{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:43:31Z","timestamp":1791877411816,"version":"4.3.4"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007707","name":"UC Davis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007707","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.563372","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T07:13:25Z","timestamp":1604042005000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Cadherin-11 Is Required for Neural Crest Specification and Survival"],"prefix":"10.3389","volume":"11","author":[{"given":"Subrajaa","family":"Manohar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Camacho-Magallanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Camilo","family":"Echeverria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal D.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.ydbio.2015.07.018","article-title":"ADAM13 cleavage of cadherin-11 promotes CNC migration independently of the homophilic binding site","volume":"415","author":"Abbruzzese","year":"2016","journal-title":"Dev. Biol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nature04684","article-title":"Specification of the neural crest occurs during gastrulation and requires Pax7","volume":"441","author":"Basch","year":"2006","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e40556","DOI":"10.7554\/eLife.40556","article-title":"Control of neural crest multipotency by Wnt signaling and the Lin28\/let-7 axis","volume":"7","author":"Bhattacharya","year":"2018","journal-title":"elife"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1242\/dev.128.16.3049","article-title":"Xenopus cadherin-11 restrains cranial neural crest migration and influences neural crest specification","volume":"128","author":"Borchers","year":"2001","journal-title":"Development"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/path.4011","article-title":"Epigenetic disruption of cadherin-11 in human cancer metastasis","volume":"228","author":"Carmona","year":"2012","journal-title":"J. Pathol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"431","DOI":"10.4161\/cam.4.3.12138","article-title":"Regulation of cadherin expression in the chicken neural crest by the Wnt\/beta-catenin signaling pathway","volume":"4","author":"Chalpe","year":"2010","journal-title":"Cell Adhes. Migr."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e0184455","DOI":"10.1371\/journal.pone.0184455","article-title":"Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice","volume":"12","author":"Chang","year":"2017","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.2147\/OTT.S176511","article-title":"Co-expression network analysis identified CDH11 in association with progression and prognosis in gastric cancer","volume":"11","author":"Chen","year":"2018","journal-title":"Onco. Targets. Ther."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"5681","DOI":"10.1242\/dev.00808","article-title":"Neural crest development is regulated by the transcription factor Sox9","volume":"130","author":"Cheung","year":"2003","journal-title":"Development"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.devcel.2004.12.010","article-title":"The transcriptional control of trunk neural crest induction, survival, and delamination","volume":"8","author":"Cheung","year":"2005","journal-title":"Dev. Cell"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ydbio.2007.09.056","article-title":"A critical role for Cadherin6B in regulating avian neural crest emigration","volume":"312","author":"Coles","year":"2007","journal-title":"Dev. Biol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1002\/dvdy.23813","article-title":"Timing and kinetics of E\u2010 to N-cadherin switch during neurulation in the avian embryo","volume":"241","author":"Dady","year":"2012","journal-title":"Dev. Dyn."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/dvdy.10456","article-title":"Relative expression of Slug, RhoB, and HNK-1 in the cranial neural crest of the early chicken embryo","volume":"229","author":"Del Barrio","year":"2004","journal-title":"Dev. Dyn."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"10143","DOI":"10.1073\/pnas.1708116114","article-title":"Endodermal germ-layer formation through active actin-driven migration triggered by N-cadherin","volume":"114","author":"Giger","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"6487","DOI":"10.1128\/MCB.00117-06","article-title":"Actin-induced hyperactivation of the Ras signaling pathway leads to apoptosis in Saccharomyces cerevisiae","volume":"26","author":"Gourlay","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.yexcr.2017.03.001","article-title":"Evolution and diversity of cadherins and catenins","volume":"358","author":"Gul","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/s0925-4773(98)00022-7","article-title":"Xenopus cadherin-11 (Xcadherin-11) expression requires the Wg\/Wnt signal","volume":"72","author":"Hadeball","year":"1998","journal-title":"Mech. Dev."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/ajmg.a.38568","article-title":"Elsahy-waters syndrome is caused by biallelic mutations in CDH11","volume":"176","author":"Harms","year":"2018","journal-title":"Am. J. Med. Genet. A"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1006\/dbio.1995.1148","article-title":"Cloning and expression analysis of a novel mesodermally expressed cadherin","volume":"169","author":"Hoffmann","year":"1995","journal-title":"Dev. Biol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1101\/gad.198747.112","article-title":"DNA methyltransferase3A as a molecular switch mediating the neural tube-to-neural crest fate transition","volume":"26","author":"Hu","year":"2012","journal-title":"Genes Dev."