{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:39:02Z","timestamp":1784673542497,"version":"3.55.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2019.01449","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T11:23:05Z","timestamp":1574421785000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Remarkable Protective Effects of Nrf2-Mediated Antioxidant Enzymes and Tissue Specificity in Different Skeletal Muscles of Daurian Ground Squirrels Over the Torpor-Arousal Cycle"],"prefix":"10.3389","volume":"10","author":[{"given":"Yanhong","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenhui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jneumeth.2008.05.003","article-title":"The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting.","volume":"172","author":"Aldridge","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"B2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/cbf.1832","article-title":"Expression of NF-kappaB and downstream antioxidant genes in skeletal muscle of hibernating ground squirrels, Spermophilus tridecemlineatus.","volume":"30","author":"Allan","year":"2012","journal-title":"Cell Biochem. Funct."},{"key":"B3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00204-011-0674-5","article-title":"The cytoprotective role of the Keap1-Nrf2 pathway.","volume":"85","author":"Baird","year":"2011","journal-title":"Arch. Toxicol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0891-5849(92)90180-o","article-title":"Brown fat thermogenesis and exercise: two examples of physiological oxidative stress?","volume":"13","author":"Barja de Quiroga","year":"1992","journal-title":"Free Radic. Biol. Med."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.634","article-title":"Purification and properties of glyceraldehyde-3-phosphate dehydrogenase from the skeletal muscle of the hibernating ground squirrel, Ictidomys tridecemlineatus.","volume":"2","author":"Bell","year":"2014","journal-title":"PeerJ."},{"key":"B6","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/s0967-2109(02)00070-4","article-title":"The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review.","volume":"10","author":"Blaisdell","year":"2002","journal-title":"Cardiovasc. Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"R15","DOI":"10.1152\/ajpregu.00230.2011","article-title":"Mitochondrial metabolic suppression and reactive oxygen species production in liver and skeletal muscle of hibernating thirteen-lined ground squirrels.","volume":"302","author":"Brown","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.bcp.2012.11.016","article-title":"The Nrf2 cell defence pathway: keap1-dependent and -independent mechanisms of regulation.","volume":"85","author":"Bryan","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/(sici)1096-9896(200002)190:3<255::aid-path526>3.0.co;2-6","article-title":"Pathophysiology of ischaemia-reperfusion injury.","volume":"190","author":"Carden","year":"2000","journal-title":"J. Pathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1152\/physrev.00008.2003","article-title":"Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature.","volume":"83","author":"Carey","year":"2003","journal-title":"Physiol. Rev."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6126570","article-title":"An overview of seasonal changes in oxidative stress and antioxidant defence parameters in some invertebrate and vertebrate species.","volume":"2016","author":"Chainy","year":"2016","journal-title":"Scientifica"},{"key":"B12","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1042\/BJ20020320","article-title":"Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.","volume":"365","author":"Chanas","year":"2002","journal-title":"Biochem. J."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s12953-016-0105-x","article-title":"iTRAQ-based proteomic analysis of myofibrillar contents and relevant synthesis and proteolytic proteins in soleus muscle of hibernating Daurian ground squirrels (Spermophilus dauricus).","volume":"14","author":"Chang","year":"2016","journal-title":"Proteome Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"10363","DOI":"10.1074\/jbc.RA118.003044","article-title":"Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: potentials, pitfalls, and the future.","volume":"293","author":"Cheng","year":"2018","journal-title":"J. Biol. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis.","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/s0031-9384(97)00389-2","article-title":"Metabolic fuel privation in hibernating and awake ground squirrels.","volume":"63","author":"Dark","year":"1997","journal-title":"Physiol. Behav."