{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:16:29Z","timestamp":1792066589571,"version":"4.4.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703697"],"award-info":[{"award-number":["81703697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2019.01004","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T05:14:11Z","timestamp":1565068451000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Deciphering the Mechanical Network of Chronic Atrophic Gastritis: A Urinary Time-Dependent Metabonomics-Based Network Pharmacology Study"],"prefix":"10.3389","volume":"10","author":[{"given":"YueTao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenQian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XueMei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1046\/j.1523-5378.2001.00042.x","article-title":"Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study.","volume":"6","author":"Asaka","year":"2001","journal-title":"Helicobacter"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155393","article-title":"Assessment of free radical scavenging activity of dimethylglycine sodium salt and its role in providing protection against lipopolysaccharide-induced oxidative stress in mice.","volume":"11","author":"Bai","year":"2016","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1158\/1055-9965.EPI-07-2676","article-title":"Biochemical alterations from normal mucosa to gastric cancer by ex vivo magnetic resonance spectroscopy.","volume":"17","author":"Calabrese","year":"2008","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"12874","DOI":"10.3748\/wjg.v20.i36.12874","article-title":"Potential role of metabolomics in diagnosis and surveillance of gastric cancer.","volume":"20","author":"Chan","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jpba.2016.09.044","article-title":"NMR-based metabonomics and correlation analysis al potential biomarkers associated with chronic atrophic gastritis.","volume":"132","author":"Cui","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"B6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ejphar.2017.12.052","article-title":"Effect of allantoin on experimentally induced gastric ulcers: pathways of gastroprotection.","volume":"821","author":"da Silva","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1039\/c3mb70609e","article-title":"Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.","volume":"10","author":"Diao","year":"2014","journal-title":"Mol. Biosyst."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3262495","article-title":"Early effect of amyloid \u03b2-peptide on hippocampal and serum metabolism in rats studied by an integrated method of NMR-based metabolomics and ANOVA-simultaneous component analysis.","volume":"2017","author":"Du","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"B9","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics.","volume":"55","author":"Ferlay","year":"2005","journal-title":"CA Cancer J. Clin."},{"key":"B10","first-page":"405","article-title":"Cancer incidence in Korea.","volume":"34","author":"Ferlay","year":"2002","journal-title":"Globocan"},{"key":"B11","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1093\/bioinformatics\/btq048","article-title":"Metscape: a cytoscape plug-in for visualizing and interpreting metabolomic data in the context of human metabolic networks.","volume":"26","author":"Gao","year":"2010","journal-title":"Bioinformatics"},{"key":"B12","doi-asserted-by":"crossref","first-page":"R936","DOI":"10.1152\/ajpregu.00162.2006","article-title":"Oxidative phosphorylation and its coupling to mitochondrial creatine and adenylate kinases in human gastric mucosa.","volume":"291","author":"Gruno","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"9169","DOI":"10.1007\/s13277-015-4753-8","article-title":"The proliferation impairment induced by AQP3 deficiency is the result of glycerol uptake and metabolism inhibition in gastric cancer cells.","volume":"37","author":"Li","year":"2016","journal-title":"Tumour Biol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13195-5","article-title":"Comparative metabolomics study on therapeutic mechanism of electro-acupuncture and moxibustion on rats with chronic atrophic gastritis (CAG).","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00216-014-8227-4","article-title":"Combining metabolomic non-targeted GC\u00d7GC-ToF-MS analysis and chemometric ASCA-based study of variances to assess dietary influence on type 2 diabetes development in a mouse model.","volume":"407","author":"Ly-Verd\u00fa","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-017-0712-8","article-title":"Risk factors for mortality among patients admitted with upper gastrointestinal bleeding at a tertiary hospital: a prospective cohort study.","volume":"17","author":"Moledina","year":"2017","journal-title":"BMC Gastroenterol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1093\/bioinformatics\/bti476","article-title":"ANOVA-simultaneous component analysis (ASCA): a new tool for analyzing designed metabolomics data.","volume":"21","author":"Smilde","year":"2005","journal-title":"Bioinformatics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11306-009-0191-1","article-title":"Dynamic metabolomic data analysis: a tutorial review.","volume":"6","author":"Smilde","year":"2010","journal-title":"Metabolomics"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012.","author":"Torre","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1158\/1055-9965.epi-05-0931","article-title":"Prevalence of chronic atrophic gastritis in different parts of the world.","volume":"15","author":"Weck","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"14.10.1","DOI":"10.1002\/cpbi.11","article-title":"Using metaboAnalyst 3.0 for comprehensive metabolomics data analysis.","volume":"55","author":"Xia","year":"2016","journal-title":"Curr. Protoc. Bioinform."},{"key":"B22","first-page":"226","article-title":"Therapeutic effects of astragalus aaponin on rats with atrophic gastritis and MyD88, TLR4 receptor.","volume":"19","author":"Zhang","year":"2013","journal-title":"Chin. J. Exp. Trad. Med. Formulae"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10110461","article-title":"Network pharmacology to unveil the biological basis of health-strengthening herbal medicine in cancer treatment.","volume":"10","author":"Zheng","year":"2018","journal-title":"Cancers"},{"key":"B24","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/cem.1400","article-title":"ANOVA-principal component analysis and ANOVA-simultaneous component analysis: a comparison.","volume":"25","author":"Zwanenburg","year":"2011","journal-title":"J. Chemom."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.01004\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T17:45:03Z","timestamp":1569260703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.01004\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,6]]},"references-count":24,"alternative-id":["10.3389\/fphys.2019.01004"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2019.01004","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,6]]},"article-number":"1004"}}