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ydbio.2016.02.007","article-title":"E-cadherin is required for cranial neural crest migration in Xenopus laevis","volume":"411","author":"Huang","year":"2016","journal-title":"Dev. Biol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"S98","DOI":"10.1016\/j.ydbio.2018.07.004","article-title":"Migration and diversification of the vagal neural crest","volume":"444","author":"Hutchins","year":"2018","journal-title":"Dev. Biol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"14666","DOI":"10.1523\/JNEUROSCI.4821-12.2013","article-title":"C-Jun N-terminal kinase phosphorylation of heterogeneous nuclear ribonucleoprotein K regulates vertebrate axon outgrowth via a posttranscriptional mechanism","volume":"33","author":"Hutchins","year":"2013","journal-title":"J. Neurosci."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1101\/gad.519409","article-title":"Cadherin-11 regulates protrusive activity in Xenopus cranial neural crest cells upstream of trio and the small GTPases","volume":"23","author":"Kashef","year":"2009","journal-title":"Genes Dev."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1006\/dbio.1995.1149","article-title":"Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos","volume":"169","author":"Kimura","year":"1995","journal-title":"Dev. Biol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/(SICI)1097-0177(199608)206:4<455::AID-AJA11>3.0.CO;2-W","article-title":"Expression of cadherin-11 delineates boundaries, neuromeres, and nuclei in the developing mouse brain","volume":"206","author":"Kimura","year":"1996","journal-title":"Dev. Dyn."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ydbio.2013.08.007","article-title":"Loss of Xenopus cadherin-11 leads to increased Wnt\/beta-catenin signaling and up-regulation of target genes c-myc and cyclin D1 in neural crest","volume":"383","author":"Koehler","year":"2013","journal-title":"Dev. Biol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"dev186338","DOI":"10.1242\/dev.186338","article-title":"The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled","volume":"147","author":"Kratzer","year":"2020","journal-title":"Development"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"10909","DOI":"10.1038\/ncomms10909","article-title":"Cadherin-11 localizes to focal adhesions and promotes cell-substrate adhesion","volume":"7","author":"Langhe","year":"2016","journal-title":"Nat. Commun."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1158\/1541-7786.MCR-13-0108","article-title":"Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis","volume":"11","author":"Lee","year":"2013","journal-title":"Mol. Cancer Res."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3901","DOI":"10.1038\/onc.2011.541","article-title":"The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt\/beta-catenin signaling and silenced in common carcinomas","volume":"31","author":"Li","year":"2012","journal-title":"Oncogene"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00441-008-0664-y","article-title":"Cadherin-7 function in zebrafish development","volume":"334","author":"Liu","year":"2008","journal-title":"Cell Tissue Res."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"S337","DOI":"10.1016\/j.ydbio.2018.09.017","article-title":"Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit","volume":"444","author":"Lopez","year":"2018","journal-title":"Dev. Biol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e1000923","DOI":"10.1371\/journal.pgen.1000923","article-title":"Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death","volume":"6","author":"Marchong","year":"2010","journal-title":"PLoS Genet."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.tig.2017.07.015","article-title":"Regulatory logic underlying diversification of the neural crest","volume":"33","author":"Martik","year":"2017","journal-title":"Trends Genet."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e0188963","DOI":"10.1371\/journal.pone.0188963","article-title":"The ectodomain of cadherin-11 binds to erbB2 and stimulates Akt phosphorylation to promote cranial neural crest cell migration","volume":"12","author":"Mathavan","year":"2017","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1242\/dev.017350","article-title":"Directional migration of neural crest cells in vivo is regulated by Syndecan-4\/Rac1 and non-canonical Wnt signaling\/RhoA","volume":"135","author":"Matthews","year":"2008","journal-title":"Development"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1091\/mbc.e08-05-0535","article-title":"Extracellular cleavage of cadherin-11 by ADAM metalloproteases is essential for Xenopus cranial neural crest cell migration","volume":"20","author":"McCusker","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/19336918.2015.1005466","article-title":"N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development","volume":"9","author":"Miyamoto","year":"2015","journal-title":"Cell Adhes. Migr."},{"key":"ref40","first-page":"1013","article-title":"The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells","volume":"27","author":"Neradil","year":"2005","journal-title":"Int. J. Oncol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/jop.12471","article-title":"CDH11 inhibits proliferation and invasion in head and neck cancer","volume":"46","author":"Piao","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1242\/dev.048439","article-title":"Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration","volume":"137","author":"Piloto","year":"2010","journal-title":"Development"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ydbio.2013.12.010","article-title":"Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers","volume":"386","author":"Plouhinec","year":"2014","journal-title":"Dev. Biol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.semcdb.2013.03.014","article-title":"Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals","volume":"24","author":"Reissmann","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1242\/dev.053645","article-title":"p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition\/delamination