{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:11:36Z","timestamp":1785456696795,"version":"3.56.0"},"reference-count":149,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL134610"],"award-info":[{"award-number":["HL134610"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2019.00511","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T13:35:37Z","timestamp":1556285737000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury"],"prefix":"10.3389","volume":"10","author":[{"given":"Gabriel T.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Faraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emin","family":"Maltepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Fineman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1096\/fasebj.3.12.2477294","article-title":"Ion channels and regulation of intracellular calcium in vascular endothelial cells.","volume":"3","author":"Adams","year":"1989","journal-title":"FASEB J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"5188","DOI":"10.1242\/jcs.109884","article-title":"Syndecan-1 controls cell migration by activating Rap1 to regulate focal adhesion disassembly.","author":"Altemeier","year":"2012","journal-title":"J. Cell Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1161\/01.res.0000247065.11756.19","article-title":"Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury.","volume":"99","author":"Alvarez","year":"2006","journal-title":"Circ. Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3623","DOI":"10.1038\/emboj.2009.287","article-title":"The structure of an integrin\/talin complex reveals the basis of inside-out signal transduction.","volume":"28","author":"Anthis","year":"2009","journal-title":"EMBO J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/micc.12063","article-title":"Loss of focal adhesion kinase enhances endothelial barrier function and increases focal adhesions.","volume":"20","author":"Arnold","year":"2013","journal-title":"Microcirculation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1513\/pats.200502-013ac","article-title":"Genetic determinants and ethnic disparities in sepsis-associated acute lung injury.","volume":"2","author":"Barnes","year":"2005","journal-title":"Proc. Am. Thor. Soc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1007\/s00018-017-2511-3","article-title":"Vinculin in cell-cell and cell-matrix adhesions.","volume":"74","author":"Bays","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1002\/bies.950191104","article-title":"Zyxin: zinc fingers at sites of cell adhesion.","volume":"19","author":"Beckerle","year":"1997","journal-title":"Bioessays"},{"key":"B9","doi-asserted-by":"publisher","first-page":"F307","DOI":"10.1136\/archdischild-2017-313493","article-title":"Frequency, duration and cause of ventilator alarms on a neonatal intensive care unit.","volume":"103","author":"Belteki","year":"2018","journal-title":"Arch. Dis. Child. Fetal Neonatal Edn."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.4161\/cc.26388","article-title":"Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta.","volume":"12","author":"Bianchi-Smiraglia","year":"2013","journal-title":"Cell Cycle"},{"key":"B11","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/978-0-387-87429-6_64","article-title":"\u201cVentilator-induced mechancial stress and lung vascular dysfunction,\u201d in","author":"Birukov","year":"2011","journal-title":"Textbook of Pulmonary Vascular Disease"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1089\/ars.2008.2390","article-title":"Cyclic stretch, reactive oxygen species, and vascular remodeling.","volume":"11","author":"Birukov","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.2353\/ajpath.2006.050431","article-title":"Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch.","volume":"168","author":"Birukova","year":"2006","journal-title":"Am. J. Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1165\/rcmb.2015-0328oc","article-title":"Selective role of vinculin in contractile mechanisms of endothelial permeability.","volume":"55","author":"Birukova","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"7228","DOI":"10.1074\/jbc.m510397200","article-title":"The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin.","volume":"281","author":"Bois","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"30588","DOI":"10.1074\/jbc.m313244200","article-title":"Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation.","volume":"279","author":"Boutahar","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B17","first-page":"1651","article-title":"Expression of the beta 7 integrin by human endothelial cells.","volume":"149","author":"Brezinschek","year":"1996","journal-title":"Am. J. Pathol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1152\/physrev.00002.2004","article-title":"Paxillin: adapting to change.","volume":"84","author":"Brown","year":"2004","journal-title":"Physiol. Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cub.2013.01.009","article-title":"Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner.","volume":"23","author":"Carisey","year":"2013","journal-title":"Curr. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/ncb3180","article-title":"Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions.","volume":"17","author":"Case","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"B21","doi-asserted-by":"crossref","first-page":"C1701","DOI":"10.1152\/ajpcell.00529.2006","article-title":"Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1\/2 phosphorylation in human H441 pulmonary epithelial cells.","volume":"292","author":"Chaturvedi","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"40389","DOI":"10.1074\/jbc.m607324200","article-title":"Coincidence of actin filaments and talin is required to activate vinculin.","volume":"281","author":"Chen","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1083\/jcb.200410100","article-title":"Spatial distribution and functional significance of activated vinculin in living cells.","volume":"169","author":"Chen","year":"2005","journal-title":"J. Cell Biol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/srep16529","article-title":"Role of integrin beta4 in lung endothelial cell inflammatory responses to mechanical stress.","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"48152","DOI":"10.1074\/jbc.m110937200","article-title":"Cyclic strain activates redox-sensitive proline-rich tyrosine kinase 2 (PYK2) in endothelial cells.","volume":"277","author":"Cheng","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1243\/09544119jeim428","article-title":"An analysis of the strain field in biaxial Flexcell membranes for different waveforms and frequencies.","volume":"222","author":"Colombo","year":"2008","journal-title":"Proc. Inst. Mech. Eng. Part H J. Eng. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"4467","DOI":"10.1128\/mcb.6.12.4467","article-title":"Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.","volume":"6","author":"Cooper","year":"1986","journal-title":"Mol. Cell. Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"4232","DOI":"10.1073\/pnas.85.12.4232","article-title":"Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.","volume":"85","author":"Cooper","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s00063-017-0376-8","article-title":"Role of the extracellular matrix in the genesis of ventilator-induced lung injury.","author":"Cruz","year":"2018","journal-title":"Medizinische Klinik, Intensivmedizin und Notfallmedizin."},{"key":"B30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.biocel.2016.07.012","article-title":"Modulation of TRPV4 by diverse mechanisms.","volume":"78","author":"Darby","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0084-9","article-title":"A general model of focal adhesion orientation dynamics in response to static and cyclic stretch.","volume":"1","author":"De","year":"2018","journal-title":"Commun. Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0091-679X(10)98007-2","article-title":"Theoretical concepts and models of cellular mechanosensing.","volume":"98","author":"De","year":"2010","journal-title":"Methods Cell Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"L520","DOI":"10.1152\/ajplung.00076.2009","article-title":"Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells.","volume":"297","author":"Desai","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1152\/jappl.2000.89.4.1645","article-title":"Invited review: mechanisms of ventilator-induced lung injury: a perspective.","volume":"89","author":"Dos Santos","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1164\/ajrccm.157.1.9604014","article-title":"Ventilator-induced lung injury: lessons from experimental studies.","volume":"157","author":"Dreyfuss","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.semcancer.2014.07.009","article-title":"Focal adhesion signaling and therapy resistance in cancer.","volume":"31","author":"Eke","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1083\/jcb.200109079","article-title":"Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.","volume":"157","author":"Eliceiri","year":"2002","journal-title":"J. Cell Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/ncb3336","article-title":"Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity.","volume":"18","author":"Elosegui-Artola","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/CCM.0b013e31819292ea","article-title":"Racial and ethnic disparities in mortality from acute lung injury.","volume":"37","author":"Erickson","year":"2009","journal-title":"Crit. Care Med."},{"key":"B40","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1055\/s-2006-948287","article-title":"Epidemiology of acute lung injury and acute respiratory distress syndrome.","volume":"27","author":"Frutos-Vivar","year":"2006","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"B41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00075198-200402000-00001","article-title":"Epidemiology of acute lung injury and acute respiratory distress syndrome.","volume":"10","author":"Frutos-Vivar","year":"2004","journal-title":"Curr. Opin. Crit. Care"},{"key":"B42","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1007\/s00134-005-2625-1","article-title":"Ventilator settings as a risk factor for acute respiratory distress syndrome in mechanically ventilated patients.","volume":"31","author":"Gajic","year":"2005","journal-title":"Intens. Care Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1165\/rcmb.2005-0404oc","article-title":"Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury.","volume":"34","author":"Gao","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/s1097-2765(02)00823-7","article-title":"Structural determinants of integrin recognition by talin.","volume":"11","author":"Garcia-Alvarez","year":"2003","journal-title":"Mol. Cell."