{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:12:46Z","timestamp":1792080766353,"version":"4.4.0"},"reference-count":267,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.00354","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T01:55:33Z","timestamp":1587434133000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":53,"title":["Regulation of Energy Metabolism by Receptor Tyrosine Kinase Ligands"],"prefix":"10.3389","volume":"11","author":[{"given":"Meng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin J.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.2337\/db17-1539","article-title":"Increased hepatic PDGF-AA signaling mediates liver insulin resistance in obesity-associated type 2 diabetes.","volume":"67","author":"Abderrahmani","year":"2018","journal-title":"Diabetes"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049977","article-title":"FGF21 requires betaklotho to act in vivo.","volume":"7","author":"Adams","year":"","journal-title":"PLoS ONE"},{"key":"B3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.molmet.2012.08.007","article-title":"The breadth of FGF21\u2019s metabolic actions are governed by FGFR1 in adipose tissue.","volume":"2","author":"Adams","year":"","journal-title":"Mol. Metab."},{"key":"B4","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1042\/CS20070122","article-title":"Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet.","volume":"114","author":"Agerkvist","year":"2008","journal-title":"Clin. Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1101\/gad.1653708.revealing","article-title":"Role of platelet-derived growth factors in physiology and medicine.","volume":"22","author":"Andrae","year":"2008","journal-title":"Genes Dev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.mce.2003.12.017","article-title":"Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo.","volume":"218","author":"Asaki","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"B7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/(SICI)1097-4652(199912)181:3<433::AID-JCP7>3.0.CO;2-Y","article-title":"Noninsulin-dependent diabetes mellitus occurs in mice ectopically expressing the human Axl tyrosine kinase receptor.","volume":"181","author":"Augustine","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1053\/j.gastro.2006.09.015","article-title":"Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia.","volume":"131","author":"Baek","year":"2006","journal-title":"Gastroenterology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biomedicines3010001","article-title":"Physiological signaling and structure of the HGF receptor MET.","volume":"3","author":"Baldanzi","year":"2014","journal-title":"Biomedicines"},{"key":"B10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.metabol.2015.10.023","article-title":"Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus: the multi-ethnic study of atherosclerosis (MESA).","volume":"65","author":"Bancks","year":"2016","journal-title":"Metabolism"},{"key":"B11","first-page":"390","article-title":"Fibroblast growth factor-19 levels in type 2 diabetic patients with metabolic syndrome.","volume":"41","author":"Barutcuoglu","year":"2011","journal-title":"Ann. Clin. Lab. Sci."},{"key":"B12","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/S0006-291X(05)80320-1","article-title":"Effects of epidermal growth factor on glycolysis in A431 cells.","volume":"183","author":"Baulida","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00174.2006","article-title":"Adipose tissue production of hepatocyte growth factor contributes to elevated serum HGF in obesity.","volume":"291","author":"Bell","year":"2006","journal-title":"Am. J. Physiol. Metab."},{"key":"B14","doi-asserted-by":"publisher","first-page":"10325","DOI":"10.1074\/jbc.M611770200","article-title":"Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1\/phosphatidylinositol 3-kinase\/Glut4 pathway.","volume":"282","author":"Bertola","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"670","DOI":"10.3109\/0886022X.2012.674438","article-title":"Urinary platelet-derived growth factor-BB as an early marker of nephropathy in patients with type 2 diabetes: an Egyptian study.","volume":"34","author":"Bessa","year":"2012","journal-title":"Ren. Fail."},{"key":"B16","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cytogfr.2004.03.005","article-title":"Insight into the physiological functions of PDGF through genetic studies in mice.","volume":"15","author":"Betsholtz","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1172\/JCI1744","article-title":"Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.","volume":"101","author":"Bezerra","year":"1998","journal-title":"J. Clin. Invest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"10023","DOI":"10.1074\/jbc.M808818200","article-title":"Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis.","volume":"284","author":"Bhatnagar","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1002\/hep.30696","article-title":"Pharmacologic inhibition of epidermal growth factor receptor suppresses nonalcoholic fatty liver disease in a murine fast-food diet model.","volume":"70","author":"Bhushan","year":"2019","journal-title":"Hepatology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/376768a0","article-title":"Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud.","volume":"376","author":"Bladt","year":"1995","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.cmet.2017.03.005","article-title":"FGF21 regulates metabolism through adipose-dependent and-independent mechanisms.","volume":"25","author":"BonDurant","year":"2017","journal-title":"Cell Metab."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1038\/nm.3249","article-title":"FGF21 regulates metabolism and circadian behavior by acting on the nervous system.","volume":"19","author":"Bookout","year":"2013","journal-title":"Nat. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1042\/bj2390523","article-title":"Epidermal growth factor mimics insulin effects in rat hepatocytes.","volume":"239","author":"Bosch","year":"1986","journal-title":"Biochem. J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"4653","DOI":"10.1200\/JCO.2004.04.156","article-title":"Imatinib mesylate may improve fasting blood glucose in diabetic Ph+ chronic myelogenous leukemia patients responsive to treatment.","volume":"22","author":"Breccia","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"8221","DOI":"10.1128\/MCB.24.18.8221-8226.2004","article-title":"Generation and characterization of neuregulin-2-deficient mice.","volume":"24","author":"Britto","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/s0896-6273(00)80324-4","article-title":"Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis.","volume":"18","author":"Burden","year":"1997","journal-title":"Neuron"},{"key":"B27","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1146\/annurev.bi.58.070189.003043","article-title":"The heparin-binding (fibroblast) growth factor family of proteins.","volume":"58","author":"Burgess","year":"1989","journal-title":"Annu. Rev. Biochem."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0703-6","article-title":"Association of circulating neuregulin 4 with metabolic syndrome in obese adults: a cross-sectional study.","volume":"14","author":"Cai","year":"2016","journal-title":"BMC Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.2337\/db06-1726","article-title":"Neuregulins increase mitochondrial oxidative capacity and insulin sensitivity in skeletal muscle cells.","volume":"56","author":"Canto","year":"2007","journal-title":"Diabetes"},{"key":"B30","doi-asserted-by":"publisher","first-page":"12260","DOI":"10.1074\/jbc.M308554200","article-title":"Neuregulin signaling on glucose transport in muscle cells\u2217.","volume":"279","author":"Cant\u00f3","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"12260","DOI":"10.1074\/jbc.M308554200","article-title":"Neuregulin signaling on glucose transport in muscle cells.","volume":"279","author":"Canto","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B32","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1210\/endo.138.12.5601","article-title":"Hepatic expression of ErbB3 is repressed by insulin in a pathway sensitive to PI-3 kinase inhibitors.","volume":"138","author":"Carver","year":"1997","journal-title":"Endocrinology"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2016.79","article-title":"MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.","volume":"48","author":"Chanda","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"28510","DOI":"10.1074\/jbc.M109.022244","article-title":"Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes.","volume":"284","author":"Chanda","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.2337\/dc11-0294","article-title":"High plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects.","volume":"34","author":"Chen","year":"2011","journal-title":"Diabetes Care"},{"key":"B36","first-page":"59","article-title":"Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines.","volume":"26","author":"Chen","year":"1997","journal-title":"Hepatology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.molmet.2017.03.016","article-title":"Nrg4 promotes fuel oxidation and a healthy adipokine pro fi le to ameliorate diet-induced metabolic disorders.","volume":"6","author":"Chen","year":"2017","journal-title":"Mol. Metab."