{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:17:51Z","timestamp":1773296271809,"version":"3.50.1"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2019.00170","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T09:22:46Z","timestamp":1552382566000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Moderate Physical Training Ameliorates Cardiovascular Dysfunction Induced by High Fat Diet After Cessation of Training in Adult Rats"],"prefix":"10.3389","volume":"10","author":[{"given":"Laize Peron","family":"T\u00f3folo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane Barreto","family":"G\u00f4ngora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Cristina Ianoni","family":"Matiusso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrei","family":"Pavanello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananda","family":"Malta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas Lopes","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane Aparecida","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Rebeka","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Natalia Chimirri","family":"Peres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Andrew","family":"Armitage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Cezar de Freitas","family":"Mathias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kesia","family":"Palma-Rigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052569","article-title":"Detraining differentially preserved beneficial effects of exercise on hypertension: effects on blood pressure, cardiac function, brain inflammatory cytokines and oxidative stress.","volume":"7","author":"Agarwal","year":"2012","journal-title":"PLoS ONE"},{"key":"B2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1161\/HYPERTENSIONAHA.111.190413","article-title":"Rapid onset of renal sympathetic nerve activation in rabbits fed a high-fat diet.","volume":"60","author":"Armitage","year":"2012","journal-title":"Hypertension"},{"key":"B3","first-page":"52","article-title":"Exercise training improves cardiovascular autonomic activity and attenuates renal damage in spontaneously hypertensive rats.","volume":"12","author":"Barbosa Neto","year":"2013","journal-title":"J Sports Sci Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1055\/s-0032-1306300","article-title":"Early exposure to a high-fat diet has more drastic consequences on metabolism compared with exposure during adulthood in rats.","volume":"44","author":"Barella","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1113\/expphysiol.2014.082982","article-title":"Vagus nerve contributes to metabolic syndrome in high-fat diet-fed young and adult rats.","volume":"100","author":"Barella","year":"2015","journal-title":"Exp. Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0361-9230(03)00188-6","article-title":"High fat feeding is associated with increased blood pressure, sympathetic nerve activity and hypothalamic mu opioid receptors.","volume":"61","author":"Barnes","year":"2003","journal-title":"Brain Res. Bull."},{"key":"B7","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1139\/apnm-2016-0037","article-title":"Light-intensity and high-intensity interval training improve cardiometabolic health in rats.","volume":"41","author":"Batacan","year":"2016","journal-title":"Appl Physiol Nutr Metab"},{"key":"B8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1042\/CS20050026","article-title":"Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds.","volume":"109","author":"Berlanga","year":"2005","journal-title":"Clin Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s00421-010-1406-x","article-title":"Exercise training-induced enhancement in myocardial mechanics is lost after 2 weeks of detraining in rats.","volume":"109","author":"Bocalini","year":"2010","journal-title":"Eur. J. Appl. Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"633","DOI":"10.2165\/00007256-200838080-00002","article-title":"Autonomic control of heart rate during and after exercise : measurements and implications for monitoring training status.","volume":"38","author":"Borresen","year":"2008","journal-title":"Sports Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1016\/j.lfs.2005.03.021","article-title":"High-fat diet induces increased tissue expression of TNF-alpha.","volume":"77","author":"Borst","year":"2005","journal-title":"Life Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/oby.2007.608","article-title":"High-fat diets: modeling the metabolic disorders of human obesity in rodents.","volume":"15","author":"Buettner","year":"2007","journal-title":"Obesity"},{"key":"B13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.yjmcc.2013.01.013","article-title":"The benefits of endurance training in cardiomyocyte function in hypertensive rats are reversed within four weeks of detraining.","volume":"57","author":"Carneiro-Junior","year":"2013","journal-title":"J. Mol. Cell Cardiol."