},{"key":"B45","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/s0092-8674(02)00831-0","article-title":"Exploring the neighborhood: adhesion-coupled cell mechanosensors.","volume":"110","author":"Geiger","year":"2002","journal-title":"Cell"},{"key":"B46","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrm2593","article-title":"Environmental sensing through focal adhesions.","volume":"10","author":"Geiger","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.tips.2007.08.004","article-title":"Targeting integrin beta4 for cancer and anti-angiogenic therapy.","volume":"28","author":"Giancotti","year":"2007","journal-title":"Trends Pharmacol Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"8866","DOI":"10.1074\/jbc.M805937200","article-title":"Structural determinants of integrin binding to the talin rod.","volume":"284","author":"Gingras","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B49","doi-asserted-by":"publisher","first-page":"37217","DOI":"10.1074\/jbc.m508060200","article-title":"Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.","volume":"280","author":"Gingras","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068117","article-title":"Desmoglein-2-integrin Beta-8 interaction regulates actin assembly in endothelial cells: deregulation in systemic sclerosis.","volume":"8","author":"Giusti","year":"2013","journal-title":"PLoS One"},{"key":"B51","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1006\/jsbi.1994.1002","article-title":"Native talin is a dumbbell-shaped homodimer when it interacts with actin.","volume":"112","author":"Goldmann","year":"1994","journal-title":"J. Struct. Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.bpj.2010.05.024","article-title":"A molecular dynamics investigation of vinculin activation.","volume":"99","author":"Golji","year":"2010","journal-title":"Biophys. J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.bpj.2014.08.038","article-title":"The talin dimer structure orientation is mechanically regulated.","volume":"107","author":"Golji","year":"2014","journal-title":"Biophys. J."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1016\/j.bpj.2012.01.062","article-title":"Phosphorylation primes vinculin for activation.","volume":"102","author":"Golji","year":"2012","journal-title":"Biophys. J."},{"key":"B55","doi-asserted-by":"publisher","first-page":"4931","DOI":"10.1242\/jcs.02696","article-title":"FAK phosphorylation sites mapped by mass spectrometry.","author":"Grigera","year":"2005","journal-title":"J. Cell Sci."},{"key":"B56","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1242\/jcs.109.11.2715","article-title":"Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site.","author":"Hemmings","year":"1996","journal-title":"J. Cell Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1080\/10623320701746248","article-title":"Role of ligand-specific integrins in endothelial cell alignment and elongation induced by cyclic strain.","volume":"14","author":"Hirayama","year":"2007","journal-title":"Endothelium"},{"key":"B58","doi-asserted-by":"publisher","first-page":"6470","DOI":"10.1073\/pnas.83.17.6470","article-title":"Phosphorylation of the fibronectin receptor complex in cells transformed by oncogenes that encode tyrosine kinases.","volume":"83","author":"Hirst","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B59","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1002\/j.1460-2075.1990.tb08171.x","article-title":"Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain.","volume":"9","author":"Hogervorst","year":"1990","journal-title":"EMBO J."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012470","article-title":"Stretch-induced stress fiber remodeling and the activations of JNK and ERK depend on mechanical strain rate, but not FAK.","volume":"5","author":"Hsu","year":"2010","journal-title":"PLoS One"},{"key":"B61","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/jcp.24154","article-title":"Integrin bi-directional signaling across the plasma membrane.","volume":"228","author":"Hu","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-011-0194-7","article-title":"Role of intercellular junctions in redistribution of focal adhesions and orientation of vascular endothelial cells exposed to cyclic stretching.","volume":"4","author":"Huang","year":"2011","journal-title":"Cell. Mol. Bioeng."