},{"key":"B38","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/bs.ctdb.2016.10.004.Regulation","article-title":"Regulation of embryonic and postnatal development by the CSF-1 receptor.","volume":"123","author":"Chitu","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s13105-016-0468-6","article-title":"Increased expression of FGF1-mediated signaling molecules in adipose tissue of obese mice.","volume":"72","author":"Choi","year":"2016","journal-title":"J. Physiol. Biochem."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210828","article-title":"Epidermal growth factor receptor inhibition attenuates non-alcoholic fatty liver disease in diet-induced obese mice.","volume":"14","author":"Choung","year":"2019","journal-title":"PLoS ONE"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1038\/ijo.2014.27","article-title":"NAG-1\/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism.","volume":"38","author":"Chrysovergis","year":"2014","journal-title":"Int. J. Obes."},{"key":"B42","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3109\/10799899109064689","article-title":"Estrone modulates the EGF receptor in the liver of db\/db mouse.","volume":"11","author":"Chua","year":"1991","journal-title":"J. Recept. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1083\/jcb.201607110","article-title":"Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.","volume":"216","author":"Chung","year":"2017","journal-title":"J. Cell Biol."},{"key":"B44","first-page":"243","article-title":"A morphological study of the adipocyte precursor.","volume":"16","author":"Cinti","year":"1984","journal-title":"J. Submicrosc. Cytol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.2337\/db15-0318","article-title":"Brown and beige fat: molecular parts of a thermogenic machine.","volume":"64","author":"Cohen","year":"2015","journal-title":"Diabetes"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2530","article-title":"Drug development of MET inhibitors: targeting oncogene addiction and expedience.","volume":"7","author":"Comoglio","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"B47","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1210\/en.2008-0816","article-title":"Fibroblast growth factor 21 corrects obesity in mice.","volume":"149","author":"Coskun","year":"2008","journal-title":"Endocrinology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1053\/j.gastro.2005.08.004","article-title":"Expression and role of Gas6 protein and of its receptor Axl in hepatic regeneration from oval cells in the rat.","volume":"129","author":"Couchie","year":"2005","journal-title":"Gastroenterology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.metabol.2012.10.013","article-title":"Insulin infusion reduces hepatocyte growth factor in lean humans.","volume":"62","author":"Courten","year":"2013","journal-title":"Metabolism"},{"key":"B50","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1084\/jem.180.2.705","article-title":"Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.","volume":"180","author":"de Villiers","year":"1994","journal-title":"J. Exp. Med."},{"key":"B51","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1515\/hmbci-2015-0041","article-title":"Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle.","volume":"26","author":"Deshmukh","year":"2016","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"B52","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/S0021-9258(17)38184-X","article-title":"Glycolysis in quiescent cultures of 3T3 cells. Stimulation by serum, epidermal growth factor, and insulin in intact cells and persistence of the stimulation after cell homogenization.","volume":"253","author":"Diamond","year":"1978","journal-title":"J. Biol. Chem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.cmet.2012.08.002","article-title":"betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism.","volume":"16","author":"Ding","year":"2012","journal-title":"Cell Metab."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.1210\/en.2014-2001","article-title":"Central fibroblast growth factor 21 browns white fat via sympathetic action in male mice.","volume":"156","author":"Douris","year":"2015","journal-title":"Endocrinology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1038\/nm.4393","article-title":"The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.","volume":"23","author":"Emmerson","year":"2017","journal-title":"Nat. Med."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130568","article-title":"Neuregulin 1 improves glucose tolerance in db\/db Mice.","volume":"10","author":"Ennequin","year":"2015","journal-title":"PLoS ONE"},{"key":"B57","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.diabet.2014.12.002","article-title":"Neuregulin 1 affects leptin levels, food intake and weight gain in normal-weight, but not obese, db\/db mice.","volume":"41","author":"Ennequin","year":"2014","journal-title":"Diabetes Metab."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1038\/nm.2531.A","article-title":"A hepatocyte growth factor receptor (Met)\u2013insulin receptor hybrid governs hepatic glucose metabolism.","volume":"17","author":"Fafalios","year":"2011","journal-title":"Nat. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1210\/en.2003-1336","article-title":"Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans.","volume":"145","author":"Fain","year":"2004","journal-title":"Endocrinology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/cbf.3120","article-title":"Platelet-derived growth factor (PDGF) signalling in cancer: rapidly emerging signalling landscape.","volume":"33","author":"Farooqi","year":"2015","journal-title":"Cell Biochem. Funct."},{"key":"B61","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1080\/0886022X.2018.1455594","article-title":"Fibroblast growth factor-23 is a strong predictor of insulin resistance among chronic kidney disease patients.","volume":"40","author":"Fayed","year":"2018","journal-title":"Ren. Fail."},{"key":"B62","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/ar.1092240402","article-title":"Circadian variation of epidermal growth factor receptor in mouse liver.","volume":"224","author":"Feuers","year":"1989","journal-title":"Anat. Rec."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.2337\/db10-0193","article-title":"Obesity is a fibroblast growth factor 21 (FGF21)-resistant state.","volume":"59","author":"Fisher","year":"2010","journal-title":"Diabetes"},{"key":"B64","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1210\/en.2011-0281","article-title":"Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.","volume":"152","author":"Fisher","year":"2011","journal-title":"Endocrinology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1101\/gad.177857.111","article-title":"FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.","volume":"26","author":"Fisher","year":"2012","journal-title":"Genes Dev."},{"key":"B66","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1530\/JME-12-0003","article-title":"Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretion.","volume":"48","author":"Fitter","year":"2012","journal-title":"J. Mol. Endocrinol."