{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:06:56Z","timestamp":1791558416325,"version":"4.3.4"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.00349","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T04:42:06Z","timestamp":1590036126000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Aerobic Exercise Training in Patients With mtDNA-Related Mitochondrial Myopathy"],"prefix":"10.3389","volume":"11","author":[{"given":"Tina Dysgaard","family":"Jeppesen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1212\/wnl.49.3.837","article-title":"Measurement of tissue oxygen consumption in patients with mitochondrial myopathy by noninvasive tissue oximetry.","volume":"49","author":"Abe","year":"1997","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"crossref","first-page":"E672","DOI":"10.1152\/ajpendo.00043.2007","article-title":"The effect of training on the expression of mitochondrial biogenesis- and apoptosis-related proteins in skeletal muscle of patients with mtDNA defects.","volume":"293","author":"Adhihetty","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1113\/jphysiol.1985.sp015794","article-title":"Maximal perfusion of skeletal muscle in man.","volume":"366","author":"Andersen","year":"1985","journal-title":"J. Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1152\/physiologyonline.1988.3.3.100","article-title":"Sculpturing new muscle phenotypes.","volume":"3","author":"Babij","year":"1988","journal-title":"News Physiol. Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"996","DOI":"10.2215\/cjn.09141209","article-title":"Resistance training increases muscle mitochondrial biogenesis in patients with chronic kidney disease.","volume":"5","author":"Balakrishnan","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B6","doi-asserted-by":"crossref","first-page":"R899","DOI":"10.1152\/ajpregu.2000.279.3.R899","article-title":"Muscle oxygen kinetics at onset of intense dynamic exercise in humans.","volume":"279","author":"Bangsbo","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1002\/ana.410360606","article-title":"An oxidative defect in metabolic myopathies: diagnosis by noninvasive tissue oximetry.","volume":"36","author":"Bank","year":"1994","journal-title":"Ann. Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/978-1-4615-6111-8_1","article-title":"Diagnosis of defects in oxidative muscle metabolism by non-invasive tissue oximetry.","volume":"174","author":"Bank","year":"1997","journal-title":"Mol. Cell Biochem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1365-2796.1991.tb00319.x","article-title":"Effect of recombinant human erythropoietin treatment on blood pressure and some haematological parameters in healthy men.","volume":"229","author":"Berglund","year":"1991","journal-title":"J. Intern. Med."},{"key":"B10","first-page":"2293","article-title":"Control of adaptations in protein levels in response to exercise.","volume":"44","author":"Booth","year":"1985","journal-title":"Fed. Proc."},{"key":"B11","first-page":"1196","article-title":"Improvements in insulin resistance with aerobic exercise training: a lipocentric approach.","volume":"36","author":"Bruce","year":"2004","journal-title":"Med. Sci. Sports Exerc."},{"key":"B12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/bf00421747","article-title":"Physical training in man. Skeletal muscle metabolism in relation to muscle morphology and running ability.","volume":"36","author":"Bylund","year":"1977","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/mus.20368","article-title":"Exercise training in mitochondrial myopathy: a randomized controlled trial.","volume":"32","author":"Cejudo","year":"2005","journal-title":"Muscle Nerve."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1086\/302311","article-title":"Relaxed replication of mtDNA: a model with implications for the expression of disease.","volume":"64","author":"Chinnery","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040076","article-title":"Calorie restriction increases muscle mitochondrial biogenesis in healthy humans.","volume":"4","author":"Civitarese","year":"2007","journal-title":"PLoS Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1097\/hjh.0b013e32835ca964","article-title":"Endurance exercise beneficially affects ambulatory blood pressure: a systematic review and meta-analysis.","volume":"31","author":"Cornelissen","year":"2013","journal-title":"J. Hypertens."},{"key":"B17","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/bf00423244","article-title":"Anaerobic threshold and lactate turnpoint.","volume":"50","author":"Davis","year":"1983","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1249\/00005768-198205000-00005","article-title":"Effect of ramp slope on determination of aerobic parameters from the ramp exercise test.","volume":"14","author":"Davis","year":"1982","journal-title":"Med. Sci. Sports Exerc."