},{"key":"B63","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.bbrc.2012.01.083","article-title":"Role of paxillin in the early phase of orientation of the vascular endothelial cells exposed to cyclic stretching.","volume":"418","author":"Huang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B64","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines.","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"B65","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1006\/bbrc.1999.0532","article-title":"Phosphatidylinositol-3 kinase dependent MAP kinase activation via p21ras in endothelial cells exposed to cyclic strain.","volume":"257","author":"Ikeda","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B66","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.mvr.2011.09.011","article-title":"Endothelial FAK as a therapeutic target in disease.","volume":"83","author":"Infusino","year":"2012","journal-title":"Microvasc. Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/nrm3903","article-title":"Appreciating force and shape-the rise of mechanotransduction in cell biology.","volume":"15","author":"Iskratsch","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nature02281","article-title":"Vinculin activation by talin through helical bundle conversion.","volume":"427","author":"Izard","year":"2004","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/nature01805","article-title":"Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin.","volume":"424","author":"Jiang","year":"2003","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1016\/s0959-8049(00)00153-2","article-title":"Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase.","volume":"36","author":"Jones","year":"2000","journal-title":"Eur. J. Cancer"},{"key":"B71","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/1357-2725(95)00024-j","article-title":"Signalling by the p60c-src family of protein-tyrosine kinases.","volume":"27","author":"Kefalas","year":"1995","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-cellbio-100109-104104","article-title":"Regulation of integrin activation.","volume":"27","author":"Kim","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s10753-006-9001-3","article-title":"The role of endogenous histamine on the pathogenesis of the lipopolysaccharide (LPS)-induced, acute lung injury: a pilot study.","volume":"29","author":"Kim","year":"2005","journal-title":"Inflammation"},{"key":"B74","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1242\/jcs.190991","article-title":"Talin - the master of integrin adhesions.","volume":"130","author":"Klapholz","year":"2017","journal-title":"J. Cell Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/ncb2216","article-title":"Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for beta-Pix in negative regulation of focal adhesion maturation.","volume":"13","author":"Kuo","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/75\/11\/116601","article-title":"Physically based principles of cell adhesion mechanosensitivity in tissues.","volume":"75","author":"Ladoux","year":"2012","journal-title":"Rep. Progr. Phys. Phys. Soc."},{"key":"B77","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1164\/rccm.201612-2415CI","article-title":"Fifty years of research in ARDS. insight into acute respiratory distress syndrome. from models to patients.","volume":"196","author":"Laffey","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1146\/annurev-cellbio-100109-104027","article-title":"Force generation, transmission, and integration during cell and tissue morphogenesis.","volume":"27","author":"Lecuit","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1016\/j.jbiomech.2007.04.006","article-title":"Force-induced activation of talin and its possible role in focal adhesion mechanotransduction.","volume":"40","author":"Lee","year":"2007","journal-title":"J. Biomech."},{"key":"B80","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00075198-200502000-00013","article-title":"Overview of ventilator-induced lung injury mechanisms.","volume":"11","author":"Lionetti","year":"2005","journal-title":"Curr. Opin. Crit. Care"},{"key":"B81","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1146\/annurev.immunol.25.022106.141618","article-title":"Structural basis of integrin regulation and signaling.","volume":"25","author":"Luo","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1097\/00003246-200208000-00001","article-title":"Race and gender differences in acute respiratory distress syndrome deaths in the United States: an analysis of multiple-cause mortality data (1979- 1996).","volume":"30","author":"Moss","year":"2002","journal-title":"Crit. Care Med."},{"key":"B83","doi-asserted-by":"crossref","first-page":"27155","DOI":"10.1016\/S0021-9258(19)61492-4","article-title":"Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells.","volume":"275","author":"Nakamura","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/s0014-5793(98)01528-2","article-title":"Uni-axial cyclic stretch induces c-src activation and translocation in human endothelial cells via SA channel activation.","volume":"441","author":"Naruse","year":"","journal-title":"FEBS Lett."},{"key":"B85","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/sj.onc.1201950","article-title":"Pp125FAK is required for stretch dependent morphological response of endothelial cells.","volume":"17","author":"Naruse","year":"","journal-title":"Oncogene"},{"key":"B86","doi-asserted-by":"publisher","first-page":"H1532","DOI":"10.1152\/ajpheart.1998.274.5.H1532","article-title":"Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch.","author":"Naruse","year":"","journal-title":"Am. J. Physiol."