{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:29:00Z","timestamp":1784302140748,"version":"3.55.0"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL 088555"],"award-info":[{"award-number":["R01-HL 088555"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK098240-01"],"award-info":[{"award-number":["R01 DK098240-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Sarcolipin (SLN) is a regulator of sarco\/endo plasmic reticulum Ca<jats:sup>2+<\/jats:sup>-ATPase (SERCA) pump and has been shown to be involved in muscle nonshivering thermogenesis (NST) and energy metabolism. Interestingly, SLN expression is significantly upregulated both during muscle development and in several disease states. However, the significance of altered SLN expression in muscle patho-physiology is not completely understood. We have previously shown that transgenic over-expression of SLN in skeletal muscle is not detrimental, and can promote oxidative metabolism and exercise capacity. In contrast, some studies have suggested that SLN upregulation in disease states is deleterious for muscle function and ablation of SLN can be beneficial. In this perspective article, we critically examine both published and some new data to determine the relevance of SLN expression to disease pathology. The new data presented in this paper show that SLN levels are induced in muscle during systemic bacterial (<jats:italic>Salmonella<\/jats:italic>) infection or lipopolysaccharides (LPS) treatment. We also present data showing that SLN expression is significantly upregulated in different types of muscular dystrophies including myotubular myopathy. These data taken together reveal that upregulation of SLN expression in muscle disease is progressive and increases with severity. Therefore, we suggest that increased SLN expression should not be viewed as the cause of the disease; rather, it is a compensatory response to meet the higher energy demand of the muscle. We interpret that higher SLN\/SERCA ratio positively modulate cytosolic Ca<jats:sup>2+<\/jats:sup> signaling pathways to promote mitochondrial biogenesis and oxidative metabolism to meet higher energy demand in muscle.<\/jats:p>","DOI":"10.3389\/fphys.2021.633058","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T04:22:49Z","timestamp":1614572569000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Is Upregulation of Sarcolipin Beneficial or Detrimental to Muscle Function?"],"prefix":"10.3389","volume":"12","author":[{"given":"Naresh C.","family":"Bal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subash C.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Pant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danesh H.","family":"Sopariwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Gonzalez-Escobedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Gunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Pierson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott Q.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill A.","family":"Rafael-Fortney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthu","family":"Periasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"536","DOI":"10.2174\/1389203720666190402100902","article-title":"Mitochondrial dysfunction in skeletal muscle pathologies","volume":"20","author":"Abrigo","year":"2019","journal-title":"Curr. 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Physiol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3871","DOI":"10.1096\/fj.13-230631","article-title":"Sarcolipin trumps beta-adrenergic receptor signaling as the favored mechanism for muscle-based diet-induced thermogenesis","volume":"27","author":"Bombardier","year":"","journal-title":"FASEB J."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1016\/j.febslet.2013.04.019","article-title":"Ablation of sarcolipin decreases the energy requirements for Ca2+ transport by sarco(endo)plasmic reticulum Ca2+-ATPases in resting skeletal muscle","volume":"587","author":"Bombardier","year":"","journal-title":"FEBS Lett."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"714","DOI":"10.3389\/fphys.2018.00714","article-title":"Sarcolipin makes heat, but is it adaptive thermogenesis?","volume":"9","author":"Campbell","year":"2018","journal-title":"Front. Physiol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3389\/fendo.2018.00447","article-title":"Brown adipose tissue energy metabolism in humans","volume":"9","author":"Carpentier","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"R1071","DOI":"10.1152\/ajpregu.00036.2012","article-title":"Postprandial heat production in skeletal muscle is associated with altered mitochondrial function and altered futile calcium cycling","volume":"303","author":"Clarke","year":"2012","journal-title":"Am. J. Phys. Regul. Integr. Comp. 