},{"key":"B19","first-page":"2260","article-title":"Pulmonary control systems in exercise: update.","volume":"44","author":"Dempsey","year":"1985","journal-title":"Fed. Proc."},{"key":"B20","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/(sici)1097-4598(199604)19:4<456::aid-mus5>3.0.co;2-b","article-title":"Muscle fatigue, lactate, and pyruvate in mitochondrial myopathy with progressive external ophthalmoplegia.","volume":"19","author":"Dengler","year":"1996","journal-title":"Muscle Nerve"},{"key":"B21","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1530\/JOE-17-0186","article-title":"Improvement of obesity-linked skeletal muscle insulin resistance by strength and endurance training.","volume":"234","author":"Di Meo","year":"2017","journal-title":"J. Endocrinol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1007\/s00421-003-0926-z","article-title":"Factors limiting maximal performance in humans.","volume":"90","author":"di Prampero","year":"2003","journal-title":"Eur. J. Appl. Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/s0022-510x(98)00170-1","article-title":"Lactate stress test in the diagnosis of mitochondrial myopathy.","volume":"159","author":"Finsterer","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1164\/ajrccm.164.3.2005110","article-title":"Unexplained exertional limitation: characterization of patients with a mitochondrial myopathy.","volume":"164","author":"Flaherty","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/978-1-4684-5481-9_23","article-title":"Breathing during exercise: demands, regulation, limitations.","volume":"227","author":"Forster","year":"1988","journal-title":"Adv. Exp. Med. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1136\/jmg.2005.039339","article-title":"Tissue specific distribution of the 3243A->G mtDNA mutation.","volume":"43","author":"Frederiksen","year":"2006","journal-title":"J. Med. Genet."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1021\/bk-1986-0294.ch002","article-title":"Adaptations in mitochondrial enzymatic activity occurs independent of genomic dosage in response to aerobic exercise training and deconditioning in human skeletal muscle.","volume":"12","author":"Fritzen","year":"2019","journal-title":"Cells"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1093\/hmg\/5.11.1835","article-title":"A novel heteroplasmic tRNAleu(CUN) mtDNA point mutation in a sporadic patient with mitochondrial encephalomyopathy segregates rapidly in skeletal muscle and suggests an approach to therapy.","volume":"5","author":"Fu","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"B29","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1152\/jappl.1975.39.5.697","article-title":"Effects of expiratory threshold loading during steady-state exercise.","volume":"39","author":"Goldstein","year":"1975","journal-title":"J. Appl. Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1249\/00005768-198410000-00006","article-title":"Pathophysiology of exercise performance in muscle disease.","volume":"16","author":"Haller","year":"1984","journal-title":"Med. Sci. Sports Exerc."},{"key":"B31","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1172\/jci114135","article-title":"Exercise intolerance, lactic acidosis, and abnormal cardiopulmonary regulation in exercise associated with adult skeletal muscle cytochrome c oxidase deficiency.","volume":"84","author":"Haller","year":"1989","journal-title":"J. Clin. Invest."},{"key":"B32","first-page":"6","article-title":"Mitochondrial myopathy presenting as exercise intolerance.","volume":"103","author":"Haller","year":"1978","journal-title":"Trans. Am. Neurol. Assoc."},{"key":"B33","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1152\/japplphysiol.00949.2010","article-title":"Nutritional modulation of training-induced skeletal muscle adaptations.","volume":"110","author":"Hawley","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"B34","doi-asserted-by":"crossref","first-page":"R873","DOI":"10.1152\/ajpregu.00001.2011","article-title":"Exertional dyspnea in mitochondrial myopathy: clinical features and physiological mechanisms.","volume":"301","author":"Heinicke","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B35","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/S0021-9258(18)96046-1","article-title":"Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.","volume":"242","author":"Holloszy","year":"1967","journal-title":"J. Biol. Chem."