{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:16:30Z","timestamp":1789402590050,"version":"build-2803163510"},"reference-count":180,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2019.01129","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T07:30:11Z","timestamp":1567150211000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":50,"title":["The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?"],"prefix":"10.3389","volume":"10","author":[{"given":"Marko","family":"Stupin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Kibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Stupin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Selthofer-Relati\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Mati\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Mihalj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zrinka","family":"Mihaljevi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Juki\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Drenjan\u010devi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003177.pub3","article-title":"Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.","volume":"7","author":"Abdelhamid","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/ni.3772","article-title":"Limiting inflammation-the negative regulation of NF-\u03baB and the NLRP3 inflammasome.","volume":"18","author":"Afonina","year":"2017","journal-title":"Nat. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jnutbio.2018.02.012","article-title":"Omega-3 fatty acids in obesity and metabolic syndrome: a mechanistic update.","volume":"58","author":"Albracht-Schulte","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00394-009-0057-3","article-title":"Effect of polyunsaturated fatty acids on the reactive oxygen and nitrogen species production by raw 264.7 macrophages.","volume":"49","author":"Ambrozova","year":"2010","journal-title":"Eur. J. Nutr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.plefa.2007.08.010","article-title":"Effects of the fish-oil supplementation on the immune and inflammatory responses in elite swimmers.","volume":"77","author":"Andrade","year":"2007","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1002\/ar.23177","article-title":"Long-term therapy with omega-3 ameliorates myonecrosis and benefits skeletal muscle regeneration in mdx mice.","volume":"298","author":"Apolin\u00e1rio","year":"2015","journal-title":"Anat. Rec."},{"key":"B7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1042\/CS20070277","article-title":"Fish oil fatty acids improve postprandial vascular reactivity in healthy men.","volume":"114","author":"Armah","year":"2008","journal-title":"Clin. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2165\/00007256-199112030-00004","article-title":"Mechanisms of exercise-induced muscle fibre injury.","volume":"12","author":"Armstrong","year":"1991","journal-title":"Sport. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/fjc.0000000000000382","article-title":"Potential of food and natural products to promote endothelial and vascular health.","volume":"68","author":"Auger","year":"2016","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/s11745-006-0162-5","article-title":"Dietary fatty acid profile affects endurance in rats.","volume":"32","author":"Ayre","year":"1997","journal-title":"Lipids"},{"key":"B11","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/s0952-3278(99)80011-8","article-title":"Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: a mechanism for decreased body fat deposition.","volume":"60","author":"Baillie","year":"1999","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"B12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s12192-010-0217-7","article-title":"Acute exercise activates myocardial nuclear factor kappa B.","volume":"16","author":"Balan","year":"2011","journal-title":"Cell Stress Chaperones"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/j.bbalip.2010.06.006","article-title":"Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties.","volume":"1801","author":"Balvers","year":"2010","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"B14","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1113\/JP274036","article-title":"\u03b1-Linolenic acid and exercise training independently, and additively, decrease blood pressure and prevent diastolic dysfunction in obese Zucker rats.","volume":"595","author":"Barbeau","year":"2017","journal-title":"J. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/15287399409531917","article-title":"Modulation of exercise-induced immunosuppression by dietary polyunsaturated fatty acids in mice.","volume":"43","author":"Benquet","year":"1994","journal-title":"J. Toxicol. Environ. Health"},{"key":"B16","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.ihj.2018.01.030","article-title":"Acute effects of diets rich in almonds and walnuts on endothelial function.","volume":"70","author":"Bhardwaj","year":"2018","journal-title":"Indian Heart J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1111\/j.1651-2227.2008.01213.x","article-title":"Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study.","volume":"98","author":"Biltagi","year":"2009","journal-title":"Acta Paediatr."},{"key":"B18","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1055\/s-0032-1323829","article-title":"Effects of exercise intensity on flow mediated dilation in healthy humans.","volume":"34","author":"Birk","year":"2012","journal-title":"Int. J. Sports Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1080\/17461391.2018.1491626","article-title":"Adding omega-3 fatty acids to a protein-based supplement during pre-season training results in reduced muscle soreness and the better maintenance of explosive power in professional Rugby Union players.","volume":"18","author":"Black","year":"2018","journal-title":"Eur. J. Sport Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3511","DOI":"10.1113\/jphysiol.2008.153742","article-title":"Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels.","volume":"586","author":"Black","year":"2008","journal-title":"J. Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.15407\/fz62.02.047","article-title":"Induction of oxidative and nitrosative stress in boys in adapting to physical stress during training and competitive periods.","volume":"62","author":"Bogdanovskaya","year":"2016","journal-title":"Fiziol. Zh."},{"key":"B22","first-page":"1137","article-title":"Nature, origin and role of fatty acids of the nervous system: an essential fatty acid, an alpha-linolenic acid, changing the structure and the cerebral function.","volume":"173","author":"Bourre","year":"1989","journal-title":"Bull. Acad. Natl. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0021-9150(87)90067-0","article-title":"Fish oil increases peripheral capillary blood cell velocity in humans.","volume":"66","author":"Bruckner","year":"1987","journal-title":"Atherosclerosis"},{"key":"B24","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1189\/jlb.0505247","article-title":"Physical activity and modulation of systemic low-level inflammation.","volume":"78","author":"Bruunsgaard","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1505S","DOI":"10.1093\/ajcn\/83.6.1505S","article-title":"n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases.","volume":"83","author":"Calder","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"B26","doi-asserted-by":"publisher","first-page":"592S","DOI":"10.3945\/jn.111.155259","article-title":"Mechanisms of action of (n-3) fatty acids.","volume":"142","author":"Calder","year":"2012","journal-title":"J. Nutr."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1042\/BST20160474","article-title":"Omega-3 fatty acids and inflammatory processes: from molecules to man.","volume":"45","author":"Calder","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"B28","doi-asserted-by":"publisher","first-page":"116","DOI":"10.20517\/2574-1209.2017.14","article-title":"Omega-3 polyunsaturated fatty acids and cardiovascular health: a molecular view into structure and function.","volume":"1","author":"Calvo","year":"2017","journal-title":"Vessel Plus"},{"key":"B29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jash.2016.10.004","article-title":"Omega-3 fatty acids supplementation improves endothelial function and arterial stiffness in hypertensive patients with hypertriglyceridemia and high cardiovascular risk.","volume":"11","author":"Casanova","year":"2016","journal-title":"J. Am. Soc. Hypertens."},{"key":"B30","doi-asserted-by":"publisher","first-page":"R1322","DOI":"10.1152\/ajpregu.00388.2009","article-title":"Eicosapentaenoic acid attenuates arthritis-induced muscle wasting acting on atrogin-1 and on myogenic regulatory factors.","volume":"297","author":"Castillero","year":"2009","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1345-8","article-title":"Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1.","volume":"15","author":"Chen","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf7483","article-title":"Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses.","volume":"8","author":"Chiurchi\u00f9","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/s0735-1097(99)00036-4","article-title":"Exercise training enhances endothelial function in young men.","volume":"33","author":"Clarkson","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/s1056-8727(01)00222-7","article-title":"Chronic exercise is associated with enhanced cutaneous blood flow in type 2 diabetes.","volume":"16","author":"Colberg","year":"2002","journal-title":"J. Diabetes Complications"},{"key":"B35","first-page":"176","article-title":"Effects of short-term docosahexaenoic acid supplementation on markers of inflammation after eccentric strength exercise in women.","volume":"15","author":"Corder","year":"2016","journal-title":"J. Sports Sci. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer.","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.4067\/S0034-98872012001000007","article-title":"Efecto del ejercicio agudo sobre la expresi\u00f3n del receptor tipo Toll-4 y los mecanismos inflamatorios en coraz\u00f3n de rata.","volume":"140","author":"Cristi-Montero","year":"2012","journal-title":"Rev. Med. Chil."},{"key":"B38","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.metabol.2016.10.007","article-title":"Fit with good fat? The role of n-3 polyunsaturated fatty acids on exercise performance.","volume":"66","author":"Da Boit","year":"2017","journal-title":"Metabolism"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32553-5","article-title":"Omega-3 from flaxseed oil protects obese mice against diabetic retinopathy through GPR120 receptor.","volume":"8","author":"D\u00e1tilo","year":"2018","journal-title":"Sci. Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1051\/rnd:2000124","article-title":"Effect of dietary polyunsaturated fatty acids on contractile function of hearts isolated from sedentary and trained rats.","volume":"40","author":"Demaison","year":"2000","journal-title":"Reprod. Nutr. Dev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.cardiores.2006.06.014","article-title":"Pro- and antiarrhythmic properties of a diet rich in fish oil.","volume":"73","author":"Den Ruijter","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1519\/JSC.0000000000000617","article-title":"Docosahexaenoic acid affects markers of inflammation and muscle damage after eccentric exercise.","volume":"28","author":"DiLorenzo","year":"2014","journal-title":"J. Strength Cond. Res."},{"key":"B43","doi-asserted-by":"crossref","DOI":"10.5772\/67033","article-title":"The effect of dietary intake of Omega-3 polyunsaturated fatty acids on cardiovascular health: revealing potentials of functional food","author":"Drenjan\u010devi\u0107","year":"2017","journal-title":"Superfood and Functional Food - The Development of Superfoods and Their Roles as Medicine"},{"key":"B44","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1152\/japplphysiol.00924.2016","article-title":"Lower limb explosive strength capacity in elderly women: effects of resistance training and healthy diet.","volume":"123","author":"Edholm","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1017\/S0007114514002001","article-title":"Effects of an energy-restricted diet rich in plant-derived a -linolenic acid on systemic inflammation and endothelial function in overweight-to-obese patients with metabolic syndrome traits.","volume":"112","author":"Egert","year":"2014","journal-title":"Br. J. Nutr."