{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:56:39Z","timestamp":1792515399449,"version":"4.5.0"},"reference-count":116,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1I1A1A01069274"],"award-info":[{"award-number":["NRF-2020R1I1A1A01069274"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Hyponatremia is frequently encountered in clinical practice and usually induced by renal water retention. Many medications are considered to be among the various causes of hyponatremia, because they either stimulate the release of arginine vasopressin (AVP) or potentiate its action in the kidney. Antidepressants, anticonvulsants, antipsychotics, diuretics, and cytotoxic agents are the major causes of drug-induced hyponatremia. However, studies addressing the potential of these drugs to increase AVP release from the posterior pituitary gland or enhance urine concentration through intrarenal mechanisms are lacking. We previously showed that in the absence of AVP, sertraline, carbamazepine, haloperidol, and cyclophosphamide each increased vasopressin V2 receptor (V2R) mRNA and aquaporin-2 (AQP2) protein and mRNA expression in primary cultured inner medullary collecting duct cells. The upregulation of AQP2 was blocked by the V2R antagonist tolvaptan or protein kinase A (PKA) inhibitors. These findings led us to conclude that the nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is the main mechanism of drug-induced hyponatremia. Previous studies have also shown that the V2R has a role in chlorpropamide-induced hyponatremia. Several other agents, including metformin and statins, have been found to induce antidiuresis and AQP2 upregulation through various V2R-independent pathways in animal experiments but are not associated with hyponatremia despite being frequently used clinically. In brief, drug-induced hyponatremia can be largely explained by AQP2 upregulation from V2R-cAMP-PKA signaling in the absence of AVP stimulation. This paper reviews the central and nephrogenic mechanisms of drug-induced hyponatremia and discusses the importance of the canonical pathway of AQP2 upregulation in drug-induced NSIAD.<\/jats:p>","DOI":"10.3389\/fphys.2021.797039","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T08:09:03Z","timestamp":1639123743000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["The Role of Vasopressin V2 Receptor in Drug-Induced Hyponatremia"],"prefix":"10.3389","volume":"12","author":[{"given":"Sua","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chor Ho","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheun-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1056\/nejm200005253422107","article-title":"Hyponatremia","volume":"342","author":"Adrogu\u00e9","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1136\/bmj.1.6069.1134","article-title":"Water intoxication associated with oxytocin infusion","volume":"51","author":"Ahmad","year":"1975","journal-title":"Postgrad. Med. J."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1001\/archinte.1989.00390050095019","article-title":"Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus","volume":"149","author":"Allen","year":"1989","journal-title":"Arch. Intern. Med."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/0002-9343(81)90822-6","article-title":"Thiazide-induced hyponatremia associated with death or neurologic damage in outpatients","volume":"70","author":"Ashraf","year":"1981","journal-title":"Am. J. Med."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1136\/bmj.1.6069.1134","article-title":"Water intoxication associated with carbamazepine treatment","volume":"1","author":"Ashton","year":"1977","journal-title":"Br. Med. J."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1097\/00045391-200607000-00014","article-title":"Aripiprazole-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH)","volume":"13","author":"Bachu","year":"2006","journal-title":"Am. J. Ther."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3389\/fnins.2015.00335","article-title":"Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits","volume":"9","author":"Baribeau","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/bf01788840","article-title":"Hyponatremia related to medical anticancer treatment","volume":"4","author":"Berghmans","year":"1996","journal-title":"Support Care Cancer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/mpo.2950080312","article-title":"Studies on the antidiuretic effect of cyclophosphamide: vasopressin release and sodium excretion","volume":"8","author":"Bode","year":"1980","journal-title":"Med. Pediatr. Oncol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1515\/cclm-2014-0379","article-title":"Copeptin (CTproAVP), a new tool for understanding the role of vasopressin in pathophysiology","volume":"52","author":"Bolignano","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"F1103","DOI":"10.1152\/ajprenal.00337.2004","article-title":"Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra)","volume":"288","author":"Bouley","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/archinte.1985.00360030196034","article-title":"Water intoxication following moderate-dose intravenous cyclophosphamide","volume":"145","author":"Bressler","year":"1985","journal-title":"Arch. Intern. Med."