},{"key":"B67","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1210\/jc.2010-0086","article-title":"Plasma adiponectin levels are markedly elevated in patients: a mechanism for improved insulin sensitivity in type 2 diabetic CML patients?","volume":"95","author":"Fitter","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/0092-8674(91)90326-t","article-title":"Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.","volume":"64","author":"Flanagan","year":"1991","journal-title":"Cell"},{"key":"B69","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1038\/sj.onc.1203620","article-title":"Cross-talk between the proto-oncogenes Met and Ron.","volume":"19","author":"Follenzi","year":"2000","journal-title":"Oncogene"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004690","article-title":"Treating diabetes and obesity with an FGF21-mimetic antibody activating the \u03b2Klotho\/FGFR1c receptor complex.","volume":"4","author":"Foltz","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nature13498","article-title":"The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function.","volume":"514","author":"Fonseca-Pereira","year":"2014","journal-title":"Nature"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1152\/ajpgi.00311.2010","article-title":"Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice.","volume":"300","author":"Fourcot","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1096S","DOI":"10.1093\/ajcn\/62.5.1096S","article-title":"Control of energy intake by energy metabolism.","volume":"62","author":"Friedman","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"B74","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1242\/dev.126.3.457","article-title":"Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.","volume":"126","author":"Fruttiger","year":"1999","journal-title":"Development"},{"key":"B75","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1210\/en.2003-1671","article-title":"Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes.","volume":"145","author":"Fu","year":"2004","journal-title":"Endocrinology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nrendo.2017.78","article-title":"FGF1 - a new weapon to control type 2 diabetes mellitus.","volume":"13","author":"Gasser","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"B77","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1002\/j.1460-2075.1994.tb06659.x","article-title":"RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.","volume":"13","author":"Gaudino","year":"1994","journal-title":"EMBO J."},{"key":"B78","doi-asserted-by":"publisher","first-page":"34533","DOI":"10.1074\/jbc.M111.248591","article-title":"Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor\/Ets-like protein-1 in adipocytes.","volume":"286","author":"Ge","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.05871","article-title":"Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish.","volume":"2015","author":"Gemberling","year":"2015","journal-title":"Elife"},{"key":"B80","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1210\/en.2018-00208","article-title":"Parsing the potential neuroendocrine actions of FGF21 in primates.","volume":"159","author":"Gillum","year":"2018","journal-title":"Endocrinology"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-018-0303-x","article-title":"Effect of imatinib on plasma glucose concentration in subjects with chronic myeloid leukemia and gastrointestinal stromal tumor.","volume":"18","author":"G\u00f3mez-s\u00e1mano","year":"2018","journal-title":"BMC Endocr. Disord."},{"key":"B82","first-page":"471","article-title":"Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts.","volume":"12","author":"Goruppi","year":"1996","journal-title":"Oncogene"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1038\/mt.2014.112","article-title":"Characterisation of a novel fc conjugate of macrophage colony-stimulating factor.","volume":"22","author":"Gow","year":"2014","journal-title":"Mol. Ther."},{"key":"B84","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1172\/JCI96324","article-title":"Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression.","volume":"127","author":"Guo","year":"2017","journal-title":"J. Clin. Invest."},{"key":"B85","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.cmet.2012.01.010","article-title":"Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells.","volume":"15","author":"Gupta","year":"2012","journal-title":"Cell Metab."},{"key":"B86","doi-asserted-by":"publisher","first-page":"8132","DOI":"10.1073\/pnas.91.17.8132","article-title":"Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.","volume":"91","author":"Guy","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B87","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1538\/expanim.63.85","article-title":"Fibroblast growth factor-5 participates in the progression of hepatic fibrosis.","volume":"63","author":"Hanaka","year":"2014","journal-title":"Exp. Anim."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1038\/sj.onc.1202631","article-title":"Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase.","volume":"18","author":"Harari","year":"1999","journal-title":"Oncogene"},{"key":"B89","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000445836","article-title":"Neuregulin 3 knockout mice exhibit behaviors consistent with psychotic disorders.","volume":"2","author":"Hayes","year":"2016","journal-title":"Mol. Neuropsychiatry"},{"key":"B90","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1101\/gad.293704.116","article-title":"Sorting out adipocyte precursors and their role in physiology and disease.","volume":"31","author":"Hepler","year":"2017","journal-title":"Genes Dev."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1210\/jc.2004-1588","article-title":"Strong association between serum hepatocyte growth factor and metabolic syndrome.","volume":"90","author":"Hiratsuka","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B92","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"B93","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s40273-014-0243-x","article-title":"The epidemiology of obesity: a big picture.","volume":"33","author":"Hruby","year":"2015","journal-title":"Pharmacoeconomics"},{"key":"B94","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nature24042","article-title":"Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.","volume":"550","author":"Hsu","year":"2017","journal-title":"Nature"},{"key":"B95","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1146\/annurev-physiol-030212-183727","article-title":"Fibroblast growth factor 23 and klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.","volume":"75","author":"Hu","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.numecd.2017.10.009","article-title":"Association of serum fibroblast growth factor 19 levels with visceral fat accumulation is independent of glucose tolerance status.","volume":"28","author":"Hu","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.2337\/db07-0648.Additional","article-title":"FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet \u2013 Induced fatty liver.","volume":"56","author":"Huang","year":"2007","journal-title":"Diabetes"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms5282","article-title":"The stem cell factor\/Kit signalling pathway regulates mitochondrial function and energy expenditure.","volume":"5","author":"Huang","year":"2014","journal-title":"Nat. Commun."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1016\/j.celrep.2017.06.063","article-title":"Uncoupling the mitogenic and metabolic functions of FGF1 by tuning FGF1-FGF receptor dimer stability.","volume":"20","author":"Huang","year":"2017","journal-title":"Cell Rep."},{"key":"B100","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/nrm1399","article-title":"Juxtamembrane autoinhibition in receptor tyrosine kinases.","volume":"5","author":"Hubbard","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1182\/blood-2011-09-379214","article-title":"Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling.","volume":"119","author":"Hume","year":"2012","journal-title":"Blood"},{"key":"B102","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/nature18644","article-title":"Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence.","volume":"535","author":"Ibiza","year":"2016","journal-title":"Nature"},{"key":"B103","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1159\/000094533","article-title":"Does epidermal growth factor participate in the regulation of glucose, insulin and glucagon levels?","author":"Jansen","year":"2006","journal-title":"Eur. Surg. Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/carcin\/bgr086","article-title":"IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migration.","volume":"32","author":"Jaquish","year":"2011","journal-title":"Carcinogenesis"},{"key":"B105","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.it.2014.06.006","article-title":"Homeostasis in the mononuclear phagocyte system.","volume":"35","author":"Jenkins","year":"2014","journal-title":"Trends Immunol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1161\/01.atv.17.1.18","article-title":"Effects of CSF-1 on cholesterol accumulation and efflux by macrophages.","volume":"17","author":"Jessup","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/srep36710","article-title":"Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults.","volume":"6","author":"Jiang","year":"2016","journal-title":"Sci. Rep."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.celrep.2014.09.049","article-title":"Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis.","volume":"9","author":"Jiang","year":"2014","journal-title":"Cell Rep."},{"key":"B109","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/s0014-5793(99)00283-5","article-title":"Binding specificities and affinities of egf domains for ErbB receptors.","volume":"447","author":"Jones","year":"1999","journal-title":"FEBS Lett."},{"key":"B110","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/nature10998","article-title":"A PPAR$\u03b3$-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.","volume":"485","author":"Jonker","year":"2012","journal-title":"Nature"},{"key":"B111","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/hep.510270523","article-title":"Hepatocyte growth factor stimulates synthesis of lipids and secretion of lipoproteins in rat hepatocytes.","volume":"27","author":"Kaibori","year":"1998","journal-title":"Hepatology"},{"key":"B112","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1073\/pnas.92.4.1077","article-title":"Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor.","volume":"92","author":"Kamohara","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B113","doi-asserted-by":"crossref","first-page":"13641","DOI":"10.1016\/S0021-9258(18)77397-3","article-title":"Toxicity and effects of epidermal growth factor on glucose metabolism of MDA-468 human breast cancer cells.","volume":"265","author":"Kaplan","year":"1990","journal-title":"J. Biol. Chem."},{"key":"B114","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1073\/pnas.86.19.7644","article-title":"Epidermal growth factor deficiency associated with diabetes mellitus.","volume":"86","author":"Kasayama","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B115","doi-asserted-by":"publisher","first-page":"495","DOI":"10.3892\/br.2017.1001","article-title":"Biological roles of hepatocyte growth factor-Met signaling from genetically modified animals.","volume":"7","author":"Kato","year":"2017","journal-title":"Biomed. Rep."},{"key":"B116","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.molmet.2013.12.003","article-title":"Inventing new medicines: the FGF21 story.","volume":"3","author":"Kharitonenkov","year":"2014","journal-title":"Mol. Metab."},{"key":"B117","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.tem.2015.09.007","article-title":"FGF21 revolutions: recent advances illuminating FGF21 biology and medicinal properties.","volume":"26","author":"Kharitonenkov","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator.","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-25098-0","article-title":"Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice.","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1126\/science.1198363","article-title":"FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.","volume":"331","author":"Kir","year":"","journal-title":"Science (80-)"},{"key":"B121","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1101\/sqb.2011.76.010710","article-title":"Roles of FGF19 in liver metabolism.","volume":"76","author":"Kir","year":"","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/ki.2009.44","article-title":"Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells.","volume":"75","author":"Kobayashi","year":"2009","journal-title":"Kidney Int."},{"key":"B123","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1152\/ajpgi.00021.2007","article-title":"HGF ameliorates a high-fat diet-induced fatty liver.","volume":"293","author":"Kosone","year":"2007","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050039","article-title":"Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system.","volume":"5","author":"Kramer","year":"2007","journal-title":"PLoS Biol."},{"key":"B125","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1210\/en.2007-0387","article-title":"c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic? -Cells in c-Kit W-v Mutant Mice.","volume":"148","author":"Krishnamurthy","year":"2007","journal-title":"Endocrinology"},{"key":"B126","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/hep.21237","article-title":"Induction of Gas6 protein in CCl4-induced rat liver injury and anti-apoptotic effect on hepatic stellate cells.","volume":"44","author":"Lafdil","year":"2006","journal-title":"Hepatology"},{"key":"B127","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jhep.2009.02.030","article-title":"Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice.","volume":"51","author":"Lafdil","year":"2009","journal-title":"J. Hepatol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/0896-6273(91)90167-x","article-title":"An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system.","volume":"6","author":"Lai","year":"1991","journal-title":"Neuron"},{"key":"B129","doi-asserted-by":"publisher","first-page":"709.e","DOI":"10.1016\/j.cmet.2017.09.005","article-title":"FGF19, FGF21, and an FGFR1\/\u03b2-klotho-activating antibody act on the nervous system to regulate body weight and glycemia.","volume":"26","author":"Lan","year":"2017","journal-title":"Cell Metab."},{"key":"B130","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1182\/blood.V81.3.656.656","article-title":"Soluble stem cell factor in human serum.","volume":"81","author":"Langley","year":"1993","journal-title":"Blood"},{"key":"B131","doi-asserted-by":"publisher","first-page":"C1149","DOI":"10.1152\/ajpcell.00487.2002","article-title":"Regulation of neuregulin\/ErbB signaling by contractile activity in skeletal muscle.","volume":"284","author":"Lebrasseur","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1111\/j.1582-4934.2007.00169.x","article-title":"Epidermal growth factor increases insulin secretion and lowers blood glucose in diabetic mice.","volume":"12","author":"Lee","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"115","DOI":"10.4162\/nrp.2016.10.1.115","article-title":"Genome-wide association study for the interaction between BMR and BMI in obese Korean women including overweight.","volume":"10","author":"Lee","year":"2016","journal-title":"Nutr. Res. Pract."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","article-title":"Cell signaling by receptor tyrosine kinases.","volume":"141","author":"Lemmon","year":"2010","journal-title":"Cell"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1101\/gad.8.16.1875","article-title":"Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.","volume":"8","author":"Leveen","year":"1994","journal-title":"Genes Dev."},{"key":"B136","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.jhep.2010.05.018","article-title":"Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride.","volume":"53","author":"Li","year":"2010","journal-title":"J. Hepatol."