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Phys."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10540-005-2884-7","article-title":"Role of sarco\/endoplasmic reticulum Ca(2+)-ATPase in thermogenesis","volume":"25","author":"de Meis","year":"2005","journal-title":"Biosci. Rep."},{"key":"ref24","author":"de Snoo","year":"2009"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"R744","DOI":"10.1152\/ajpregu.1989.257.4.R744","article-title":"Nonshivering thermogenesis and adaptation to fasting in king penguin chicks","volume":"257","author":"Duchamp","year":"1989","journal-title":"Am. J. Phys."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"R744","DOI":"10.1152\/ajpregu.1989.257.4.R744","article-title":"Nonshivering thermogenesis and adaptation to fasting in king penguin chicks","volume":"257","author":"Duchamp","year":"1991","journal-title":"Am. J. Phys."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"R1084","DOI":"10.1152\/ajpregu.1993.265.5.R1084","article-title":"Increased role of skeletal muscle in the calorigenic response to glucagon of cold-acclimated ducklings","volume":"265","author":"Duchamp","year":"1993","journal-title":"Am. J. Phys."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"C507","DOI":"10.1152\/ajpcell.1993.265.2.C507","article-title":"Sarcoplasmic reticulum Ca(2+)-ATPase and ryanodine receptor in cold-acclimated ducklings and thermogenesis","volume":"265","author":"Dumonteil","year":"1993","journal-title":"Am. J. Phys."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1113\/jphysiol.1994.sp020275","article-title":"Effects of palmitoyl carnitine and related metabolites on the avian Ca(2+)-ATPase and Ca2+ release channel","volume":"479","author":"Dumonteil","year":"1994","journal-title":"J. Physiol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"C955","DOI":"10.1152\/ajpcell.1995.269.4.C955","article-title":"Expression of sarcoplasmic-reticulum Ca2+ transport proteins in cold-acclimating ducklings","volume":"269","author":"Dumonteil","year":"1995","journal-title":"Am. J. Phys. Cell Phys."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/387090a0","article-title":"Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese","volume":"387","author":"Enerback","year":"1997","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"5863","DOI":"10.1096\/fj.201902945R","article-title":"The generation of immune-induced fever and emotional stress-induced hyperthermia in mice does not involve brown adipose tissue thermogenesis","volume":"34","author":"Eskilsson","year":"2020","journal-title":"FASEB J."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1093\/hmg\/ddy302","article-title":"Sarcolipin deletion in mdx mice impairs calcineurin signalling and worsens dystrophic pathology","volume":"27","author":"Fajardo","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e0173708","DOI":"10.1371\/journal.pone.0173708","article-title":"Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice","volume":"12","author":"Fajardo","year":"","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"C154","DOI":"10.1152\/ajpcell.00291.2016","article-title":"Effects of sarcolipin deletion on skeletal muscle adaptive responses to functional overload and unload","volume":"313","author":"Fajardo","year":"","journal-title":"Am. J. Phys. Cell Phys."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1152\/ajpregu.00411.2010","article-title":"Uncoupling protein 1 expression and high-fat diets","volume":"300","author":"Fromme","year":"2011","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/nature04422","article-title":"Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1","volume":"439","author":"Gabellini","year":"2006","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1139\/apnm-2019-0067","article-title":"The sarcoplasmic reticulum and SERCA: a nexus for muscular adaptive thermogenesis","volume":"45","author":"Gamu","year":"2020","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/s41422-018-0078-7","article-title":"Skeletal muscle mitochondrial remodeling in exercise and diseases","volume":"28","author":"Gan","year":"2018","journal-title":"Cell Res."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e1602878","DOI":"10.1126\/sciadv.1602878","article-title":"Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades","volume":"3","author":"Gaudry","year":"2017","journal-title":"Sci. Adv."