{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:16:47Z","timestamp":1753892207358,"version":"3.41.2"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["100868"],"award-info":[{"award-number":["100868"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1105526","APP1110195"],"award-info":[{"award-number":["APP1105526","APP1110195"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003747","name":"Department of Health, State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012256","name":"Cerebral Palsy Alliance Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.00119","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T14:22:49Z","timestamp":1582294969000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Umbilical Cord Blood Cells Do Not Reduce Ventilation-Induced Lung Injury in Preterm Lambs"],"prefix":"10.3389","volume":"11","author":[{"given":"Madeleine J.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyra Y. Y.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paris","family":"Papagianis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Nitsos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Zahra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Allison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme R.","family":"Polglase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney A.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1242\/jcs.01488","article-title":"In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions.","volume":"117","author":"Anjos-Afonso","year":"2004","journal-title":"J. Cell Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1113\/JP271104","article-title":"Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb.","volume":"594","author":"Aridas","year":"2016","journal-title":"J. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1159\/000371415","article-title":"Human amnion epithelial cells modulate ventilation-induced white matter pathology in preterm lambs.","volume":"37","author":"Barton","year":"2015","journal-title":"Dev. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.stem.2013.09.006","article-title":"Mesenchymal stromal cells: sensors and switchers of inflammation.","volume":"13","author":"Bernardo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/S0140-6736(12)60820-4","article-title":"National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications.","volume":"379","author":"Blencowe","year":"2012","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3727\/096368909788809857","article-title":"Transplantation of allogeneic and xenogeneic placenta-derived cells reduces bleomycin-induced lung fibrosis.","volume":"18","author":"Cargnoni","year":"2009","journal-title":"Cell Transplant."},{"key":"B7","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3727\/096368909X471189","article-title":"Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats.","volume":"18","author":"Chang","year":"2009","journal-title":"Cell Transplant."},{"key":"B8","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1183\/09031936.00153211","article-title":"Pre-treatment with mesenchymal stem cells reduces ventilator-induced lung injury.","volume":"40","author":"Chimenti","year":"2012","journal-title":"Eur. Respir. J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1136\/thoraxjnl-2011-201059","article-title":"Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat.","volume":"67","author":"Curley","year":"2012","journal-title":"Thorax"},{"key":"B10","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.ajpath.2010.11.062","article-title":"Alveolar epithelial cell therapy with human cord blood-derived hematopoietic progenitor cells.","volume":"178","author":"De Paepe","year":"2011","journal-title":"Am. J. Pathol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1056\/NEJMoa1700827","article-title":"Ventilation in extremely preterm infants and respiratory function at 8 years.","volume":"377","author":"Doyle","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"B12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01709236","article-title":"Barotrauma is volutrauma, but which volume is the one responsible?","volume":"18","author":"Dreyfuss","year":"1992","journal-title":"Intensive Care Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1165\/rcmb.2012-0198OC","article-title":"Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment.","volume":"48","author":"Garibaldi","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.4103\/2045-8932.97603","article-title":"Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension.","volume":"2","author":"Hansmann","year":"2012","journal-title":"Pulm. Circ."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-015-0065-y","article-title":"Mesenchymal stromal cells are more effective than the MSC secretome in diminishing injury and enhancing recovery following ventilator-induced lung injury.","volume":"3","author":"Hayes","year":"2015","journal-title":"Intensive Care Med. Exp."},{"key":"B16","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1203\/PDR.0b013e3181c1b09e","article-title":"Airway injury from initiating ventilation in preterm sheep.","volume":"67","author":"Hillman","year":"2010","journal-title":"Pediatr. Res."},{"key":"B17","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1164\/rccm.200701-051OC","article-title":"Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep.","volume":"176","author":"Hillman","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"L232","DOI":"10.1152\/ajplung.00294.2010","article-title":"Inflammation and lung maturation from stretch injury in preterm fetal sheep.","volume":"300","author":"Hillman","year":"2011","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"448.e8","DOI":"10.1016\/j.ajog.2012.02.038","article-title":"Human amnion epithelial cells reduce ventilation-induced preterm lung injury in fetal sheep.","volume":"206","author":"Hodges","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088814","article-title":"Human CD34+ progenitor cells freshly isolated from umbilical cord blood attenuate inflammatory lung injury following LPS challenge.","volume":"9","author":"Huang","year":"2014","journal-title":"PLoS One"},{"key":"B21","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3109\/01902148.2013.816803","article-title":"Mesenchymal stem cell therapy in lung disorders: pathogenesis of lung diseases and mechanism of action of mesenchymal stem cell.","volume":"39","author":"Inamdar","year":"2013","journal-title":"Exp. Lung Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/MOP.0b013e3283423e6b","article-title":"The new bronchopulmonary dysplasia.","volume":"23","author":"Jobe","year":"2011","journal-title":"Curr. Opin. Pediatr."