},{"key":"B46","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/j.1365-2796.1989.tb01446.x","article-title":"Effects of n-3 fatty acids on blood rheology.","volume":"225","author":"Ernst","year":"1989","journal-title":"J. Intern. Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1139\/H10-020","article-title":"The effect of acute fish-oil supplementation on endothelial function and arterial stiffness following a high-fat meal.","volume":"35","author":"Fahs","year":"2010","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"B48","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.atherosclerosis.2008.12.013","article-title":"Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: the heart and soul study.","volume":"205","author":"Farzaneh-Far","year":"2009","journal-title":"Atherosclerosis"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1161\/ATVBAHA.111.228593","article-title":"Reduced thrombin formation and altered fibrin clot properties induced by polyunsaturated omega-3 fatty acids on top of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention (OMEGA-PCI Clot).","volume":"31","author":"Gajos","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu11010046","article-title":"Omega-3 polyunsaturated fatty acids: benefits and endpoints in sport.","volume":"11","author":"Gammone","year":"2018","journal-title":"Nutrients"},{"key":"B51","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1113\/jphysiol.2006.121079","article-title":"Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity.","volume":"579","author":"Gingras","year":"2007","journal-title":"J. Physiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/nri3041","article-title":"The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease.","volume":"11","author":"Gleeson","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jnutbio.2012.07.012","article-title":"Treatment with n-3 polyunsaturated fatty acids reverses endothelial dysfunction and oxidative stress in experimental menopause.","volume":"24","author":"Gortan","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1123\/ijsnem.201-0325","article-title":"n-3 fatty acid supplementation during 4 weeks of training leads to improved anaerobic endurance capacity, but not maximal strength, speed, or power in soccer players.","volume":"27","author":"Gravina","year":"2017","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.bbi.2012.08.002","article-title":"Fish oil supplementation augments post-exercise immune function in young males.","volume":"26","author":"Gray","year":"2012","journal-title":"Brain. Behav. Immun."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-13-17","article-title":"Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications\u2013a review.","volume":"13","author":"Grygiel-G\u00f3rniak","year":"2014","journal-title":"Nutr. J."},{"key":"B57","doi-asserted-by":"publisher","first-page":"R1405","DOI":"10.1152\/ajpregu.00267.2001","article-title":"Seasonal dynamics of flight muscle fatty acid binding protein and catabolic enzymes in a migratory shorebird.","volume":"282","author":"Guglielmo","year":"2002","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1161\/01.CIR.0000074229.93804.5C","article-title":"Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase.","volume":"107","author":"Hambrecht","year":"2003","journal-title":"Circulation"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1016\/j.ijcard.2012.05.110","article-title":"Long-chain, n-3 fatty acids and physical activity \u2014 Independent and interactive associations with cardiac autonomic control.","volume":"167","author":"Harbaugh","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.cell.2014.10.029","article-title":"Integrative biology of exercise.","volume":"159","author":"Hawley","year":"2014","journal-title":"Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1194\/jlr.M003319","article-title":"Metabolic switching of human myotubes is improved by n-3 fatty acids.","volume":"51","author":"Hessvik","year":"2010","journal-title":"J. Lipid Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"H645","DOI":"10.1152\/ajpheart.01087.2006","article-title":"Frequency-dependent response of the vascular endothelium to pulsatile shear stress.","volume":"293","author":"Himburg","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.226118","article-title":"Dietary alpha-linolenic acid inhibits arterial thrombus formation, platelet activation, and tissue factor expression.","volume":"31","author":"Holy","year":"2010","journal-title":"Eur. Heart J."},{"key":"B64","author":"Hopp","year":"2018","journal-title":"Use of Omega-3 Supplements in the United States."},{"key":"B65","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1055\/s-0038-1673618","article-title":"Influence of exercise on platelet function in patients with cardiovascular disease.","volume":"44","author":"Hvas","year":"2018","journal-title":"Semin. Thromb. Hemost."},{"key":"B66","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.clnu.2011.05.002","article-title":"Anti-in fl ammatory and anti-angiogenic effect of long chain n-3 polyunsaturated fatty acids in intestinal microvascular endothelium.","volume":"30","author":"Ibrahim","year":"2011","journal-title":"Clin. Nutr."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.3945\/ajcn.112.037432","article-title":"Long-chain n-3 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized controlled trial.","volume":"96","author":"Itariu","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"B68","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.clnu.2017.03.027","article-title":"Fish oil LC-PUFAs do not affect blood coagulation parameters and bleeding manifestations: analysis of 8 clinical studies with selected patient groups on omega-3-enriched medical nutrition.","volume":"37","author":"Jeansen","year":"2018","journal-title":"Clin. Nutr."