{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:32:15Z","timestamp":1789947135452,"version":"4.0.1"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/11\/18\/29257"],"award-info":[{"award-number":["RG\/11\/18\/29257"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2019.00826","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T10:28:05Z","timestamp":1562581685000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart"],"prefix":"10.3389","volume":"10","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Yanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Anwar","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Jit R. J.","family":"Logantha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kassab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Boyett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J.","family":"Gardiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Christopher","family":"Howarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halina","family":"Dobrzynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1172\/JCI59327","article-title":"MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death.","volume":"122","author":"Aurora","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1093\/eurheartj\/16.suppl_c.38","article-title":"Collagen turnover and its regulation in the normal and hypertrophying heart.","author":"Bishop","year":"1995","journal-title":"Eur. Heart J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.carpath.2009.07.003","article-title":"Chronic type 1 diabetes in spontaneously hypertensive rats leads to exacerbated cardiac fibrosis.","volume":"19","author":"Black","year":"2010","journal-title":"Cardiovasc. Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s0014-5793(00)01979-7","article-title":"Expression of T- and L-type calcium channel mRNA in murine sinoatrial node.","volume":"481","author":"Bohn","year":"2000","journal-title":"FEBS Lett."},{"key":"B5","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1159\/000092569","article-title":"Connexins in the sinoatrial and atrioventricular nodes.","volume":"42","author":"Boyett","year":"2006","journal-title":"Adv. Cardiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1196\/annals.1372.018","article-title":"Effects of streptozotocin-induced diabetes on contraction and calcium transport in rat ventricular cardiomyocytes.","volume":"1084","author":"Bracken","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sj.bjp.0703538","article-title":"Prevention by dexrazoxane of down-regulation of ryanodine receptor gene expression in anthracycline cardiomyopathy in the rat.","volume":"131","author":"Burke","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.yjmcc.2014.06.006","article-title":"Deletion of FoxO1 leads to shortening of QRS by increasing Na+ channel activity through enhanced expression of both cardiac Nav1.5 and beta3 subunit.","volume":"74","author":"Cai","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119134","article-title":"Regulation of neuronal Cav3.1 channels by cyclin-dependent kinase 5 (Cdk5).","volume":"10","author":"Calderon-Rivera","year":"2015","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1172\/JCI36154","article-title":"MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.","volume":"119","author":"Callis","year":"2009","journal-title":"J. Clin. Invest."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00127-0","article-title":"Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.","volume":"8","author":"Cerrone","year":"2017","journal-title":"Nat. Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1161\/CIRCEP.111.000206","article-title":"MOG1 rescues defective trafficking of Nav1.5 mutations in Brugada syndrome and sick sinus syndrome.","volume":"6","author":"Chakrabarti","year":"2013","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1161\/CIRCULATIONAHA.108.804369","article-title":"Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker.","volume":"119","author":"Chandler","year":"2009","journal-title":"Circulation"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.3892\/etm.2019.7222","article-title":"Decoy receptor-3 regulates inflammation and apoptosis via PI3K\/AKT signaling pathway in coronary heart disease.","volume":"17","author":"Chen","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1161\/CIRCEP.114.001973","article-title":"Loss of microRNA-106b-25 cluster promotes Atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.","volume":"7","author":"Chiang","year":"2014","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1111\/j.1471-4159.2009.06052.x","article-title":"RE1 silencing transcription factor is involved in regulating neuron-specific expression of alpha-internexin and neurofilament