},{"key":"B87","doi-asserted-by":"crossref","first-page":"C1037","DOI":"10.1152\/ajpcell.1993.264.4.C1037","article-title":"Involvement of stretch-activated ion channels in Ca2+ mobilization to mechanical stretch in endothelial cells.","author":"Naruse","year":"1993","journal-title":"Am. J. Physiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s10439-009-9826-7","article-title":"Effect of focal adhesion proteins on endothelial cell adhesion, motility and orientation response to cyclic strain.","volume":"38","author":"Ngu","year":"2010","journal-title":"Ann. Biomed. Eng."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-017-0121-x","article-title":"Personalizing mechanical ventilation according to physiologic parameters to stabilize alveoli and minimize ventilator induced lung injury (VILI).","volume":"5","author":"Nieman","year":"2017","journal-title":"Intens. Care Med. Exp."},{"key":"B90","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.yexcr.2005.12.001","article-title":"Threonine 788 in integrin subunit beta1 regulates integrin activation.","volume":"312","author":"Nilsson","year":"2006","journal-title":"Exp. Cell Res."},{"key":"B91","doi-asserted-by":"crossref","first-page":"28708","DOI":"10.1016\/S0021-9258(19)61963-0","article-title":"Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.","volume":"269","author":"Nishimura","year":"1994","journal-title":"J. Biol. Chem."},{"key":"B92","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1513\/pats.200501-005ac","article-title":"Functional genomic insights into acute lung injury: role of ventilators and mechanical stress.","volume":"2","author":"Nonas","year":"2005","journal-title":"Proc. Am. Thor. Soc."},{"key":"B93","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ceb.2014.06.003","article-title":"Stressing the limits of focal adhesion mechanosensitivity.","volume":"30","author":"Oakes","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2502-0","article-title":"Research advances on structure and biological functions of integrins.","volume":"5","author":"Pan","year":"2016","journal-title":"SpringerPlus"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1152\/jappl.1998.84.4.1113","article-title":"Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lungs.","volume":"84","author":"Parker","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.2174\/1381612054065765","article-title":"Integrin function and signaling as pharmacological targets in cardiovascular diseases and in cancer.","volume":"11","author":"Paulhe","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"B97","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1586\/ers.10.28","article-title":"The physical basis of ventilator-induced lung injury.","volume":"4","author":"Plataki","year":"2010","journal-title":"Expert Rev. Respir. Med."},{"key":"B98","doi-asserted-by":"crossref","first-page":"21785","DOI":"10.1074\/jbc.R000003200","article-title":"Ligand binding to integrins.","volume":"275","author":"Plow","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B99","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1128\/mcb.24.10.4351-4360.2004","article-title":"Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes.","volume":"24","author":"Rabinovitz","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"B100","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/cc2327","article-title":"ICU cornerstone: high frequency ventilation is here to stay.","volume":"7","author":"Rimensberger","year":"2003","journal-title":"Crit. Care"},{"key":"B101","doi-asserted-by":"publisher","first-page":"24212","DOI":"10.1074\/jbc.M709704200","article-title":"The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges.","volume":"283","author":"Rodius","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B102","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1161\/01.res.0000207408.31270.db","article-title":"Focal adhesions: paradigm for a signaling nexus.","volume":"98","author":"Romer","year":"2006","journal-title":"Circ. Res."},{"key":"B103","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/0955-0674(93)90031-k","article-title":"Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling.","volume":"5","author":"Sastry","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1083\/jcb.200110068","article-title":"Force transduction by Triton cytoskeletons.","volume":"156","author":"Sawada","year":"2002","journal-title":"J. Cell Biol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1083\/jcb.130.5.1181","article-title":"Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.","volume":"130","author":"Schaller","year":"1995","journal-title":"J. Cell Biol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1128\/mcb.15.5.2635","article-title":"pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk.","volume":"15","author":"Schaller","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1042\/bj3600057","article-title":"Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin.","author":"Schaller","year":"2001","journal-title":"Biochem. J."