{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T08:09:04Z","timestamp":1771747744605,"version":"3.50.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2019.00283","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T14:00:30Z","timestamp":1553263230000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Human Umbilical Cord Therapy Improves Long-Term Behavioral Outcomes Following Neonatal Hypoxic Ischemic Brain Injury"],"prefix":"10.3389","volume":"10","author":[{"given":"Tayla R.","family":"Penny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy E.","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie G.","family":"Mihelakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madison C. B.","family":"Paton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joohyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Jenkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Fahey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney A.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5409\/wjcp.v5.i1.67","article-title":"Short and long term prognosis in perinatal asphyxia: an update.","volume":"5","author":"Ahearne","year":"2016","journal-title":"World J. Clin. Pediatr."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1113\/JP271104","article-title":"Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb.","volume":"594","author":"Aridas","year":"2016","journal-title":"J. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.expneurol.2014.07.009","article-title":"Detecting brain injury in neonatal hypoxic ischemic encephalopathy: closing the gap between experimental and clinical research.","volume":"261","author":"Aridas","year":"2014","journal-title":"Exp. Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/ana.22670","article-title":"Cell therapy for neonatal hypoxia\u2013ischemia and cerebral palsy.","volume":"71","author":"Bennet","year":"2012","journal-title":"Ann. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijdevneu.2014.10.001","article-title":"Postnatal alterations in GABAB receptor tone produce sensorimotor gating deficits and protein level differences in adulthood.","volume":"41","author":"Bolton","year":"2015","journal-title":"Int. J. Dev. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/sctm.18-0251","article-title":"White matter tract changes associated with clinical improvement in an open-label trial assessing autologous umbilical cord blood for treatment of young children with autism.","volume":"8","author":"Carpenter","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3390\/brainsci3010191","article-title":"Neuroprotective therapies after perinatal hypoxic-ischemic brain injury.","volume":"3","author":"Cerio","year":"2013","journal-title":"Brain Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-2094-11-98","article-title":"Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.","volume":"11","author":"Cherry","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"B9","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.pedneo.2016.11.001","article-title":"Therapeutic hypothermia for neonates with hypoxic ischemic encephalopathy.","volume":"58","author":"Chiang","year":"2017","journal-title":"Pediatr. Neonatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/S0140-6736(13)61835-8","article-title":"Cerebral palsy.","volume":"383","author":"Colver","year":"2014","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.036","article-title":"Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy.","volume":"164","author":"Cotten","year":"2014","journal-title":"J. Pediatr."},{"key":"B12","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.siny.2010.05.005","article-title":"Mechanisms of hypothermic neuroprotection.","volume":"15","author":"Drury","year":"2010","journal-title":"Semin. Fetal Neonatal Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1007\/s11064-010-0308-y","article-title":"Perspectives on neonatal hypoxia\/ischemia-induced edema formation.","volume":"35","author":"Ferrari","year":"2010","journal-title":"Neurochem. Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1177\/135245859900500409","article-title":"The Multiple Sclerosis Functional Composite measure (MSFC): an integrated approach to MS clinical outcome assessment.","volume":"5","author":"Fischer","year":"1999","journal-title":"Mult. Scler. J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/S1474-4422(12)70058-3","article-title":"Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?","volume":"11","author":"Fleiss","year":"2012","journal-title":"Lancet Neurol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-60761-303-9","article-title":"The Open Field Test","author":"Gould","year":"2009","journal-title":"Mood and Anxiety Related Phenotypes in Mice"},{"key":"B17","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.nurx.2006.01.007","article-title":"Hypothermic neuroprotection.","volume":"3","author":"Gunn","year":"2006","journal-title":"NeuroRx"},{"key":"B18","doi-asserted-by":"publisher","first-page":"F541","DOI":"10.1136\/archdischild-2014-306284","article-title":"New horizons for newborn brain protection: enhancing endogenous neuroprotection.","volume":"100","author":"Hassell","year":"2015","journal-title":"Arch. Dis. Child."},{"key":"B19","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3727\/096368914X678300","article-title":"Umbilical cord blood: a trustworthy source of multipotent stem cells for regenerative medicine.","volume":"23","author":"Jaing","year":"2014","journal-title":"Cell Transplant."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1717426","article-title":"First autologous cord blood therapy for pediatric ischemic stroke and cerebral palsy caused by cephalic molding during birth: individual treatment with mononuclear cells.","volume":"2016","author":"Jensen","year":"2016","journal-title":"Case Rep. Transplant."