genes.","volume":"109","author":"Ching","year":"2009","journal-title":"J. Neurochem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"6327","DOI":"10.1113\/jphysiol.2012.239954","article-title":"Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node.","volume":"590","author":"Christel","year":"2012","journal-title":"J. Physiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1096\/fj.12-221994","article-title":"Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis.","volume":"27","author":"Danielson","year":"2013","journal-title":"FASEB J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.pharmthera.2013.04.010","article-title":"Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues.","volume":"139","author":"Dobrzynski","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"B20","doi-asserted-by":"publisher","first-page":"8218","DOI":"10.1074\/jbc.RA119.007648","article-title":"(Pro)renin receptor-mediated myocardial injury, apoptosis, and inflammatory response in rats with diabetic cardiomyopathy.","volume":"294","author":"Dong","year":"2019","journal-title":"J. Biol. Chem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.117.311607","article-title":"Targeting miR-423-5p reverses exercise training-induced HCN4 channel remodeling and sinus bradycardia.","volume":"121","author":"D\u2019Souza","year":"2017","journal-title":"Circ. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s13105-016-0481-9","article-title":"beta1-Adrenergic blocker bisoprolol reverses down-regulated ion channels in sinoatrial node of heart failure rats.","volume":"72","author":"Du","year":"2016","journal-title":"J. Physiol. Biochem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3382","DOI":"10.1172\/JCI94351","article-title":"Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome.","volume":"128","author":"Dulon","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153934","article-title":"Different profile of mRNA expression in sinoatrial node from streptozotocin-induced diabetic rat.","volume":"11","author":"Ferdous","year":"2016","journal-title":"PLoS One"},{"key":"B25","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.yjmcc.2004.07.008","article-title":"Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats.","volume":"37","author":"Fiordaliso","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.lfs.2005.12.036","article-title":"Cardiovascular oxidative stress is reduced by an ACE inhibitor in a rat model of streptozotocin-induced diabetes.","volume":"79","author":"Fiordaliso","year":"2006","journal-title":"Life Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/labinvest.3780057","article-title":"Myocyte death in streptozotocin-induced diabetes in rats in angiotensin II- dependent.","volume":"80","author":"Fiordaliso","year":"2000","journal-title":"Lab. Invest."},{"key":"B28","doi-asserted-by":"crossref","first-page":"S400","DOI":"10.1016\/S0002-8703(99)70042-6","article-title":"Hypertension and diabetes: current issues.","volume":"138","author":"Furberg","year":"1999","journal-title":"Am. Heart J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1111\/j.1540-8159.1990.tb06947.x","article-title":"Symptoms, cardiovascular risk profile and spontaneous ECG in paced patients: a five-year follow-up study.","volume":"13","author":"Grimm","year":"1990","journal-title":"Pacing Clin. Electrophysiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1248\/bpb.28.957","article-title":"Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes.","volume":"28","author":"Gurusamy","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"B31","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1152\/japplphysiol.01090.2016","article-title":"Reduced collagen accumulation and augmented MMP-2 activity in left ventricle of old rats submitted to high-intensity resistance training.","volume":"123","author":"Guzzoni","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"R227","DOI":"10.1152\/ajpregu.00276.2014","article-title":"Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice.","volume":"308","author":"Hansen","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B33","first-page":"1427","article-title":"Non-viral delivery of the connexin 43 gene with histone deacetylase inhibitor to human nasopharyngeal tumor cells enhances gene expression and inhibits in vivo tumor growth.","volume":"30","author":"Hattori","year":"2007","journal-title":"Int. J. Oncol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/cvr\/26.2.101","article-title":"Reperfusion induced injury: manifestations, mechanisms, and clinical relevance.","volume":"26","author":"Hearse","year":"1992","journal-title":"Cardiovasc. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s11010-008-9883-5","article-title":"Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle.","volume":"319","author":"Howarth","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1113\/expphysiol.2005.031252","article-title":"Long-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats.","volume":"90","author":"Howarth","year":"2005","journal-title":"Exp. Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1139\/cjpp-2016-0418","article-title":"Reduced expression of HCN channels in the sinoatrial node of streptozotocin-induced diabetic rats.","volume":"95","author":"Huang","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s10059-011-0075-x","article-title":"Effects of amyloid-beta peptides on voltage-gated L-type Cav1.2 and Cav1.3 Ca2+ channels.","volume":"32","author":"Kim","year":"2011","journal-title":"Mol. Cells"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/396414","article-title":"Mild type 2 diabetes mellitus reduces the susceptibility of the heart to ischemia\/reperfusion injury: identification of underlying gene expression changes.","volume":"2015","author":"Korkmaz-Icoz","year":"2015","journal-title":"J. Diabetes Res."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19102941","article-title":"MicroRNA-204 is necessary for aldosterone-stimulated T-type calcium channel expression in cardiomyocytes.","volume":"19","author":"Koyama","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B41","first-page":"430","article-title":"Control of heart rate by the autonomic nervous system in acute spinal cord injury.","volume":"52","author":"Krstacic","year":"2013","journal-title":"Acta Clin. Croat."},{"key":"B42","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1124\/pr.115.012062","article-title":"Connexins in cardiovascular and neurovascular health and disease: pharmacological implications.","volume":"69","author":"Leybaert","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1159\/000489185","article-title":"MicroRNA-223 regulates cardiac fibrosis after myocardial infarction by targeting RASA1.","volume":"46","author":"Liu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00210-017-1443-7","article-title":"Transient receptor potential vanilloid-3 (TRPV3) activation plays a central role in cardiac fibrosis induced by pressure overload in rats via TGF-beta1 pathway.","volume":"391","author":"Liu","year":"2018","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1042\/BCJ20160362","article-title":"GDF-15 enhances intracellular Ca2+ by increasing Cav1.3 expression in rat cerebellar granule neurons.","volume":"473","author":"Lu","year":"2016","journal-title":"Biochem. J."},{"key":"B46","doi-asserted-by":"publisher","first-page":"251","DOI":"10.4161\/chan.5.3.15266","article-title":"Functional roles of Cav1.3, Cav3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.","volume":"5","author":"Marger","year":"2011","journal-title":"Channels"},{"key":"B47","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1152\/physiol.00054.2012","article-title":"Modern concepts concerning the origin of the heartbeat.","volume":"28","author":"Monfredi","year":"2013","journal-title":"Physiology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/j.1463-1326.2006.00609.x","article-title":"Diabetes as a risk factor for cardiac conduction defects: a review.","volume":"9","author":"Movahed","year":"2007","journal-title":"Diabetes Obes. Metab."},{"key":"B49","first-page":"335","article-title":"Are diabetic patients at increased risk of arrhythmias?","volume":"53","author":"Nakou","year":"2012","journal-title":"Hellenic J. Cardiol."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4729284","article-title":"Neutrophils infiltrate the spinal cord parenchyma of rats with experimental diabetic neuropathy.","volume":"2017","author":"Newton","year":"2017","journal-title":"J. Diabetes Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/cvr\/24.5.381","article-title":"Chronic diabetes mellitus prolongs action potential duration of rat ventricular muscles: circumstantial evidence for impaired Ca2+ channel.","volume":"24","author":"Nobe","year":"1990","journal-title":"Cardiovasc. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.yjmcc.2014.04.024","article-title":"Downregulation of connexin43 by microRNA-130a in cardiomyocytes results in cardiac arrhythmias.","volume":"74","author":"Osbourne","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1093\/jnen\/62.3.260","article-title":"Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 diabetic neuropathy.","volume":"62","author":"Pierson","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.ajhg.2016.02.022","article-title":"Cryptic amyloidogenic elements in the 3\u2032 UTRs of neurofilament genes trigger axonal neuropathy.","volume":"98","author":"Rebelo","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"B55","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1111\/bph.13148","article-title":"Effects of chronic treatment with the new ultra-long-acting beta2 -adrenoceptor agonist indacaterol alone or in combination with the beta1 -adrenoceptor blocker metoprolol on cardiac remodelling.","volume":"172","author":"Rinaldi","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1161\/01.cir.0000160853.19867.61","article-title":"Mouse model of SCN5A-linked hereditary Lenegre\u2019s disease: age-related conduction slowing and myocardial fibrosis.","volume":"111","author":"Royer","year":"2005","journal-title":"Circulation"},{"key":"B57","first-page":"2517","article-title":"Diabetes mellitus and impaired atrioventricular conduction.","volume":"75","author":"Rubler","year":"1975","journal-title":"N. Y. State J. Med."