{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:57:01Z","timestamp":1785902221816,"version":"3.56.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Aims:<\/jats:bold> We examined the change in endogenous hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) production and its role in sepsis-induced myocardial dysfunction (SIMD).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Significant elevations in plasma cardiac troponin I (cTnI), creatine kinase (CK), tumor necrosis factor-\u03b1 (TNF-\u03b1), and interleukin-1\u03b2 (IL-1\u03b2) were noted in SIMD patients, whereas left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), and plasma H<jats:sub>2<\/jats:sub>S were significantly decreased relative to those in the controls. Plasma H<jats:sub>2<\/jats:sub>S was linearly related to LVEF and LVFS. Subsequently, an SIMD model was developed in mice by injecting lipopolysaccharide (LPS), and NaHS, an H<jats:sub>2<\/jats:sub>S donor, was used to elucidate the pathophysiological role of H<jats:sub>2<\/jats:sub>S. The mice showed decreased ventricular function and increased levels of TNF-\u03b1, IL-1\u03b2, cTnI, and CK after LPS injections. Toll-like receptor (TLR) 4 protein and endoplasmic reticulum stress (ERS) proteins were over expressed in the SIMD mice. All of the parameters above showed more noticeable variations in cystathionine \u03b3-lyase knockout mice relative to those in wild type mice. The administration of NaHS could improve ventricular function and attenuate inflammation and ERS in the heart.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Overall, these findings indicated that endogenous H<jats:sub>2<\/jats:sub>S deficiency contributed to SIMD and exogenous H<jats:sub>2<\/jats:sub>S ameliorated sepsis-induced myocardial dysfunction by suppressing inflammation and ERS via inhibition of the TLR4 pathway.<\/jats:p>","DOI":"10.3389\/fphys.2021.653601","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T10:31:10Z","timestamp":1623234670000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Hydrogen Sulfide Attenuated Sepsis-Induced Myocardial Dysfunction Through TLR4 Pathway and Endoplasmic Reticulum Stress"],"prefix":"10.3389","volume":"12","author":[{"given":"Yu-hong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-yang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications.","volume":"286","author":"Almanza","year":"2019","journal-title":"FEBS J."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9070621","article-title":"Hydrogen Sulfide: From a Toxic Molecule to a Key Molecule of Cell Life.","volume":"9","author":"Aroca","year":"2020","journal-title":"Antioxidants"},{"key":"B3","article-title":"Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress.","volume":"2018","author":"Chen","year":"2018","journal-title":"Oxid. 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