{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:44:16Z","timestamp":1787795056572,"version":"build-2784847793"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Currently, the prediction of rupture risk in abdominal aortic aneurysms (AAAs) solely relies on maximum diameter. However, wall mechanics and hemodynamics have shown to provide better risk indicators. Patient-specific fluid-structure interaction (FSI) simulations based on a non-invasive image modality are required to establish a patient-specific risk indicator. In this study, a robust framework to execute FSI simulations based on time-resolved three-dimensional ultrasound (3D+t US) data was obtained and employed on a data set of 30 AAA patients. Furthermore, the effect of including a pre-stress estimation (PSE) to obtain the stresses present in the measured geometry was evaluated. The established workflow uses the patient-specific 3D+t US-based segmentation and brachial blood pressure as input to generate meshes and boundary conditions for the FSI simulations. The 3D+t US-based FSI framework was successfully employed on an extensive set of AAA patient data. Omitting the pre-stress results in increased displacements, decreased wall stresses, and deviating time-averaged wall shear stress and oscillatory shear index patterns. These results underline the importance of incorporating pre-stress in FSI simulations. After validation, the presented framework provides an important tool for personalized modeling and longitudinal studies on AAA growth and rupture risk.<\/jats:p>","DOI":"10.3389\/fphys.2021.717593","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T12:21:39Z","timestamp":1628857299000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Ultrasound-Based Fluid-Structure Interaction Modeling of Abdominal Aortic Aneurysms Incorporating Pre-stress"],"prefix":"10.3389","volume":"12","author":[{"given":"Judith H. C.","family":"Fonken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther J.","family":"Maas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjet H. M.","family":"Nievergeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R. H. M.","family":"van Sambeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans N.","family":"van de Vosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G. P.","family":"Lopata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"B1","volume-title":"Ansys Fluent User's Guide, Release 20.1","year":"2020"},{"key":"B2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1017\/S0022112007005344","article-title":"A wave propagation model of blood flow in large vessels using an approximate velocity profile function","volume":"580","author":"Bessems","year":"2007","journal-title":"J. Fluid Mech"},{"key":"B3","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1007\/s10439-009-9843-6","article-title":"Hemodynamics of the normal aorta compared to fusiform and saccular abdominal aortic aneurysms with emphasis on a potential thrombus formation mechanism","volume":"38","author":"Biasetti","year":"2010","journal-title":"Ann. Biomed. Eng"},{"key":"B4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.cam.2012.10.034","article-title":"A computational method to assess the in vivo stresses and unloaded configuration of patient-specific blood vessels","volume":"246","author":"Bols","year":"2013","journal-title":"J. Comput. Appl. Math"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1016\/j.jvs.2015.01.040","article-title":"Low wall shear stress predominates at sites of abdominal aortic aneurysm rupture","volume":"63","author":"Boyd","year":"2016","journal-title":"J. Vasc. Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jvs.2017.10.044","article-title":"The society for vascular surgery practice guidelines on the care of patients with an abdominal aortic aneurysm","volume":"67","author":"Chaikof","year":"2018","journal-title":"J. Vasc. Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1067\/mva.2002.107","article-title":"Comparison of abdominal aortic hemodynamics between men and women at rest and during lower limb exercise","volume":"37","author":"Cheng","year":"2003","journal-title":"J. Vasc. Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0140-6736(05)74979-5","article-title":"UK small aneurysms trial","volume":"353","author":"Collin","year":"1999","journal-title":"Lancet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.jbiomech.2006.04.019","article-title":"Patient-specific initial wall stress in abdominal aortic aneurysms with a backward incremental method","volume":"40","author":"de Putter","year":"2007","journal-title":"J. Biomech."