{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:18:31Z","timestamp":1770819511210,"version":"3.50.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2021.734418","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T04:37:02Z","timestamp":1630989422000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Acid-Sensing Ion Channel 1 Contributes to Weak Acid-Induced Migration of Human Malignant Glioma Cells"],"prefix":"10.3389","volume":"12","author":[{"given":"Sareena","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Cegielski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Ping","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15023","DOI":"10.1074\/jbc.M300991200","article-title":"Acid-sensing ion channels in malignant gliomas","volume":"278","author":"Berdiev","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1111\/bph.13533","article-title":"The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC): IUPHAR Review 19","volume":"173","author":"Boscardin","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"C1282","DOI":"10.1152\/ajpcell.00077.2004","article-title":"Cation selectivity and inhibition of malignant glioma Na+ channels by Psalmotoxin 1","volume":"287","author":"Bubien","year":"2004","journal-title":"Am. J. Physiol,. Cell Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.3390\/cancers12071837","article-title":"Mambalgin-2 induces cell cycle arrest and apoptosis in glioma cells via interaction with ASIC1a","volume":"12","author":"Bychkov","year":"2020","journal-title":"Cancers"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.15252\/emmm.201302627","article-title":"Emerging treatment strategies for glioblastoma multiforme","volume":"6","author":"Carlsson","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1152\/physrev.00010.2003","article-title":"Regulation and modulation of pH in the brain","volume":"83","author":"Chesler","year":"2003","journal-title":"Physiol. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s12975-013-0305-y","article-title":"Acid-sensing ion channels contribute to neurotoxicity","volume":"5","author":"Chu","year":"2014","journal-title":"Transl. Stroke Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"263","DOI":"10.2174\/138945012799201685","article-title":"Physiological and pathological functions of acid-sensing ion channels in the central nervous system","volume":"13","author":"Chu","year":"2012","journal-title":"Curr. Drug Targets."},{"key":"B9","doi-asserted-by":"publisher","first-page":"395","DOI":"10.4103\/1673-5374.245466","article-title":"Basics on the use of acid-sensing ion channels' inhibitors as therapeutics","volume":"14","author":"Dibas","year":"2019","journal-title":"Neural Regen. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.3390\/cancers12103068","article-title":"Ion channels as therapeutic targets in high grade gliomas","volume":"12","author":"Griffin","year":"2020","journal-title":"Cancers"},{"key":"B11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuropharm.2014.12.016","article-title":"Biophysical properties of acid-sensing ion channels (ASICs)","volume":"94","author":"Gr\u00fcnder","year":"2015","journal-title":"Neuropharmacology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fphys.2013.00316","article-title":"Involvement of tumor acidification in brain cancer pathophysiology","volume":"4","author":"Honasoge","year":"2013","journal-title":"Front. Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuropharm.2014.12.010","article-title":"Two aspects of ASIC function: synaptic plasticity and neuronal injury","volume":"94","author":"Huang","year":"2015","journal-title":"Neuropharmacology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neuroscience.2009.04.029","article-title":"Characterization of acid-sensing ion channels in medium spiny neurons of mouse striatum","volume":"162","author":"Jiang","year":"2009","journal-title":"Neuroscience"},{"key":"B15","doi-asserted-by":"publisher","first-page":"24526","DOI":"10.1074\/jbc.M109.037390","article-title":"Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration","volume":"284","author":"Kapoor","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"C1246","DOI":"10.1152\/ajpcell.00199.2010","article-title":"Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes","volume":"300","author":"Kapoor","year":"2011","journal-title":"Am. J. Physiol,. Cell Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/pr.114.009225","article-title":"International union of basic and clinical pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel","volume":"67","author":"Kellenberger","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3390\/ph13110389","article-title":"The landscape of novel therapeutics and challenges in glioblastoma multiforme: contemporary state and future directions","volume":"13","author":"Khaddour","year":"2020","journal-title":"Pharmaceuticals"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.neuropharm.2014.12.014","article-title":"Receptor for protons: First observations on acid sensing ion channels","volume":"94","author":"Krishtal","year":"2015","journal-title":"Neuropharmacology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e12665","DOI":"10.1371\/journal.pone.0012665","article-title":"High-density expression of Ca2+\u2013permeable ASIC1a channels in NG2 glia of rat hippocampus","volume":"5","author":"Lin","year":"2010","journal-title":"PLoS ONE"},{"key":"B21","doi-asserted-by":"publisher","first-page":"E2504","DOI":"10.1073\/pnas.1620508114","article-title":"Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive","volume":"114","author":"MacLean","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1080\/14737140.2018.1496824","article-title":"Highlighting