{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T09:48:31Z","timestamp":1785664111170,"version":"3.56.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.579015","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T15:08:58Z","timestamp":1601478538000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Pathogenesis of Molar Hypomineralisation: Aged Albumin Demarcates Chalky Regions of Hypomineralised Enamel"],"prefix":"10.3389","volume":"11","author":[{"given":"Vidal A.","family":"Perez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Mangum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/BF03262713","article-title":"Aetiology of molar-incisor hypomineralisation: a systematic review","volume":"11","author":"Alaluusua","year":"2010","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3389\/fphys.2017.00343","article-title":"Disruption of steroid axis, a new paradigm for molar incisor hypomineralization (MIH)","volume":"8","author":"Babajko","year":"2017","journal-title":"Front. Physiol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/eos.12214","article-title":"Identification of proteins from human permanent erupted enamel","volume":"123","author":"Castiblanco","year":"2015","journal-title":"Eur. J. Oral Sci."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/BF00298435","article-title":"Immunoblotting studies on artifactual contamination of enamel homogenates by albumin and other proteins","volume":"57","author":"Chen","year":"1995","journal-title":"Calcif. Tissue Int."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF02556008","article-title":"Mouse ameloblasts do not transcribe the albumin gene","volume":"45","author":"Couwenhoven","year":"1989","journal-title":"Calcif. Tissue Int."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.cca.2011.11.009","article-title":"Albumin modification and fragmentation in renal disease","volume":"413","author":"Donadio","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.jdent.2010.04.012","article-title":"Protein content of molar-incisor hypomineralisation enamel","volume":"38","author":"Farah","year":"2010","journal-title":"J. Dent."},{"key":"ref8","first-page":"1209","article-title":"Rachitis and enamel hypoplasia","volume":"62","author":"Gottlieb","year":"1920","journal-title":"Dent. Cosmos."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.adaj.2018.03.013","article-title":"Molar hypomineralization: what is the US experience?","volume":"149","author":"Hubbard","year":"2018","journal-title":"J. Am. Dent. Assoc."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3389\/fphys.2017.00546","article-title":"Molar hypomineralisation: a call to arms for enamel researchers","volume":"8","author":"Hubbard","year":"2017","journal-title":"Front. Physiol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1001\/archpedi.1949.02030040068005","article-title":"Developmental opacities of teeth in a New England community; their relation to fluorine toxicosis","volume":"77","author":"Hurme","year":"1949","journal-title":"Am. J. Dis. Child."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/eos.12594","article-title":"Proteomic analysis of dentin-enamel junction and adjacent protein-containing enamel matrix layer of healthy human molar teeth","volume":"127","author":"Jagr","year":"2019","journal-title":"Eur. J. Oral Sci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1034\/j.1600-0722.2001.00047.x","article-title":"Etiologic factors influencing the prevalence of demarcated opacities in permanent first molars in a group of Swedish children","volume":"109","author":"Jalevik","year":"2001","journal-title":"Eur. J. Oral Sci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1177\/10454411930040031601","article-title":"Hydroxyapatite binding domains in salivary proteins","volume":"4","author":"Johnsson","year":"1993","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3389\/fphys.2017.00513","article-title":"Enamel research: priorities and future directions","volume":"8","author":"Kirkham","year":"2017","journal-title":"Front. Physiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1600-0722.2004.00162.x","article-title":"Mechanical properties across hypomineralized\/hypoplastic enamel of first permanent molar teeth","volume":"112","author":"Mahoney","year":"2004","journal-title":"Eur. J. Oral Sci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1177\/0022034510375824","article-title":"Surface integrity governs the proteome of hypomineralized enamel","volume":"89","author":"Mangum","year":"","journal-title":"J. Dent. Res."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/978-1-60761-820-1_19","article-title":"Proteomic analysis of dental tissue microsamples","volume":"666","author":"Mangum","year":"","journal-title":"Methods Mol. Biol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1177\/00220345550340011201","article-title":"A study of the ultrastructure of chalky white enamel","volume":"34","author":"Myers","year":"1955","journal-title":"J. Dent. Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1016\/j.bbrc.2017.12.040","article-title":"Direct evidence that KLK4 is a hydroxyapatite-binding protein","volume":"495","author":"Perez","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3389\/fphys.2014.00388","article-title":"Enamel maturation: a brief background with implications for some enamel dysplasias","volume":"5","author":"Robinson","year":"2014","journal-title":"Front. Physiol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/BF00298561","article-title":"Uptake and metabolism of albumin by rodent incisor enamel in vivo and postmortem: implications for control of mineralization by albumin","volume":"55","author":"Robinson","year":"1994","journal-title":"Calcif. Tissue Int."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1177\/00220345920710060101","article-title":"The role of albumin in developing rodent dental enamel: a possible explanation for white spot hypoplasia","volume":"71","author":"Robinson","year":"1992","journal-title":"J. Dent. Res."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e84552","DOI":"10.1371\/journal.pone.0084552","article-title":"Oxidation enhances human serum albumin thermal stability and changes the routes of amyloid fibril formation","volume":"9","author":"Sancataldo","year":"2014","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/03008208909114126","article-title":"Major \u201cenamelin\u201d protein in enamel of developing bovine teeth is albumin","volume":"22","author":"Strawich","year":"1989","journal-title":"Connect. Tissue Res."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1177\/08959374890030022901","article-title":"Developmental defects of enamel-historical and present-day perspectives of their pathogenesis","volume":"3","author":"Suckling","year":"1989","journal-title":"Adv. Dent. Res."},{"key":"ref27","first-page":"9","article-title":"History of the DDE indices","volume":"94","author":"Suckling","year":"1998","journal-title":"N. Z. Dent. J."},{"key":"ref28","first-page":"201","article-title":"Developmental defects of enamel in New Zealand children","volume":"72","author":"Suckling","year":"1976","journal-title":"N. Z. Dent. J."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1177\/08959374890030021901","article-title":"Enamel hypomineralization viewed from the pattern of progressive mineralization of human and monkey developing enamel","volume":"3","author":"Suga","year":"1989","journal-title":"Adv. Dent. Res."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/s1079-2104(98)90068-3","article-title":"Immunochemical and biochemical characteristics of enamel proteins in hypocalcified amelogenesis imperfecta","volume":"85","author":"Takagi","year":"1998","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/hep.1840090512","article-title":"Hepatitis B surface antigen binds to human serum albumin cross-linked by transglutaminase","volume":"9","author":"Thung","year":"1989","journal-title":"Hepatology"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.archoralbio.2017.03.001","article-title":"The proteomic profile of the acquired enamel pellicle according to its location in the dental arches","volume":"79","author":"Ventura","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"ref33","first-page":"114","article-title":"Molar incisor hypomineralisation (MIH)","volume":"4","author":"Weerheijm","year":"2003","journal-title":"Eur. J. Paediatr. Dent."},{"key":"ref34","first-page":"110","article-title":"Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003","volume":"4","author":"Weerheijm","year":"2003","journal-title":"Eur. J. Paediatr. Dent."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3389\/fphys.2020.00619","article-title":"Pathogenesis of molar hypomineralisation: hypomineralised 6-year molars contain traces of fetal serum albumin","volume":"11","author":"Williams","year":"2020","journal-title":"Front. Physiol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s0003-9969(96)00096-9","article-title":"The enamel proteins in human amelogenesis imperfecta","volume":"42","author":"Wright","year":"1997","journal-title":"Arch. Oral Biol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.579015\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T15:09:02Z","timestamp":1601478542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2020.579015\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":36,"alternative-id":["10.3389\/fphys.2020.579015"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.579015","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]},"article-number":"579015"}}