},{"key":"B36","first-page":"155","article-title":"Adaptation of skeletal muscle to endurance exercise.","volume":"7","author":"Holloszy","year":"1975","journal-title":"Med. Sci. Sports"},{"key":"B37","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/00005768-200301000-00016","article-title":"Plasticity of skeletal muscle mitochondria: structure and function.","volume":"35","author":"Hoppeler","year":"2003","journal-title":"Med. Sci. Sports Exerc."},{"key":"B38","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1242\/jeb.201.8.1051","article-title":"Limits for oxygen and substrate transport in mammals.","volume":"201","author":"Hoppeler","year":"1998","journal-title":"J. Exp. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.mito.2009.01.011","article-title":"PET imaging of redox and energy states in stroke-like episodes of MELAS.","volume":"9","author":"Ikawa","year":"2009","journal-title":"Mitochondrion"},{"key":"B40","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1152\/japplphysiol.00445.2013","article-title":"Improvements in exercise performance with high-intensity interval training coincide with an increase in skeletal muscle mitochondrial content and function.","volume":"115","author":"Jacobs","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1111\/j.1468-1331.2009.02660.x","article-title":"Short- and long-term effects of endurance training in patients with mitochondrial myopathy.","volume":"16","author":"Jeppesen","year":"","journal-title":"Eur. J. Neurol."},{"key":"B42","first-page":"365","article-title":"Fat metabolism during exercise in patients with mitochondrial disease.","volume":"66","author":"Jeppesen","year":"","journal-title":"Arch. Neurol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.nmd.2013.05.007","article-title":"Lactate metabolism during exercise in patients with mitochondrial myopathy.","volume":"23","author":"Jeppesen","year":"2013","journal-title":"Neuromuscul. Disord."},{"key":"B44","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/archneur.63.12.1701","article-title":"Muscle phenotype and mutation load in 51 persons with the 3243A>G mitochondrial DNA mutation.","volume":"63","author":"Jeppesen","year":"","journal-title":"Arch. Neurol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1093\/brain\/awl149","article-title":"Aerobic training is safe and improves exercise capacity in patients with mitochondrial myopathy.","volume":"129","author":"Jeppesen","year":"","journal-title":"Brain"},{"key":"B46","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/ana.10594","article-title":"Oxidative capacity correlates with muscle mutation load in mitochondrial myopathy.","volume":"54","author":"Jeppesen","year":"2003","journal-title":"Ann. Neurol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.mito.2011.11.003","article-title":"Influence of erythrocyte oxygenation and intravascular ATP on resting and exercising skeletal muscle blood flow in humans with mitochondrial myopathy.","volume":"12","author":"Jeppesen","year":"2012","journal-title":"Mitochondrion"},{"key":"B48","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1113\/jphysiol.1993.sp019823","article-title":"Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training.","volume":"469","author":"Kiens","year":"1993","journal-title":"J. Physiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3349","DOI":"10.1113\/jphysiol.2012.230185","article-title":"Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects.","volume":"590","author":"Larsen","year":"2012","journal-title":"J. Physiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1136\/jnnp.27.5.361","article-title":"Hereditary metabolic myopathy with paroxysmal myoglobinuria due to abnormal glycolysiS.","volume":"27","author":"Larsson","year":"1964","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"B51","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1203\/00006450-199008000-00011","article-title":"Progressive increase of the mutated mitochondrial DNA fraction in Kearns-Sayre syndrome.","volume":"28","author":"Larsson","year":"1990","journal-title":"Pediatr. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.bbadis.2009.05.005","article-title":"Activation of PKCdelta and ERK1\/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA.","volume":"1792","author":"Liu","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"B53","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ymgme.2003.08.005","article-title":"Increased expression of manganese-superoxide dismutase in fibroblasts of patients with CPEO syndrome.","volume":"80","author":"Lu","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"B54","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1152\/jappl.1979.46.2.322","article-title":"CO2 and exercise tidal volume.","volume":"46","author":"Martin","year":"1979","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1093\/gerona\/61.6.534","article-title":"Effects of exercise on mitochondrial content and function in aging human skeletal muscle.","volume":"61","author":"Menshikova","year":"2006","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1172\/jci103636","article-title":"The physiological meaning of the maximal oxygen intake test.","volume":"37","author":"Mitchell","year":"1958","journal-title":"J. Clin. Invest."