{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:24:26Z","timestamp":1787027066200,"version":"build-2736575974"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.00833","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:32:45Z","timestamp":1598488365000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["A Cold Environment Aggravates Cough Hyperreactivity in Guinea Pigs With Cough by Activating the TRPA1 Signaling Pathway in Skin"],"prefix":"10.3389","volume":"11","author":[{"given":"Ran","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyangzi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghuai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1164\/arrd.1985.131.3.362","article-title":"The tussive effect of hyperpnea with cold air.","volume":"131","author":"Banner","year":"1985","journal-title":"Am. Rev. Respir. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1164\/rccm.200905-0665OC","article-title":"TRPA1 agonists evoke coughing in guinea pig and human volunteers.","volume":"180","author":"Birrell","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.pupt.2009.01.003","article-title":"Central regulation of the cough reflex: therapeutic implications.","volume":"22","author":"Canning","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1034\/j.1398-9995.2003.00183.x","article-title":"Enhanced cough response to hyperpnea with cold air challenge in chronic cough patients showing increased cough sensitivity to inhaled capsaicin.","volume":"58","author":"Cho","year":"2003","journal-title":"Allergy"},{"key":"B5","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.pupt.2011.01.012","article-title":"Chronic \u2018cough hypersensitivity syndrome\u2019: a more precise label for chronic cough.","volume":"24","author":"Chung","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"B6","first-page":"289","article-title":"Cough reflex testing with inhaled capsaicin and TRPV1 activation in asthma and comorbid conditions.","volume":"23","author":"Couto","year":"2013","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.resp.2019.02.002","article-title":"Induction of airway remodeling and persistent cough by repeated citric acid exposure in a guinea pig cough model.","volume":"263","author":"Cui","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1146\/annurev.neuro.29.051605.112958","article-title":"Trp ion channels and temperature sensation.","volume":"29","author":"Dhaka","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1111\/bph.14360","article-title":"Central adenosine A1 receptors inhibit cough via suppression of excitatory glutamatergic and tachykininergic neurotransmission.","volume":"175","author":"El-Hashim","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/cea.13308","article-title":"Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea pigs.","volume":"49","author":"Fang","year":"2019","journal-title":"Clin. Exp. Allergy"},{"key":"B11","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1517\/13543776.2012.711320","article-title":"Advances in modulating thermosensory TRP channels.","volume":"22","author":"Ferrer-Montiel","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"B12","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1378\/chest.125.2.482","article-title":"Gender differences in health-related quality of life in patients complaining of chronic cough.","volume":"125","author":"French","year":"2004","journal-title":"Chest"},{"key":"B13","doi-asserted-by":"publisher","first-page":"S63","DOI":"10.1007\/s00408-009-9201-3","article-title":"Cough: the emerging role of the TRPA1 channel.","volume":"188","author":"Geppetti","year":"2010","journal-title":"Lung"},{"key":"B14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1378\/chest.15-1496","article-title":"Treatment of unexplained chronic cough: CHEST guideline and expert panel report.","volume":"149","author":"Gibson","year":"2016","journal-title":"Chest"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1111\/bph.12538","article-title":"Transient receptor potential (TRP) channels in the airway: role in airway disease.","volume":"171","author":"Grace","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3967\/bes2015.008","article-title":"Ambient temperature and outpatient visits for acute exacerbation of chronic bronchitis in Shanghai: a time series analysis.","volume":"28","author":"Huang","year":"2015","journal-title":"Biomed. Environ. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rmed.2016.02.005","article-title":"Asthma control and cold weather-related respiratory symptoms.","volume":"113","author":"Hyrkas","year":"2016","journal-title":"Respir. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1164\/ajrccm\/141.3.640","article-title":"Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy.","volume":"141","author":"Irwin","year":"1990","journal-title":"Am. Rev. Respir. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s00403-002-0378-z","article-title":"Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema.","volume":"295","author":"Jarvikallio","year":"2003","journal-title":"Arch. Dermatol. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.resinv.2016.07.002","article-title":"\u201cCold air\u201d and\/or \u201ctalking\u201d as cough triggers, a sign for the diagnosis of cough variant asthma.","volume":"54","author":"Kanemitsu","year":"2016","journal-title":"Respir. Investig."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1183\/09031936.95.08122088","article-title":"Facial cooling, but not nasal breathing of cold air, induces bronchoconstriction: a study in asthmatic and healthy subjects.","volume":"8","author":"Koskela","year":"1995","journal-title":"Eur. Respir. J."},{"key":"B22","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3402\/ijch.v66i2.18237","article-title":"Cold air-provoked respiratory symptoms: the mechanisms and management.","volume":"66","author":"Koskela","year":"2007","journal-title":"Int. J. Circumpolar Health"},{"key":"B23","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1378\/chest.12-0441","article-title":"A prospective, multicenter survey on causes of chronic cough in China.","volume":"143","author":"Lai","year":"2013","journal-title":"Chest"},{"key":"B24","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1046\/j.1365-2222.2001.00989.x","article-title":"Characterization of increased cough sensitivity after antigen challenge in guinea pigs.","volume":"31","author":"Liu","year":"2001","journal-title":"Clin. Exp. Allergy"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1077-z","article-title":"Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough.","volume":"20","author":"Long","year":"2019","journal-title":"Respir. Res."