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1089\/scd.2015.0074","article-title":"Involvement of immune responses in the efficacy of cord blood cell therapy for cerebral palsy.","volume":"24","author":"Kang","year":"2015","journal-title":"Stem Cells Dev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1111\/j.1471-4159.2006.03964.x","article-title":"Hypoxic damage to the periventricular white matter in neonatal brain: role of vascular endothelial growth factor, nitric oxide and excitotoxicity.","volume":"98","author":"Kaur","year":"2006","journal-title":"J. Neurochem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.neuron.2015.03.024","article-title":"Motor cortex is required for learning but not for executing a motor skill.","volume":"86","author":"Kawai","year":"2015","journal-title":"Neuron"},{"key":"B24","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia.","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol. Rev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1023\/A:1026463900925","article-title":"Umbilical cord blood transplantation in severe T-cell immunodeficiency disorders: two-year experience.","volume":"20","author":"Knutsen","year":"2000","journal-title":"J. Clin. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.expneurol.2016.06.017","article-title":"Preterm white matter brain injury is prevented by early administration of umbilical cord blood cells.","volume":"283","author":"Li","year":"2016","journal-title":"Exp. Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.bbr.2013.12.027","article-title":"Functional assessment of sensory functions after photothrombotic stroke in the barrel field of mice.","volume":"261","author":"Liguz-Lecznar","year":"2014","journal-title":"Behav. Brain Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/aps.2013.89","article-title":"Inflammatory responses in hypoxic ischemic encephalopathy.","volume":"34","author":"Liu","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"B29","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial activation and chronic neurodegeneration.","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"B30","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function.","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"5968","DOI":"10.4049\/jimmunol.174.10.5968","article-title":"Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells.","volume":"174","author":"Maeda","year":"2005","journal-title":"J. Immunol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1089-5","article-title":"ffects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury.","volume":"15","author":"McDonald","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"B33","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/stem.1304","article-title":"Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial.","volume":"31","author":"Min","year":"2013","journal-title":"Stem Cells"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1285","DOI":"10.1542\/peds.2012-0924","article-title":"Clinical prognostic messages from a systematic review on cerebral palsy.","volume":"130","author":"Novak","year":"2012","journal-title":"Pediatrics"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120893","article-title":"Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy.","volume":"10","author":"Park","year":"2015","journal-title":"PLoS One"},{"key":"B36","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/pr.2015.100","article-title":"Therapeutic hypothermia and hypoxia-ischemia in the term-equivalent neonatal rat: characterization of a translational preclinical model.","volume":"78","author":"Patel","year":"2015","journal-title":"Pediatr. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.jcyt.2015.02.010","article-title":"Human allogeneic AB0\/Rh-identical umbilical cord blood cells in the treatment of juvenile patients with cerebral palsy.","volume":"17","author":"Romanov","year":"2015","journal-title":"Cytotherapy"},{"key":"B38","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1136\/bmj.326.7396.970","article-title":"Cerebral palsy: what parents and doctors want to know.","volume":"326","author":"Rosenbaum","year":"2003","journal-title":"Br. Med. J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/ene.13529","article-title":"The Parkinson\u2019s disease composite scale: results of the first validation study.","volume":"25","author":"Stocchi","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.bbi.2016.10.010","article-title":"Maternal obesity increases inflammation and exacerbates damage following neonatal hypoxic-ischaemic brain injury in rats.","volume":"63","author":"Teo","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/506320","article-title":"Molecular mechanisms of neonatal brain injury.","volume":"2012","author":"Thornton","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"B42","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00277-011-1288-y","article-title":"unctional analysis and gene expression profile of umbilical cord blood regulatory T cells.","volume":"91","author":"Torelli","year":"2012","journal-title":"Ann. Hematol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1055\/s-2000-9293","article-title":"Hypoxic-ischemic encephalopathy.","volume":"17","author":"Vannucci","year":"2000","journal-title":"Am. J. Perinatol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.imbio.2008.11.009","article-title":"Alternative activation of macrophages: immune function and cellular biology.","volume":"214","author":"Varin","year":"2009","journal-title":"Immunobiology"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.00283\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T14:00:32Z","timestamp":1553263232000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.00283\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,22]]},"references-count":44,"alternative-id":["10.3389\/fphys.2019.00283"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2019.00283","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,22]]},"article-number":"283"}}