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1002\/elps.200500785","article-title":"Beta-actin is not a reliable loading control in western blot analysis.","volume":"27","author":"Dittmer","year":"2006","journal-title":"Electrophoresis"},{"key":"B18","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.abb.2004.11.020","article-title":"Up-regulation of a thioredoxin peroxidase-like protein, proliferation-associated gene, in hibernating bats.","volume":"435","author":"Eddy","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"B19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.redox.2015.07.008","article-title":"Antioxidant responses and cellular adjustments to oxidative stress.","volume":"6","author":"Espinosa-Diez","year":"2015","journal-title":"Redox Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/pmic.200400941","article-title":"Housekeeping proteins: a preliminary study illustrating some limitations as useful references in protein expression studies.","volume":"5","author":"Ferguson","year":"2005","journal-title":"Proteomics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1086\/physzool.65.5.30158549","article-title":"The influence of dietary fatty acids on hibernation by golden-mantled ground squirrels (Spermophilus lateralis).","volume":"65","author":"Frank","year":"1992","journal-title":"Physiol. Zool."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/srep27020","article-title":"Remarkable preservation of Ca(2+) homeostasis and inhibition of apoptosis contribute to anti-muscle atrophy effect in hibernating Daurian ground squirrels.","volume":"6","author":"Fu","year":"2016","journal-title":"Sci. Rep."},{"key":"B23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.cbpa.2011.11.009","article-title":"Skeletal muscle is protected from disuse in hibernating dauria ground squirrels.","volume":"161","author":"Gao","year":"2012","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1146\/annurev.physiol.66.032102.115105","article-title":"Metabolic rate and body temperature reduction during hibernation and daily torpor.","volume":"66","author":"Geiser","year":"2004","journal-title":"Annu. Rev. Physiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"R188","DOI":"10.1016\/j.cub.2013.01.062","article-title":"Hibernation.","volume":"23","author":"Geiser","year":"2013","journal-title":"Curr. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cbpa.2019.04.004","article-title":"Twenty years of the \u2018preparation for oxidative stress\u2019 (POS) theory: ecophysiological advantages and molecular strategies.","volume":"234","author":"Giraud-Billoud","year":"2019","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"B27","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4615-4131-8","author":"Gunstone","year":"1996","journal-title":"Fatty Acid and Lipid Chemistry."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1289\/ehp.94102s105","article-title":"Oxygen-derived species: their relation to human disease and environmental stress.","volume":"102","author":"Halliwell","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"B29","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/s1532-0456(02)00080-7","article-title":"Animal response to drastic changes in oxygen availability and physiological oxidative stress.","volume":"133","author":"Hermes-Lima","year":"2002","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1242\/jeb.080663","article-title":"The effects of hibernation on the contractile and biochemical properties of skeletal muscles in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus.","volume":"216","author":"James","year":"2013","journal-title":"J. Exp. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.redox.2013.01.014","article-title":"Teaching the basics of redox biology to medical and graduate students: oxidants, antioxidants and disease mechanisms.","volume":"1","author":"Kalyanaraman","year":"2013","journal-title":"Redox Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2011.09.030","article-title":"Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations.","volume":"52","author":"Kalyanaraman","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"18399","DOI":"10.1074\/jbc.M100103200","article-title":"Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors.","volume":"276","author":"Kim","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1080\/01926230290166724","article-title":"Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification.","volume":"30","author":"Kohen","year":"2002","journal-title":"Toxicol. Pathol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ab.2003.10.047","article-title":"Visible fluorescent detection of proteins in polyacrylamide gels without staining.","volume":"326","author":"Ladner","year":"2004","journal-title":"Anal. Biochem."},{"key":"B36","first-page":"183","article-title":"Mechanism and prevention of skeletal muscle ischemia-reperfusion injury.","volume":"44","author":"Li","year":"2015","journal-title":"Chin. J. Med. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.lfs.2013.02.014","article-title":"An old method facing a new challenge: re-visiting housekeeping proteins as internal reference control for neuroscience research.","volume":"92","author":"Li","year":"2013","journal-title":"Life Sci."