\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T01:13:07Z","timestamp":1543799587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01735\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":55,"alternative-id":["10.3389\/fphys.2018.01735"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.01735","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]},"article-number":"1735"}}