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1002\/mp.13960","article-title":"Automated 3D geometry segmentation of the healthy and diseased carotid artery in free-hand, probe tracked ultrasound images","volume":"47","author":"de Ruijter","year":"2020","journal-title":"Med. Phys"},{"key":"B11","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.compstruc.2009.12.006","article-title":"Performance of partitioned procedures in fluid-structure interaction","volume":"88","author":"Degroote","year":"2010","journal-title":"Comput. Struct"},{"key":"B12","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S1350-4533(01)00093-5","article-title":"Fluid-structure interaction within realistic 3d models of the aneurysmatic aorta as a guidance to assess the risk of rupture of the aneurysm","volume":"23","author":"Di Martino","year":"2001","journal-title":"Med. Eng. Phys"},{"key":"B13","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jbiomech.2017.06.029","article-title":"Haemodynamics and stresses in abdominal aortic aneurysms: a fluid-structure interaction study into the effect of proximal neck and iliac bifurcation angle","volume":"60","author":"Drewe","year":"2017","journal-title":"J. Biomech"},{"key":"B14","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1067\/mva.2003.213","article-title":"Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter","volume":"37","author":"Fillinger","year":"2003","journal-title":"J. Vasc. Surg"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1109\/TMI.2007.899180","article-title":"Real-time vessel segmentation and tracking for ultrasound imaging applications","volume":"26","author":"Guerrero","year":"2007","journal-title":"IEEE Trans. Med. Imag"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-017-0973-8","article-title":"Fluid-structure interaction modelling and stabilisation of a patient-specific arteriovenous access fistula","author":"Guess","year":"2017","journal-title":"arXiv Preprint"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/0-306-48389-0_1","article-title":"A new constitutive framework for arterial wall mechanics and a comparative study of material models","volume":"61","author":"Holzapfel","year":"2012","journal-title":"J. Elast"},{"key":"B18","article-title":"\u201cBiomechanic and hemodynamic perspectives in abdominal aortic aneurysm rupture risk assessment,\u201d","volume-title":"Abdominal Aortic Aneurysm - From Basic Research to Clinical Practice","author":"Kontopodis","year":"2018"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1056\/NEJMoa012573","article-title":"Immediate repair compared with surveillance of small abdominal aortic aneurysms","volume":"346","author":"Lederle","year":"2002","journal-title":"N. Engl. J. Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1007\/s10439-010-9949-x","article-title":"Quantification of hemodynamics in abdominal aortic aneurysms during rest and exercise using magnetic resonance imaging and computational fluid dynamics","volume":"38","author":"Les","year":"2010","journal-title":"Ann. Biomed. Eng"},{"key":"B21","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.euromechflu.2007.03.003","article-title":"A comparison between different asymmetric abdominal aortic aneurysm morphologies employing computational fluid-structure interaction analysis","volume":"26","author":"Li","year":"2007","journal-title":"Eur. J. Mech"},{"key":"B22","doi-asserted-by":"publisher","first-page":"7023078","DOI":"10.1155\/2017\/7023078","article-title":"Fluid-structure interaction in abdominal aortic aneurysm: effect of modeling techniques","volume":"2017","author":"Lin","year":"2017","journal-title":"BioMed Res. Int"},{"key":"B23","volume-title":"Ultrasound-Based Mechanical Modeling of Abdominal Aortic Aneurysms: Model Input and Boundary Conditions","author":"Petterson","year":"2020"},{"key":"B24","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fcvm.2015.00019","article-title":"The abdominal aortic aneurysm and intraluminal thrombus: current concepts of development and treatment","volume":"2","author":"Piechota-Polanczyk","year":"2015","journal-title":"Front. Cardiovasc. Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"031001","DOI":"10.1115\/1.3005200","article-title":"Abdominal aortic aneurysm risk of rupture: patient-specific FSI simulations using anisotropic model","volume":"131","author":"Rissland","year":"2008","journal-title":"J. Biomech. Eng"},{"key":"B26","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3389\/fbioe.2019.00111","article-title":"Biomechanical investigation of disturbed hemodynamics-induced tissue degeneration in abdominal aortic aneurysms using computational and experimental techniques","volume":"7","author":"Salman","year":"2019","journal-title":"Front. Bioeng. Biotechnol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1080\/10255840701827412","article-title":"Wall stress and flow dynamics in abdominal aortic aneurysms: finite element analysis vs. fluid-structure interaction","volume":"11","author":"Scotti","year":"2008","journal-title":"Comput. Methods Biomech. Biomed. Eng"},{"key":"B28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1475-925X-4-64","article-title":"Fluid-structure interaction in abdominal aortic aneurysms: effects of