},{"key":"B14","article-title":"\u201cHypothalamic fatty acid sensing in the normal and disease states,\u201d in","author":"Chari","year":"2010","journal-title":"Fat Detection: Taste, Texture, and Post Ingestive Effects"},{"key":"B15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1037\/h0039787","article-title":"Palatability, Food Intake, and Obesity in Normal and Hyperhagic Rats.","volume":"58","author":"Corbit","year":"1964","journal-title":"J Comp Physiol Psychol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.autneu.2011.07.006","article-title":"COX-2 inhibition does not reverse the increased sympathetic modulation in MSG obese rats.","volume":"165","author":"da Cunha","year":"2011","journal-title":"Auton. Neurosci."},{"key":"B17","first-page":"384","article-title":"Value of pulse pressure as a cardiovascular risk marker.","volume":"126","author":"de la Sierra","year":"2006","journal-title":"Med Clin."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/656303","article-title":"Abdominal obesity is characterized by higher pulse pressure: possible role of free triiodothyronine.","volume":"2012","author":"De Pergola","year":"2012","journal-title":"J. Obes."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1109\/IEMBS.2010.5626844","article-title":"The sequence technique revised: additional concepts on the assessment of spontaneous baroreflex function.","volume":"2010","author":"Di Rienzo","year":"2010","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"B20","author":"Donaldson","year":"2017","journal-title":"Healthier, Fairer, Safer: The Global Health Journey."},{"key":"B21","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1159\/000354439","article-title":"Moderate exercise restores pancreatic Beta-cell function and autonomic nervous system activity in obese rats induced by high-fat diet.","volume":"32","author":"Gomes","year":"2013","journal-title":"Cell Physiol. Biochem"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1097\/00004872-200412000-00019","article-title":"Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives.","volume":"22","author":"Grassi","year":"2004","journal-title":"J. Hypertens."},{"key":"B23","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1590\/S0100-879X2000000600001","article-title":"Role of sympathetic nervous system and neuropeptides in obesity hypertension.","volume":"33","author":"Hall","year":"2000","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/phy2.268","article-title":"Dichotomous mechanisms of aortic stiffening in high-fat diet fed young and old B6D2F1 mice.","volume":"2","author":"Henson","year":"2014","journal-title":"Physiol Rep"},{"key":"B25","doi-asserted-by":"crossref","first-page":"S515","DOI":"10.33549\/physiolres.933524","article-title":"Hypertriglyceridemic rats fed high fat diet as a model of metabolic syndrome.","author":"Kaprinay","year":"2016","journal-title":"Physiol. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1016\/j.metabol.2012.03.005","article-title":"Altered baroreflex and autonomic modulation in monosodium glutamate-induced hyperadipose rats.","volume":"61","author":"Karlen-Amarante","year":"2012","journal-title":"Metabolism"},{"key":"B27","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1208\/s12249-014-0245-1","article-title":"Anti-Obesity Effects of Melastoma malabathricum var Alba Linn in Rats Fed with a High-Fat Diet.","volume":"16","author":"Karupiah","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1161\/01.CIR.0000129308.04757.72","article-title":"Aerobic fitness is associated with cardiomyocyte contractile capacity and endothelial function in exercise training and detraining.","volume":"109","author":"Kemi","year":"2004","journal-title":"Circulation"},{"key":"B29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s11010-015-2627-4","article-title":"Detraining reverses exercise-induced improvement in blood pressure associated with decrements of oxidative stress in various tissues in spontaneously hypertensive rats.","volume":"412","author":"Kilic-Erkek","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3233\/BIR-14030","article-title":"Exercise training and detraining modify hemorheological parameters of spontaneously hypertensive rats.","volume":"51","author":"Kilic-Erkek","year":"2014","journal-title":"Biorheology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3275\/7238","article-title":"Effects of low- and high-intensity exercise training on body composition and substrate metabolism in obese adolescents.","volume":"34","author":"Lazzer","year":"2011","journal-title":"J. Endocrinol. Invest."