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-5-7","article-title":"Changes in health-related quality of life and clinical implications in Chinese patients with chronic cough.","volume":"5","author":"Ma","year":"2009","journal-title":"Cough"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1172\/JCI112052","article-title":"Intraairway thermal profiles during exercise and hyperventilation in normal man.","volume":"76","author":"McFadden","year":"1985","journal-title":"J. Clin. Invest."},{"key":"B28","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.rmed.2012.11.017","article-title":"Inhalation of menthol reduces capsaicin cough sensitivity and influences inspiratory flows in chronic cough.","volume":"107","author":"Millqvist","year":"2013","journal-title":"Respir. Med."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-9-14","article-title":"Chronic cough hypersensitivity syndrome.","volume":"9","author":"Morice","year":"2013","journal-title":"Cough"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00439-2019","article-title":"The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study.","volume":"54","author":"Morice","year":"2019","journal-title":"Eur. Respir. J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.ceca.2006.07.008","article-title":"Many cold sensitive peripheral neurons of the mouse do not express TRPM8 or TRPA1.","volume":"41","author":"Munns","year":"2007","journal-title":"Cell Calcium"},{"key":"B32","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.resinv.2016.06.005","article-title":"Airway remodeling associated with cough hypersensitivity as a consequence of persistent cough: an experimental study.","volume":"54","author":"Nakaji","year":"2016","journal-title":"Respir. Investig."},{"key":"B33","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s00424-017-2085-9","article-title":"Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature.","volume":"470","author":"Pan","year":"2018","journal-title":"Pflugers. Arch."},{"key":"B34","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nrn1141","article-title":"ThermoTRP channels and beyond: mechanisms of temperature sensation.","volume":"4","author":"Patapoutian","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S1094-5539(02)00214-6","article-title":"Cough sensitivity in atopic dermatitis.","volume":"16","author":"Pecova","year":"","journal-title":"Pulm. Pharmacol. Ther."},{"key":"B36","first-page":"25","article-title":"Cough sensitivity in localized scleroderma with no clinical symptoms from lower airways.","volume":"54","author":"Pecova","year":"","journal-title":"J. Physiol. Pharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1152\/japplphysiol.01144.2012","article-title":"The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol.","volume":"115","author":"Plevkova","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.neuron.2018.02.022","article-title":"Regulation of body temperature by the nervous system.","volume":"98","author":"Tan","year":"2018","journal-title":"Neuron"},{"key":"B39","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1254\/jphs.fpj05014x","article-title":"Mechanisms of capsaicin- and citric-acid-induced cough reflexes in guinea pigs.","volume":"99","author":"Tanaka","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-8-2","article-title":"Seasonal variations of cough reflex sensitivity in elite athletes training in cold air environment.","volume":"8","author":"Turmel","year":"2012","journal-title":"Cough"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119953","article-title":"Olodaterol attenuates citric acid-induced cough in naive and ovalbumin-sensitized and challenged guinea pigs.","volume":"10","author":"Wex","year":"2015","journal-title":"PLoS One"},{"key":"B42","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.pupt.2010.12.010","article-title":"Workshop: tuning the \u2018cough center\u2019.","volume":"24","author":"Widdicombe","year":"2011","journal-title":"Pulm Pharmacol Ther"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00209","article-title":"Cold Temperature Encoding by Cutaneous TRPA1 and TRPM8-Carrying Fibers in the Mouse.","volume":"10","author":"Winter","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-4-22","article-title":"TRPM8 mechanism of autonomic nerve response to cold in respiratory airway.","volume":"4","author":"Xing","year":"2008","journal-title":"Mol. Pain"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1177\/0300060518778951","article-title":"Association of cough hypersensitivity with tracheal TRPV1 activation and neurogenic inflammation in a novel guinea pig model of citric acid-induced chronic cough.","volume":"46","author":"Xu","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2220\/biomedres.17.271","article-title":"Skin stimulation with cold water inhibits capsaicin induced cough, and decreases substance P-like immunoreactivity in guinea-pig lungs.","volume":"17","author":"Yoshihara","year":"1996","journal-title":"Biomed. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"G34","DOI":"10.1016\/S0016-5085(09)60634-X","article-title":"TRPA1 in mast cell activation-induced long-lasting mechanical hypersensitivity of vagal afferent C fibers in guinea pig esophagus.","volume":"297","author":"Yu","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/cphy.c120001","article-title":"Molecular mechanism of TRP channels.","volume":"3","author":"Zheng","year":"2013","journal-title":"Compr. Physiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.resp.2011.05.011","article-title":"Sensitivity of bronchopulmonary receptors to cold and heat mediated by transient receptor potential cation channel subtypes in an ex vivo rat lung preparation.","volume":"177","author":"Zhou","year":"2011","journal-title":"Respir. Physiol. Neurobiol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00833\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:32:50Z","timestamp":1598488370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.00833\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,27]]},"references-count":49,"alternative-id":["10.3389\/fphys.2020.00833"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.00833","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,27]]},"article-number":"833"}}