{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:49:55Z","timestamp":1780055395329,"version":"3.54.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.533690","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T10:31:11Z","timestamp":1600425071000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Hydrogen Sulfide Alleviates Skeletal Muscle Fibrosis via Attenuating Inflammation and Oxidative Stress"],"prefix":"10.3389","volume":"11","author":[{"given":"Linlin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s00011-015-0862-5","article-title":"Protective effect of hydrogen sulfide on TNF-alpha and IFN-gamma-induced injury of intestinal epithelial barrier function in Caco-2 monolayers.","volume":"64","author":"Chen","year":"2015","journal-title":"Inflamm. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.4161\/cam.3.4.9338","article-title":"Role of matrix metalloproteinases in skeletal muscle: migration, differentiation, regeneration and fibrosis.","volume":"3","author":"Chen","year":"2009","journal-title":"Cell Adh. Migr."},{"key":"B3","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1021\/bi00591a005","article-title":"Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.","volume":"18","author":"Chirgwin","year":"1979","journal-title":"Biochemistry"},{"key":"B4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s10103-016-1888-9","article-title":"Light-emitting diode therapy increases collagen deposition during the repair process of skeletal muscle.","volume":"31","author":"de Melo","year":"2016","journal-title":"Lasers Med. Sci."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13177","article-title":"Exercise training ameliorates bleomycin-induced epithelial mesenchymal transition and lung fibrosis through restoration of H2 S synthesis.","volume":"225","author":"Du","year":"2019","journal-title":"Acta Physiol. (Oxf)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1177\/03635465010290040201","article-title":"The use of an antifibrosis agent to improve muscle recovery after laceration.","volume":"29","author":"Fukushima","year":"2001","journal-title":"Am. J. Sports Med."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147198","article-title":"Comparative study of injury models for studying muscle regeneration in mice.","volume":"11","author":"Hardy","year":"2016","journal-title":"PLoS One"},{"key":"B8","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.jvs.2010.10.094","article-title":"Therapeutic delivery of hydrogen sulfide for salvage of ischemic skeletal muscle after the onset of critical ischemia.","volume":"53","author":"Henderson","year":"2011","journal-title":"J. Vasc. Surg."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072121","article-title":"Matrix metalloproteinase-9 inhibition improves proliferation and engraftment of myogenic cells in dystrophic muscle of mdx mice.","volume":"8","author":"Hindi","year":"2013","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"923","DOI":"10.3892\/mmr.2012.748","article-title":"Hydrogen sulfide attenuates cardiac hypertrophy and fibrosis induced by abdominal aortic coarctation in rats.","volume":"5","author":"Huang","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"B11","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1089\/ars.2009.2956","article-title":"Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation?","volume":"12","author":"Jain","year":"2010","journal-title":"Antioxid. Redox Sign."},{"key":"B12","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1089\/met.2014.0022","article-title":"hydrogen sulfide upregulates glutamate\u2013cysteine ligase catalytic subunit, glutamate\u2013cysteine ligase modifier subunit, and glutathione and inhibits interleukin-1\u03b2 secretion in monocytes exposed to high glucose levels.","volume":"12","author":"Jain","year":"2014","journal-title":"Metab. Syndr. Relat. D."},{"key":"B13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1177\/096368979800700609","article-title":"Development of approaches to improve the healing following muscle contusion.","volume":"7","author":"Kasemkijwattana","year":"1998","journal-title":"Cell Transplant."},{"key":"B14","doi-asserted-by":"publisher","first-page":"248","DOI":"10.2353\/ajpath.2010.091176","article-title":"Matrix metalloproteinase inhibitor batimastat alleviates pathology and improves skeletal muscle function in dystrophin-deficient mdx mice.","volume":"177","author":"Kumar","year":"2010","journal-title":"Am. J. Pathol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1055\/s-0031-1279771","article-title":"Antifibrotic effects of Smad4 small interfering RNAs in injured skeletal muscle after acute contusion.","volume":"32","author":"Li","year":"2011","journal-title":"Int. J. Sports Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1007\/s00421-012-2584-5","article-title":"Treatment with exogenous hydrogen sulfide attenuates hyperoxia-induced acute lung injury in mice.","volume":"113","author":"Li","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1080\/0886022X.2016.1257433","article-title":"H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-beta1 expression.","volume":"39","author":"Li","year":"2017","journal-title":"Ren. Fail."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.3892\/etm.2017.5625","article-title":"Changes in inflammatory and oxidative stress factors and the protein synthesis pathway in injured skeletal muscle after contusion.","volume":"15","author":"Liu","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00601","article-title":"Impaired skeletal muscle regeneration induced by macrophage depletion could be partly ameliorated by MGF injection.","volume":"10","author":"Liu","year":"","journal-title":"Front. Physiol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00087","article-title":"BMSC transplantation aggravates inflammation, oxidative stress, and fibrosis and impairs skeletal muscle regeneration.","volume":"10","author":"Liu","year":"","journal-title":"Front. Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B22","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1159\/000441504","article-title":"Hydrogen sulfide alleviates peritoneal fibrosis via attenuating inflammation and TGF-beta1 synthesis.","volume":"131","author":"Lu","year":"2015","journal-title":"Nephron"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1002\/term.2193","article-title":"Human amnion favours tissue repair by inducing the M1-to-M2 switch and enhancing M2 macrophage features.","volume":"11","author":"Magatti","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"C609","DOI":"10.1152\/ajpcell.00147.2018","article-title":"Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury.","volume":"315","author":"Majumder","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172404","article-title":"4-Methylbenzenecarbothioamide, a hydrogen sulfide donor, inhibits tumor necrosis factor-alpha and CXCL1 production and exhibits activity in models of pain and inflammation.","volume":"856","author":"Melo","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1177\/0363546511415239","article-title":"Intramuscular transplantation of muscle-derived stem cells accelerates skeletal muscle healing after contusion injury via enhancement of angiogenesis.","volume":"39","author":"Ota","year":"2011","journal-title":"Am. J. Sports Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.biopha.2018.02.091","article-title":"Curcumin protects against hepatic stellate cells activation and migration by inhibiting the CXCL12\/CXCR4 biological axis in liver fibrosisA study in vitro and in vivo.","volume":"101","author":"Qin","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B28","doi-asserted-by":"publisher","first-page":"430","DOI":"10.7150\/ijbs.3632","article-title":"Hydrogen sulfide mitigates cardiac remodeling during myocardial infarction via improvement of angiogenesis.","volume":"8","author":"Qipshidze","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.1016\/j.yexcr.2010.05.035","article-title":"Regulation and dysregulation of fibrosis in skeletal muscle.","volume":"316","author":"Serrano","year":"2010","journal-title":"Exp. Cell Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/ki.2013.449","article-title":"Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy.","volume":"85","author":"Song","year":"2014","journal-title":"Kidney Int."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025943","article-title":"Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats.","volume":"6","author":"Tan","year":"2011","journal-title":"PLoS One"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1002\/cphy.c100092","article-title":"Mechanisms of muscle injury, repair, and regeneration.","volume":"1","author":"Tidball","year":"2011","journal-title":"Compr. Physiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.niox.2014.11.012","article-title":"Role of hydrogen sulfide in skeletal muscle biology and metabolism.","volume":"46","author":"Veeranki","year":"2015","journal-title":"Nitric Oxide"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9752698","article-title":"Endogenous CSE\/Hydrogen sulfide system regulates the effects of glucocorticoids and insulin on muscle protein synthesis.","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxid Med. Cell Longev."},{"key":"B35","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1055\/s-2004-821303","article-title":"Treatment of muscle injuries by local administration of autologous conditioned serum: animal experiments using a muscle contusion model.","volume":"25","author":"Wright-Carpenter","year":"2004","journal-title":"Int. J. Sports Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"S2033","DOI":"10.3233\/BME-151508","article-title":"Effects of hydrogen sulfide on myocardial fibrosis in diabetic rats: changes in matrix metalloproteinases parameters.","volume":"26","author":"Xiao","year":"2015","journal-title":"Biomed. Mater. Eng."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1007\/s10753-016-0438-8","article-title":"Macrophage depletion impairs skeletal muscle regeneration: the roles of pro-fibrotic factors.","volume":"39","author":"Xiao","year":"2016","journal-title":"Inflam. Oxid. Stress Inflam."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021971","article-title":"Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS\/NF-kappaB\/COX-2 pathway.","volume":"6","author":"Yang","year":"2011","journal-title":"PLoS One"},{"key":"B39","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.brainres.2012.10.046","article-title":"Exogenous hydrogen sulfide protects against global cerebral ischemia\/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats.","volume":"1491","author":"Yin","year":"2013","journal-title":"Brain Res."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041147","article-title":"Hydrogen sulfide inhibits the development of atherosclerosis with suppressing CX3CR1 and CX3CL1 expression.","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1007\/s10495-015-1174-5","article-title":"The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation.","volume":"20","author":"Zhu","year":"2015","journal-title":"Apoptosis"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.533690\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T10:31:13Z","timestamp":1600425073000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.533690\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":41,"alternative-id":["10.3389\/fphys.2020.533690"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.533690","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]},"article-number":"533690"}}