},{"key":"B69","doi-asserted-by":"publisher","first-page":"6977","DOI":"10.3390\/md13116977","article-title":"Omega-3 fatty acids and skeletal muscle health.","volume":"13","author":"Jeromson","year":"2015","journal-title":"Mar. Drugs"},{"key":"B70","first-page":"432","article-title":"The effect of Omega-3 fatty acid supplementation on the inflammatory response to eccentric strength exercise.","volume":"10","author":"Jouris","year":"2011","journal-title":"J. Sports Sci. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1113\/jphysiol.2009.179432","article-title":"Exercise protects the cardiovascular system: effects beyond traditional risk factors.","volume":"587","author":"Joyner","year":"2009","journal-title":"J. Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1620\/tjem.205.45","article-title":"Endothelial flow-mediated dilatation and exercise capacity in highly trained endurance athletes.","volume":"205","author":"Kasikcioglu","year":"2005","journal-title":"Tohoku J. Exp. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1080\/09168451.2014.946392","article-title":"Supplementation with eicosapentaenoic acid-rich fish oil improves exercise economy and reduces perceived exertion during submaximal steady-state exercise in normal healthy untrained men.","volume":"78","author":"Kawabata","year":"2014","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B74","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jjcc.2014.02.004","article-title":"Association of n-3 polyunsaturated fatty acids with soluble thrombomodulin as a marker of endothelial damage?: a cross-sectional pilot study.","volume":"64","author":"Kawauchi","year":"2014","journal-title":"J. Cardiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/s0008-6363(03)00395-x","article-title":"The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects.","volume":"59","author":"Khan","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.mvr.2009.03.002","article-title":"Exercise training improves cutaneous microvascular endothelial function in post-surgical varicose vein patients.","volume":"78","author":"Klonizakis","year":"2009","journal-title":"Microvasc. Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.metabol.2014.04.005","article-title":"A fish-based diet intervention improves endothelial function in postmenopausal women with type 2 diabetes mellitus: a randomized crossover trial.","volume":"63","author":"Kondo","year":"2014","journal-title":"Metabolism"},{"key":"B78","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1159\/000485837","article-title":"n-3 polyunsaturated fatty acids and cardiovascular disease: principles, practices, pitfalls, and promises - a contemporary review.","volume":"26","author":"Kones","year":"2017","journal-title":"Med. Princ. Pract."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.3945\/jn.113.174383","article-title":"n3 PUFAs do not affect adipose tissue inflammation in overweight to moderately obese men and women.","volume":"143","author":"Kratz","year":"2013","journal-title":"J. Nutr."},{"key":"B80","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s12603-015-0497-9","article-title":"Serum polyunsaturated fatty acid composition and serum high-sensitivity C-Reactive protein levels in healthy japanese residents: the KOBE study.","volume":"19","author":"Kubota","year":"2015","journal-title":"J. Nutr. Health Aging"},{"key":"B81","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s004210050469","article-title":"Enhanced endothelium-dependent vasodilatation in human skin vasculature induced by physical conditioning.","volume":"79","author":"Kvernmo","year":"1998","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1139\/apnm-2015-0490","article-title":"A single Mediterranean meal does not impair postprandial flow-mediated dilatation in healthy men with subclinical metabolic dysregulations.","volume":"41","author":"Lacroix","year":"2016","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"B83","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s40264-016-0438-5","article-title":"Benefit\u2013Risk assessment of fish oil in preventing cardiovascular disease.","volume":"39","author":"Lands","year":"2016","journal-title":"Drug Saf."},{"key":"B84","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1152\/japplphysiol.01096.2007","article-title":"Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype.","volume":"104","author":"Laughlin","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0163-7827(00)00017-5","article-title":"The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina.","volume":"40","author":"Lauritzen","year":"2001","journal-title":"Prog. Lipid Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.thromres.2005.07.018","article-title":"Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction.","volume":"118","author":"Lee","year":"2006","journal-title":"Thromb. Res."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-015-0089-4","article-title":"21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function and performance in male athletes compared to olive oil placebo.","volume":"12","author":"Lewis","year":"2015","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"B88","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1197\/j.jht.2008.06.007","article-title":"Rotator cuff tendinopathy: is there a role for polyunsaturated fatty acids and antioxidants?.","volume":"22","author":"Lewis","year":"2009","journal-title":"J. Hand Ther."},{"key":"B89","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis.","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00636","article-title":"moderate exercise suppresses NF-\u03baB signaling and activates the SIRT1-AMPK-PGC1\u03b1 axis to attenuate muscle loss in diabetic db\/db Mice.","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Physiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.3945\/jn.113.176255","article-title":"Fish oil increases muscle protein mass and modulates Akt\/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.","volume":"143","author":"Liu","year":"2013","journal-title":"J. Nutr."