{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:16:18Z","timestamp":1777536978034,"version":"3.51.4"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    Zika virus (ZIKV) is a global public health emergency due to its association with microcephaly, Guillain-Barr\u00e9 syndrome, neuropathy, and myelitis in children and adults. A total of 87 countries have had evidence of autochthonous mosquito-borne transmission of ZIKV, distributed across four continents, and no antivirus therapy or vaccines are available. Therefore, several strategies have been developed to target the main mosquito vector,\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    , to reduce the burden of different arboviruses. Among such strategies, the use of the maternally-inherited endosymbiont\n                    <jats:italic>Wolbachia pipientis<\/jats:italic>\n                    has been applied successfully to reduce virus susceptibility and decrease transmission. However, the mechanisms by which\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    orchestrate resistance to ZIKV infection remain to be elucidated. In this study, we apply isobaric labeling quantitative mass spectrometry (MS)-based proteomics to quantify proteins and identify pathways altered during ZIKV infection;\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    infection; co-infection with\n                    <jats:italic>Wolbachia\/<\/jats:italic>\n                    ZIKV in the\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    heads and salivary glands. We show that\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    regulates proteins involved in reactive oxygen species production, regulates humoral immune response, and antioxidant production. The reduction of ZIKV polyprotein in the presence of\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    in mosquitoes was determined by MS and corroborates the idea that\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    helps to block ZIKV infections in\n                    <jats:italic>A. aegypti.<\/jats:italic>\n                    The present study offers a rich resource of data that may help to elucidate mechanisms by which\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    orchestrate resistance to ZIKV infection in\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    , and represents a step further on the development of new targeted methods to detect and quantify ZIKV and\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    directly in complex tissues.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2021.642237","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T04:23:32Z","timestamp":1614227012000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Comprehensive Quantitative Proteome Analysis of Aedes aegypti Identifies Proteins and Pathways Involved in Wolbachia pipientis and Zika Virus Interference Phenomenon"],"prefix":"10.3389","volume":"12","author":[{"given":"Michele","family":"Martins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Felipe Costa","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy Rodriguez","family":"Murillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie Serafim","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto Barbosa","family":"Domont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Maria Perp\u00e9tua","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Dias","family":"Mesquita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio C\u00e9sar Sousa","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Maciel-de-Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magno","family":"Junqueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nature19949","article-title":"Mass-spectrometric exploration of proteome structure and function.","volume":"537","author":"Aebersold","year":"2016","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004677","article-title":"The wMel strain of Wolbachia reduces transmission of Chikungunya virus in Aedes aegypti.","volume":"10","author":"Aliota","year":"2016","journal-title":"PLoS Negl. 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