the need for reliable clinical trials in glioblastoma","volume":"18","author":"Mandel","year":"2018","journal-title":"Expert Rev. Anticancer Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11060-020-03448-1","article-title":"A review of glioblastoma immunotherapy","volume":"151","author":"Medikonda","year":"2021","journal-title":"J. Neurooncol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3728096","DOI":"10.1155\/2017\/3728096","article-title":"Acid-sensing ion channels as potential therapeutic targets in neurodegeneration and neuroinflammation","volume":"2017","author":"Ortega-Ram\u00edrez","year":"2017","journal-title":"Mediators Inflamm"},{"key":"B25","doi-asserted-by":"crossref","DOI":"10.1093\/neuonc\/noaa200","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017","volume-title":"Neuro Oncol.","author":"Ostrom","year":"2020"},{"key":"B26","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3390\/ijms22010351","article-title":"Molecular mechanisms of treatment resistance in glioblastoma","volume":"22","author":"Ou","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/S0196-0644(85)80055-X","article-title":"Brain acidosis","volume":"14","author":"Rehncrona","year":"2005","journal-title":"Ann. Emerg. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"4053","DOI":"10.1074\/jbc.M111.311688","article-title":"Glioma-specific cation conductance regulates migration and cell cycle progression","volume":"287","author":"Rooj","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B29","first-page":"997","article-title":"Acid-sensing ion channel 1 (ASIC1) mediates weak acid-induced migration of human malignant glioma cells","volume":"11","author":"Sheng","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1124\/pr.117.014944","article-title":"Current challenges and opportunities in treating glioblastoma","volume":"70","author":"Shergalis","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0079-6123(08)63257-4","article-title":"Acidosis-related brain damage","volume":"96","author":"Siesj,\u00f6","year":"1993","journal-title":"Prog. Brain Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/9780470720691.ch5","article-title":"Lactic acidosis in the brain: occurrence, triggering mechanisms and pathophysiological importance","volume":"87","author":"Siesj\u00f6","year":"1982","journal-title":"Ciba Found. Symp."},{"key":"B33","article-title":"Acid-sensing ion channels: focus on physiological and some pathological roles in the brain","volume-title":"Curr. Neuropharmacol.","author":"Storozhuka","year":"2021"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.3892\/or.2013.2777","article-title":"Regulation of ASIC1 by Ca2+\/calmodulin-dependent protein kinase II in human glioblastoma multiforme","volume":"30","author":"Sun","year":"2013","journal-title":"Oncol. Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"105060","DOI":"10.1016\/j.nbd.2020.105060","article-title":"Epigenetic pathways and plasticity in brain tumors","volume":"145","author":"Suter","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"13674","DOI":"10.1038\/s41598-017-13666-9","article-title":"Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3","volume":"7","author":"Tian","year":"2017","journal-title":"Sci. Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e22120","DOI":"10.1002\/syn.22120","article-title":"Synaptic signals mediated by protons and acid-sensing ion channels","volume":"73","author":"Uchitel","year":"2019","journal-title":"Synapse"},{"key":"B38","doi-asserted-by":"publisher","first-page":"104166","DOI":"10.1016\/j.phrs.2019.02.005","article-title":"A molecular view of the function and pharmacology of acid-sensing ion channels","volume":"154","author":"Vullo","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/386173a0","article-title":"A proton-gated cation channel involved in acid-sensing","volume":"386","author":"Waldmann","year":"1997","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","first-page":"11593","DOI":"10.1038\/srep11593","article-title":"Ion channel gene expression predicts survival in glioma patients","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nrn3529","article-title":"Acid-sensing ion channels in pain and disease","volume":"14","author":"Wemmie","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1093\/neuonc\/noaa106","article-title":"Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions","volume":"22","author":"Wen","year":"2020","journal-title":"Neuro-oncology."},{"key":"B43","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.cell.2004.08.026","article-title":"Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels","volume":"118","author":"Xiong","year":"2004","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1055\/s-0040-1713172","article-title":"Aggressive treatment in glioblastoma: what determines the survival of patients?","volume":"82","author":"Yu","year":"2021","journal-title":"J. Neurol. Surg. A Cent. Eur. Neurosurg."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2021.734418\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T04:37:07Z","timestamp":1630989427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2021.734418\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,7]]},"references-count":44,"alternative-id":["10.3389\/fphys.2021.734418"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2021.734418","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,7]]},"article-number":"734418"}}