},{"key":"B92","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1152\/ajpheart.01145.2003","article-title":"Upregulation of endothelial nitric oxide synthase in rat aorta after ingestion of fish oil-rich diet.","volume":"287","author":"Lo","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1055\/s-2007-973047","article-title":"Alteration of cardiovascular function in trained rats fed with fish oil.","volume":"16","author":"Lortet","year":"1995","journal-title":"Int. J. Sports Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1096\/fj.201500198R","article-title":"Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication.","volume":"30","author":"Mackey","year":"2016","journal-title":"FASEB J."},{"key":"B95","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1242\/jeb.02660","article-title":"Relationship between n-3 PUFA content and energy metabolism in the flight muscles of a migrating shorebird: evidence for natural doping.","volume":"210","author":"Maillet","year":"2007","journal-title":"J. Exp. Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.plefa.2014.03.001","article-title":"Temporal changes in human skeletal muscle and blood lipid composition with fish oil supplementation.","volume":"90","author":"McGlory","year":"2014","journal-title":"Prostaglandins, Leukot. Essent. Fat. Acids"},{"key":"B97","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1007779619087","article-title":"Dietary fatty acid composition influences swimming performance in Atlantic salmon (Salmo salar) in seawater.","volume":"19","author":"McKenzie","year":"1998","journal-title":"Fish Physiol. Biochem."},{"key":"B98","doi-asserted-by":"publisher","first-page":"F189","DOI":"10.1152\/ajprenal.00224.2003","article-title":"Lipoxins: endogenous regulators of inflammation.","volume":"286","author":"McMahon","year":"2004","journal-title":"Am. J. Physiol. Physiol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.jnutbio.2014.02.004","article-title":"Increasing long-chain n-3PUFA consumption improves small peripheral artery function in patients at intermediate-high cardiovascular risk.","volume":"25","author":"Merino","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-015-0073-z","article-title":"The effects PCSO-524\u00ae, a patented marine oil lipid and omega-3 PUFA blend derived from the New Zealand green lipped mussel (Perna canaliculus), on indirect markers of muscle damage and inflammation after muscle damaging exercise in untrained men: a random.","volume":"12","author":"Mickleborough","year":"2015","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.biopha.2014.10.008","article-title":"Omega-3 fatty acids improve postprandial lipemia and associated endothelial dysfunction in healthy individuals \u2013 a randomized cross-over trial.","volume":"68","author":"Miyoshi","year":"2014","journal-title":"Biomed. Pharmacother."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5987082","article-title":"Omega-3 polyunsaturated fatty acids in critical illness: anti-inflammatory, proresolving, or both?.","volume":"2017","author":"Molfino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B103","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.amjcard.2005.08.075","article-title":"Effects of dietary Omega-3 fatty acid supplementation on endothelium-dependent vasodilation in patients with chronic heart failure.","volume":"97","author":"Morgan","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1039\/c4fo00393d","article-title":"Omega-3 fatty acids and cardiovascular disease: epidemiology and effects on cardiometabolic risk factors.","volume":"5","author":"Mori","year":"2014","journal-title":"Food Funct."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.amjcard.2010.11.040","article-title":"Relation of whole blood n-3 fatty acid levels to exercise parameters in patients with stable coronary artery disease (from the heart and soul study).","volume":"107","author":"Moyers","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1016\/j.clnu.2016.09.018","article-title":"Dietary fat composition, total body fat and regional body fat distribution in two caucasian populations of middle-aged and older adult women.","volume":"36","author":"Muka","year":"2017","journal-title":"Clin. Nutr."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1242\/jeb.027888","article-title":"Mimicking the natural doping of migrant sandpipers in sedentary quails: effects of dietary n-3 fatty acids on muscle membranes and PPAR expression.","volume":"212","author":"Nagahuedi","year":"2009","journal-title":"J. Exp. Biol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ejphar.2011.05.047","article-title":"Possible involvement of \u03b2-endorphin in docosahexaenoic acid-induced antinociception.","volume":"666","author":"Nakamoto","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1024\/0300-9831.73.5.389","article-title":"Effects of lifestyle modification and lipid intake variations on patients with peripheral vascular disease.","volume":"73","author":"Nestares","year":"2003","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"B110","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.jacc.2010.11.017","article-title":"Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy.","volume":"57","author":"Nodari","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1161\/01.ATV.20.1.259","article-title":"Effect of omega-3 fatty acids and simvastatin on hemostatic risk factors and postprandial hyperlipemia in patients with combined hyperlipemia.","volume":"20","author":"Nord\u00f8y","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1055\/s-2007-1024743","article-title":"Immunologic mediators as parameters of the reaction to strenuous exercise.","volume":"12","author":"Northoff","year":"1991","journal-title":"Int. J. Sports Med."},{"key":"B113","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1055\/s-0038-1648914","article-title":"Both fish oil and olive oil lowered plasma fibrinogen in women with high baseline fibrinogen levels.","volume":"72","author":"Oosthuizen","year":"1994","journal-title":"Thromb. Haemost."