{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:21:31Z","timestamp":1790018491462,"version":"4.0.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2020.595382","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T05:42:50Z","timestamp":1605159770000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Liver Metabolomics Reveals the Effect of Lactobacillus reuteri on Alcoholic Liver Disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Tian-xiang","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-lin","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-chao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-lin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-guang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-zhou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/apha.12695","article-title":"Lactobacillus reuteri increases mucus thickness and ameliorates dextran sulphate sodium-induced colitis in mice.","volume":"217","author":"Ahl","year":"2016","journal-title":"Acta Physiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jpeds.2014.09.020","article-title":"Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938.","volume":"166","author":"Chau","year":"2015","journal-title":"J. Pediatr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1053\/j.gastro.2014.09.014","article-title":"Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice.","volume":"148","author":"Chen","year":"2015","journal-title":"Gastroenterology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.3945\/ajcn.2009.28500","article-title":"Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP study.","volume":"91","author":"Choo","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00563","article-title":"Gut microbiota modulation and its relationship with obesity using prebiotic fibers and probiotics: a review.","volume":"8","author":"Dahiya","year":"2017","journal-title":"Front. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jare.2018.12.006","article-title":"Beneficial role of bioactive lipids in the pathobiology, prevention, and management of HBV, HCV and alcoholic hepatitis, NAFLD, and liver cirrhosis: a review.","volume":"17","author":"Das","year":"2019","journal-title":"J. Adv. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1161\/circulationaha.114.010236","article-title":"Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies.","volume":"130","author":"Farvid","year":"2014","journal-title":"Circulation"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01358-15","article-title":"Histamine H2 receptor-mediated suppression of intestinal inflammation by probiotic Lactobacillus reuteri.","volume":"6","author":"Gao","year":"2015","journal-title":"mBio"},{"key":"B9","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s12223-017-0524-9","article-title":"Analysis of antimicrobial and immunomodulatory substances produced by heterofermentative Lactobacillus reuteri.","volume":"62","author":"Greifova","year":"2017","journal-title":"Folia Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1084\/jem.20160961","article-title":"Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors.","volume":"214","author":"He","year":"2017","journal-title":"J. Exp. Med."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-10-35","article-title":"Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats.","volume":"10","author":"Hsieh","year":"2013","journal-title":"Nutr. Metab."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1017\/s0007114517001039","article-title":"Lactobacillus paracasei GMNL-32, Lactobacillus reuteri GMNL-89 and L. reuteri GMNL-263 ameliorate hepatic injuries in lupus-prone mice.","volume":"117","author":"Hsu","year":"2017","journal-title":"Br. J. Nutr."},{"key":"B13","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.cbi.2008.05.018","article-title":"Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL\/6 Cr Slc mice.","volume":"174","author":"Jang","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e904","DOI":"10.1542\/peds.2013-0652","article-title":"Diarrhea in preschool children and Lactobacillus reuteri: a randomized controlled trial.","volume":"133","author":"Jimenez-Gutierrez","year":"2014","journal-title":"Pediatrics"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030293","article-title":"Hypocholesterolemic effects of probiotic mixture on diet-induced hypercholesterolemic rats.","volume":"9","author":"Kim","year":"2017","journal-title":"Nutrients"},{"key":"B16","doi-asserted-by":"publisher","first-page":"G608","DOI":"10.1152\/ajpgi.00266.2011","article-title":"Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-kappaB signaling in the intestine.","volume":"302","author":"Liu","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.2337\/dc14-2690","article-title":"Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose-tolerant humans: a proof of concept.","volume":"38","author":"Marie-Christine","year":"2015","journal-title":"Diabetes Care"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1161\/CIRCULATIONAHA.118.038908","article-title":"Biomarkers of dietary omega-6 fatty acids and incident cardiovascular disease and mortality.","volume":"139","author":"Marklund","year":"2019","journal-title":"Circulation"},{"key":"B19","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.bbagen.2015.12.013","article-title":"Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice.","volume":"1860","author":"Mir","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.1007\/s00394-018-1855-2","article-title":"Metabolomics analysis revealed metabolic changes in patients with diarrhea-predominant irritable bowel syndrome and metabolic responses to a synbiotic yogurt intervention.","volume":"58","author":"Noorbakhsh","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.chembiol.2018.04.017","article-title":"PDn-3 DPA pathway regulates human monocyte differentiation and macrophage function.","volume":"25","author":"Pistorius","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jhep.2013.03.007","article-title":"Global burden of alcoholic liver diseases.","volume":"59","author":"Rehm","year":"2013","journal-title":"J. Hepatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3164\/jcbn.12-79","article-title":"Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis a pilot study.","volume":"53","author":"Risti-Medi","year":"2013","journal-title":"J. Clin. Biochem. Nutr."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease.","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat. Rev. Dis. Primers."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1021\/pr501121c","article-title":"Hepatic and fecal metabolomic analysis of the effects of Lactobacillus rhamnosus GG on alcoholic fatty liver disease in mice.","volume":"14","author":"Shi","year":"2015","journal-title":"J. Proteome Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1053\/j.gastro.2015.06.006","article-title":"Comparative effectiveness of pharmacological interventions for severe alcoholic hepatitis: a systematic review and network meta-analysis.","volume":"149","author":"Singh","year":"2015","journal-title":"Gastroenterology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1056\/NEJMoa1412278","article-title":"Prednisolone or pentoxifylline for alcoholic hepatitis.","volume":"372","author":"Thursz","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.5650\/jos.ess17111","article-title":"Docosapentaenoic Acid (22:5n-3) downregulates mRNA expression of pro-inflammatory factors in LPS-activated murine macrophage like RAW264.7 Cells.","volume":"66","author":"Tian","year":"2017","journal-title":"J. Oleo Sci."},{"key":"B29","year":"2018","journal-title":"Global Status Report on Alcohol and Health 2018."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00762","article-title":"Reutericyclin producing Lactobacillus reuteri modulates development of fecal microbiota in weanling pigs.","volume":"6","author":"Yang","year":"2015","journal-title":"Front. Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"4199","DOI":"10.1039\/C8FO02338G","article-title":"Docosapentaenoic acid (DPA, 22:5n-3) ameliorates inflammation in an ulcerative colitis model.","volume":"10","author":"Zheng","year":"2019","journal-title":"Food Funct."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2020.595382\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T05:42:53Z","timestamp":1605159773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2020.595382\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,12]]},"references-count":31,"alternative-id":["10.3389\/fphys.2020.595382"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2020.595382","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,12]]},"article-number":"595382"}}