{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:05:39Z","timestamp":1791363939377,"version":"4.3.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Supraventricular tachycardia (SVT) occurs commonly and is strongly correlated with clinical deterioration in patients with pulmonary hypertension (PH). This study aimed to investigate the feasibility and long-term outcome of radiofrequency catheter ablation (RFCA) in PH patients with SVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Consecutive PH patients with SVT who were scheduled to undergo electrophysiological study and RFCA between September 2010 and July 2019 were included. The acute results and long-term success of RFCA were assessed after the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 71 PH patients with 76 episodes of SVT were analyzed. Cavotricuspid isthmus-dependent atrial flutter (<jats:italic>n<\/jats:italic> = 33, 43.5%) was the most common SVT type, followed by atrioventricular nodal reentrant tachycardia (<jats:italic>n<\/jats:italic> = 16, 21.1%). Of the 71 patients, 60 (84.5%) underwent successful electrophysiological study and were subsequently treated by RFCA. Among them, acute sinus rhythm was restored in 54 (90.0%) patients, and procedure-related complications were observed in 4 (6.7%) patients. Univariate logistic regression analysis showed that cavotricuspid isthmus-independent atrial flutter [odds ratio (OR) 25.00, 95% confidence interval (CI) 3.45\u2013180.98, <jats:italic>p<\/jats:italic> = 0.001] and wider pulmonary artery diameter (OR 1.19, 95% CI 1.03\u20131.38; <jats:italic>p<\/jats:italic> = 0.016) were associated with RFCA failure. During a median follow-up of 36 (range, 3\u2013108) months, 7 patients with atrial flutter experienced recurrence, yielding a 78.3% 3-year success rate for RFCA treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings suggest that RFCA of SVT in PH patients is feasible and has a good long-term success rate. Cavotricuspid isthmus-independent atrial flutter and a wider PAD could increase the risk for ablation failure.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphys.2021.674909","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T05:45:16Z","timestamp":1623995116000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Radiofrequency Catheter Ablation of Supraventricular Tachycardia in Patients With Pulmonary Hypertension: Feasibility and Long-Term Outcome"],"prefix":"10.3389","volume":"12","author":[{"given":"Bin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Qin","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Xian","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Zhe","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Yuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jie","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Zhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Qi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Cheng","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/s0140-6736(97)05281-1","article-title":"Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 patients in randomised trials. Amiodarone Trials Meta-Analysis Investigators.","volume":"350","year":"1997","journal-title":"Lancet"},{"key":"B2","first-page":"330","article-title":"[Adults with congenital heart defects\u2013clinical spectrum and surgical management].","volume":"21","author":"Berdjis","year":"1996","journal-title":"Herz"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2012.10.009","article-title":"Echocardiography in pulmonary arterial hypertension: from diagnosis to prognosis.","volume":"26","author":"Bossone","year":"2013","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1111\/j.1540-8167.2012.02387.x","article-title":"Catheter ablation of typical atrial flutter in severe pulmonary hypertension.","volume":"23","author":"Bradfield","year":"2012","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.amjcard.2015.09.039","article-title":"Supraventricular arrhythmias in patients with pulmonary arterial hypertension.","volume":"116","author":"Cannillo","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"B6","doi-asserted-by":"crossref","DOI":"10.1177\/2045894019834890","article-title":"Pathophysiology, incidence, management, and consequences of cardiac arrhythmia in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.","volume":"9","author":"Cirulis","year":"2019","journal-title":"Pulm. Circ"},{"key":"B7","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1161\/01.cir.92.3.436","article-title":"Coronary sinus morphology in patients with atrioventricular junctional reentry tachycardia and other supraventricular tachyarrhythmias.","volume":"92","author":"Doig","year":"1995","journal-title":"Circulation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0140-6736(94)91895-3","article-title":"Randomised trial of low-dose amiodarone in severe congestive heart failure. Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina (GESICA).","volume":"344","author":"Doval","year":"1994","journal-title":"Lancet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.5603\/cj.a2013.0088","article-title":"Coronary sinus diameter by echocardiography to differentiate atrioventricular nodal reentrant tachycardia from atrioventricular reentrant tachycardia.","volume":"21","author":"Ezhumalai","year":"2014","journal-title":"Cardiol. J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: the Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur. Heart J"},{"key":"B11","first-page":"I212","article-title":"Right atrial and ventricular adaptation to chronic right ventricular pressure overload.","volume":"112","author":"Gaynor","year":"","journal-title":"Circulation"},{"key":"B12","doi-asserted-by":"publisher","first-page":"H2140","DOI":"10.1152\/ajpheart.00566.2004","article-title":"Reservoir and conduit function of right atrium: impact on right ventricular filling and cardiac output.","volume":"288","author":"Gaynor","year":"","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1093\/europace\/euu322","article-title":"The first Latin American catheter ablation registry.","volume":"17","author":"Keegan","year":"2015","journal-title":"Europace"},{"key":"B14","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.hlc.2012.06.005","article-title":"Ablation of typical right atrial flutter in patients with pulmonary hypertension.","volume":"21","author":"Luesebrink","year":"2012","journal-title":"Heart Lung Circ."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1016\/j.jacc.2015.03.540","article-title":"Management of pulmonary arterial hypertension.","volume":"65","author":"McLaughlin","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/j.1540-8167.2011.02255.x","article-title":"Atrial electrical and structural remodeling associated with longstanding pulmonary hypertension and right ventricular hypertrophy in humans.","volume":"23","author":"Medi","year":"2012","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00169","article-title":"Arrhythmic burden and outcomes in pulmonary arterial hypertension.","volume":"6","author":"Middleton","year":"2019","journal-title":"Front. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1016\/s0735-1097(00)00635-5","article-title":"Prospective randomized comparison of antiarrhythmic therapy versus first-line radiofrequency ablation in patients with atrial flutter.","volume":"35","author":"Natale","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1046\/j.1540-8167.2004.03114.x","article-title":"Comparison of coronary sinus morphology in patients with and without atrioventricular nodal reentrant tachycardia by intracardiac echocardiography.","volume":"15","author":"Okumura","year":"2004","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/j.jacc.2015.09.019","article-title":"ACC\/AHA\/HRS guideline for the management of adult patients with supraventricular tachycardia: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.","volume":"67","author":"Page","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ijcard.2011.02.059","article-title":"Right atrial flutter isthmus ablation is feasible and results in acute clinical improvement in patients with persistent atrial flutter and severe pulmonary arterial hypertension.","volume":"149","author":"Showkathali","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension.","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur. Respir. J."},{"key":"B23","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ahj.2006.09.008","article-title":"Incidence and clinical relevance of supraventricular tachyarrhythmias in pulmonary hypertension.","volume":"153","author":"Tongers","year":"2007","journal-title":"Am. Heart J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.15420\/aer.2018.3.2","article-title":"Atrial arrhythmias in pulmonary hypertension: pathogenesis, prognosis and management.","volume":"7","author":"Wanamaker","year":"2018","journal-title":"Arrhythm. Electrophysiol. Rev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1016\/j.amjcard.2014.07.079","article-title":"Frequency of supraventricular arrhythmias in patients with idiopathic pulmonary arterial hypertension.","volume":"114","author":"Wen","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1007\/s00330-017-5172-6","article-title":"Transoesophageal echocardiography prior to catheter ablation could be avoided in atrial fibrillation patients with a low risk of stroke and without filling defects in the late-phase MDCT scan: a retrospective analysis of 783 patients.","volume":"28","author":"Zhai","year":"2018","journal-title":"Eur. Radiol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2021.674909\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T05:45:22Z","timestamp":1623995122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2021.674909\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,18]]},"references-count":26,"alternative-id":["10.3389\/fphys.2021.674909"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2021.674909","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,18]]},"article-number":"674909"}}