processes","volume":"138","author":"Rinon","year":"2011","journal-title":"Development"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"e322","DOI":"10.1002\/wdev.322","article-title":"Specifying neural crest cells: from chromatin to morphogens and factors in between","volume":"7","author":"Rogers","year":"2018","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1083\/jcb.201305050","article-title":"Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT","volume":"203","author":"Rogers","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.mod.2018.07.003","article-title":"A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices","volume":"152","author":"Rogers","year":"2018","journal-title":"Mech. Dev."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1242\/jcs.183772","article-title":"Cadherin-11 is a novel regulator of extracellular matrix synthesis and tissue mechanics","volume":"129","author":"Row","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3390\/jcm8020148","article-title":"Cadherin 11 inhibition downregulates beta-catenin, deactivates the canonical WNT Signalling pathway and suppresses the cancer stem cell-like phenotype of triple negative breast cancer","volume":"8","author":"Satriyo","year":"2019","journal-title":"J. Clin. Med."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0091-679X(08)00212-4","article-title":"Gain\u2010 and loss-of-function approaches in the chick embryo","volume":"87","author":"Sauka-Spengler","year":"2008","journal-title":"Methods Cell Biol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.devcel.2015.06.012","article-title":"Cadherin switch during EMT in neural crest cells leads to contact inhibition of locomotion via repolarization of forces","volume":"34","author":"Scarpa","year":"2015","journal-title":"Dev. Cell"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1091\/mbc.E13-08-0459","article-title":"Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest","volume":"25","author":"Schiffmacher","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1083\/jcb.201604006","article-title":"Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation","volume":"215","author":"Schiffmacher","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.devcel.2015.06.024","article-title":"Axud1 integrates Wnt signaling and transcriptional inputs to drive neural crest formation","volume":"34","author":"Simoes-Costa","year":"2015","journal-title":"Dev. Cell"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1083\/jcb.201203098","article-title":"A PHD12-Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition","volume":"198","author":"Strobl-Mazzulla","year":"2012","journal-title":"J. Cell Biol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1242\/dev.02834","article-title":"Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest","volume":"134","author":"Taneyhill","year":"2007","journal-title":"Development"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"dvg.23028","DOI":"10.1002\/dvg.23028","article-title":"Should I stay or should I go? Cadherin function and regulation in the neural crest","volume":"55","author":"Taneyhill","year":"2017","journal-title":"Genesis"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1242\/dev.111997","article-title":"Snail2\/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development","volume":"142","author":"Tien","year":"2015","journal-title":"Development"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ydbio.2004.07.041","article-title":"A balance between the anti-apoptotic activity of Slug and the apoptotic activity of msx1 is required for the proper development of the neural crest","volume":"275","author":"Tribulo","year":"2004","journal-title":"Dev. Biol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/s0925-4773(98)00099-9","article-title":"Xenopus cadherin-11 is expressed in different populations of migrating neural crest cells","volume":"75","author":"Vallin","year":"1998","journal-title":"Mech. Dev."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/nprot.2008.10","article-title":"Spatially and temporally controlled electroporation of early chick embryos","volume":"3","author":"Voiculescu","year":"2008","journal-title":"Nat. Protoc."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.devcel.2019.10.003","article-title":"Reconstruction of the global neural crest gene regulatory network in vivo","volume":"51","author":"Williams","year":"2019","journal-title":"Dev. Cell"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1111\/jphp.12410","article-title":"Quantitative analysis of cadherin-11 and beta-catenin signalling during proliferation of rheumatoid arthritis-derived synovial fibroblast cells","volume":"67","author":"Yoshioka","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"11549","DOI":"10.1074\/jbc.274.17.11549","article-title":"An APAF-1.Cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9","volume":"274","author":"Zou","year":"1999","journal-title":"J. Biol. Chem."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2020.563372\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T15:13:02Z","timestamp":1669389182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2020.563372\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,30]]},"references-count":65,"alternative-id":["10.3389\/fphys.2020.563372"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.563372","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.18.066613","asserted-by":"object"}]},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,30]]},"article-number":"563372"}}