{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:37:48Z","timestamp":1786653468853,"version":"build-2736575974"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:title>Graphical Abstract<\/jats:title><jats:p\/>","DOI":"10.3389\/fphys.2021.735915","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T09:41:14Z","timestamp":1634377274000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Classical and Non-classical Fibrosis Phenotypes Are Revealed by Lung and Cardiac Like Microvascular Tissues On-Chip"],"prefix":"10.3389","volume":"12","author":[{"given":"Akinola","family":"Akinbote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Beltran-Sastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cherubini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Visone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Hajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defne","family":"Cobanoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Haase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41586-019-1546-z","article-title":"Targeting cardiac fibrosis with engineered T cells.","volume":"573","author":"Aghajanian","year":"2019","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1161\/01.RES.0000255691.76142.4a","article-title":"Phenotypic heterogeneity of the endothelium.","volume":"100","author":"Aird","year":"2007","journal-title":"Circ. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"8758","DOI":"10.1073\/pnas.1618333114","article-title":"Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell\u2013endothelial cell-regulated barrier function.","volume":"114","author":"Alimperti","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B4","doi-asserted-by":"publisher","first-page":"L896","DOI":"10.1152\/ajplung.00084.2017","article-title":"An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices.","volume":"312","author":"Alsafadi","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0002-9149(91)90256-K","article-title":"Cellular basis of ventricular remodeling after myocardial infarction.","volume":"68","author":"Anversa","year":"1991","journal-title":"Am. J. Cardiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1172\/JCI3145","article-title":"Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer.","volume":"102","author":"Arenberg","year":"1998","journal-title":"J. Clin. Invest."},{"key":"B7","doi-asserted-by":"publisher","first-page":"eaal2379","DOI":"10.1126\/science.aal2379","article-title":"Organotypic vasculature: from descriptive heterogeneity to functional pathophysiology.","volume":"357","author":"Augustin","year":"2017","journal-title":"Science"},{"key":"B8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/kisup.2014.9","article-title":"Tipping the balance from angiogenesis to fibrosis in CKD.","volume":"4","author":"Ballermann","year":"2014","journal-title":"Kidney Int. Suppl."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/nm.2208","article-title":"Allosteric inhibition of lysyl oxidase\u2013like-2 impedes the development of a pathologic microenvironment.","volume":"16","author":"Barry-Hamilton","year":"2010","journal-title":"Nat. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-021-03549-5","article-title":"Cross-tissue organization of the fibroblast lineage.","volume":"593","author":"Buechler","year":"2021","journal-title":"Nature"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1054\/bjoc.2001.1831","article-title":"Spectrum of matrix metalloproteinase expression in primary and metastatic colon cancer: relationship to the tissue inhibitors of metalloproteinases and membrane type-1-matrix metalloproteinase.","volume":"84","author":"Collins","year":"2001","journal-title":"Br. J. Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/jcmm.12730","article-title":"Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2.","volume":"20","author":"de Jong","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.devcel.2009.01.004","article-title":"The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications.","volume":"16","author":"Dejana","year":"2009","journal-title":"Dev. Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nrc.2017.93","article-title":"Transport of drugs from blood vessels to tumour tissue.","volume":"17","author":"Dewhirst","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"B15","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1172\/JCI93558","article-title":"The perivascular origin of pathological fibroblasts.","volume":"128","author":"Di Carlo","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B16","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.yjmcc.2010.10.033","article-title":"Transforming growth factor (TGF)-\u03b2 signaling in cardiac remodeling.","volume":"51","author":"Dobaczewski","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.msec.2017.02.001","article-title":"Impact of matrix stiffness on fibroblast function.","volume":"74","author":"El-Mohri","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"B18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1755-1536-5-15","article-title":"Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease.","volume":"5","author":"Fan","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e0171427","DOI":"10.1371\/journal.pone.0171427","article-title":"Metalloproteinase-9 contributes to endothelial dysfunction in atherosclerosis via protease activated receptor-1.","volume":"12","author":"Florence","year":"2017","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling.","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e0241390","DOI":"10.1371\/journal.pone.0241390","article-title":"Maintaining resting cardiac fibroblasts in vitro by disrupting mechano- transduction.","volume":"15","author":"Gilles","year":"2020","journal-title":"PLoS OnE"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1900878","DOI":"10.1002\/advs.201900878","article-title":"Pericytes contribute to dysfunction in a human 3D model of placental microvasculature through VEGF\u2212Ang\u2212Tie2 signaling.","volume":"6","author":"Haase","year":"2019","journal-title":"Adv. