{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:19:02Z","timestamp":1780049942188,"version":"3.53.1"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012428","name":"Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["2020TD37"],"award-info":[{"award-number":["2020TD37"]}],"id":[{"id":"10.13039\/501100012428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:italic>Streptococcus<\/jats:italic> has greatly restricted the development of healthy tilapia aquaculture. As a green and efficient feed addition, <jats:italic>Acanthopanax senticosus<\/jats:italic> (APS) has been increasingly used in culture, but it is unclear whether it represents a disease-resistant feed. Genetically improved farmed tilapia (GIFT, <jats:italic>Oreochromis niloticus<\/jats:italic>) was fed with a feed supplemented with 0 (control), 0.5, 1, 2, 4, and 8\u2030 APS for 56 days, after which fish were injected with 5.9 \u00d7 10<jats:sup>6<\/jats:sup> CFU\/ml <jats:italic>Streptococcus iniae<\/jats:italic> into the abdominal cavity. At 96 h after infection, the cumulative survival of GIFT in control and 0.5\u2030 APS treatments was significantly lower than in other treatments; at APS supplementation rates of 1 and 2\u2030, serum glucose, triglycerides, and cholesterol contents were all significantly lower than in control treatment fish. Hepatic glycogen and triglyceride contents of 1\u2030 APS treatment fish were significantly higher than those in fish in control treatment. Transcription levels of peroxisome proliferator activated receptor \u03b1 (PPAR), fatty acid synthase (FAS), and lipoprotein Lipase (LPL) genes were upregulated, and their expression levels in fish in 1, 2, and 4\u2030 treatments were significantly higher than those in fish in control treatment at 96 h after <jats:italic>S. iniae<\/jats:italic> infection. After 96 h of infection, the red blood cells, hemoglobin, hematocrit, and white blood cells of fish in 1\u2030 APS treatment were significantly lower than those of fish in 4 and 8\u2030 treatments; hepatic catalase activity was activated at 48 h, superoxide dismutase activity was also significantly upregulated at 96 h, and the malondialdehyde content significantly decreased. It is noted that 0.5\u20132\u2030 APS treatments significantly activated the expression of PI3K and AKT in the liver, while inhibiting the expression of Caspase-9. Therefore, feed with 1\u2030 APS can promote hepatic glycogen and lipid metabolism in GIFT after infection with <jats:italic>S. iniae<\/jats:italic>, which is beneficial to alleviating oxidative stress damage and cell apoptosis in liver tissue.<\/jats:p>","DOI":"10.3389\/fphys.2021.699247","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T09:50:41Z","timestamp":1625824241000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Acanthopanax senticosus Promotes Survival of Tilapia Infected With Streptococcus iniae by Regulating the PI3K\/AKT and Fatty Acid Metabolism Signaling Pathway"],"prefix":"10.3389","volume":"12","author":[{"given":"Hong Xia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang You","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/jfd.13164","article-title":"The nature and consequences of co-infections in tilapia: a review.","volume":"43","author":"Abdel-Latif","year":"2020","journal-title":"J. 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