{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T18:56:19Z","timestamp":1775588179701,"version":"3.50.1"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>In type 1 diabetes mellitus (T1DM), chronic hyperglycemia causes reactive oxygen and nitrogen species production. Exercise alters the oxidant-antioxidant balance. We evaluated the aerobic capacity and oxidant-antioxidant balance changes after maximum-intensity exercise in T1DM patients. The study involved 30 T1DM participants and 23 controls. The patients\u2019 average age was 23.4 \u00b1 5.1 years, with a body mass index of 24.3 \u00b1 3.1 kg m<jats:sup>\u20132<\/jats:sup> and with satisfactory glycemic control. Among the controls, the respective values equaled 24.7 \u00b1 2.9 years and 22.9 \u00b1 2.1 kg m<jats:sup>\u20132<\/jats:sup>. Aerobic capacity was assessed with a treadmill test. Peak minute oxygen uptake was significantly lower in T1DM compared with the controls (44.7 \u00b1 5.7 vs. 56.0 \u00b1 7.3 mL kg<jats:sup>\u20131<\/jats:sup> min<jats:sup>\u20131<\/jats:sup>). The total oxidant capacity measured by total oxidative status\/total oxidative capacity (TOS\/TOC) equaled 321.5 \u00b1 151 \u03bcmol L<jats:sup>\u20131<\/jats:sup> before and 380.1 \u00b1 153 \u03bcmol L<jats:sup>\u20131<\/jats:sup> after exercise in T1DM, and 164.1 \u00b1 75 and 216.6 \u00b1 75 \u03bcmol L<jats:sup>\u20131<\/jats:sup> in the controls (<jats:italic>p<\/jats:italic> &amp;lt; 0.05 for all comparisons). A significant difference in the ratio of total antioxidant status\/total antioxidant capacity (TAS\/TAC) between the groups after the treadmill test was observed (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Nitrosative stress indicators where significantly higher in the T1DM group both before and after the exercise. In conclusion, diabetic patients demonstrated a lower aerobic capacity. The TOS\/TOC and nitrosative stress indicators were significantly higher in T1DM before and after the test.<\/jats:p>","DOI":"10.3389\/fphys.2021.672403","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T08:56:43Z","timestamp":1628240203000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Changes in Oxidative and Nitrosative Stress Indicators and Vascular Endothelial Growth Factor After Maximum-Intensity Exercise Assessing Aerobic Capacity in Males With Type 1 Diabetes Mellitus"],"prefix":"10.3389","volume":"12","author":[{"given":"\u0141ukasz","family":"Tota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart\u0142omiej","family":"Matejko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Morawska-Tota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanda","family":"Pilch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Mrozi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Pa\u0142ka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Klupa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej T.","family":"Malecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107810","article-title":"Benefits of physical activity in children and adolescents with type 1 diabetes: a systematic review.","volume":"156","author":"Absil","year":"2019","journal-title":"Diabetes Res. 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