},{"key":"B114","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1152\/physiol.00052.2010","article-title":"Vascular effects of exercise: endothelial adaptations beyond active muscle beds.","volume":"26","author":"Padilla","year":"2011","journal-title":"Physiology"},{"key":"B115","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1017\/S0007114508888708","article-title":"Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with \u03b1-linolenic acid on postprandial endothelial function in healthy men.","volume":"100","author":"Pe","year":"2008","journal-title":"Br. J. Nutr."},{"key":"B116","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1136\/bjsm.34.4.246","article-title":"Effects of exercise on lymphocytes and cytokines.","volume":"34","author":"Pedersen","year":"2000","journal-title":"Br. J. Sports Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.plefa.2018.07.017","article-title":"Acute fish oil supplementation modulates the inflammatory response after strenuous exercise in obese men: a cross-over study.","volume":"137","author":"Peres","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"B118","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.jnutbio.2014.05.001","article-title":"Reduction of prothrombin and Factor V levels following supplementation with omega-3 fatty acids is sex dependent: a randomised controlled study.","volume":"25","author":"Phang","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"B119","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1194\/jlr.M087734","article-title":"Relative quantification of deuterated omega-3 and -6 fatty acids and their lipid turnover in PC12 cell membranes using TOF-SIMS.","volume":"59","author":"Philipsen","year":"2018","journal-title":"J. Lipid Res."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117494","article-title":"Dietary enrichment with fish oil prevents high fat-induced metabolic dysfunction in skeletal muscle in mice.","volume":"10","author":"Philp","year":"2015","journal-title":"PLoS One"},{"key":"B121","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/15438627.2018.1550401","article-title":"Applications of omega-3 polyunsaturated fatty acid supplementation for sport performance.","volume":"27","author":"Philpott","year":"2019","journal-title":"Res. Sport. Med."},{"key":"B122","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1080\/03008207.2017.1385605","article-title":"Leptin alone and in combination with interleukin-1-beta induced cartilage degradation potentially inhibited by EPA and DHA.","volume":"59","author":"Phitak","year":"2018","journal-title":"Connect. Tissue Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","article-title":"2016 European guidelines on cardiovascular disease prevention in clinical practice.","volume":"37","author":"Piepoli","year":"2016","journal-title":"Eur. Heart J."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12933-017-0523-9","article-title":"Treatment with high-dose n-3 PUFAs has no effect on platelet function, coagulation, metabolic status or inflammation in patients with atherosclerosis and type 2 diabetes.","volume":"16","author":"Poreba","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/ejcn.2011.195","article-title":"Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men.","volume":"66","author":"Reinders","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"B126","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.atherosclerosis.2009.03.006","article-title":"Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes.","volume":"206","author":"Rizzaa","year":"2009","journal-title":"Atherosclerosis"},{"key":"B127","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3945\/ajcn.111.021915","article-title":"Fish-oil supplementation enhances the effects of strength training in elderly women.","volume":"95","author":"Rodacki","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"B128","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3233\/CH-2011-1469","article-title":"Effects of exercise training on blood rheology: A meta-analysis.","volume":"49","author":"Romain","year":"2011","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"B129","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/s0828-282x(10)70395-0","article-title":"Improvements in heart rate variability with exercise therapy.","volume":"26","author":"Routledge","year":"2010","journal-title":"Can. J. Cardiol."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000065","article-title":"Running speed in mammals increases with muscle n-6 polyunsaturated fatty acid content.","volume":"1","author":"Ruf","year":"2006","journal-title":"PLoS One"},{"key":"B131","doi-asserted-by":"publisher","first-page":"10070","DOI":"10.1074\/jbc.X112.351437","article-title":"Role of basic science in the development of new medicines: examples from the eicosanoid field.","volume":"287","author":"Samuelsson","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1126\/science.2820055","article-title":"Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.","volume":"237","author":"Samuelsson","year":"1987","journal-title":"Science"},{"key":"B133","doi-asserted-by":"publisher","first-page":"973","DOI":"10.3945\/ajcn.111.018036","article-title":"Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial.","volume":"94","author":"Sanders","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2018-000414","article-title":"A randomised controlled trial of long-chain omega-3 polyunsaturated fatty acids in the management of rotator cuff related shoulder pain.","volume":"4","author":"Sandford","year":"2018","journal-title":"BMJ Open Sport Exerc. Med."