},{"key":"B23","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1159\/000143721","article-title":"Injury and inflammation from resuscitation of the preterm infant.","volume":"94","author":"Jobe","year":"2008","journal-title":"Neonatology"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/732742","article-title":"MSCs: delivery routes and engraftment, cell-targeting strategies, and immune modulation.","volume":"2013","author":"Kean","year":"2013","journal-title":"Stem Cells Int."},{"key":"B25","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/S0140-6736(06)68615-7","article-title":"Bronchopulmonary dysplasia.","volume":"367","author":"Kinsella","year":"2006","journal-title":"Lancet"},{"key":"B26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.4103\/0366-6999.150106","article-title":"Mesenchymal stem cell attenuates neutrophil-predominant inflammation and acute lung injury in an in vivo rat model of ventilator-induced lung injury.","volume":"128","author":"Lai","year":"2015","journal-title":"Chin. Med. J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1038\/pr.2017.170","article-title":"Term vs. preterm cord blood cells for the prevention of preterm brain injury.","volume":"82","author":"Li","year":"2017","journal-title":"Pediatr. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.expneurol.2016.06.017","article-title":"Preterm white matter brain injury is prevented by early administration of umbilical cord blood cells.","volume":"283","author":"Li","year":"2016","journal-title":"Exp. Neurol."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1089-5","article-title":"Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury.","volume":"15","author":"McDonald","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173572","article-title":"Human amnion epithelial cells modulate the inflammatory response to ventilation in preterm lambs.","volume":"12","author":"Melville","year":"2017","journal-title":"PLoS One"},{"key":"B31","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1080\/01902148.2017.1300713","article-title":"Effects of human umbilical cord blood mononuclear cells on respiratory system mechanics in a murine model of neonatal lung injury.","volume":"43","author":"Mills","year":"2017","journal-title":"Exp. Lung Res."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074740","article-title":"Human umbilical cord blood mononuclear cells in a double-hit model of bronchopulmonary dysplasia in neonatal mice.","volume":"8","author":"Monz","year":"2013","journal-title":"PLoS One"},{"key":"B33","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1440-1681.2006.04359.x","article-title":"Respiratory consequences of preterm birth.","volume":"33","author":"Moss","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/s41390-019-0366-z","article-title":"Umbilical cord blood versus mesenchymal stem cells for inflammation-induced preterm brain injury in fetal sheep.","volume":"86","author":"Paton","year":"2019","journal-title":"Pediatr. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1159\/000490943","article-title":"Human umbilical cord blood therapy protects cerebral white matter from systemic LPS exposure in preterm fetal sheep.","volume":"40","author":"Paton","year":"2018","journal-title":"Dev. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1152\/japplphysiol.00783.2016","article-title":"Effects of antenatal melatonin therapy on lung structure in growth-restricted newborn lambs.","volume":"123","author":"Polglase","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"B37","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1365-3083.2007.01905.x","article-title":"Mesenchymal stem cells stimulate antibody secretion in human B cells.","volume":"65","author":"Rasmusson","year":"2007","journal-title":"Scand. J. Immunol."},{"key":"B38","first-page":"17","article-title":"Circulatory changes during the perinatal period.","volume":"4","author":"Rudolph","year":"1983","journal-title":"Pediatr. Cardiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"F393","DOI":"10.1136\/adc.2009.174003","article-title":"Assessment of tidal volume and gas leak during mask ventilation of preterm infants in the delivery room.","volume":"95","author":"Schm\u00f6lzer","year":"2010","journal-title":"Arch. Dis. Child."},{"journal-title":"Chow, Prudence Creighton, Vinosan Kander, Ross Haslam, Lui K. Australian and New Zealand Neonatal Network.","year":"2016","author":"Sharon","key":"B40"},{"key":"B41","doi-asserted-by":"publisher","first-page":"156.e26","DOI":"10.1016\/j.ajog.2011.03.054","article-title":"Human amnion epithelial cells as a treatment for inflammation-induced fetal lung injury in sheep.","volume":"205","author":"Vosdoganes","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1159\/000346683","article-title":"Human amnion epithelial cells reduce fetal brain injury in response to intrauterine inflammation.","volume":"35","author":"Yawno","year":"2013","journal-title":"Dev. Neurosci."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00119\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T14:22:55Z","timestamp":1582294975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00119\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":42,"alternative-id":["10.3389\/fphys.2020.00119"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.00119","relation":{},"ISSN":["1664-042X"],"issn-type":[{"type":"electronic","value":"1664-042X"}],"subject":[],"published":{"date-parts":[[2020,2,21]]},"article-number":"119"}}