{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:06:19Z","timestamp":1774497979616,"version":"3.50.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE14-0023"],"award-info":[{"award-number":["ANR-18-CE14-0023"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2021.668267","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T06:54:45Z","timestamp":1618210485000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Experimental TASK-1 Potassium Channel Inhibitor A293 Can Be Employed for Rhythm Control of Persistent Atrial Fibrillation in a Translational Large Animal Model"],"prefix":"10.3389","volume":"12","author":[{"given":"H\u00e9l\u00e8ne","family":"Le Ribeuz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Montani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Antigny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1161\/CIRCULATIONAHA.115.020951","article-title":"Potassium channel subfamily K member 3 (KCNK3) contributes to the development of pulmonary arterial hypertension","volume":"133","author":"Antigny","year":"2016","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00424-014-1633-9","article-title":"The role of pH-sensitive TASK channels in central respiratory chemoreception","volume":"467","author":"Bayliss","year":"2015","journal-title":"Pflugers Arch."},{"key":"B3","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.expneurol.2012.08.021","article-title":"The TASK1 channel inhibitor A293 shows efficacy in a mouse model of multiple sclerosis","volume":"238","author":"Bittner","year":"2012","journal-title":"Exp. Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1177\/1756285613487782","article-title":"Targeting ion channels for the treatment of autoimmune neuroinflammation","volume":"6","author":"Bittner","year":"2013","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"B5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.resp.2017.06.009","article-title":"Abnormal respiration under hyperoxia in TASK-1\/3 potassium channel double knockout mice","volume":"244","author":"Buehler","year":"2017","journal-title":"Respir. Physiol. Neurobiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.chest.2020.09.238","article-title":"Characteristics and long-term outcomes of pulmonary venoocclusive disease induced by mitomycin C","volume":"159","author":"Certain","year":"2020","journal-title":"Chest"},{"key":"B7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.mce.2015.09.011","article-title":"Potassium channels related to primary aldosteronism: expression similarities and differences between human and rat adrenals","volume":"417","author":"Chen","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1210\/me.2014-1321","article-title":"TASK-1 potassium channels limit pancreatic \u03b1-cell calcium influx and glucagon secretion","volume":"29","author":"Dadi","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/sj.emboj.7601934","article-title":"Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis","volume":"27","author":"Heitzmann","year":"2008","journal-title":"EMBO J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1530\/REP-11-0225","article-title":"K(+) efflux through two-pore domain K(+) channels is required for mouse embryonic development","volume":"143","author":"Hur","year":"2012","journal-title":"Reprod. Camb. Engl."},{"key":"B11","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1093\/cvr\/cvy016","article-title":"Loss of KCNK3 is a hallmark of RV hypertrophy\/dysfunction associated with pulmonary hypertension","volume":"114","author":"Lambert","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1161\/CIRCRESAHA.119.314793","article-title":"Characterization of Kcnk3-mutated rat, a novel model of pulmonary hypertension","volume":"125","author":"Lambert","year":"2019","journal-title":"Circ. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3390\/biom10091261","article-title":"Implication of potassium channels in the pathophysiology of pulmonary arterial hypertension","volume":"10","author":"Le Ribeuz","year":"","journal-title":"Biomolecules"},{"key":"B14","doi-asserted-by":"publisher","first-page":"7400","DOI":"10.3390\/ijms21197400","article-title":"Proteomic analysis of KCNK3 loss of expression identified dysregulated pathways in pulmonary vascular cells","volume":"21","author":"Le Ribeuz","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.yjmcc.2013.12.014","article-title":"Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis","volume":"67","author":"Liang","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"14559","DOI":"10.1074\/jbc.M800637200","article-title":"TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions","volume":"283","author":"Meuth","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1183\/09059180.00003313","article-title":"Drug-induced pulmonary arterial hypertension: a recent outbreak","volume":"22","author":"Montani","year":"2013","journal-title":"Eur. Respir. Rev. Off. J. Eur. Respir. Soc."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1801899","DOI":"10.1183\/13993003.01899-2018","article-title":"Genetics and genomics of pulmonary arterial hypertension","volume":"53","author":"Morrell","year":"2019","journal-title":"Eur. Respir. J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1161\/01.RES.0000219677.12988.e9","article-title":"Impact of TASK-1 in human pulmonary artery smooth muscle cells","volume":"98","author":"Olschewski","year":"2006","journal-title":"Circ. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1700754","DOI":"10.1183\/13993003.00754-2017","article-title":"TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications","volume":"50","author":"Olschewski","year":"2017","journal-title":"Eur. Respir. J."},{"key":"B21","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1161\/CIRCULATIONAHA.114.012657","article-title":"Upregulation of K(2P)3.1 K+ current causes action potential shortening in patients with chronic atrial fibrillation","volume":"132","author":"Schmidt","year":"2015","journal-title":"Circulation"},{"key":"B22","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/MCP.0000000000000412","article-title":"Pulmonary arterial hypertension induced by tyrosine kinase inhibitors","volume":"23","author":"Weatherald","year":"2017","journal-title":"Curr. Opin. Pulm. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e015751","DOI":"10.1161\/JAHA.119.015751","article-title":"Pharmacologic TWIK-related acid-sensitive K+ channel (TASK-1) potassium channel inhibitor A293 facilitates acute cardioversion of paroxysmal atrial fibrillation in a porcine large animal model","volume":"9","author":"Wiedmann","year":"","journal-title":"J. Am. Heart Assoc."},{"key":"B24","doi-asserted-by":"publisher","first-page":"629421","DOI":"10.3389\/fphys.2020.629421","article-title":"The experimental TASK-1 potassium channel inhibitor A293 can be employed for rhythm control of persistent atrial fibrillation in a translational large animal model","volume":"11","author":"Wiedmann","year":"","journal-title":"Front. Physiol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2021.668267\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T06:54:47Z","timestamp":1618210487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2021.668267\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,12]]},"references-count":24,"alternative-id":["10.3389\/fphys.2021.668267"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2021.668267","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,12]]},"article-number":"668267"}}