},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163843","article-title":"Macrophage stimulating protein enhances hepatic inflammation in a NASH model.","volume":"11","author":"Li","year":"2016","journal-title":"PLoS ONE"},{"key":"B138","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1152\/ajpendo.00172.2007","article-title":"Expression of c-Kit receptor tyrosine kinase and effect on $\u03b2$-cell development in the human fetal pancreas.","volume":"293","author":"Li","year":"2019","journal-title":"Am. J. Physiol. Metab."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.2337\/db17-1513","article-title":"Inhibition of epidermal growth factor receptor activation is associated with improved diabetic nephropathy and insulin resistance in type 2 diabetes.","volume":"67","author":"Li","year":"2018","journal-title":"Diabetes"},{"key":"B140","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1124\/jpet.110.178046.tion","article-title":"Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice.","volume":"337","author":"Lijnen","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B141","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.molmet.2017.12.003","article-title":"A gut\u2013brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus.","volume":"8","author":"Liu","year":"2018","journal-title":"Mol. Metab."},{"key":"B142","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.cmet.2014.03.025","article-title":"A smooth muscle-like origin for beige adipocytes.","volume":"19","author":"Long","year":"2014","journal-title":"Cell Metab."},{"key":"B143","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1126\/science.1061663","article-title":"Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.","volume":"293","author":"Lu","year":"2001","journal-title":"Science"},{"key":"B144","doi-asserted-by":"publisher","first-page":"26178","DOI":"10.1074\/jbc.M114.586826","article-title":"Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.","volume":"289","author":"Macdonald-Obermann","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034868","article-title":"Macrophage inhibitory cytokine 1 (MIC-1\/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets.","volume":"7","author":"Macia","year":"2012","journal-title":"PLoS ONE"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-7-81","article-title":"KIT is required for hepatic function during mouse post-natal development.","volume":"7","author":"Magnol","year":"2007","journal-title":"BMC Dev. Biol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1161\/01.ATV.0000160611.68791.c6","article-title":"Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice.","volume":"25","author":"Maquoi","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.yexcr.2017.05.006","article-title":"Fatty liver and FGF21 physiology.","volume":"360","author":"Maratos-Flier","year":"2017","journal-title":"Exp. Cell Res."},{"key":"B149","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.molmet.2013.10.002","article-title":"Central action of FGF19 reduces hypothalamic AGRP\/NPY neuron activity and improves glucose metabolism.","volume":"3","author":"Marcelin","year":"2014","journal-title":"Mol. Metab."},{"key":"B150","doi-asserted-by":"publisher","first-page":"4057","DOI":"10.2337\/db14-0595","article-title":"Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.","volume":"63","author":"Markan","year":"2014","journal-title":"Diabetes"},{"key":"B151","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.semcdb.2015.09.021","article-title":"Metabolic fibroblast growth factors (FGFs): mediators of energy homeostasis.","volume":"53","author":"Markan","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/dmrr.1177","article-title":"Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity.","volume":"27","author":"Mashili","year":"2011","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B153","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1053\/jhep.1997.v26.pm0009214455","article-title":"Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis\/cirrhosis.","volume":"26","author":"Matsuda","year":"1997","journal-title":"Hepatology"},{"key":"B154","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1038\/sj.onc.1210394","article-title":"Integrating signals from RTKs to ERK\/MAPK.","volume":"26","author":"McKay","year":"2007","journal-title":"Oncogene"},{"key":"B155","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/378386a0","article-title":"Multiple essential functions of neuregulin in development.","volume":"378","author":"Meyer","year":"1995","journal-title":"Nature"},{"key":"B156","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1128\/mcb.20.6.2260-2268.2000","article-title":"Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice.","volume":"20","author":"Miller","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.celrep.2016.08.086","article-title":"mTORC1 is a major regulatory node in the FGF21 signaling network in adipocytes.","volume":"17","author":"Minard","year":"2016","journal-title":"Cell Rep."},{"key":"B158","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1182\/blood.V85.3.641.bloodjournal853641","article-title":"Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form.","volume":"85","author":"Miyazawa","year":"1995","journal-title":"Blood"},{"key":"B159","doi-asserted-by":"publisher","first-page":"4799","DOI":"10.1172\/JCI70710","article-title":"FGF19 action in the brain induces insulin-independent glucose lowering.","volume":"123","author":"Morton","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/JCP","article-title":"Molecular determinants of FGF-21 activity\u2014synergy and cross-talk with PPAR\u03b3 signaling.","volume":"210","author":"Moyers","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1038\/nm.4392","article-title":"GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.","volume":"23","author":"Mullican","year":"2017","journal-title":"Nat. Med."},{"key":"B162","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nrc3680","article-title":"RET revisited: expanding the oncogenic portfolio.","volume":"14","author":"Mulligan","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00199-4","article-title":"Hepatocyte growth factor prevented high-fat diet-induced obesity and improved insulin resistance in mice.","volume":"7","author":"Muratsu","year":"2017","journal-title":"Sci. Rep."},{"key":"B164","doi-asserted-by":"publisher","first-page":"30022","DOI":"10.1074\/jbc.271.47.30022","article-title":"Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.","volume":"271","author":"Nagata","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B165","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/0014-5793(87)80475-1","article-title":"Purification and subunit structure of hepatocyte growth factor from rat platelets.","volume":"224","author":"Nakamura","year":"1987","journal-title":"FEBS Lett."},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1038\/342440a0","article-title":"Molecular cloning and expression of human hepatocyte growth factor.","volume":"342","author":"Nakamura","year":"1989","journal-title":"Nature"},{"key":"B167","doi-asserted-by":"publisher","first-page":"5702","DOI":"10.1074\/jbc.270.11.5702","article-title":"Vascular smooth muscle cell-derived, Gla-containing growth-potentiating factor for Ca(2+)-mobilizing growth factors.","volume":"270","author":"Nakano","year":"1995","journal-title":"J. Biol. Chem."},{"key":"B168","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1001\/jama.2015.9536","article-title":"Diabetes: advances in diagnosis and treatment.","volume":"314","author":"Nathan","year":"2015","journal-title":"JAMA"},{"key":"B169","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/S0140-6736_16_30054-X","article-title":"Trends in adult body-mass index in 200 countries from 1975 to 2014: (A)pooled analysis of 1698 population-based measurement studies with 19.2 million participants.","volume":"387","year":"2016","journal-title":"Lancet"},{"key":"B170","first-page":"159","article-title":"Differentiation of adipocyte precursors in a serum-free medium is influenced by glucocorticoids and endogenously produced insulin-like growth factor-I.","volume":"17","author":"Nougues","year":"1993","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.2337\/db16-0881","article-title":"PDGFR b regulates adipose tissue expansion and glucose metabolism via vascular remodeling in diet-induced obesity.","volume":"66","author":"Onogi","year":"2017","journal-title":"Diabetes"},{"key":"B172","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1210\/endo.137.7.8770939","article-title":"A role for hepatocyte growth factor\/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth.","volume":"137","author":"Otonkoski","year":"1996","journal-title":"Endocrinology"},{"key":"B173","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.cmet.2014.07.012","article-title":"FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.","volume":"20","author":"Owen","year":"2014","journal-title":"Cell Metab."