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1146\/annurev.physiol.63.1.579","article-title":"G protein-coupled prostanoid receptors and the kidney","volume":"63","author":"Breyer","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/ki.1990.251","article-title":"Cellular mechanisms of prostaglandin E2 and vasopressin interactions in the collecting duct","volume":"38","author":"Breyer","year":"1990","journal-title":"Kidney Int."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1515\/jpem.2000.13.6.673","article-title":"Cyclophosphamide and water retention: mechanism revisited","volume":"13","author":"Campbell","year":"2000","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/oxfordjournals.annonc.a057728","article-title":"Encephalopathy with hyponatremia and inappropriate arginine vasopressin secretion following an intravenous ifosfamide infusion","volume":"1","author":"Cantwell","year":"1990","journal-title":"Ann. Oncol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"F756","DOI":"10.1152\/ajprenal.1999.277.5.F756","article-title":"Thiazide induces water absorption in the inner medullary collecting duct of normal and Brattleboro rats","volume":"277","author":"C\u00e9sar","year":"1999","journal-title":"Am. J. Phys."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1677\/jme-08-0123","article-title":"Vasopressin-independent mechanisms in controlling water homeostasis","volume":"43","author":"Cheng","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1681\/asn.2015080903","article-title":"EGF receptor inhibition by Erlotinib increases aquaporin 2-mediated renal water reabsorption","volume":"27","author":"Cheung","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1159\/000381562","article-title":"The risk of hyponatremia with desmopressin use for nocturnal polyuria","volume":"41","author":"Choi","year":"2015","journal-title":"Am. J. Nephrol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"F78","DOI":"10.1152\/ajprenal.1995.269.1.F78","article-title":"Oxytocin as an antidiuretic hormone. II. Role of V2 vasopressin receptor","volume":"269","author":"Chou","year":"","journal-title":"Am. J. Phys."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"F70","DOI":"10.1152\/ajprenal.1995.269.1.F70","article-title":"Oxytocin as an antidiuretic hormone. I. Concentration dependence of action","volume":"269","author":"Chou","year":"","journal-title":"Am. J. Phys."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1210\/jcem-30-4-528","article-title":"Effect of chlorpropamide on urinary excretion of water and solute in patients with diabetes insipidus and on water flow across isolated toad bladder","volume":"30","author":"Danisi","year":"1970","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3840","DOI":"10.1093\/ndt\/gfq317","article-title":"Carbamazepine can induce kidney water absorption by increasing aquaporin 2 expression","volume":"25","author":"De Bragan\u00e7a","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.psym.2014.01.010","article-title":"Antidepressants and the risk of hyponatremia: a class-by-class review of literature","volume":"55","author":"De Picker","year":"2014","journal-title":"Psychosomatics"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3390\/medicina48120090","article-title":"Nonsteroidal anti-inflammatory drug-induced severe hyponatremia","volume":"48","author":"Demir","year":"2012","journal-title":"Medicina"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88409","article-title":"Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus","volume":"1","author":"Efe","year":"2016","journal-title":"JCI Insight"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1056\/NEJMcp066837","article-title":"Clinical practice. The syndrome of inappropriate antidiuresis","volume":"356","author":"Ellison","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ejim.2018.11.011","article-title":"Antipsychotics and severe hyponatremia: A Swedish population-based case-control study","volume":"60","author":"Falhammar","year":"2019","journal-title":"Eur. J. Intern. Med."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1056\/NEJMoa042743","article-title":"Nephrogenic syndrome of inappropriate antidiuresis","volume":"352","author":"Feldman","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"853","DOI":"10.7326\/0003-4819-75-6-853","article-title":"Diuretic-induced hyponatremia","volume":"75","author":"Fichman","year":"1971","journal-title":"Ann. Intern. Med."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1053\/j.ajkd.2019.07.011","article-title":"Thiazide-associated hyponatremia: clinical manifestations and pathophysiology","volume":"75","author":"Filippone","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"83","DOI":"10.7326\/0003-4819-72-1-83","article-title":"Hyponatremia due to chlorpropamide. A syndrome resembling inappropriate secretion of antidiuretic hormone","volume":"72","author":"Fine","year":"1970","journal-title":"Ann. Intern. Med."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1097\/hjh.0000000000000423","article-title":"Thiazide-induced hyponatraemia is associated with increased water intake and impaired urea-mediated water excretion at low plasma antidiuretic hormone and urine aquaporin-2","volume":"33","author":"Frenkel","year":"2015","journal-title":"J. Hypertens."