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7238960","article-title":"The protective effects of fasciotomy on reperfusion injury of skeletal muscle of rabbits.","volume":"2017","author":"Li","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"B39","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3233\/CH-170276","article-title":"Ryanodine receptor antagonism alleviates skeletal muscle ischemia reperfusion injury by modulating TNF-alpha and IL-10.","volume":"70","author":"Lin","year":"2018","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"B40","first-page":"9186","article-title":"Mechanism of skeletal muscle ischemia\/reperfusion injury.","volume":"11","author":"Liu","year":"2007","journal-title":"Chin. J. Clin. Rehabil. Tissue Eng. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.cbpc.2010.10.004","article-title":"Adaptive response to oxidative stress: bacteria, fungi, plants and animals.","volume":"153","author":"Lushchak","year":"2011","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/736837","article-title":"Glutathione homeostasis and functions: potential targets for medical interventions.","volume":"2012","author":"Lushchak","year":"2012","journal-title":"J. Amino Acids"},{"key":"B43","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.cbi.2014.10.016","article-title":"Free radicals, reactive oxygen species, oxidative stress and its classification.","volume":"224","author":"Lushchak","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"B44","doi-asserted-by":"publisher","first-page":"R1297","DOI":"10.1152\/ajpregu.00260.2005","article-title":"Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels.","volume":"289","author":"Ma","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00360-016-1022-0","article-title":"Regulation of mitochondrial metabolism during hibernation by reversible suppression of electron transport system enzymes.","volume":"187","author":"Mathers","year":"2017","journal-title":"J. Comp. Physiol. B"},{"key":"B46","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s11010-008-9727-3","article-title":"Expression of Nrf2 and its downstream gene targets in hibernating 13-lined ground squirrels, Spermophilus tridecemlineatus.","volume":"312","author":"Morin","year":"2008","journal-title":"Mol. Cell Biochem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.abb.2007.01.035","article-title":"Antioxidant defense in hibernation: cloning and expression of peroxiredoxins from hibernating ground squirrels, Spermophilus tridecemlineatus.","volume":"461","author":"Morin","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"B48","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.molmed.2004.09.003","article-title":"Nrf2-Keap1 defines a physiologically important stress response mechanism.","volume":"10","author":"Motohashi","year":"2004","journal-title":"Trends Mol. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1086\/501053","article-title":"Mitochondrial metabolism in hibernation: metabolic suppression, temperature effects, and substrate preferences.","volume":"79","author":"Muleme","year":"2006","journal-title":"Physiol. Biochem. Zool."},{"key":"B50","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1139\/Y10-017","article-title":"Heme oxygenase expression and Nrf2 signaling during hibernation in ground squirrels.","volume":"88","author":"Ni","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.cbpc.2006.05.002","article-title":"Enhanced antioxidant defense due to extracellular catalase activity in Syrian hamster during arousal from hibernation.","volume":"143","author":"Ohta","year":"2006","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.cbpc.2006.05.003","article-title":"Up-regulation of an extracellular superoxide dismutase-like activity in hibernating hamsters subjected to oxidative stress in mid- to late arousal from torpor.","volume":"144","author":"Okamoto","year":"2006","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"B53","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1023\/A:1020600509965","article-title":"The transcriptional activation of the human copper\/zinc superoxide dismutase gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the antioxidant responsive element and xenobiotic responsive element.","volume":"240","author":"Park","year":"2002","journal-title":"Mol. Cell Biochem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1021\/bi00764a013","article-title":"Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits.","volume":"11","author":"Peter","year":"1972","journal-title":"Biochemistry"},{"key":"B55","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s11010-014-2070-y","article-title":"Characterization of adipocyte stress response pathways during hibernation in thirteen-lined ground squirrels.","volume":"393","author":"Rouble","year":"2014","journal-title":"Mol. Cell Biochem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1152\/ajplung.1991.261.4.L81","article-title":"Free radical metabolites in myocardium during ischemia and reperfusion.","volume":"261","author":"Ruuge","year":"1991","journal-title":"Am. J. Physiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s12035-012-8344-z","article-title":"Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation.","volume":"47","author":"Sanderson","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/s0378-1119(96)00494-5","article-title":"Occurrence