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1056\/nejm198905183202001","article-title":"Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome.","volume":"320","author":"Moraes","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1006\/bbrc.1995.2150","article-title":"Extensive tissue oxygenation associated with mitochondrial DNA mutations.","volume":"213","author":"Ozawa","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4795","DOI":"10.1113\/jphysiol.2010.199448","article-title":"Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle.","volume":"588","author":"Perry","year":"2010","journal-title":"J. Physiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"52873","DOI":"10.1074\/jbc.m308366200","article-title":"Cardiolipin stabilizes respiratory chain supercomplexes.","volume":"278","author":"Pfeiffer","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1152\/japplphysiol.00885.2015","article-title":"Home-based aerobic exercise training improves skeletal muscle oxidative metabolism in patients with metabolic myopathies.","volume":"121","author":"Porcelli","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"B62","doi-asserted-by":"crossref","first-page":"E301","DOI":"10.1152\/ajpendo.2001.280.2.E301","article-title":"Aerobic metabolism of human quadriceps muscle: in vivo data parallel measurements on isolated mitochondria.","volume":"280","author":"Rasmussen","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B63","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/9780470715420.ch3","article-title":"Muscle fibre recruitment and metabolism in prolonged exhaustive dynamic exercise.","volume":"82","author":"Saltin","year":"1981","journal-title":"Ciba Found Symp."},{"key":"B64","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.0954-6820.1986.tb08928.x","article-title":"Physiological adaptation to physical conditioning. Old problems revisited.","volume":"711","author":"Saltin","year":"1986","journal-title":"Acta Med. Scand. Suppl."},{"key":"B65","doi-asserted-by":"crossref","first-page":"752S","DOI":"10.1093\/ajcn\/57.5.752S","article-title":"Free fatty acids and exercise.","volume":"57","author":"Saltin","year":"1993","journal-title":"Am. J. Clin. Nutr."},{"key":"B66","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1249\/00005768-199201000-00007","article-title":"Maximal oxygen uptake: \u201cold\u201d and \u201cnew\u201d arguments for a cardiovascular limitation.","volume":"24","author":"Saltin","year":"1992","journal-title":"Med. Sci. Sports Exerc."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1073\/pnas.86.5.1583","article-title":"Oxidative capacity of muscle and mitochondria: correlation of physiological, biochemical, and morphometric characteristics.","volume":"86","author":"Schwerzmann","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B68","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/s0960-8966(99)00068-1","article-title":"Effects of aerobic training on lactate and catecholaminergic exercise responses in mitochondrial myopathies.","volume":"10","author":"Siciliano","year":"2000","journal-title":"Neuromuscul. Disord."},{"key":"B69","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1016\/j.nmd.2012.10.005","article-title":"Effects of aerobic training on exercise-related oxidative stress in mitochondrial myopathies.","volume":"22","author":"Siciliano","year":"2012","journal-title":"Neuromuscul. Disord."},{"key":"B70","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1093\/brain\/awn189","article-title":"Endurance training improves fitness and strength in patients with Becker muscular dystrophy.","volume":"131","author":"Sveen","year":"2008","journal-title":"Brain"},{"key":"B71","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1212\/01.wnl.0000250358.32199.24","article-title":"Endurance training: an effective and safe treatment for patients with LGMD2I.","volume":"68","author":"Sveen","year":"2007","journal-title":"Neurology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/ana.10027","article-title":"Venous oxygen levels during aerobic forearm exercise: an index of impaired oxidative metabolism in mitochondrial myopathy.","volume":"51","author":"Taivassalo","year":"2002","journal-title":"Ann. Neurol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1212\/wnl.50.4.1055","article-title":"Effects