},{"key":"ref41","article-title":"Ferret odor, but not mild stress, rapidly induces sustained muscle thermogenesis","volume-title":"2019\u2014Kent State University Undergraduate Symposium on Research, Scholarship and Creative Activity","author":"Gibson","year":"2019"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"jeb218479","DOI":"10.1242\/jeb.218479","article-title":"Skeletal muscle thermogenesis induction by exposure to predator odor","volume":"223","author":"Gorrell","year":"2020","journal-title":"J. Exp. Biol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"H1933","DOI":"10.1152\/ajpheart.00026.2009","article-title":"Pulmonary artery banding alters the expression of Ca2+ transport proteins in the right atrium in rabbits","volume":"296","author":"Gupta","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/nm.3891","article-title":"Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus","volume":"21","author":"Hanssen","year":"2015","journal-title":"Nat. Med."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1089\/thy.2019.0749","article-title":"Thyroid deficiency before birth alters the adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity","volume":"30","author":"Harris","year":"2020","journal-title":"Thyroid"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1210\/en.2007-1311","article-title":"Profiling postprandial thermogenesis in muscle and fat of sheep and the central effect of leptin administration","volume":"149","author":"Henry","year":"2008","journal-title":"Endocrinology"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"22544","DOI":"10.1073\/pnas.2008919117","article-title":"The paradoxical lean phenotype of hypothyroid mice is marked by increased adaptive thermogenesis in the skeletal muscle","volume":"117","author":"Kaspari","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00249-008-0358-0","article-title":"Is the Ca2+-ATPase from sarcoplasmic reticulum also a heat pump?","volume":"38","author":"Kjelstrup","year":"2008","journal-title":"Eur. Biophys. J."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.biochi.2016.10.012","article-title":"UCP1\u2014a sophisticated energy valve","volume":"134","author":"Klingenberg","year":"2017","journal-title":"Biochimie"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1113\/eph8802508","article-title":"Cold-induced recruitment of brown adipose tissue thermogenesis","volume":"88","author":"Klingenspor","year":"2003","journal-title":"Exp. Physiol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.3727\/096368914X683494","article-title":"Syngeneic myoblast transplantation improves muscle function in a murine model of X-linked myotubular myopathy","volume":"24","author":"Lim","year":"2015","journal-title":"Cell Transplant."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.metabol.2018.05.004","article-title":"Skeletal muscle-specific Sidt2 knockout in mice induced muscular dystrophy-like phenotype","volume":"85","author":"Liu","year":"2018","journal-title":"Metabolism"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3390\/cells9010201","article-title":"Comprehensive analysis of the characteristics and differences in adult and newborn brown adipose tissue (BAT): newborn BAT is a more active\/dynamic BAT","volume":"9","author":"Liu","year":"2020","journal-title":"Cell"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"36597","DOI":"10.1074\/jbc.M606869200","article-title":"The presence of sarcolipin results in increased heat production by Ca(2+)-ATPase","volume":"281","author":"Mall","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"R1239","DOI":"10.1152\/ajpregu.90723.2008","article-title":"Nonshivering thermogenesis without interscapular brown adipose tissue involvement during conditioned fear in the rat","volume":"296","author":"Marks","year":"2009","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"10840","DOI":"10.1074\/jbc.M115.636878","article-title":"Sarcolipin is a key determinant of the basal metabolic rate, and its overexpression enhances energy expenditure and resistance against diet-induced obesity","volume":"290","author":"Maurya","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1016\/j.celrep.2018.08.036","article-title":"Sarcolipin signaling promotes mitochondrial biogenesis and oxidative metabolism in skeletal muscle","volume":"24","author":"Maurya","year":"2018","journal-title":"Cell Rep."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.phrs.2015.10.020","article-title":"Sarcolipin is a novel regulator of muscle metabolism and obesity","volume":"102","author":"Maurya","year":"2015","journal-title":"Pharmacol. Res."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"9570","DOI":"10.1074\/jbc.m213132200","article-title":"Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling","volume":"278","author":"Minamisawa","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"100767","DOI":"10.1016\/j.bbrep.2020.100767","article-title":"Activation of sarcolipin expression and altered calcium cycling in LMNA cardiomyopathy","volume":"22","author":"Morales Rodriguez","year":"2020","journal-title":"Biochem. Biophys. Rep."