of a differential expression of the glyceraldehyde-3-phosphate dehydrogenase gene in muscle and liver from euthermic and induced hibernating jerboa (Jaculus orientalis).","volume":"181","author":"Soukri","year":"1996","journal-title":"Gene"},{"key":"B59","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1159\/000228829","article-title":"Out cold: biochemical regulation of mammalian hibernation - a mini-review.","volume":"56","author":"Storey","year":"2010","journal-title":"Gerontology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"6334","DOI":"10.1128\/MCB.00630-07","article-title":"Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.","volume":"27","author":"Sun","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"B61","doi-asserted-by":"crossref","first-page":"R572","DOI":"10.1152\/ajpregu.2001.281.2.R572","article-title":"Ascorbate dynamics and oxygen consumption during arousal from hibernation in Arctic ground squirrels.","volume":"281","author":"Toien","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species.","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease.","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1152\/japplphysiol.00840.2014","article-title":"GAPDH and beta-actin protein decreases with aging, making stain-Free technology a superior loading control in Western blotting of human skeletal muscle.","volume":"118","author":"Vigelso","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.freeradbiomed.2013.08.188","article-title":"The impact of cold acclimation and hibernation on antioxidant defenses in the ground squirrel (Spermophilus citellus): an update.","volume":"65","author":"Vucetic","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"B66","author":"Wang","year":"2013","journal-title":"Pathophysiology."},{"key":"B67","doi-asserted-by":"publisher","first-page":"8711","DOI":"10.1002\/jcp.26751","article-title":"Unexpected regulation pattern of the IKKbeta\/NF-kappaB\/MuRF1 pathway with remarkable muscle plasticity in the Daurian ground squirrel (Spermophilus dauricus).","volume":"233","author":"Wei","year":"","journal-title":"J. Cell Physiol."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.180068","article-title":"Controllable oxidative stress and tissue specificity in major tissues during the torpor-arousal cycle in hibernating Daurian ground squirrels.","volume":"8","author":"Wei","year":"","journal-title":"Open. Biol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nchembio.85","article-title":"Reconciling the chemistry and biology of reactive oxygen species.","volume":"4","author":"Winterbourn","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s11010-014-1969-7","article-title":"FoxO3a-mediated activation of stress responsive genes during early torpor in a mammalian hibernator.","volume":"390","author":"Wu","year":"2014","journal-title":"Mol. Cell Biochem."},{"key":"B71","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.expneurol.2013.01.005","article-title":"Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization.","volume":"247","author":"Xu","year":"2013","journal-title":"Exp. Neurol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cbpa.2014.05.022","article-title":"Changes in calpains and calpastatin in the soleus muscle of Daurian ground squirrels during hibernation.","volume":"176","author":"Yang","year":"2014","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152135","article-title":"Antioxidant Defenses in the brains of bats during hibernation.","volume":"11","author":"Yin","year":"2016","journal-title":"PLoS One"},{"key":"B74","doi-asserted-by":"publisher","first-page":"19728","DOI":"10.1002\/jcp.28572","article-title":"Prosurvival roles mediated by the PERK signaling pathway effectively prevent excessive endoplasmic reticulum stress-induced skeletal muscle loss during high-stress conditions of hibernation.","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell Physiol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/j.acra.2018.03.020","article-title":"Color-coded digital subtraction angiography for assessing acute skeletal muscle ischemia-reperfusion injury in a rabbit model.","volume":"25","author":"Zhang","year":"2018","journal-title":"Acad. Radiol."},{"key":"B76","first-page":"1139","article-title":"Lipoxin A4 pretreatment mitigates skeletal muscle ischemia-reperfusion injury in rats.","volume":"9","author":"Zong","year":"2017","journal-title":"Am. J. Transl. Res."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.01449\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T11:23:09Z","timestamp":1574421789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2019.01449\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":76,"alternative-id":["10.3389\/fphys.2019.01449"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2019.01449","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,22]]},"article-number":"1449"}}