of aerobic training in patients with mitochondrial myopathies.","volume":"50","author":"Taivassalo","year":"1998","journal-title":"Neurology"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1002\/(sici)1097-4598(199909)22:9<1239::aid-mus11>3.0.co;2-w","article-title":"Short-term aerobic training response in chronic myopathies.","volume":"22","author":"Taivassalo","year":"1999","journal-title":"Muscle Nerve"},{"key":"B75","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.1093\/brain\/awl282","article-title":"Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions.","volume":"129","author":"Taivassalo","year":"2006","journal-title":"Brain"},{"key":"B76","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1249\/01.mss.0000177446.97671.2a","article-title":"Exercise and training in mitochondrial myopathies.","volume":"37","author":"Taivassalo","year":"2005","journal-title":"Med. Sci. Sports Exerc."},{"key":"B77","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/brain\/awg028","article-title":"The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients.","volume":"126","author":"Taivassalo","year":"2003","journal-title":"Brain"},{"key":"B78","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1212\/wnl.47.2.529","article-title":"Combined aerobic training and dichloroacetate improve exercise capacity and indices of aerobic metabolism in muscle cytochrome oxidase deficiency.","volume":"47","author":"Taivassalo","year":"1996","journal-title":"Neurology"},{"key":"B79","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/ana.1050","article-title":"Aerobic conditioning in patients with mitochondrial myopathies: physiological, biochemical, and genetic effects.","volume":"50","author":"Taivassalo","year":"2001","journal-title":"Ann. Neurol."},{"key":"B80","doi-asserted-by":"crossref","first-page":"R1271","DOI":"10.1152\/ajpregu.00472.2006","article-title":"Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity.","volume":"292","author":"Tarnopolsky","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B81","first-page":"852","article-title":"Heteroplasmic mtDNA mutation (T\u2014-G) at 8993 can cause Leigh disease when the percentage of abnormal mtDNA is high.","volume":"50","author":"Tatuch","year":"1992","journal-title":"Am. J. Hum. Genet."},{"key":"B82","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1046\/j.1365-201x.1997.00246.x","article-title":"Effects of endurance training on oxidative capacity and structural composition of human arm and leg muscles.","volume":"161","author":"Turner","year":"1997","journal-title":"Acta Physiol. Scand."},{"key":"B83","doi-asserted-by":"crossref","first-page":"E193","DOI":"10.1152\/ajpendo.00273.2002","article-title":"Leg and arm lactate and substrate kinetics during exercise.","volume":"284","author":"Van Hall","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B84","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.molmet.2016.06.012","article-title":"Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity.","volume":"5","author":"van Moorsel","year":"2016","journal-title":"Mol. Metab."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1172\/jci555","article-title":"Sympathetic activation in exercise is not dependent on muscle acidosis. Direct evidence from studies in metabolic myopathies.","volume":"101","author":"Vissing","year":"1998","journal-title":"J. Clin. Invest."},{"key":"B86","first-page":"373","article-title":"A new mtDNA mutation showing accumulation with time and restriction to skeletal muscle.","volume":"60","author":"Weber","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"B87","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s12035-010-8123-7","article-title":"Mitochondrial DNA mutation-elicited oxidative stress, oxidative damage, and altered gene expression in cultured cells of patients with MERRF syndrome.","volume":"41","author":"Wu","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1113\/expphysiol.2012.069443","article-title":"Training-induced acceleration of O(2) uptake on-kinetics precedes muscle mitochondrial biogenesis in humans.","volume":"98","author":"Zoladz","year":"2013","journal-title":"Exp. Physiol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00349\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T12:20:10Z","timestamp":1666614010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00349\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,21]]},"references-count":88,"alternative-id":["10.3389\/fphys.2020.00349"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.00349","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,21]]},"article-number":"349"}}