},{"key":"B135","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1159\/000170386","article-title":"Effect of n-3 polyunsaturated fatty acids in asthma after low-dose allergen challenge.","volume":"148","author":"Schubert","year":"2009","journal-title":"Int. Arch. Allergy Immunol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1152\/jappl.1995.79.3.675","article-title":"Oxidants and antioxidants in exercise.","volume":"79","author":"Sen","year":"1995","journal-title":"J. Appl. Physiol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0005-2760(94)90185-6","article-title":"Lipoxin biosynthesis and its impact in inflammatory and vascular events.","volume":"1212","author":"Serhan","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"B138","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1096\/fj.11-201442","article-title":"Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain.","volume":"26","author":"Serhan","year":"2012","journal-title":"FASEB J."},{"key":"B139","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1177\/1074248407304749","article-title":"Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers.","volume":"12","author":"Shah","year":"2007","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1161\/01.ATV.13.8.1205","article-title":"Associations of fish intake and dietary n-3 polyunsaturated fatty acids with a hypocoagulable profile. the atherosclerosis risk in communities (ARIC) study.","volume":"13","author":"Shahar","year":"1993","journal-title":"Arterioscler. Thromb. A J. Vasc. Biol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.cyto.2017.10.001","article-title":"T-cells and their cytokine production: the anti-inflammatory and immunosuppressive effects of strenuous exercise.","volume":"104","author":"Shaw","year":"2018","journal-title":"Cytokine"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000283","article-title":"Docosahexaenoic acid supplementation, vascular function and risk factors for cardiovascular disease: a randomized controlled trial in young adults.","volume":"2","author":"Singhal","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"B143","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1159\/000456723","article-title":"Systematic review on N-3 and N-6 polyunsaturated fatty acid intake in european countries in light of the current recommendations - focus on specific population groups.","volume":"70","author":"Sioen","year":"2017","journal-title":"Ann. Nutr. Metab."},{"key":"B144","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3945\/ajcn.110.003871","article-title":"Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia.","volume":"93","author":"Skulas-Ray","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"B145","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3945\/ajcn.110.005611","article-title":"Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial.","volume":"93","author":"Smith","year":"","journal-title":"Am. J. Clin. Nutr."},{"key":"B146","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1042\/CS20100597","article-title":"Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia\u2013hyperaminoacidaemia in healthy young and middle-aged men and women.","volume":"121","author":"Smith","year":"","journal-title":"Clin. Sci."},{"key":"B147","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1161\/CIR.0b013e318235eb4d","article-title":"AHA\/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update.","volume":"124","author":"Smith","year":"","journal-title":"Circulation"},{"key":"B148","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3945\/ajcn.114.105833","article-title":"Fish oil\u2013derived n-3 PUFA therapy increases muscle mass and function in healthy older adults1.","volume":"102","author":"Smith","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"B149","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1139\/apnm-2017-0735","article-title":"Omega-3 polyunsaturated fatty acids-enriched hen eggs consumption enhances microvascular reactivity in young healthy individuals.","volume":"43","author":"Stupin","year":"2018","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"B150","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00421-017-3790-y","article-title":"Acute exhaustive rowing exercise reduces skin microvascular dilator function in young adult rowing athletes.","volume":"118","author":"Stupin","year":"2018","journal-title":"Eur. J. Appl. Physiol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/9634803","article-title":"Maresin 1 ameliorates lung ischemia\/reperfusion injury by suppressing oxidative stress via activation of the Nrf-2-mediated HO-1 signaling pathway.","volume":"2017","author":"Sun","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.3390\/nu10030309","article-title":"Potential roles of n-3 PUFAs during skeletal muscle growth and regeneration.","volume":"10","author":"Tachtsis","year":"2018","journal-title":"Nutrients"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013487","article-title":"Randomized controlled trial of fish oil and montelukast and their combination on airway inflammation and hyperpnea-induced bronchoconstriction.","volume":"5","author":"Tecklenburg-Lund","year":"2010","journal-title":"PLoS One"},{"key":"B154","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00421-009-1342-9","article-title":"Effects of ageing and fitness on skin-microvessel vasodilator function in humans.","volume":"109","author":"Tew","year":"2010","journal-title":"Eur. J. Appl. Physiol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s11745-001-0831-4","article-title":"Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults.","volume":"36","author":"Thies","year":"","journal-title":"Lipids"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1093\/jn\/131.7.1918","article-title":"Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans.","volume":"131","author":"Thies","year":"","journal-title":"J. Nutr."