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1242\/jeb.00158","article-title":"Characterization of ryanodine receptor and Ca2+-ATPase isoforms in the thermogenic heater organ of blue marlin (Makaira nigricans)","volume":"206","author":"Morrissette","year":"2003","journal-title":"J. Exp. Biol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/sj.embor.7400532","article-title":"Uncoupling proteins: current status and therapeutic prospects","volume":"6","author":"Nedergaard","year":"2005","journal-title":"EMBO Rep."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"C813","DOI":"10.1152\/ajpcell.00146.2019","article-title":"Sarcolipin overexpression impairs myogenic differentiation in Duchenne muscular dystrophy","volume":"317","author":"Niranjan","year":"2019","journal-title":"Am. J. Phys. Cell Phys."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"889","DOI":"10.3389\/fphys.2017.00889","article-title":"Muscle non-shivering thermogenesis and its role in the evolution of endothermy","volume":"8","author":"Nowack","year":"2017","journal-title":"Front. Physiol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"6378","DOI":"10.1038\/s41598-019-42756-z","article-title":"Muscle nonshivering thermogenesis in a feral mammal","volume":"9","author":"Nowack","year":"2019","journal-title":"Sci. Rep."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neulet.2018.11.059","article-title":"Turning down the heat: down-regulation of sarcolipin in a hibernating mammal","volume":"696","author":"Oliver","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1096\/fj.07-104372","article-title":"Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle","volume":"22","author":"Ottenheijm","year":"2008","journal-title":"FASEB J."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1172\/JCI60433","article-title":"Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans","volume":"122","author":"Ouellet","year":"2012","journal-title":"J. Clin. Invest."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1242\/jeb.119164","article-title":"Cold adaptation overrides developmental regulation of sarcolipin expression in mice skeletal muscle: SOS for muscle-based thermogenesis?","volume":"218","author":"Pant","year":"","journal-title":"J. Exp. Biol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.tem.2016.08.006","article-title":"Sarcolipin: a key thermogenic and metabolic regulator in skeletal muscle","volume":"27","author":"Pant","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"e0123875","DOI":"10.1371\/journal.pone.0123875","article-title":"Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy","volume":"10","author":"Pant","year":"","journal-title":"PLoS One"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1002\/oby.21123","article-title":"Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity","volume":"23","author":"Paran","year":"2015","journal-title":"Obesity"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"327","DOI":"10.4093\/dmj.2017.41.5.327","article-title":"Skeletal muscle thermogenesis and its role in whole body energy metabolism","volume":"41","author":"Periasamy","year":"2017","journal-title":"Diabetes Metab. J."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1093\/hmg\/ddr512","article-title":"Modeling the human MTM1 p.R69C mutation in murine Mtm1 results in exon 4 skipping and a less severe myotubular myopathy phenotype","volume":"21","author":"Pierson","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1093\/hmg\/ddx109","article-title":"Misregulation of calcium-handling proteins promotes hyperactivation of calcineurin-NFAT signaling in skeletal muscle of DM1 mice","volume":"26","author":"Ravel-Chapuis","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1042\/BCJ20190464","article-title":"Functional characterization of human brown adipose tissue metabolism","volume":"477","author":"Richard","year":"2020","journal-title":"Biochem. J."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3233\/JND-150113","article-title":"Current translational research and murine models for duchenne muscular dystrophy","volume":"3","author":"Rodrigues","year":"2016","journal-title":"J. Neuromuscul. Dis."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"12282","DOI":"10.1074\/jbc.M115.637603","article-title":"Uncoupling protein 1 and Sarcolipin are required to maintain optimal thermogenesis, and loss of both systems compromises survival of mice under cold stress","volume":"290","author":"Rowland","year":"","journal-title":"J. Biol. Chem."