{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:53:47Z","timestamp":1776750827064,"version":"3.51.2"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/16\/35\/31952"],"award-info":[{"award-number":["FS\/16\/35\/31952"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/16\/35\/31952"],"award-info":[{"award-number":["FS\/16\/35\/31952"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/19\/16\/34169"],"award-info":[{"award-number":["FS\/19\/16\/34169"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/19\/12\/34204"],"award-info":[{"award-number":["FS\/19\/12\/34204"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/15\/91\/31812"],"award-info":[{"award-number":["PG\/15\/91\/31812"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/13\/43\/30324"],"award-info":[{"award-number":["FS\/13\/43\/30324"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/17\/30\/32961"],"award-info":[{"award-number":["PG\/17\/30\/32961"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["AA\/18\/2\/34218"],"award-info":[{"award-number":["AA\/18\/2\/34218"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["109604\/Z\/15\/Z"],"award-info":[{"award-number":["109604\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["(16CVD02"],"award-info":[{"award-number":["(16CVD02"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["RHYTHM"],"award-info":[{"award-number":["RHYTHM"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.00465","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T04:50:35Z","timestamp":1589863835000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The Amplitude-Normalized Area of a Bipolar Electrogram as a Measure of Local Conduction Delay in the Heart"],"prefix":"10.3389","volume":"11","author":[{"given":"Caroline","family":"Mendonca Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace C.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique M. F.","family":"Meijborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"O\u2019Shea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Shattock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Coronel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Niederer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davor","family":"Pavlovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarvinder","family":"Dhanjal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01832","article-title":"Fibrosis microstructure modulates reentry in non-ischemic dilated cardiomyopathy: insights from imaged guided 2D computational modeling.","volume":"9","author":"Balaban","year":"2018","journal-title":"Front. Physiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1540-8159.1988.tb04559.x","article-title":"Computed bipolar electrograms from unipolar epicardial recordings","author":"Blanchard","year":"1988","journal-title":"Proceedings Computers in Cardiology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"H1378","DOI":"10.1152\/ajpheart.00185.2003","article-title":"Computer model of action potential of mouse ventricular myocytes.","volume":"287","author":"Bondarenko","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1161\/CIRCRESAHA.113.301565","article-title":"Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract.","volume":"113","author":"Boukens","year":"2013","journal-title":"Circ. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1161\/01.cir.69.6.1103","article-title":"The value of catheter mapping during sinus rhythm to localize site of origin of ventricular tachycardia.","volume":"69","author":"Cassidy","year":"","journal-title":"Circulation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1161\/01.CIR.70.1.37","article-title":"Endocardial mapping in humans in sinus rhythm with normal left ventricles: activation patterns and characteristics of electrograms.","volume":"70","author":"Cassidy","year":"","journal-title":"Circulation"},{"key":"B7","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1161\/01.CIR.73.4.645","article-title":"Endocardial catheter mapping in patients in sinus rhythm: relationship to underlying heart disease and ventricular arrhythmias.","volume":"73","author":"Cassidy","year":"1986","journal-title":"Circulation"},{"key":"B8","first-page":"373","article-title":"Automatic parameterization strategy for cardiac electrophysiology simulations.","volume":"40","author":"Costa","year":"2013","journal-title":"Comp. Cardiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1016\/0735-1097(90)92832-m","article-title":"Ventricular tachyrdia in the infarcted, Langendorff-perfused human heart: role of the arrangement of surviving cardiac fibers.","volume":"15","author":"de Baker","year":"1990","journal-title":"J. Am. Coll. Cardiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.hrthm.2009.02.026","article-title":"Genesis of complex fractionated atrial electrograms in zones of slow conduction: a computer model of microfibrosis.","volume":"6","author":"Jacquemet","year":"2009","journal-title":"Heart Rhythm"},{"key":"B11","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jacep.2015.09.001","article-title":"Substrate mapping for ventricular tachycardia. Assumptions and Misconceptions.","volume":"1","author":"Josephson","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1093\/europace\/euz165","article-title":"Evaluation of a real-time magnetic resonance imaging-guided electrophysiology system for structural and electrophysiological ventricular tachycardia substrate assessment.","volume":"21","author":"Mukherjee","year":"2019","journal-title":"Europace"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1093\/europace\/euu194","article-title":"EHRA\/HRS\/APHRS expert consensus on ventricular arrhythmias.","volume":"16","author":"Pedersen","year":"2014","journal-title":"Europace"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1093\/europace\/euv319","article-title":"2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the european society of cardiology (ESC)endorsed by: association for european paediatric and congenital cardiology (AEPC).","volume":"17","author":"Priori","year":"2015","journal-title":"Europace"},{"key":"B15","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/0002-9149(85)90729-5","article-title":"Ventricular activation in normal sinus rhythm: abnormalities with recurrent sustained tachycardia and a history of myocardial infarction.","volume":"55","author":"Untereker","year":"1985","journal-title":"Am. J. Cardiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/0002-9149(86)90019-6","article-title":"Abnormalities of endocardial activation pattern in patients with previous healed myocardial infarction and ventricular tachycardia.","volume":"58","author":"Vassallo","year":"1986","journal-title":"Am. J. Cardiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1161\/CIRCEP.111.964973","article-title":"Signals and Signal Processing for the Electrophysiologist.","volume":"4","author":"Venkatachalam","year":"2011","journal-title":"Circ. Arrhythm Electrophysiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jelectrocard.2003.09.017","article-title":"Computational tools for modeling electrical activity in cardiac tissue.","volume":"36","author":"Vigmond","year":"2003","journal-title":"J. Electrocardiol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00465\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T04:50:39Z","timestamp":1589863839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00465\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":18,"alternative-id":["10.3389\/fphys.2020.00465"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.00465","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]},"article-number":"465"}}