},{"key":"B174","doi-asserted-by":"publisher","first-page":"707.e","DOI":"10.1016\/j.cmet.2018.12.016","article-title":"GDF15 provides an endocrine signal of nutritional stress in mice and humans.","volume":"29","author":"Patel","year":"2019","journal-title":"Cell Metab."},{"key":"B175","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/s0014-4827(03)00280-5","article-title":"Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor.","volume":"289","author":"Peace","year":"2003","journal-title":"Exp. Cell Res."},{"key":"B176","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0092-8674(92)90131-u","article-title":"Isolation of the neu\/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells.","volume":"69","author":"Peles","year":"1992","journal-title":"Cell"},{"key":"B177","doi-asserted-by":"publisher","first-page":"13700","DOI":"10.1074\/jbc.M707551200","article-title":"Hepatocyte growth factor is a novel stimulator of glucose uptake and metabolism in skeletal muscle cells.","volume":"283","author":"Perdomo","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms7980","article-title":"FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis.","volume":"6","author":"Perry","year":"2015","journal-title":"Nat. Commun."},{"key":"B179","doi-asserted-by":"publisher","first-page":"D746","DOI":"10.1093\/nar\/gkv1045","article-title":"Expression Atlas update\u2013an integrated database of gene and protein expression in humans, animals and plants.","volume":"44","author":"Petryszak","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B180","doi-asserted-by":"publisher","first-page":"8770","DOI":"10.1158\/0008-5472.CAN-10-1093","article-title":"Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas.","volume":"70","author":"Potratz","year":"2010","journal-title":"Cancer Res."},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00055","article-title":"The BCR-ABL1 inhibitors imatinib and ponatinib decrease plasma cholesterol and atherosclerosis, and nilotinib and ponatinib activate coagulation in a translational mouse model.","volume":"5","author":"Pouwer","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"B182","doi-asserted-by":"publisher","first-page":"G388","DOI":"10.1152\/ajpgi.00343.2017","article-title":"Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats.","volume":"314","author":"Pridans","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"13705","DOI":"10.1073\/pnas.1110105108","article-title":"Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals.","volume":"108","author":"Rabol","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B184","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1089\/dna.1994.13.1189","article-title":"Role of hepatocyte growth factor in breast cancer: a novel mitogenic factor secreted by adipocytes.","volume":"13","author":"Rahimi","year":"1994","journal-title":"DNA Cell Biol."},{"key":"B185","doi-asserted-by":"publisher","first-page":"E517","DOI":"10.1152\/ajpendo.00241.2011","article-title":"Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity.","volume":"301","author":"Raines","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B186","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.2337\/dc10-0710","article-title":"Hepatocyte growth factor and clinical diabetes in postmenopausal women.","volume":"33","author":"Rajpathak","year":"2010","journal-title":"Diabetes Care"},{"key":"B187","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.3390\/cancers7030860","article-title":"Targeting RTK signaling pathways in cancer.","volume":"7","author":"Regad","year":"2015","journal-title":"Cancers (Basel)."},{"key":"B188","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/S0735-1097(03)00231-6","article-title":"Obesity is associated with increased levels of circulating hepatocyte growth factor.","volume":"41","author":"Rehman","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"B189","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1007\/s00125-012-2481-9","article-title":"The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells.","volume":"55","author":"Rittig","year":"2012","journal-title":"Diabetologia"},{"key":"B190","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1210\/jc.2011-1033","article-title":"EGF Receptor (ERBB1) Abundance in Adipose Tissue Is Reduced in Insulin-Resistant and Type 2 Diabetic Women.","volume":"97","author":"Rogers","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B191","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.molmet.2015.05.005","article-title":"Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response.","volume":"4","author":"Rojas","year":"2015","journal-title":"Mol. Metab."},{"key":"B192","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1007\/s00018-004-4189-6","article-title":"Signal transduction via the stem cell factor receptor\/c-Kit.","volume":"61","author":"Ronnstrand","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"B193","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1093\/clinchem\/48.12.2270","article-title":"Insulin: discovery and controversy.","volume":"48","author":"Rosenfeld","year":"2002","journal-title":"Clin. Chem."},{"key":"B194","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1210\/en.2012-1891","article-title":"Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats.","volume":"154","author":"Ryan","year":"2013","journal-title":"Endocrinology"},{"key":"B195","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1101\/gad.983202","article-title":"Requirement of fibroblast growth factor 10 in development of white adipose tissue.","volume":"16","author":"Sakaue","year":"2002","journal-title":"Genes Dev."},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-016-0387-0","article-title":"Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans.","volume":"17","author":"Salinas","year":"2016","journal-title":"BMC Genet."},{"key":"B197","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism.","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"B198","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1210\/jc.2017-01257","article-title":"FGF21 is an insulin-dependent postprandial hormone in adult humans.","volume":"102","author":"Samms","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B199","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1172\/JCI77812","article-title":"The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux.","volume":"126","author":"Samuel","year":"2016","journal-title":"J. Clin. Invest."},{"key":"B200","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s13105-015-0444-6","article-title":"Targeted delivery of HGF to the skeletal muscle improves glucose homeostasis in diet-induced obese mice.","volume":"71","author":"Sanchez-encinales","year":"2015","journal-title":"J. Physiol. Biochem."},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2305-5839.2015.09.38","article-title":"A specified therapeutic window for neuregulin-1 to regenerate neonatal heart muscle.","volume":"3","author":"Santoro","year":"2015","journal-title":"Ann. Transl. Med."},{"key":"B202","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.2337\/db09-1878","article-title":"Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats.","volume":"59","author":"Sarruf","year":"2010","journal-title":"Diabetes"},{"key":"B203","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/(SICI)1097-0282(1998)47:3<243::AID-BIP4>3.0.CO;2-P","article-title":"Src homology-2 domains: structure, mechanisms, and drug discovery.","volume":"47","author":"Sawyer","year":"1998","journal-title":"Biopolymers"},{"key":"B204","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/nm.4101","article-title":"Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.","volume":"22","author":"Scarlett","year":"2016","journal-title":"Nat. Med."