{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:18:18Z","timestamp":1783736298303,"version":"3.55.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.00625","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T06:18:40Z","timestamp":1591683520000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R"],"prefix":"10.3389","volume":"11","author":[{"given":"Wen","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Chao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Long","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.2741\/4027","article-title":"Immune and non-immune functions of the immunoproteasome.","volume":"17","author":"Angeles","year":"2012","journal-title":"Front. Biosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"5284","DOI":"10.1172\/JCI70877","article-title":"Enhanced autophagy ameliorates cardiac proteinopathy.","volume":"123","author":"Bhuiyan","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B3","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.redox.2018.10.021","article-title":"Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload.","volume":"20","author":"Chen","year":"2019","journal-title":"Redox Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"513","DOI":"10.2353\/ajpath.2007.070188","article-title":"Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.","volume":"171","author":"Ding","year":"2007","journal-title":"Am. J. Pathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1038\/nm.4222","article-title":"Cardioprotection and lifespan extension by the natural polyamine spermidine.","volume":"22","author":"Eisenberg","year":"2016","journal-title":"Nat. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/B978-0-12-397863-9.00003-1","article-title":"Immunoproteasomes: structure, function, and antigen presentation.","volume":"109","author":"Ferrington","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly.","volume":"65","author":"Frey","year":"2003","journal-title":"Annu. Rev. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/s0092-8674(00)80729-1","article-title":"Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress.","volume":"97","author":"Hirota","year":"1999","journal-title":"Cell"},{"key":"B9","doi-asserted-by":"publisher","first-page":"4862","DOI":"10.1073\/pnas.92.11.4862","article-title":"Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.","volume":"92","author":"Hirota","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00476","article-title":"Proteasome inhibitor YSY01A abrogates constitutive STAT3 signaling via down-regulation of Gp130 and JAK2 in human A549 lung cancer cells.","volume":"8","author":"Huang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/j.febslet.2009.12.047","article-title":"Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems.","volume":"584","author":"Korolchuk","year":"2010","journal-title":"FEBS Lett."},{"key":"B12","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1182\/blood-2015-05-646497","article-title":"Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells.","volume":"127","author":"Larrue","year":"2016","journal-title":"Blood"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.4049\/jimmunol.1800197","article-title":"Ablation and inhibition of the immunoproteasome catalytic subunit LMP7 attenuate experimental abdominal aortic aneurysm formation in mice.","volume":"202","author":"Li","year":"2019","journal-title":"J. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1172\/JCI22220","article-title":"Atrogin-1\/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex.","volume":"114","author":"Li","year":"2004","journal-title":"J. Clin. Invest."},{"key":"B15","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1161\/HYPERTENSIONAHA.117.10390","article-title":"Novel role for the immunoproteasome subunit PSMB10 in angiotensin II-induced atrial fibrillation in mice.","volume":"71","author":"Li","year":"2018","journal-title":"Hypertension"},{"key":"B16","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1161\/HYPERTENSIONAHA.118.11813","article-title":"Immunoproteasome subunit beta5i promotes Ang II (Angiotensin II)-induced atrial fibrillation by targeting ATRAP (Ang II type I receptor-associated protein) degradation in mice.","volume":"73","author":"Li","year":"2019","journal-title":"Hypertension"},{"key":"B17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.yjmcc.2014.12.007","article-title":"Activation of the cardiac proteasome promotes angiotension II-induced hypertrophy by down-regulation of ATRAP.","volume":"79","author":"Li","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"672","DOI":"10.7150\/ijbs.11883","article-title":"Functions of autophagy in pathological cardiac hypertrophy.","volume":"11","author":"Li","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"22896","DOI":"10.1074\/jbc.M200347200","article-title":"Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart.","volume":"277","author":"Matsui","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4161\/cc.2.3.381","article-title":"Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival.","volume":"2","author":"Matsui","year":"2003","journal-title":"Cell Cycle"},{"key":"B21","doi-asserted-by":"publisher","first-page":"4415","DOI":"10.1158\/0008-5472.CAN-08-2839","article-title":"The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib.","volume":"69","author":"Milani","year":"2009","journal-title":"Cancer Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nm1574","article-title":"The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.","volume":"13","author":"Nakai","year":"2007","journal-title":"Nat. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/bf01745045","article-title":"Involvement of gp130-mediated signaling in pressure overload-induced activation of the JAK\/STAT pathway in rodent heart.","volume":"13","author":"Pan","year":"1998","journal-title":"Heart Vessels"},{"key":"B24","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/cvr\/cvp321","article-title":"The ubiquitin-proteasome system in myocardial ischaemia and preconditioning.","volume":"85","author":"Powell","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"270","DOI":"10.4161\/auto.6.2.10439","article-title":"Investigating autophagy: quantitative morphometric analysis using electron microscopy.","volume":"6","author":"Swanlund","year":"2010","journal-title":"Autophagy"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1253\/jcj.57.1120","article-title":"Insulin-like growth factor I receptors in human cardiac myocytes and their relation to myocardial hypertrophy.","volume":"57","author":"Toyozaki","year":"1993","journal-title":"Jpn. Circ. J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1093\/eurheartj\/ehy085","article-title":"CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration.","volume":"39","author":"Wang","year":"2018","journal-title":"Eur. Heart J."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1161\/CIRCULATIONAHA.115.020754","article-title":"Genetic and pharmacologic inhibition of the chemokine receptor CXCR2 prevents experimental hypertension and vascular dysfunction.","volume":"134","author":"Wang","year":"2016","journal-title":"Circulation"},{"key":"B29","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.redox.2018.02.022","article-title":"The immunoproteasome subunit LMP10 mediates angiotensin II-induced retinopathy in mice.","volume":"16","author":"Wang","year":"2018","journal-title":"Redox Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ymthe.2019.09.025","article-title":"Ablation of immunoproteasome beta5i subunit suppresses hypertensive retinopathy by blocking ATRAP degradation in mice.","volume":"28","author":"Wang","year":"2020","journal-title":"Mol. Ther."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau0495","article-title":"The immunoproteasome catalytic beta5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.","volume":"5","author":"Xie","year":"2019","journal-title":"Sci. Adv."},{"key":"B32","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s10555-010-9255-y","article-title":"Feedback regulation of proteasome gene expression and its implications in cancer therapy.","volume":"29","author":"Xie","year":"2010","journal-title":"Cancer Metastasis Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.bbrc.2017.05.011","article-title":"Knockout of immunoproteasome subunit beta2i ameliorates cardiac fibrosis and inflammation in DOCA\/Salt hypertensive mice.","volume":"490","author":"Yan","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800807","article-title":"Gallic acid suppresses cardiac hypertrophic remodeling and heart failure.","volume":"63","author":"Yan","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1172\/JCI13939","article-title":"Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways.","volume":"108","author":"Yasukawa","year":"2001","journal-title":"J. Clin. Invest."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.165551","article-title":"Chronic inhibition of chemokine receptor CXCR2 attenuates cardiac remodeling and dysfunction in spontaneously hypertensive rats.","volume":"1865","author":"Zhang","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/onc.2009.343","article-title":"Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells.","volume":"29","author":"Zhu","year":"2010","journal-title":"Oncogene"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00625\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T06:18:42Z","timestamp":1591683522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00625\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":37,"alternative-id":["10.3389\/fphys.2020.00625"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.00625","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]},"article-number":"625"}}