},{"key":"B108","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1096\/fj.03-0198com","article-title":"Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT.","volume":"17","author":"Shikata","year":"","journal-title":"FASEB J."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1152\/japplphysiol.00690.2002","article-title":"S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin.","volume":"94","author":"Shikata","year":"","journal-title":"J. Appl. Physiol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.yexcr.2004.11.001","article-title":"Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells.","volume":"304","author":"Shikata","year":"2005","journal-title":"Exp. Cell Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1083\/jcb.109.1.331","article-title":"Mechano-chemical control of human endothelium orientation and size.","volume":"109","author":"Shirinsky","year":"1989","journal-title":"J. Cell Biol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/apha.12768","article-title":"Emerging roles of calcium-activated K channels and TRPV4 channels in lung oedema and pulmonary circulatory collapse.","volume":"219","author":"Simonsen","year":"2017","journal-title":"Acta Physiol."},{"key":"B113","article-title":"Ventilator-induced lung injury.","volume":"370","author":"Slutsky","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B114","first-page":"191","article-title":"Mechanotransduction and intracellular signaling mechanisms of stretch-induced remodeling in endothelial cells.","volume":"12","author":"Sokabe","year":"1997","journal-title":"Heart Vessels"},{"key":"B115","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.cardiores.2005.03.002","article-title":"Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts.","volume":"67","author":"Stawowy","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"B116","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/(sici)1097-4652(199609)168:3<521::aid-jcp4>3.0.co;2-r","article-title":"Divalent cations regulate the organization of integrins alpha v beta 3 and alpha v beta 5 on the cell surface.","volume":"168","author":"Stuiver","year":"1996","journal-title":"J. Cell. Physiol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1165\/rcmb.2006-0238oc","article-title":"Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.","volume":"36","author":"Su","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1067\/mva.1987.avs0060252","article-title":"Mechanical stress stimulates aortic endothelial cells to proliferate.","volume":"6","author":"Sumpio","year":"1987","journal-title":"J. Vasc. Surg."},{"key":"B119","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1006\/bbrc.1997.7364","article-title":"Up-regulation of integrin beta 3 expression by cyclic stretch in human umbilical endothelial cells.","volume":"239","author":"Suzuki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.2353\/ajpath.2008.070448","article-title":"Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.","volume":"172","author":"Tabata","year":"2008","journal-title":"Am. J. Pathol."},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/srep16408","article-title":"An EGFR\/Src-dependent beta4 integrin\/FAK complex contributes to malignancy of breast cancer.","volume":"5","author":"Tai","year":"2015","journal-title":"Sci. Rep."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1161\/CIRCRESAHA.108.192930","article-title":"TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.","volume":"104","author":"Thodeti","year":"2009","journal-title":"Circ. Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"10032","DOI":"10.1074\/jbc.M115.690487","article-title":"Activation of vascular endothelial growth factor (VEGF) receptor 2 mediates endothelial permeability caused by cyclic stretch.","volume":"291","author":"Tian","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1152\/jappl.1999.86.6.2026","article-title":"Alveolar epithelial surface area-volume relationship in isolated rat lungs.","volume":"86","author":"Tschumperlin","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1164\/ajrccm.162.2.9807003","article-title":"Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude.","author":"Tschumperlin","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B126","doi-asserted-by":"crossref","first-page":"C1501","DOI":"10.1152\/ajpcell.00162.2002","article-title":"On the mechanism of thrombin-induced angiogenesis: involvement of alphavbeta3-integrin.","volume":"283","author":"Tsopanoglou","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1161\/01.res.0000125627.77235.0c","article-title":"GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions.","volume":"94","author":"van Nieuw Amerongen","year":"2004","journal-title":"Circ. Res."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1007\/s00134-011-2380-4","article-title":"The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation.","volume":"37","author":"Villar","year":"2011","journal-title":"Intens. Care Med."