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1111\/brv.12157","article-title":"The role of skeletal-muscle-based thermogenic mechanisms in vertebrate endothermy","volume":"90","author":"Rowland","year":"","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"14057","DOI":"10.1074\/jbc.M115.636738","article-title":"The N terminus of sarcolipin plays an important role in uncoupling sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) ATP hydrolysis from Ca2+ transport","volume":"290","author":"Sahoo","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"6881","DOI":"10.1074\/jbc.M112.436915","article-title":"Sarcolipin protein interaction with sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) is distinct from phospholamban protein, and only sarcolipin can promote uncoupling of the SERCA pump","volume":"288","author":"Sahoo","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s10974-013-9350-0","article-title":"Increased sarcolipin expression and decreased sarco(endo)plasmic reticulum Ca2+ uptake in skeletal muscles of mouse models of Duchenne muscular dystrophy","volume":"34","author":"Schneider","year":"2013","journal-title":"J. Muscle Res. Cell Motil."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1042\/bj3610277","article-title":"Sarcolipin uncouples hydrolysis of ATP from accumulation of Ca2+ by the Ca2+-ATPase of skeletal-muscle sarcoplasmic reticulum","volume":"361","author":"Smith","year":"2002","journal-title":"Biochem. J."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1152\/japplphysiol.01066.2014","article-title":"Sarcolipin overexpression improves muscle energetics and reduces fatigue","volume":"118","author":"Sopariwala","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.bbrc.2018.09.039","article-title":"Truncated dystrophin ameliorates the dystrophic phenotype of mdx mice by reducing sarcolipin-mediated SERCA inhibition","volume":"505","author":"Tanihata","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.cbpa.2014.05.012","article-title":"Ontogeny of non-shivering thermogenesis in Muscovy ducklings (Cairina moschata)","volume":"175","author":"Teulier","year":"2014","journal-title":"Comp. Biochem. Physiol. Part A Mol. Integr. Physiol."},{"key":"ref87","author":"Titus","year":"2017"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"R649","DOI":"10.1152\/ajpregu.00118.2019","article-title":"Cast immobilization of hindlimb upregulates sarcolipin expression in atrophied skeletal muscles and increases thermogenesis in C57BL\/6J mice","volume":"317","author":"Tomiya","year":"2019","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nature11899","article-title":"Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state","volume":"495","author":"Toyoshima","year":"2013","journal-title":"Nature"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.freeradbiomed.2012.06.041","article-title":"Functional muscle impairment in facioscapulohumeral muscular dystrophy is correlated with oxidative stress and mitochondrial dysfunction","volume":"53","author":"Turki","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1042\/BJ20050068","article-title":"Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species","volume":"389","author":"Vangheluwe","year":"2005","journal-title":"Biochem. J."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/s41467-017-01146-7","article-title":"Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice","volume":"8","author":"Voit","year":"2017","journal-title":"Nat. Commun."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1038\/mt.2011.118","article-title":"RNA interference improves myopathic phenotypes in mice over-expressing FSHD region gene 1 (FRG1)","volume":"19","author":"Wallace","year":"2011","journal-title":"Mol. Ther."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"e13090","DOI":"10.1111\/acel.13090","article-title":"Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis","volume":"19","author":"Wang","year":"2020","journal-title":"Aging Cell"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/nature11900","article-title":"The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm","volume":"495","author":"Winther","year":"2013","journal-title":"Nature"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.1242\/jeb.126128","article-title":"Acute cold and exercise training up-regulate similar aspects of fatty acid transport and catabolism in house sparrows (Passer domesticus)","volume":"218","author":"Zhang","year":"2015","journal-title":"J. Exp. Biol."},{"key":"ref97","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1086\/676832","article-title":"Seasonal variation of metabolic thermogenesis in Eurasian tree sparrows (Passer montanus) over a latitudinal gradient","volume":"87","author":"Zheng","year":"","journal-title":"Physiol. Biochem. Zool."},{"key":"ref98","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1161\/CIRCHEARTFAILURE.113.000519","article-title":"Increased sarcolipin expression and adrenergic drive in humans with preserved left ventricular ejection fraction and chronic isolated mitral regurgitation","volume":"7","author":"Zheng","year":"","journal-title":"Circ. 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