{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:42:40Z","timestamp":1786495360789,"version":"build-2736575974"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Hyperbaric oxygen (HBO<jats:sub>2<\/jats:sub>) is breathed during undersea operations and in hyperbaric medicine. However, breathing HBO<jats:sub>2<\/jats:sub> by divers and patients increases the risk of central nervous system oxygen toxicity (CNS-OT), which ultimately manifests as sympathetic stimulation producing tachycardia and hypertension, hyperventilation, and ultimately generalized seizures and cardiogenic pulmonary edema. In this study, we have tested the hypothesis that changes in electrodermal activity (EDA), a measure of sympathetic nervous system activation, precedes seizures in rats breathing 5 atmospheres absolute (ATA) HBO<jats:sub>2<\/jats:sub>. Radio telemetry and a rodent tether apparatus were adapted for use inside a sealed hyperbaric chamber. The tethered rat was free to move inside a ventilated animal chamber that was flushed with air or 100% O<jats:sub>2<\/jats:sub>. The animal chamber and hyperbaric chamber (air) were pressurized in parallel at ~1 atmosphere\/min. EDA activity was recorded simultaneously with cortical electroencephalogram (EEG) activity, core body temperature, and ambient pressure. We have captured the dynamics of EDA using time-varying spectral analysis of raw EDA (TVSymp), previously developed as a tool for sympathetic tone assessment in humans, adjusted to detect the dynamic changes of EDA in rats that occur prior to onset of CNS-OT seizures. The results show that a significant increase in the amplitude of TVSymp values derived from EDA recordings occurs on average (\u00b1SD) 1.9\u2009\u00b1\u20091.6\u2009min before HBO<jats:sub>2<\/jats:sub>-induced seizures. These results, if corroborated in humans, support the use of changes in TVSymp activity as an early \u201cphysio-marker\u201d of impending and potentially fatal seizures in divers and patients.<\/jats:p>","DOI":"10.3389\/fphys.2021.767386","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T08:29:53Z","timestamp":1641371393000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Seizures Caused by Exposure to Hyperbaric Oxygen in Rats Can Be Predicted by Early Changes in Electrodermal Activity"],"prefix":"10.3389","volume":"12","author":[{"given":"Hugo F.","family":"Posada-Quintero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol S.","family":"Landon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Stavitzski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay B.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki H.","family":"Chon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e13961","DOI":"10.14814\/phy2.13961","article-title":"Delaying latency to hyperbaric oxygen-induced CNS oxygen toxicity seizures by combinations of exogenous ketone supplements","volume":"7","author":"Ari","year":"2019","journal-title":"Phys. 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