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2002444","DOI":"10.1002\/adfm.202002444","article-title":"Endothelial regulation of drug transport in a 3D vascularized tumor model.","volume":"30","author":"Haase","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"B24","doi-asserted-by":"publisher","first-page":"eabg8139","DOI":"10.1126\/sciadv.abg8139","article-title":"The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain.","volume":"7","author":"Hajal","year":"2021","journal-title":"Sci. Adv."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1091\/mbc.E17-01-0014","article-title":"Mechanical regulation of cardiac fibroblast profibrotic phenotypes.","volume":"28","author":"Herum","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"B26","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1091\/mbc.12.9.2730","article-title":"Alpha-smooth muscle actin expression upregulates fibroblast contractile activity.","volume":"12","author":"Hinz","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1742-2094-7-88","article-title":"Transforming growth factor-\u03b21 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK- and JNK-NF-\u03baB pathways.","volume":"7","author":"Hsieh","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.3791\/2445","article-title":"Detection of functional matrix metalloproteinases by zymography.","volume":"45","author":"Hu","year":"2010","journal-title":"J. Vis. Exp."},{"key":"B29","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1039\/c3ib40267c","article-title":"Generation of 3D functional microvascular networks with mural cell-differentiated human mesenchymal stem cells in microfluidic vasculogenesis systems.","volume":"6","author":"Jeon","year":"2014","journal-title":"Integr. Biol. Quant. Biosci. Nano Macro"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3893","DOI":"10.1096\/fj.12-214189","article-title":"Apoptosis and angiogenesis: an evolving mechanism for fibrosis.","volume":"27","author":"Johnson","year":"2013","journal-title":"FASEB J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"5334","DOI":"10.1529\/biophysj.108.134874","article-title":"A method improving the accuracy of fluorescence recovery after photobleaching analysis.","volume":"95","author":"J\u00f6nsson","year":"2008","journal-title":"Biophys. J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/s41590-020-0741-2","article-title":"The mesenchymal context in inflammation, immunity and cancer.","volume":"21","author":"Koliaraki","year":"2020","journal-title":"Nat. Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e521754","DOI":"10.1155\/2014\/521754","article-title":"Transforming growth factor-beta and matrix metalloproteinases: functional interactions in tumor stroma-infiltrating myeloid cells.","volume":"2014","author":"Krstic","year":"2014","journal-title":"Sci. World J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e57474","DOI":"10.1371\/journal.pone.0057474","article-title":"TGF-\u03b2-elicited induction of tissue inhibitor of metalloproteinases (TIMP)-3 expression in fibroblasts involves complex interplay between smad3, p38\u03b1, and ERK1\/2.","volume":"8","author":"Leivonen","year":"2013","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"crossref","first-page":"eaan5174","DOI":"10.1126\/scitranslmed.aan5174","article-title":"Tissue-resident mesenchymal stromal cells: implications for tissue-specific antifibrotic therapies.","volume":"10","author":"Lemos","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.omto.2021.01.006","article-title":"Inhibition of tumor invasion and metastasis by targeting TGF-\u03b2-Smad-MMP2 pathway with Asiatic Acid and Naringenin.","volume":"20","author":"Lian","year":"2021","journal-title":"Mol. Ther. Oncol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e875742","DOI":"10.1155\/2012\/875742","article-title":"Differential expression of matrix metalloproteases in human fibroblasts with different origins.","volume":"2012","author":"Lindner","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"B38","doi-asserted-by":"publisher","first-page":"119741","DOI":"10.1016\/j.biomaterials.2019.119741","article-title":"Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing.","volume":"233","author":"Mastikhina","year":"2020","journal-title":"Biomaterials"},{"key":"B39","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1039\/D0LC00644K","article-title":"A 96-well format microvascularized human lung-on-a-chip platform for microphysiological modeling of fibrotic diseases.","volume":"20","author":"Mej\u00edas","year":"2020","journal-title":"Lab. Chip"},{"key":"B40","doi-asserted-by":"publisher","first-page":"8678","DOI":"10.1038\/s41598-017-09062-y","article-title":"Silencing of TGF-\u03b21 in tumor cells impacts MMP-9 in tumor microenvironment.","volume":"7","author":"Moore-Smith","year":"2017","journal-title":"Sci. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"777","DOI":"10.3389\/fphys.2017.00777","article-title":"The processes and mechanisms of cardiac and pulmonary fibrosis.","volume":"8","author":"Murtha","year":"2017","journal-title":"Front. Physiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"eaao5553","DOI":"10.1126\/sciadv.aao5553","article-title":"The local microenvironment limits the regenerative potential of the mouse neonatal heart.","volume":"4","author":"Notari","year":"2018","journal-title":"Sci. Adv."