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-9-67","article-title":"The beneficial effects of exercise in rodents are preserved after detraining: a phenomenon unrelated to GLUT4 expression.","volume":"9","author":"Lehnen","year":"2010","journal-title":"Cardiovasc Diabetol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1161\/01.CIR.84.2.482","article-title":"Cardiovascular neural regulation explored in the frequency domain.","volume":"84","author":"Malliani","year":"1991","journal-title":"Circulation"},{"key":"B34","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00418-007-0373-8","article-title":"Partial persistence of exercise-induced myocardial angiogenesis following 4-week detraining in the rat.","volume":"129","author":"Marini","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S1056-8719(96)00075-5","article-title":"Artifact of blood pressure recording using heparin-filled catheter: effects on blood pressure and coagulation parameters.","volume":"36","author":"Martin","year":"1996","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"B36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.autneu.2008.10.010","article-title":"Benefits of exercise training in diabetic rats persist after three weeks of detraining.","volume":"145","author":"Mostarda","year":"2009","journal-title":"Auton. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2165\/00007256-200030020-00002","article-title":"Detraining: loss of training-induced physiological and performance adaptations. Part I: short term insufficient training stimulus.","volume":"30","author":"Mujika","year":"2000","journal-title":"Sports Med"},{"key":"B38","first-page":"1045","article-title":"Vagal and sympathetic control of heart rate during exercise by sedentary and exercise-trained rats.","volume":"25","author":"Negr\u00e3o","year":"1992","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B39","first-page":"1507","article-title":"Cardiovascular rhythms and cardiac baroreflex sensitivity in AT1A receptor gain-of function mutant mice.","volume":"55","author":"Palma-Rigo","year":"2010","journal-title":"Hypertension"},{"key":"B40","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/lsm.22298","article-title":"Low-level laser therapy associated with high intensity resistance training on cardiac autonomic control of heart rate and skeletal muscle remodeling in wistar rats.","volume":"46","author":"Paolillo","year":"2014","journal-title":"Lasers Surg. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1210\/jc.2003-031311","article-title":"Lipid profile disorders induced by long-term cessation of physical activity in previously highly endurance-trained subjects.","volume":"89","author":"Petibois","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B42","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.lfs.2013.06.015","article-title":"Prolonged postsurgical recovery period and adverse effects of a leptin application in endotoxemic obese rodents.","volume":"93","author":"Poppendieck","year":"2013","journal-title":"Life Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1161\/HYPERTENSIONAHA.109.141119","article-title":"Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits.","volume":"55","author":"Prior","year":"2010","journal-title":"Hypertension"},{"key":"B44","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.1524-6175.2005.04491.x","article-title":"Effect of diet and exercise on pulse pressure and cardiac function in morbid obesity: analysis of 24-hour ambulatory blood pressure.","volume":"7","author":"Randall","year":"2005","journal-title":"J Clin Hypertens"},{"key":"B45","first-page":"165","article-title":"Exercise alone is an effective strategy for reducing obesity and related comorbidities.","volume":"28","author":"Ross","year":"2000","journal-title":"Exerc. Sport Sci. Rev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1097\/00004872-199917080-00012","article-title":"Neural mechanisms in human obesity-related hypertension.","volume":"17","author":"Rumantir","year":"1999","journal-title":"J. Hypertens."},{"key":"B47","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.autneu.2012.07.004","article-title":"Experimental gestational hypothyroidism evokes hypertension in adult offspring rats.","volume":"170","author":"Santos","year":"2012","journal-title":"Auton. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1038\/sj.ijo.0801905","article-title":"Psychobiology of food preferences.","author":"Sclafani","year":"2001","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"B49","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1093\/ajcn\/73.4.703","article-title":"Occasional physical inactivity combined with a high-fat diet may be important in the development and maintenance of obesity in human subjects.","volume":"73","author":"Shepard","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"B50","doi-asserted-by":"publisher","first-page":"571","DOI":"10.4314\/ahs.v13i3.7","article-title":"Effect of interval training programme on pulse pressure in the management of hypertension: a randomized controlled trial.","volume":"13","author":"Sikiru","year":"2013","journal-title":"Afr. Health Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.lfs.2015.01.032","article-title":"Cardiovascular and autonomic alterations in rats with Parkinsonism induced by 6-OHDA and treated with L-DOPA.","volume":"127","author":"Silva","year":"2015","journal-title":"Life Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.autneu.2011.02.003","article-title":"Comparison of the effects of aerobic and resistance training on cardiac autonomic adaptations in ovariectomized rats.","volume":"162","author":"Silveira","year":"2011","journal-title":"Auton. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.numecd.2015.01.001","article-title":"Argan oil reduces, in rats, the high fat diet-induced metabolic effects of obesity.","volume":"25","author":"Sour","year":"2015","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"B54","first-page":"430","article-title":"Evaluation of systolic, diastolic, and pulse pressure as risk factors for severe coronary arteriosclerotic disease in women with unstable angina non-ST-elevation acute myocardial infarction.","volume":"82","author":"Sousa","year":"2004","journal-title":"Arq. Bras. Cardiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.lfs.2016.01.011","article-title":"Resistance training prevents the cardiovascular changes caused by high-fat diet.","volume":"146","author":"Speretta","year":"2016","journal-title":"Life Sci."},{"key":"B56","first-page":"34","article-title":"Pulse pressure is a strong predictor of cardiovascular risk: Data of the risk factors in impaired glucose tolerance for atherosclerosis and diabetes and the Sofia Metabolic Syndrome studies.","volume":"51","author":"Temelkova-Kurktschiev","year":"2009","journal-title":"Folia Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1196\/annals.1367.010","article-title":"Sympathetic system activity in obesity and metabolic syndrome.","volume":"1083","author":"Tentolouris","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1007\/s00394-014-0816-7","article-title":"Short-term moderate exercise provides long-lasting protective effects against metabolic dysfunction in rats fed a high-fat diet.","volume":"54","author":"Tofolo","year":"2014","journal-title":"Eur J Nutr."},{"key":"B59","doi-asserted-by":"publisher","first-page":"H629","DOI":"10.1152\/ajpheart.1995.269.2.H629","article-title":"Reduced parasympathetic control of heart rate in obese dogs.","author":"Van Vliet","year":"1995","journal-title":"Am J Physiol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12302","article-title":"Cardiac adaptations from 4 weeks of intensity-controlled vigorous exercise are lost after a similar period of detraining.","volume":"3","author":"Waring","year":"2015","journal-title":"Physiol. Rep."},{"key":"B61","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.trsl.2015.06.017","article-title":"Targeting inflammation in metabolic syndrome.","volume":"167","author":"Welty","year":"2016","journal-title":"Transl Res"},{"key":"B62","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0140-6736(12)60954-4","article-title":"Stressing harms of physical inactivity to promote exercise.","volume":"380","author":"Wen","year":"2012","journal-title":"Lancet"},{"key":"B63","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.ncl.2006.03.008","article-title":"Exercise, inflammation, and innate immunity.","volume":"24","author":"Woods","year":"2006","journal-title":"Neurol. Clin."},{"key":"B64","year":"2015","journal-title":"Cardiovascular Diseases (CVDs) - Fact sheet N\u00b0317."},{"key":"B65","year":"2018","journal-title":"Noncommunicable Diseases - Fact Sheet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1161\/HYPERTENSIONAHA.115.06736","article-title":"Leptin mediates high-fat diet sensitization of angiotensin II-elicited hypertension by upregulating the brain renin-angiotensin system and inflammation.","volume":"67","author":"Xue","year":"2016","journal-title":"Hypertension"},{"key":"B67","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.intimp.2015.01.027","article-title":"Beneficial effects of neomangiferin on high fat diet-induced nonalcoholic fatty liver disease in rats.","volume":"25","author":"Zhou","year":"2015","journal-title":"Int. Immunopharmacol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.00170\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T04:04:57Z","timestamp":1606709097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.00170\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":67,"alternative-id":["10.3389\/fphys.2019.00170"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2019.00170","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]},"article-number":"170"}}