{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:23:30Z","timestamp":1783747410938,"version":"3.55.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["WM170007"],"award-info":[{"award-number":["WM170007"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JSPS\/OF317"],"award-info":[{"award-number":["JSPS\/OF317"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Cerebrovascular reactivity (CVR) to changes in the partial pressure of arterial carbon dioxide (PaCO<jats:sub>2<\/jats:sub>) is an important mechanism that maintains CO<jats:sub>2<\/jats:sub> or pH homeostasis in the brain. To what extent this is influenced by gravitational stress and corresponding implications for the regulation of cerebral blood flow (CBF) remain unclear. The present study examined the onset responses of pulmonary ventilation (V\u0307<jats:sub>E<\/jats:sub>) and anterior middle (MCA) and posterior (PCA) cerebral artery mean blood velocity (V<jats:sub>mean<\/jats:sub>) responses to acute hypercapnia (5% CO<jats:sub>2<\/jats:sub>) to infer dynamic changes in the central respiratory chemoreflex and cerebrovascular reactivity (CVR), in supine and 50\u00b0 head-up tilt (HUT) positions. Each onset response was evaluated using a single-exponential regression model consisting of the response time latency [CO<jats:sub>2<\/jats:sub>-response delay (<jats:italic>t<\/jats:italic><jats:sub>0<\/jats:sub>)] and time constant (<jats:italic>\u03c4<\/jats:italic>). Onset response of V\u0307<jats:sub>E<\/jats:sub> and PCA V<jats:sub>mean<\/jats:sub> to changes in CO<jats:sub>2<\/jats:sub> was unchanged during 50\u00b0 HUT compared with supine (<jats:italic>\u03c4<\/jats:italic>: V\u0307<jats:sub>E<\/jats:sub>, <jats:italic>p<\/jats:italic> = 0.707; PCA V<jats:sub>mean<\/jats:sub>, <jats:italic>p<\/jats:italic> = 0.071 vs. supine) but the MCA V<jats:sub>mean<\/jats:sub> onset response was faster during supine than during 50\u00b0 HUT (<jats:italic>\u03c4<\/jats:italic>: <jats:italic>p<\/jats:italic> = 0.003 vs. supine). These data indicate that gravitational stress selectively impaired dynamic CVR in the anterior cerebral circulation, whereas the posterior circulation was preserved, independent of any changes to the central respiratory chemoreflex. Collectively, our findings highlight the regional heterogeneity underlying CBF regulation that may have translational implications for the microgravity (and hypercapnia) associated with deep-space flight notwithstanding terrestrial orthostatic diseases that have been linked to accelerated cognitive decline and neurodegeneration.<\/jats:p>","DOI":"10.3389\/fphys.2021.749255","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T05:48:24Z","timestamp":1641448104000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute Gravitational Stress Selectively Impairs Dynamic Cerebrovascular Reactivity in the Anterior Circulation Independent of Changes to the Central Respiratory Chemoreflex"],"prefix":"10.3389","volume":"12","author":[{"given":"Hironori","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Washio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian Miles","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehiko","family":"Ogoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"R1473","DOI":"10.1152\/ajpregu.91008.2008","article-title":"Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation","volume":"296","author":"Ainslie","year":"2009","journal-title":"Am. 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