},{"key":"B43","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.biomaterials.2019.05.022","article-title":"An on-chip model of protein paracellular and transcellular permeability in the microcirculation.","volume":"212","author":"Offeddu","year":"2019","journal-title":"Biomaterials"},{"key":"B44","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/cr.2008.316","article-title":"Roles of TGF\u03b2 in metastasis.","volume":"19","author":"Padua","year":"2009","journal-title":"Cell Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.3390\/ijms18102157","article-title":"TGF-\u03b2-induced endothelial-mesenchymal transition in fibrotic diseases.","volume":"18","author":"Pardali","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s10456-021-09797-3","article-title":"Endothelial cell plasticity at the single-cell level.","volume":"24","author":"Pasut","year":"2021","journal-title":"Angiogenesis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1097\/WNR.0000000000001014","article-title":"Generation of human vascularized brain organoids.","volume":"29","author":"Pham","year":"2018","journal-title":"Neuroreport"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.3389\/fonc.2019.01370","article-title":"Role of matrix metalloproteinases in angiogenesis and cancer.","volume":"9","author":"Quintero-Fabi\u00e1n","year":"2019","journal-title":"Front. Oncol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.tibtech.2019.12.010","article-title":"Bioengineered 3D models to recapitulate tissue fibrosis.","volume":"38","author":"Sacchi","year":"2020","journal-title":"Trends Biotechnol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3892\/mmr.2012.1213","article-title":"Substrate stiffness influences TGF-\u03b21-induced differentiation of bronchial fibroblasts into myofibroblasts in airway remodeling.","volume":"7","author":"Shi","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"B51","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.semcdb.2019.10.015","article-title":"Endothelium-mediated contributions to fibrosis.","volume":"101","author":"Sun","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease.","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0394632015617951","article-title":"Mechanical influence of tissue culture plates and extracellular matrix on mesenchymal stem cell behavior: a topical review.","volume":"29","author":"Tatullo","year":"2016","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"12384","DOI":"10.1074\/jbc.M208544200","article-title":"Myofibroblast differentiation by transforming growth factor-\u03b21 Is dependent on cell adhesion and integrin signaling via focal adhesion kinase\u2217.","volume":"278","author":"Thannickal","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1369\/jhc.5A6835.2006","article-title":"Active remodeling in idiopathic interstitial pneumonias: evaluation of collagen types XII and XIV.","volume":"54","author":"Tzortzaki","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"9769","DOI":"10.1074\/jbc.273.16.9769","article-title":"Differential effects of transforming growth factor-\u03b2 on the expression of collagenase-1 and collagenase-3 in human fibroblasts \u2217.","volume":"273","author":"Ur\u00eda","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"20377","DOI":"10.1038\/s41598-019-56955-1","article-title":"Transcriptomic changes during TGF-\u03b2-mediated differentiation of airway fibroblasts to myofibroblasts.","volume":"9","author":"Walker","year":"2019","journal-title":"Sci. Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.bbamem.2007.09.003","article-title":"Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis.","volume":"1778","author":"Wallez","year":"2008","journal-title":"Biochim. Biophys. Acta BBA Biomembr."},{"key":"B59","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/jlb.62.5.604","article-title":"Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease.","volume":"62","author":"Walz","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"121032","DOI":"10.1016\/j.biomaterials.2021.121032","article-title":"A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts.","volume":"276","author":"Wan","year":"2021","journal-title":"Biomaterials"},{"key":"B61","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.yjmcc.2021.06.001","article-title":"Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.","volume":"159","author":"Wang","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.actbio.2020.06.032","article-title":"Microenvironment stiffness requires decellularized cardiac extracellular matrix to promote heart regeneration in the neonatal mouse heart.","volume":"113","author":"Wang","year":"2020","journal-title":"Acta Biomater."},{"key":"B63","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1089\/ten.tec.2013.0370","article-title":"Control of perfusable microvascular network morphology using a multiculture microfluidic system.","volume":"20","author":"Whisler","year":"2014","journal-title":"Tissue Eng. Part C Methods"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease.","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.biomaterials.2017.08.033","article-title":"Mechanically dynamic PDMS substrates to investigate changing cell environments.","volume":"145","author":"Yeh","year":"2017","journal-title":"Biomaterials"},{"key":"B66","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s10456-018-9631-8","article-title":"Human microvasculature-on-a chip: anti-neovasculogenic effect of nintedanib in vitro.","volume":"21","author":"Zeinali","year":"2018","journal-title":"Angiogenesis"},{"key":"B67","doi-asserted-by":"crossref","first-page":"10123","DOI":"10.1158\/0008-5472.CAN-07-3127","article-title":"Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts.","volume":"67","author":"Zeisberg","year":"","journal-title":"Cancer Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.","volume":"13","author":"Zeisberg","year":"","journal-title":"Nat. Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"C216","DOI":"10.1152\/ajpcell.00328.2012","article-title":"Cellular Mechanisms of Tissue Fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis.","volume":"304","author":"Zeisberg","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1039\/D0LC01186J","article-title":"Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature.","volume":"21","author":"Zhang","year":"2021","journal-title":"Lab. Chip"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2021.735915\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T12:42:00Z","timestamp":1673527320000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2021.735915\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":70,"alternative-id":["10.3389\/fphys.2021.735915"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2021.735915","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,6]]},"article-number":"735915"}}