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0638-z","article-title":"Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection.","volume":"16","author":"Russell","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.2337\/diabetes.52.9.2372","article-title":"Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats.","volume":"52","author":"Sayers","year":"2003","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B60","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jaci.2015.07.036","article-title":"Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by beta2-agonists, corticosteroids, and critical illness.","volume":"137","author":"Scott","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.cardiores.2003.12.007","article-title":"Gap junction alterations in human cardiac disease.","volume":"62","author":"Severs","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/230458","article-title":"The effects of C-peptide on type 1 diabetic polyneuropathies and encephalopathy in the BB\/Wor-rat.","volume":"2008","author":"Sima","year":"2008","journal-title":"Exp. Diabetes Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2013.12.031","article-title":"Reduced Na+ current density underlies impaired propagation in the diabetic rabbit ventricle.","volume":"69","author":"Stables","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07694-8","article-title":"High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling.","volume":"7","author":"Stephenson","year":"2017","journal-title":"Sci. Rep."},{"key":"B65","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/s0165-6147(98)01171-7","article-title":"Structural basis of drug binding to L Ca2+ channels.","volume":"19","author":"Striessnig","year":"1998","journal-title":"Trends Pharmacol. Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.cardiores.2003.12.011","article-title":"Transcriptional control of myocardial connexins.","volume":"62","author":"Teunissen","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"6130","DOI":"10.1021\/bi100796v","article-title":"Caveolin 3 is associated with the calcium release complex and is modified via in vivo triadin modification.","volume":"49","author":"Vassilopoulos","year":"2010","journal-title":"Biochemistry"},{"key":"B68","doi-asserted-by":"publisher","first-page":"577","DOI":"10.4330\/wjc.v6.i7.577","article-title":"Mechanisms underlying the impaired contractility of diabetic cardiomyopathy.","volume":"6","author":"Ward","year":"2014","journal-title":"World J. Cardiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"27265","DOI":"10.1074\/jbc.M109.022855","article-title":"Chronic administration of KB-R7943 induces up-regulation of cardiac NCX1.","volume":"284","author":"Xu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/s0008-6363(98)00091-1","article-title":"Low-frequency extracellular potentials recorded from the sinoatrial node.","volume":"39","author":"Yamamoto","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nm1569","article-title":"The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2.","volume":"13","author":"Yang","year":"2007","journal-title":"Nat. Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1536\/ihj.31.25","article-title":"Signal-averaging electrocardiogram in patients with diabetes mellitus.","volume":"31","author":"Yang","year":"1990","journal-title":"Jpn. Heart J."},{"key":"B73","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.yjmcc.2009.08.023","article-title":"Structural remodelling of the sinoatrial node in obese old rats.","volume":"48","author":"Yanni","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.2337\/diabetes.54.11.3082","article-title":"Effects of diabetes on ryanodine receptor Ca release channel (RyR2) and Ca2+ homeostasis in rat heart.","volume":"54","author":"Yaras","year":"2005","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B75","doi-asserted-by":"crossref","first-page":"H1137","DOI":"10.1152\/ajpheart.2001.281.3.H1137","article-title":"Altered SR protein expression associated with contractile dysfunction in diabetic rat hearts.","volume":"281","author":"Zhong","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.00826\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T23:40:38Z","timestamp":1569973238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.00826\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,8]]},"references-count":75,"alternative-id":["10.3389\/fphys.2019.00826"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2019.00826","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,8]]},"article-number":"826"}}