asymmetry and wall thickness","volume":"4","author":"Scotti","year":"2005","journal-title":"Biomed. Eng. Online"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.compstruc.2006.08.041","article-title":"Compliant biomechanics of abdominal aortic aneurysms: a fluid-structure interaction study","volume":"85","author":"Scotti","year":"2007","journal-title":"Comput. Struct"},{"key":"B30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-4020-5690-1_4","article-title":"\u201cAn overview of some mathematical models of blood rheology,\u201d","volume-title":"A Portrait of State-of-the-Art Research at the Technical University of Lisbon","author":"Sequeira","year":"2007"},{"key":"B31","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jvs.2009.08.075","article-title":"The mechanical role of thrombus on the growth rate of an abdominal aortic aneurysm","volume":"51","author":"Speelman","year":"2010","journal-title":"J. Vasc. Surg"},{"key":"B32","doi-asserted-by":"publisher","first-page":"335","DOI":"10.7461\/jcen.2014.16.4.335","article-title":"A comparative review of the hemodynamics and pathogenesis of cerebral and abdominal aortic aneurysms: lessons to learn from each other","volume":"16","author":"Tanweer","year":"2014","journal-title":"J. Cerebrovasc. Endovasc. Neurosurg"},{"key":"B33","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1023\/B:ENGI.0000007985.17625.43","article-title":"Finite-element-based computational methods for cardiovascular fluid-structure interaction","volume":"47","author":"van de Vosse","year":"2003","journal-title":"J. Eng. Math"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1016\/j.jbiomech.2016.01.020","article-title":"Influence of limited field-of-view on wall stress analysis in abdominal aortic aneurysms","volume":"49","author":"van Disseldorp","year":"2016","journal-title":"J. Biomech"},{"key":"B35","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.ejvs.2016.07.088","article-title":"Patient specific wall stress analysis and mechanical characterization of abdominal aortic aneurysms using 4D ultrasound","volume":"52","author":"van Disseldorp","year":"2016","journal-title":"Eur. J. Vasc. Endovasc. Surg"},{"key":"B36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/ehjci\/jey051","article-title":"Quantification of aortic stiffness and wall stress in healthy volunteers and abdominal aortic aneurysm patients using time-resolved 3D ultrasound: a comparison study","volume":"20","author":"van Disseldorp","year":"2018","journal-title":"Eur. Heart J"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.jvs.2008.06.060","article-title":"Biomechanical properties of abdominal aortic aneurysms assessed by simultaneously measured pressure and volume changes in humans","volume":"48","author":"van't Veer","year":"2008","journal-title":"J. Vasc. Surg"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1016\/j.jbiomech.2006.09.003","article-title":"Biomechanics of abdominal aortic aneurysm","volume":"40","author":"Vorp","year":"2007","journal-title":"J. Biomech"},{"key":"B39","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1067\/mva.2001.114813","article-title":"Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening","volume":"34","author":"Vorp","year":"2001","journal-title":"J. Vasc. Surg"},{"key":"B40","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.medengphy.2005.06.008","article-title":"A patient-specific computational model of fluid-structure interaction in abdominal aortic aneurysms","volume":"27","author":"Wolters","year":"2005","journal-title":"Med. Eng. Phys"},{"key":"B41","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/8415_2011_72","article-title":"\u201cBiomechanical aspects of abdominal aortic aneurysm (AAA): fluid structure interaction (FSI) studies of AAA behavior,\u201d","volume-title":"Biomechanics and Mechanobiology of Aneurysms. Studies in Mechanobiology, Tissue Engineering and Biomaterials","author":"Xenos","year":"2011"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1007\/s10439-015-1461-x","article-title":"Association of intraluminal thrombus, hemodynamic forces, and abdominal aortic aneurysm expansion using longitudinal ct images","volume":"44","author":"Zambrano","year":"2016","journal-title":"Ann. Biomed. Eng"}],"updated-by":[{"DOI":"10.3389\/fphys.2022.885959","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000}}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2021.717593\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T17:47:35Z","timestamp":1650304055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2021.717593\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":42,"alternative-id":["10.3389\/fphys.2021.717593"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2021.717593","relation":{"corrigendum":[{"id-type":"doi","id":"10.3389\/fphys.2022.885959","asserted-by":"object"}]},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]},"article-number":"717593"}}