},{"key":"B205","doi-asserted-by":"publisher","first-page":"G370","DOI":"10.1152\/ajpgi.00116.2013","article-title":"Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice.","volume":"306","author":"Scheving","year":"2014","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008912","article-title":"Receptor tyrosine kinases: legacy of the first two decades.","volume":"6","author":"Schlessinger","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/373699a0","article-title":"Scatter factor\/hepatocyte growth factor is essential for liver development.","volume":"373","author":"Schmidt","year":"1995","journal-title":"Nature"},{"key":"B208","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1002\/jcp.21635","article-title":"The epidermal growth factor receptor ligands at a glance.","volume":"218","author":"Schneider","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.taap.2017.06.023","article-title":"The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis.","volume":"330","author":"Schumacher","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/oby.2011.399","article-title":"Axl deficiency does not affect adipogenesis or adipose tissue development.","volume":"20","author":"Scroyen","year":"2012","journal-title":"Obesity"},{"key":"B211","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1084\/jem.173.5.1227","article-title":"Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity.","volume":"173","author":"Skeel","year":"1991","journal-title":"J. Exp. Med."},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2304931","article-title":"Gas6\/TAM signaling components as novel biomarkers of liver fibrosis.","volume":"2019","author":"Smirne","year":"2019","journal-title":"Dis. Markers"},{"key":"B213","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1210\/er.2018-00134","article-title":"Fibroblast growth factor 15\/19: from basic functions to therapeutic perspectives.","volume":"39","author":"Somm","year":"2018","journal-title":"Endocr. Rev."},{"key":"B214","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1101\/gad.8.16.1888","article-title":"Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.","volume":"8","author":"Soriano","year":"1994","journal-title":"Genes Dev."},{"key":"B215","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1210\/en.2012-2133","article-title":"The neuregulin system of ligands and their receptors in rat islets of Langerhans.","volume":"154","author":"South","year":"2013","journal-title":"Endocrinology"},{"key":"B216","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/s0092-8674(01)00240-9","article-title":"Obesity and the regulation of energy balance.","volume":"104","author":"Spiegelman","year":"2001","journal-title":"Cell"},{"key":"B217","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/0092-8674(95)90520-0","article-title":"The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3\/Axl family of receptor tyrosine kinases.","volume":"80","author":"Stitt","year":"1995","journal-title":"Cell"},{"key":"B218","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1210\/en.2011-1878","article-title":"Long-term Fgf23 deficiency does not influence aging, glucose homeostasis, or fat metabolism in mice with a nonfunctioning vitamin D receptor.","volume":"153","author":"Streicher","year":"2012","journal-title":"Endocrinology"},{"key":"B219","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1046\/j.1365-2613.2000.00138.x","article-title":"Hepatocyte growth factor\/scatter factor-induced intracellular signalling.","volume":"81","author":"Stuart","year":"2000","journal-title":"Int. J. Exp. Pathol."},{"key":"B220","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1152\/ajpendo.00467.2014","article-title":"Loss of Ron receptor signaling leads to reduced obesity, diabetic phenotypes and hepatic steatosis in response to high-fat diet in mice.","volume":"308","author":"Stuart","year":"2015","journal-title":"Am. J. Physiol. Metab."},{"key":"B221","doi-asserted-by":"publisher","first-page":"18257","DOI":"10.1074\/jbc.M008100200","article-title":"A novel role of neuregulin in skeletal muscle.","volume":"276","author":"Su\u00e1rez","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B222","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature13540","article-title":"Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.","volume":"513","author":"Suh","year":"2014","journal-title":"Nature"},{"key":"B223","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1242\/dev.135962","article-title":"PDGFR\u03b1 controls the balance of stromal and adipogenic cells during adipose tissue organogenesis.","volume":"144","author":"Sun","year":"2017","journal-title":"Development"},{"key":"B224","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1172\/JCI4433","article-title":"Hepatocyte growth factor leads to recovery from alcohol-induced fatty liver in rats.","volume":"103","author":"Tahara","year":"1999","journal-title":"J. Clin. Invest."},{"key":"B225","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1038\/sj.bjc.6604559","article-title":"Dual MET \u2013 EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer.","volume":"99","author":"Tang","year":"2008","journal-title":"Br. J. Cancer"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00419","article-title":"FGF21 as modulator of metabolism in health and disease.","volume":"10","author":"Tezze","year":"2019","journal-title":"Front. Physiol."},{"key":"B227","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1007\/s10495-013-0886-7","article-title":"Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers.","volume":"18","author":"Tiong","year":"2013","journal-title":"Apoptosis"},{"key":"B228","first-page":"1741","article-title":"Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.","volume":"143","author":"Tomlinson","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"B229","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/0092-8674(94)90006-x","article-title":"Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.","volume":"79","author":"Tontonoz","year":"1994","journal-title":"Cell"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100370","article-title":"The anorectic actions of the TGF\u03b2 cytokine MIC-1\/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract.","volume":"9","author":"Tsai","year":"2014","journal-title":"PLoS ONE"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055174","article-title":"TGF-\u03b2 superfamily cytokine MIC-1\/GDF15 is a physiological appetite and body weight regulator.","volume":"8","author":"Tsai","year":"2013","journal-title":"PLoS One"},{"key":"B232","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1365-2265.2012.04496.x","article-title":"Independent association of elevated serum hepatocyte growth factor levels with development of insulin resistance in a 10-year prospective study.","volume":"79","author":"Tsukagawa","year":"2013","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"B233","first-page":"191","article-title":"Spatial and temporal expression of the ret proto-oncongene product in embryonic, infant and adult rat tissues.","volume":"10","author":"Tsuzuki","year":"1995","journal-title":"Oncogene"},{"key":"B234","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.jcmgh.2019.10.010","article-title":"A functional role of GAS6\/TAM in nonalcoholic steatohepatitis progression implicates AXL as therapeutic target.","volume":"9","author":"Tutusaus","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B235","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1182\/blood-2013-09-528752","article-title":"TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis.","volume":"123","author":"van der Meer","year":"2014","journal-title":"Blood"},{"key":"B236","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.2337\/diab.45.11.1619","article-title":"Epidermal growth factor induces glucose storage in transgenic 3T3-L1 adipocytes overexpressing epidermal growth factor receptors.","volume":"45","author":"Van Epps-Fung","year":"1996","journal-title":"Diabetes"},{"key":"B237","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/373623a0","article-title":"Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6.","volume":"373","author":"Varnum","year":"1995","journal-title":"Nature"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00613","article-title":"The discovery of insulin: an important milestone in the history of medicine.","volume":"9","author":"Vecchio","year":"2018","journal-title":"Front. Endocrinol."