},{"key":"B129","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/MCC.0000000000000057","article-title":"The acute respiratory distress syndrome: incidence and mortality, has it changed?","volume":"20","author":"Villar","year":"2014","journal-title":"Curr. Opin. Crit. Care"},{"key":"B130","doi-asserted-by":"publisher","first-page":"30318","DOI":"10.1074\/jbc.M114.586438","article-title":"Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with alpha6beta4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival.","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B131","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1006\/bbrc.2001.5775","article-title":"Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation.","volume":"288","author":"Wang","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1016\/s0021-9290(01)00150-6","article-title":"Specificity of endothelial cell reorientation in response to cyclic mechanical stretching.","volume":"34","author":"Wang","year":"2001","journal-title":"J. Biomech."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1114\/1.1317528","article-title":"Contractility affects stress fiber remodeling and reorientation of endothelial cells subjected to cyclic mechanical stretching.","volume":"28","author":"Wang","year":"2000","journal-title":"Ann. Biomed. Eng."},{"key":"B134","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1083\/jcb.113.4.919","article-title":"Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface.","volume":"113","author":"Wayner","year":"1991","journal-title":"J. Cell Biol."},{"key":"B135","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1242\/jcs.111.8.1117","article-title":"Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A. Requirement for threonines 788-789 in receptor activation.","author":"Wennerberg","year":"1998","journal-title":"J. Cell Sci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/j.1432-1033.1997.0430a.x","article-title":"Energy-filtered electron microscopy reveals that talin is a highly flexible protein composed of a series of globular domains.","volume":"243","author":"Winkler","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0034-5687(99)00092-4","article-title":"The effects of mechanical forces on lung functions.","volume":"119","author":"Wirtz","year":"2000","journal-title":"Respir. Physiol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1113\/jphysiol.2005.096537","article-title":"Endothelial focal adhesions and barrier function.","author":"Wu","year":"2005","journal-title":"J. Physiol."},{"key":"B139","first-page":"C635","article-title":"Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain.","author":"Yano","year":"","journal-title":"Am. J. Physiol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1006\/bbrc.1996.1057","article-title":"Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells.","volume":"224","author":"Yano","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B141","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/(sici)1097-4644(19970301)64:3<505::aid-jcb17>3.0.co;2-e","article-title":"Cyclic strain induces reorganization of integrin alpha 5 beta 1 and alpha 2 beta 1 in human umbilical vein endothelial cells.","volume":"64","author":"Yano","year":"1997","journal-title":"J. Cell. Biochem."},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11966","article-title":"The mechanical response of talin.","volume":"7","author":"Yao","year":"2016","journal-title":"Nat. Commun."},{"key":"B143","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1538-7836.2011.04355.x","article-title":"Molecular mechanism of inside-out integrin regulation.","author":"Ye","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"B144","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1083\/jcb.200505018","article-title":"Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement.","volume":"171","author":"Yoshigi","year":"2005","journal-title":"J. Cell Biol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1242\/jcs.066183","article-title":"The switchable integrin adhesome.","author":"Zaidel-Bar","year":"2010","journal-title":"J. Cell Sci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1016\/j.cellsig.2009.09.002","article-title":"Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancement.","volume":"21","author":"Zhao","year":"2009","journal-title":"Cell. Signal."},{"key":"B147","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1083\/jcb.200912094","article-title":"Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development.","volume":"189","author":"Zhao","year":"2010","journal-title":"J. Cell Biol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"6354","DOI":"10.1128\/mcb.20.17.6354-6363.2000","article-title":"Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.","volume":"20","author":"Zhao","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1182\/blood-2007-03-080077","article-title":"Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.","volume":"110","author":"Zhu","year":"2007","journal-title":"Blood"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.00511\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T23:33:50Z","timestamp":1663371230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.00511\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,26]]},"references-count":149,"alternative-id":["10.3389\/fphys.2019.00511"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2019.00511","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,26]]},"article-number":"511"}}