{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:59:56Z","timestamp":1761562796211,"version":"3.41.2"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","award":["16CVD02"],"award-info":[{"award-number":["16CVD02"]}],"id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Because stretch of the atrial myocardium is proarrhythmic for atrial fibrillation (AF) and a left lateral body position increases atrial dimensions in humans, we hypothesized that left lateral recumbence is a frequent AF-triggering body position in AF patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We performed a questionnaire study of symptomatic paroxysmal AF (episodes of AF &amp;lt; 1 week) patients scheduled for a first AF ablation therapy at Catharina Hospital, Eindhoven, the Netherlands and at University Hospital, Bordeaux, France.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Ninety-four symptomatic paroxysmal AF patients were included [mean age 61 \u00b1 11 years, median AF history of 29(48) months, 31% were females]. Twenty-two percent of patients reported a specific body position as a trigger of their AF symptoms. The triggering body position was left lateral position in 57% of cases, supine position in 33%, right lateral position in 10%, and prone position in 5% (<jats:italic>p<\/jats:italic> = 0.003 overall difference in prevalence). Patients with positional AF had a higher body mass index compared to patients without nocturnal\/positional AF [28.7(4.2) and 25.4(5.2) kg\/m<jats:sup>2<\/jats:sup>, respectively, <jats:italic>p<\/jats:italic> = 0.025], but otherwise resembled these patients.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Body position, and the left lateral position, in particular, is a common trigger of AF in symptomatic AF patients. Moreover, positional AF is associated with overweight. Understanding of the underlying mechanisms of positional AF can contribute to AF treatment and prevention.<\/jats:p>","DOI":"10.3389\/fphys.2021.708650","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T16:52:51Z","timestamp":1626367971000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Self-Reported Onset of Paroxysmal Atrial Fibrillation Is Related to Sleeping Body Position"],"prefix":"10.3389","volume":"12","author":[{"given":"Lisa A.","family":"Gottlieb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Sanchez y","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9l\u00e8ze","family":"Hocini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas R. C.","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Coronel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1136\/hrt.2006.089359","article-title":"Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins","volume":"93","author":"Chang","year":"2007","journal-title":"Heart"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1161\/CIRCRESAHA.114.303772","article-title":"Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy","volume":"114","author":"Chen","year":"2014","journal-title":"Circ. 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