{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:42:24Z","timestamp":1785872544627,"version":"3.56.0"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.531933","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T06:04:22Z","timestamp":1603346662000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["The Mediator Subunit, Med23 Is Required for Embryonic Survival and Regulation of Canonical WNT Signaling During Cranial Ganglia Development"],"prefix":"10.3389","volume":"11","author":[{"given":"Soma","family":"Dash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shachi","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Sandell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngwook","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robb E.","family":"Krumlauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Trainor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/bs.ctdb.2014.11.013","article-title":"Signaling in tooth, hair, and mammary placodes.","volume":"111","author":"Ahn","year":"2015","journal-title":"Curr. Top. Dev. Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1242\/dev.054668","article-title":"Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning.","volume":"137","author":"Ahn","year":"2010","journal-title":"Development"},{"key":"B3","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1242\/dev.085118","article-title":"Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.","volume":"140","author":"Ahn","year":"2013","journal-title":"Development"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1242\/dev.150680","article-title":"Multiple modes of Lrp4 function in modulation of Wnt\/\u03b2-catenin signaling during tooth development.","volume":"144","author":"Ahn","year":"2017","journal-title":"Development"},{"key":"B5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrm3951","article-title":"The Mediator complex: a central integrator of transcription.","volume":"16","author":"Allen","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/dbio.2001.0156","article-title":"Vertebrate cranial placodes I. Embryonic induction.","volume":"232","author":"Baker","year":"2001","journal-title":"Dev. Biol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1164302","article-title":"Complexity in transcription control at the activation domain\u2013mediator interface.","volume":"2","author":"Balamotis","year":"2009","journal-title":"Sci. Signal."},{"key":"B8","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1126\/science.1062028","article-title":"Integration between the epibranchial placodes and the hindbrain.","volume":"294","author":"Begbie","year":"2001","journal-title":"Science"},{"key":"B9","author":"Behringer","year":"2014","journal-title":"Manipulating the Mouse Embryo: A Laboratory Manual"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008326","article-title":"Signals and switches in mammalian neural crest cell differentiation.","volume":"5","author":"Bhatt","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/gene.20008","article-title":"Tissue-specific expression of cre recombinase from the Pax8 locus.","volume":"38","author":"Bouchard","year":"2004","journal-title":"Genesis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-2-r9","article-title":"Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray.","volume":"4","author":"Bozdech","year":"2003","journal-title":"Genome Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1101\/gad.186601","article-title":"The transcription factor Sox10 is a key regulator of peripheral glial development.","volume":"15","author":"Britsch","year":"2001","journal-title":"Genes Dev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1128\/mcb.24.1.294-305.2004","article-title":"Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activation.","volume":"24","author":"Cesari","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"B15","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"key":"B16","doi-asserted-by":"publisher","first-page":"6161","DOI":"10.1093\/nar\/gkm661","article-title":"The Mediator subunit MED1\/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation.","volume":"35","author":"Chen","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1210\/me.2005-0318","article-title":"MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor.","volume":"20","author":"Chen","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.tibs.2005.03.002","article-title":"The mammalian Mediator complex and its role in transcriptional regulation.","volume":"30","author":"Conaway","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev.cellbio.22.010305.103814","article-title":"Neural crest stem and progenitor cells.","volume":"22","author":"Crane","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1534\/genetics.109.104372","article-title":"Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles.","volume":"183","author":"Dackor","year":"2009","journal-title":"Genetics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/aja.1001660406","article-title":"Contributions of placodal and neural crest cells to avian cranial peripheral ganglia.","volume":"166","author":"D\u2019Amico-Martel","year":"1983","journal-title":"Am. J. Anat."},{"key":"B22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1242\/dev.110.2.343","article-title":"Localization of specific retinoid-binding sites and expression of cellular retinoic-acid-binding protein (CRABP) in the early mouse embryo.","volume":"110","author":"Dencker","year":"1990","journal-title":"Development"},{"key":"B23","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/s0896-6273(00)80989-7","article-title":"The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons.","volume":"20","author":"Fode","year":"1998","journal-title":"Neuron"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1242\/dev.091033","article-title":"Cranial neural crest cells form corridors prefiguring sensory neuroblast migration.","volume":"140","author":"Freter","year":"2013","journal-title":"Development"},{"key":"B25","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.ydbio.2006.08.059","article-title":"Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo.","volume":"302","author":"Grifone","year":"2007","journal-title":"Dev. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.ydbio.2007.07.033","article-title":"Wise retained in the endoplasmic reticulum inhibits Wnt signaling by reducing cell surface LRP6.","volume":"310","author":"Guidato","year":"2007","journal-title":"Dev. Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/ccr3.1942","article-title":"Novel mutation in the MED23 gene for intellectual disability: A case report and literature review.","volume":"7","author":"Hashemi-Gorji","year":"2019","journal-title":"Clin Case Rep"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003949","article-title":"Interaction between Foxc1 and Fgf8 during Mammalian Jaw Patterning and in the Pathogenesis of Syngnathia.","volume":"9","author":"Inman","year":"2013","journal-title":"PLoS Genet"},{"key":"B29","doi-asserted-by":"publisher","first-page":"4295","DOI":"10.1242\/dev.00674","article-title":"Wise, a context-dependent activator and inhibitor of Wnt signalling.","volume":"130","author":"Itasaki","year":"2003","journal-title":"Development"},{"key":"B30","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1242\/dev.127.8.1607","article-title":"Fate of the mammalian cardiac neural crest.","volume":"127","author":"Jiang","year":"2000","journal-title":"Development"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1242\/dev.01137","article-title":"The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.","volume":"131","author":"Kelly","year":"2004","journal-title":"Development"},{"key":"B32","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1128\/MCB.01140-07","article-title":"Functional Conservation of the Glutamine-Rich Domains of Yeast Gal11 and Human SRC-1 in the Transactivation of Glucocorticoid Receptor Tau 1 in Saccharomyces cerevisiae.","volume":"28","author":"Kim","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2005.03.010","article-title":"Interactions between subunits of Drosophila Mediator and activator proteins.","volume":"30","author":"Kim","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1006\/dbio.2000.0106","article-title":"Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo.","volume":"230","author":"Kisanuki","year":"2001","journal-title":"Dev. Biol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120821","article-title":"Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling.","volume":"10","author":"Kurosaka","year":"2015","journal-title":"PLoS One"},{"key":"B36","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ydbio.2013.11.025","article-title":"Signaling mechanisms controlling cranial placode neurogenesis and delamination.","volume":"389","author":"Lassiter","year":"2014","journal-title":"Dev. Biol."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140192","article-title":"Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency.","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/76080","article-title":"Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.","volume":"25","author":"Lim","year":"2000","journal-title":"Nat. Genet."},{"key":"B39","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.ydbio.2006.11.034","article-title":"Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis.","volume":"303","author":"Lin","year":"2007","journal-title":"Dev. Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"23159","DOI":"10.1074\/jbc.M109.025478","article-title":"Characterization of wise protein and its molecular mechanism to interact with both Wnt and BMP signals.","volume":"284","author":"Lintern","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1002\/ajmg.a.37802","article-title":"MED23-associated refractory epilepsy successfully treated with the ketogenic diet.","volume":"170","author":"Lionel","year":"2016","journal-title":"Am. J. Med. Genet. A"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11149","article-title":"Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development.","volume":"7","author":"Liu","year":"2016","journal-title":"Nat. Commun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1161\/CIRCGENETICS.113.000264","article-title":"Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.","volume":"7","author":"L\u00fcneburg","year":"2014","journal-title":"Circ. Cardiovasc. Genet."},{"key":"B44","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/s0896-6273(00)80988-5","article-title":"neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia.","volume":"20","author":"Ma","year":"1998","journal-title":"Neuron"},{"key":"B45","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases.","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"key":"B46","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/s0968-0004(00)01596-6","article-title":"Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells.","volume":"25","author":"Malik","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ydbio.2004.06.013","article-title":"A screen for downstream effectors of Neurogenin2 in the embryonic neocortex.","volume":"273","author":"Mattar","year":"2004","journal-title":"Dev. Biol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05967-y","article-title":"Crystal structure of human Mediator subunit MED23.","volume":"9","author":"Mont\u00e9","year":"2018","journal-title":"Nat. Commun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/gene.20017","article-title":"Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome.","volume":"38","author":"Ohyama","year":"2004","journal-title":"Genesis"},{"key":"B50","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1002\/dvg.22961","article-title":"Inhibition of P-TEFb disrupts global transcription, oocyte maturation, and embryo development in the mouse.","volume":"54","author":"Oqani","year":"2016","journal-title":"Genesis"},{"key":"B51","doi-asserted-by":"publisher","first-page":"8709","DOI":"10.1128\/MCB.20.23.8709-8719.2000","article-title":"In Vivo Requirement of Activator-Specific Binding Targets of Mediator.","volume":"20","author":"Park","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature26002","article-title":"Placentation defects are highly prevalent in embryonic lethal mouse mutants.","volume":"555","author":"Perez-Garcia","year":"2018","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3109\/10409238.2013.840259","article-title":"The Mediator complex and transcription regulation.","volume":"48","author":"Poss","year":"2013","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"9940","DOI":"10.1523\/JNEUROSCI.3467-05.2005","article-title":"Vascular development of the brain requires beta8 integrin expression in the neuroepithelium.","volume":"25","author":"Proctor","year":"2005","journal-title":"J. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.biochi.2017.10.012","article-title":"Therapeutic potential of Mediator complex subunits in metabolic diseases.","volume":"144","author":"Ranjan","year":"2018","journal-title":"Biochimie"},{"key":"B56","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ydbio.2010.03.019","article-title":"The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development.","volume":"342","author":"Risley","year":"2010","journal-title":"Dev. Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1007\/s00018-013-1277-5","article-title":"Neurovascular development and links to disease.","volume":"70","author":"Ruhrberg","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ydbio.2014.02.011","article-title":"Establishing the pre-placodal region and breaking it into placodes with distinct identities.","volume":"389","author":"Saint-Jeannet","year":"2014","journal-title":"Dev. Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ydbio.2013.11.009","article-title":"Cochleovestibular nerve development is integrated with migratory neural crest cells.","volume":"385","author":"Sandell","year":"2014","journal-title":"Dev. Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/dvg.20727","article-title":"A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development.","volume":"49","author":"Sandell","year":"2011","journal-title":"Genesis"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1101\/gad.1533407","article-title":"RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.","volume":"21","author":"Sandell","year":"2007","journal-title":"Genes Dev."},{"key":"B62","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/978-0-387-46954-6_5","article-title":"Neural crest cell plasticity. size matters.","volume":"589","author":"Sandell","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.ydbio.2006.03.009","article-title":"Induction and specification of cranial placodes.","volume":"294","author":"Schlosser","year":"2006","journal-title":"Dev. Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1084\/jem.184.4.1561","article-title":"Inactivation of the IL-6 gene prevents development of multicentric Castleman\u2019s disease in C\/EBP beta-deficient mice.","volume":"184","author":"Screpanti","year":"1996","journal-title":"J. Exp. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/376062a0","article-title":"Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.","volume":"376","author":"Shalaby","year":"1995","journal-title":"Nature"},{"key":"B66","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nn2051","article-title":"Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion.","volume":"11","author":"Shiau","year":"2008","journal-title":"Nat. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ydbio.2008.04.033","article-title":"Wise promotes coalescence of cells of neural crest and placode origins in the trigeminal region during head development.","volume":"319","author":"Shigetani","year":"2008","journal-title":"Dev. Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1101\/gad.9.18.2251","article-title":"sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.","volume":"9","author":"Singh","year":"1995","journal-title":"Genes Dev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/wdev.226","article-title":"The molecular basis of craniofacial placode development.","volume":"5","author":"Singh","year":"2016","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"B70","year":"2008","journal-title":"StemBook."},{"key":"B71","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1126\/science.1068943","article-title":"Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit.","volume":"296","author":"Stevens","year":"2002","journal-title":"Science"},{"key":"B72","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0092-8674(01)00224-0","article-title":"Neurogenin Promotes Neurogenesis and Inhibits Glial Differentiation by Independent Mechanisms.","volume":"104","author":"Sun","year":"2001","journal-title":"Cell"},{"key":"B73","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/ncb2772","article-title":"Chase-and-run between adjacent cell populations promotes directional collective migration.","volume":"15","author":"Theveneau","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/bs.ctdb.2015.11.029","article-title":"Developmental biology: we are all walking mutants.","volume":"117","author":"Trainor","year":"2016","journal-title":"Curr. Top. Dev. Biol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.molcel.2005.02.010","article-title":"Mediator requirement for both recruitment and postrecruitment steps in transcription initiation.","volume":"17","author":"Wang","year":"2005","journal-title":"Mol. Cell"},{"key":"B76","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.devcel.2009.04.006","article-title":"Mediator MED23 links insulin signaling to the adipogenesis transcription cascade.","volume":"16","author":"Wang","year":"2009","journal-title":"Dev. Cell"},{"key":"B77","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1146\/annurev.cellbio.14.1.59","article-title":"Mechanisms of Wnt signaling in development.","volume":"14","author":"Wodarz","year":"1998","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1016\/j.celrep.2017.07.056","article-title":"Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF.","volume":"20","author":"Xia","year":"2017","journal-title":"Cell Rep."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06372-1","article-title":"Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.","volume":"9","author":"Xu","year":"2018","journal-title":"Nat. Commun."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1101\/gad.192666.112","article-title":"Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation.","volume":"26","author":"Yin","year":"2012","journal-title":"Genes Dev."},{"key":"B81","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1242\/dev.098392","article-title":"The Mediator complex: a master coordinator of transcription and cell lineage development.","volume":"141","author":"Yin","year":"2014","journal-title":"Development"},{"key":"B82","doi-asserted-by":"publisher","first-page":"6871","DOI":"10.1128\/MCB.24.15.6871-6886.2004","article-title":"A Triad of Subunits from the Gal11\/Tail Domain of Srb Mediator Is an In Vivo Target of Transcriptional Activator Gcn4p.","volume":"24","author":"Zhang","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1242\/dev.112946","article-title":"Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling.","volume":"142","author":"Zhu","year":"2015","journal-title":"Development"},{"key":"B84","doi-asserted-by":"publisher","first-page":"5561","DOI":"10.1242\/dev.01437","article-title":"Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes.","volume":"131","author":"Zou","year":"2004","journal-title":"Development"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2020.531933\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T06:40:32Z","timestamp":1669272032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2020.531933\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":84,"alternative-id":["10.3389\/fphys.2020.531933"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.531933","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]},"article-number":"531933"}}