},{"key":"B157","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1139\/H07-021","article-title":"Interaction of exercise training and n -3 fatty acid supplementation on postprandial lipemia.","volume":"32","author":"Thomas","year":"2007","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"B158","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1159\/000492116","article-title":"High dietary \u03c9-6:\u03c9-3 PUFA ratio is positively associated with excessive adiposity and waist circumference.","volume":"11","author":"Torres-Castillo","year":"2018","journal-title":"Obes. Facts"},{"key":"B159","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.atherosclerosis.2013.10.014","article-title":"Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiin fl ammatory effect in adults with metabolic syndrome.","volume":"232","author":"Tousoulis","year":"2014","journal-title":"Atherosclerosis"},{"key":"B160","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1161\/01.atv.0000137119.28893.0b","article-title":"Variable hypocoagulant effect of fish oil intake in humans.","volume":"24","author":"Vanschoonbeek","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3109\/00365519509075377","article-title":"The effect of n-3 fatty acids on neutrophil chemiluminescence.","volume":"55","author":"Varming","year":"1995","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"B162","doi-asserted-by":"publisher","first-page":"R667","DOI":"10.1152\/ajpregu.00336.2011","article-title":"Resistance exercise increases NF-\u03baB activity in human skeletal muscle.","volume":"302","author":"Vella","year":"2012","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1160\/th14-12-1003","article-title":"Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients.","volume":"114","author":"V\u00e9ricel","year":"2015","journal-title":"Thromb. Haemost."},{"key":"B164","doi-asserted-by":"publisher","first-page":"22254","DOI":"10.1074\/jbc.M703169200","article-title":"Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products.","volume":"282","author":"Wada","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B165","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0165-6147(03)00166-4","article-title":"A magic bullet for mucosal protection\u2026and aspirin is the trigger!","volume":"24","author":"Wallace","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"B166","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00421-006-0190-0","article-title":"Supplementation with omega-3 polyunsaturated fatty acids augments brachial artery dilation and blood flow during forearm contraction.","volume":"97","author":"Walser","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1111\/bph.13844","article-title":"Hydroxyeicosapentaenoic acids and epoxyeicosatetraenoic acids attenuate early occurrence of nonalcoholic fatty liver disease.","volume":"174","author":"Wang","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00421-004-1176-4","article-title":"Effects of exercise training and detraining on cutaneous microvascular function in man: the regulatory role of endothelium-dependent dilation in skin vasculature.","volume":"93","author":"Wang","year":"2005","journal-title":"Eur. J. Appl. Physiol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.atherosclerosis.2012.01.006","article-title":"Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials.","volume":"221","author":"Wang","year":"2012","journal-title":"Atherosclerosis"},{"key":"B170","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jnutbio.2010.01.007","article-title":"Docosahexaenoic acid attenuates VCAM-1 expression and NF-\u03baB activation in TNF-\u03b1-treated human aortic endothelial cells.","volume":"22","author":"Wang","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"B171","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/HCO.0000000000000437","article-title":"Health benefits of physical activity: a systematic review of current systematic reviews.","volume":"32","author":"Warburton","year":"2017","journal-title":"Curr. Opin. Cardiol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nature01325","article-title":"Inflammation and therapeutic vaccination in CNS diseases.","volume":"420","author":"Weiner","year":"2002","journal-title":"Nature"},{"key":"B173","first-page":"3604","article-title":"Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid.","volume":"61","author":"Whitehouse","year":"2001","journal-title":"Cancer Res."},{"key":"B174","doi-asserted-by":"publisher","first-page":"11000","DOI":"10.1073\/pnas.92.24.11000","article-title":"Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes.","volume":"92","author":"Xiao","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046028","article-title":"Effect of fish oil supplementation on fasting vascular endothelial function in humans: a meta-analysis of randomized controlled trials.","volume":"7","author":"Xin","year":"2012","journal-title":"PLoS One"},{"key":"B176","doi-asserted-by":"publisher","first-page":"447","DOI":"10.5551\/jat.26914","article-title":"Effects of docosahexaenoic acid on the endothelial function in patients with coronary artery disease.","volume":"22","author":"Yagi","year":"2015","journal-title":"J. Atheroscler. Thromb."},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12785","article-title":"Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults.","volume":"4","author":"Yoshino","year":"2016","journal-title":"Physiol. Rep."},{"key":"B178","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1139\/H10-022","article-title":"Dietary fish oil alleviates soleus atrophy during immobilization in association with Akt signaling to p70s6k and E3 ubiquitin ligases in rats.","volume":"35","author":"You","year":"2010","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"B179","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/s0749-0704(05)70160-3","article-title":"Lipid modulation and systemic inflammation.","volume":"17","author":"Zaloga","year":"2001","journal-title":"Crit. Care Clin."},{"key":"B180","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1024\/0301-1526\/a000311","article-title":"Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms.","volume":"42","author":"Zhang","year":"2013","journal-title":"VASA J. Vasc. Dis."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.01129\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T07:30:20Z","timestamp":1567150220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.01129\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,30]]},"references-count":180,"alternative-id":["10.3389\/fphys.2019.01129"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2019.01129","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,30]]},"article-number":"1129"}}