},{"key":"B239","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1056\/NEJM200503103521023","article-title":"Imatinib and regression of type 2 diabetes.","volume":"352","author":"Veneri","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"B240","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/nrendo.2016.136","article-title":"Brown adipose tissue as a secretory organ.","volume":"13","author":"Villarroya","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"B241","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/03014460701822003","article-title":"Genetic and environmental determinants of hepatocyte growth factor levels and their association with obesity and blood pressure.","volume":"35","author":"Vistoropsky","year":"2009","journal-title":"Ann. Hum. Biol."},{"key":"B242","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1530\/ec-18-0141","article-title":"Characterization of fibroblast growth factor 1 in obese children and adolescents.","volume":"7","author":"Wang","year":"2018","journal-title":"Endocr. Connect."},{"key":"B243","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1038\/nm.3713","article-title":"The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis.","volume":"20","author":"Wang","year":"2014","journal-title":"Nat. Med."},{"key":"B244","doi-asserted-by":"crossref","first-page":"690","DOI":"10.18632\/aging.100687","article-title":"hNAG - 1 increases lifespan by regulating energy metabolism and insulin\/IGF.","volume":"6","author":"Wang","year":"2014","journal-title":"Aging (Albany NY)."},{"key":"B245","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/j.1745-7254.2006.00361.x","article-title":"Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers 1.","volume":"27","author":"Wang","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"B246","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cob.12289","article-title":"Decreased serum neuregulin 4 levels associated with non-alcoholic fatty liver disease in children with obesity.","author":"Wang","year":"2019"},{"key":"B247","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1210\/en.2003-0480","article-title":"Platelet-derived growth factor (pdgf) stimulates glucose transport in 3T3-L1 Adipocytes overexpressing PDGF receptor by a pathway independent of insulin.","volume":"144","author":"Whiteman","year":"2003","journal-title":"Endocrinology"},{"key":"B248","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1007\/s00018-008-7440-8","article-title":"The epidermal growth factor receptor family: biology driving targeted therapeutics.","volume":"65","author":"Wieduwilt","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"B249","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.4049\/jimmunol.181.4.2303","article-title":"The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity.","volume":"181","author":"Wilson","year":"2008","journal-title":"J. Immunol."},{"key":"B250","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2008.11.008","article-title":"Functional selectivity of EGF family peptide growth factors: implications for cancer.","volume":"122","author":"Wilson","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"B251","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1515\/jpem-2012-0253","article-title":"A decrease in fasting FGF19 levels is associated with the development of non-alcoholic fatty liver disease in obese adolescents.","volume":"25","author":"Wojcik","year":"2012","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017868","article-title":"FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways.","volume":"6","author":"Wu","year":"2011","journal-title":"PLoS ONE"},{"key":"B253","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1194\/jlr.M027094","article-title":"Dual actions of fibroblast growth factor 19 on lipid metabolism.","volume":"54","author":"Wu","year":"2013","journal-title":"J. Lipid Res."},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003794","article-title":"Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.","volume":"3","author":"Wu","year":"2008","journal-title":"PLoS ONE"},{"key":"B255","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scitranslmed.aan8732","article-title":"Long-acting MIC-1\/GDF15 molecules to treat obesity: evidence from mice to monkeys.","volume":"9","author":"Xiong","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"B256","doi-asserted-by":"publisher","first-page":"250","DOI":"10.2337\/db08-0392","article-title":"Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.","volume":"58","author":"Xu","year":"2009","journal-title":"Diabetes"},{"key":"B257","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1038\/nm.4394","article-title":"GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.","volume":"23","author":"Yang","year":"2017","journal-title":"Nat. Med."},{"key":"B258","first-page":"3639","article-title":"Distribution and function of EGFR in human tissue and the effect of EGFR tyrosine kinase inhibition.","volume":"23","author":"Yano","year":"2003","journal-title":"Anticancer Res."},{"key":"B259","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1002\/dvdy.10496","article-title":"Characterization of c-Kit and nestin expression during islet cell development in the prenatal and postnatal rat pancreas.","volume":"229","author":"Yashpal","year":"2004","journal-title":"Dev. Dyn. an Off. Publ. Am. Assoc. Anat."},{"key":"B260","doi-asserted-by":"publisher","first-page":"256","DOI":"10.4049\/jimmunol.1600450","article-title":"The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis.","volume":"197","author":"Yu","year":"2016","journal-title":"J. Immunol."},{"key":"B261","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.2337\/diabetes.53.11.2776","article-title":"Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing platelet-derived growth factor receptor in the muscle, but it does not affect blood glucose levels.","volume":"53","author":"Yuasa","year":"2004","journal-title":"Diabetes"},{"key":"B262","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1083\/jcb.129.5.1177","article-title":"Mini-review the many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis.","volume":"129","author":"Zarnegar","year":"1995","journal-title":"J. Cell Biol."},{"key":"B263","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.98522","article-title":"NRG1-Fc improves metabolic health via dual hepatic and central action.","volume":"3","author":"Zhang","year":"2018","journal-title":"JCI Insight"},{"key":"B264","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.2337\/db07-1476.Additional","article-title":"Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans.","volume":"57","author":"Zhang","year":"2008","journal-title":"Diabetes"},{"key":"B265","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications.","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"B266","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1194\/jlr.M089961","article-title":"Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis.","volume":"60","author":"Zhou","year":"2019","journal-title":"J. Lipid Res."},{"key":"B267","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1055\/s-0043-104532","article-title":"Serum fibroblast growth factor 1 is associated with the decreased risk of obesity in human.","volume":"125","author":"Zhu","year":"2017","journal-title":"Exp. Clin. Endocrinol. Diabetes"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00354\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:41:19Z","timestamp":1696034479000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00354\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":267,"alternative-id":["10.3389\/fphys.2020.00354"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.00354","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737907472.793574673","asserted-by":"object"}]},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]},"article-number":"354"}}