{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:18:21Z","timestamp":1790248701811,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.01770","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T05:07:03Z","timestamp":1545368823000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Identification of Cardiomyopathy-Associated Circulating miRNA Biomarkers in Muscular Dystrophy Female Carriers Using a Complementary Cardiac Imaging and Plasma Profiling Approach"],"prefix":"10.3389","volume":"9","author":[{"given":"Anca","family":"Florian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Patrascu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Tremmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"R\u00f6sch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Sechtem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Schaeffeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"C209","DOI":"10.1152\/ajpcell.00185.2016","article-title":"Muscle-specific microRNA-206 targets multiple components in dystrophic skeletal muscle representing beneficial adaptations.","volume":"312","author":"Amirouche","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081334","article-title":"Serum levels of MicroRNA-206 and novel mini-STR assays for carrier detection in duchenne muscular dystrophy.","volume":"17","author":"Anaya-Segura","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00415-009-0055-7","article-title":"Cardiac magnetic resonance imaging and management of dilated cardiomyopathy in a Duchenne muscular dystrophy manifesting carrier.","volume":"256","author":"Barison","year":"2009","journal-title":"J. Neurol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-016-0244-3","article-title":"Identification of cardiomyopathy associated circulating miRNA biomarkers in patients with muscular dystrophy using a complementary cardiovascular magnetic resonance and plasma profiling approach.","volume":"18","author":"Becker","year":"2016","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B5","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cmet.2010.07.008","article-title":"MicroRNAs involved in molecular circuitries relevant for the Duchenne muscular dystrophy pathogenesis are controlled by the dystrophin\/nNOS pathway.","volume":"12","author":"Cacchiarelli","year":"2010","journal-title":"Cell Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1038\/mt.2012.178","article-title":"Exon 45 skipping through U1-snRNA antisense molecules recovers the Dys-nNOS pathway and muscle differentiation in human DMD myoblasts.","volume":"20","author":"Cazzella","year":"2012","journal-title":"Mol. Ther."},{"key":"B7","doi-asserted-by":"publisher","first-page":"C117","DOI":"10.1152\/ajpcell.00254.2014","article-title":"miR-29c induction contributes to downregulation of vascular extracellular matrix proteins by glucocorticoids.","volume":"309","author":"Chuang","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7267910","article-title":"MicroRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance.","volume":"2017","author":"Esteves","year":"2017","journal-title":"J. Diabetes Res."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00536","article-title":"Diabetes modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p expression in muscle: possible role in GLUT4 and HK2 repression.","volume":"9","author":"Esteves","year":"2018","journal-title":"Front. Endocrinol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s00392-005-0297-z","article-title":"The heart in muscular dystrophies.","volume":"94","author":"Finsterer","year":"2005","journal-title":"Z. Kardiol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-014-0081-1","article-title":"Left ventricular systolic function and the pattern of late-gadolinium-enhancement independently and additively predict adverse cardiac events in muscular dystrophy patients.","volume":"16","author":"Florian","year":"","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e482","DOI":"10.1161\/CIRCULATIONAHA.113.006891","article-title":"Cause of cardiac disease in a female carrier of Duchenne muscular dystrophy: myocarditis versus genetic cardiomyopathy without skeletal myopathy?","volume":"129","author":"Florian","year":"","journal-title":"Circulation"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1093\/ehjci\/jeu050","article-title":"Myocardial fibrosis imaging based on T1-mapping and extracellular volume fraction (ECV) measurement in muscular dystrophy patients: diagnostic value compared with conventional late gadolinium enhancement (LGE) imaging.","volume":"15","author":"Florian","year":"","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"B14","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1093\/ehjci\/jev161","article-title":"Cardiac involvement in female duchenne and becker muscular dystrophy carriers in comparison to their first-degree male relatives: a comparative cardiovascular magnetic resonance study.","volume":"17","author":"Florian","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-16-45","article-title":"Patterns of late gadolinium enhancement in Duchenne muscular dystrophy carriers.","volume":"16","author":"Giglio","year":"2014","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B16","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1161\/CIRCGENETICS.110.958363","article-title":"Circulating microRNAs as biomarkers and potential paracrine mediators of cardiovascular disease.","volume":"35","author":"Gupta","year":"2010","journal-title":"Circ. Cardiovasc. Genet."},{"key":"B17","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.nmd.2010.04.008","article-title":"Hereditary muscular dystrophies and the heart.","volume":"20","author":"Hermans","year":"2010","journal-title":"Neuromuscul. Disord."},{"key":"B18","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1212\/WNL.42.5.967","article-title":"Dystrophinopathy in isolated cases of myopathy in females.","volume":"42","author":"Hoffman","year":"1992","journal-title":"Neurology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1016\/S0140-6736(98)10028-4","article-title":"Signs and symptoms of Duchenne muscular dystrophy and Becker muscular dystrophy among carriers in The Netherlands: a cohort study.","volume":"353","author":"Hoogerwaard","year":"1999","journal-title":"Lancet"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/srep28097","article-title":"Circulating miRNAs are generic and versatile therapeutic monitoring biomarkers in muscular dystrophies.","volume":"6","author":"Israeli","year":"2016","journal-title":"Sci. Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1016\/j.jacc.2016.02.081","article-title":"Dystrophin-deficient cardiomyopathy.","volume":"67","author":"Kamdar","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0111-7","article-title":"Normal values for cardiovascular magnetic resonance in adults and children.","volume":"17","author":"Kawel-Boehm","year":"2015","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B23","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jcmg.2012.09.017","article-title":"CMR detects subclinical cardiomyopathy in mother-carriers of Duchenne and Becker muscular dystrophy.","volume":"6","author":"Mavrogeni","year":"2013","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B24","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.nmd.2010.06.009","article-title":"Cardiovascular magnetic resonance imaging evaluation of two families with Becker muscular dystrophy.","volume":"20","author":"Mavrogeni","year":"2010","journal-title":"Neuromuscul. Disord."},{"key":"B25","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1002\/mus.25445","article-title":"Cardiac involvement in female carriers of duchenne or becker muscular dystrophy.","volume":"55","author":"Mccaffrey","year":"2016","journal-title":"Muscle Nerve"},{"key":"B26","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S0960-8966(98)00071-6","article-title":"Cardiac transplantation in a Duchenne muscular dystrophy carrier.","volume":"8","author":"Melacini","year":"1998","journal-title":"Neuromuscul. Disord."},{"key":"B27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1172\/JCI62876","article-title":"MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment.","volume":"123","author":"Quiat","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/867273","article-title":"Evidence of insulin resistance and other metabolic alterations in boys with duchenne or becker muscular dystrophy.","volume":"2015","author":"Rodriguez-Cruz","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1136\/heartjnl-2013-305402","article-title":"MicroRNAs in cardiovascular disease: an introduction for clinicians.","volume":"101","author":"Romaine","year":"2015","journal-title":"Heart"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-88","article-title":"Brain natriuretic peptide is not predictive of dilated cardiomyopathy in Becker and Duchenne muscular dystrophy patients and carriers.","volume":"13","author":"Schade van Westrum Dekker","year":"2013","journal-title":"BMC Neurol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1212\/WNL.0b013e318221ad14","article-title":"Cardiac abnormalities in a follow-up study on carriers of Duchenne and Becker muscular dystrophy.","volume":"77","author":"Schade","year":"2011","journal-title":"Neurology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1016\/j.jacc.2006.10.078","article-title":"Myocardial delayed enhancement by magnetic resonance imaging in patients with muscular dystrophy.","volume":"49","author":"Silva","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.nmd.2010.05.010","article-title":"Clinical and genetic characterization of manifesting carriers of DMD mutations.","volume":"20","author":"Soltanzadeh","year":"2010","journal-title":"Neuromuscul. Disord."},{"key":"B34","doi-asserted-by":"publisher","first-page":"13027","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis.","volume":"105","author":"van Re","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1161\/CIRCIMAGING.110.960740","article-title":"Cardiac involvement in patients with muscular dystrophies: magnetic resonance imaging phenotype and genotypic considerations.","volume":"4","author":"Verhaert","year":"2011","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"B36","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ccr.2008.10.006","article-title":"NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma.","volume":"4","author":"Wang","year":"2008","journal-title":"Cancer Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/mt.2012.35","article-title":"Loss of miR-29 in myoblasts contributes to dystrophic muscle pathogenesis.","volume":"20","author":"Wang","year":"2012","journal-title":"Mol. Ther."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-016-0281-y","article-title":"Myocardial late gadolinium enhancement is associated with clinical presentation in Duchenne muscular dystrophy carriers.","volume":"18","author":"Wexberg","year":"2016","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-10-50","article-title":"Cardiac involvement in patients with Becker muscular dystrophy: new diagnostic and pathophysiological insights by a CMR approach.","volume":"10","author":"Yilmaz","year":"2008","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e237","DOI":"10.1161\/CIR.0b013e3181d74468","article-title":"Images in cardiovascular medicine. Cardiomyopathy in a Duchenne muscular dystrophy carrier and her diseased son: similar pattern revealed by cardiovascular MRI.","volume":"121","author":"Yilmaz","year":"2010","journal-title":"Circulation"},{"key":"B41","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1136\/heartjnl-2011-300254","article-title":"Cardiac involvement in muscular dystrophy: advances in diagnosis and therapy.","volume":"98","author":"Yilmaz","year":"2012","journal-title":"Heart"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01770\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T05:07:04Z","timestamp":1545368824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.01770\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,21]]},"references-count":41,"alternative-id":["10.3389\/fphys.2018.01770"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.01770","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,21]]},"article-number":"1770"}}