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"24","DOI":"10.7326\/0003-4819-110-1-24","article-title":"Thiazide-induced hyponatremia. Reproducibility by single dose rechallenge and an analysis of pathogenesis","volume":"110","author":"Friedman","year":"1989","journal-title":"Ann. Intern. Med."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1093\/annonc\/mdp312","article-title":"Successful treatment of ifosfamide-induced hyponatremia with AVP receptor antagonist without interruption of hydration for prevention of hemorrhagic cystitis","volume":"20","author":"Glezerman","year":"2009","journal-title":"Ann. Oncol."},{"key":"ref37","first-page":"1301","article-title":"Erlotinib in the treatment of non-small cell lung cancer: current status and future developments","volume":"30","author":"Gridelli","year":"2010","journal-title":"Anticancer Res."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/ki.2011.78","article-title":"Vaptans are not the mainstay of treatment in hyponatremia: perhaps not yet","volume":"80","author":"Gross","year":"2011","journal-title":"Kidney Int."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"F643","DOI":"10.1152\/ajprenal.1993.265.5.F643","article-title":"Evidence that separate PGE2 receptors modulate water and sodium transport in rabbit cortical collecting duct","volume":"265","author":"H\u00e9bert","year":"1993","journal-title":"Am. J. Phys."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1530\/eje.0.1320459","article-title":"Water retention after oral chlorpropamide is associated with an increase in renal papillary arginine vasopressin receptors","volume":"132","author":"Hensen","year":"1995","journal-title":"Eur. J. Endocrinol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/j.1476-5381.1991.tb12466.x","article-title":"Transepithelial water movement in response to carbamazepine, chlorpropamide and demeclocycline in toad urinary bladder","volume":"104","author":"Hirji","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.semnephrol.2011.09.010","article-title":"Diuretic-associated hyponatremia","volume":"31","author":"Hix","year":"2011","journal-title":"Semin. Nephrol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1210\/jcem-29-5-738","article-title":"Evidence that chlorpropamide and vasopressin share a common site of action","volume":"29","author":"Ingelfinger","year":"1969","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"vii","DOI":"10.1016\/s0889-8529(03)00004-5","article-title":"Evaluation and management of hypo-osmolality in hospitalized patients","volume":"32","author":"Janicic","year":"2003","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1159\/000066651","article-title":"Oxytocin induces apical and basolateral redistribution of aquaporin-2 in rat kidney","volume":"93","author":"Jeon","year":"2003","journal-title":"Nephron Exp. Nephrol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1055\/s-0029-1210692","article-title":"Hyponatremia and increased secretion of vasopressin induced by vincristine administration in rat","volume":"90","author":"J\u00f3j\u00e1rt","year":"1987","journal-title":"Exp. Clin. Endocrinol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1093\/ndt\/gfh413","article-title":"Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2","volume":"19","author":"Joo","year":"2004","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"F1318","DOI":"10.1152\/ajprenal.00485.2016","article-title":"Molecular mechanisms regulating aquaporin-2 in kidney collecting duct","volume":"311","author":"Jung","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jemermed.2005.02.020","article-title":"Severe hyponatremia due to desmopressin","volume":"30","author":"Kelleher","year":"2006","journal-title":"J. Emerg. Med."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1210\/jcem-47-1-204","article-title":"Lack of arginine vasopressin response to central dopamine blockade in normal adults","volume":"47","author":"Kendler","year":"1978","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"F474","DOI":"10.1152\/ajprenal.00477.2014","article-title":"Cyclophosphamide-induced vasopressin-independent activation of aquaporin-2 in the rat kidney","volume":"309","author":"Kim","year":"2015","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"F702","DOI":"10.1152\/ajprenal.00366.2007","article-title":"Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2","volume":"294","author":"Kim","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"F96","DOI":"10.1152\/ajprenal.1999.276.1.F96","article-title":"Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle\u2019s loop","volume":"276","author":"Kim","year":"1999","journal-title":"Am. J. Phys."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"F963","DOI":"10.1152\/ajprenal.00576.2020","article-title":"Psychotropic drugs upregulate aquaporin-2 via vasopressin-2 receptor\/cAMP\/protein kinase A signaling in inner medullary collecting duct cells","volume":"320","author":"Kim","year":"2021","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1097\/01.Asn.0000143476.93376.04","article-title":"Antidiuretic effect of hydrochlorothiazide in lithium-induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin-2, Na-cl co-transporter, and epithelial sodium channel","volume":"15","author":"Kim","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1016\/s0959-8049(97)00329-8","article-title":"Recurrent ifosfamide-induced hyponatraemia","volume":"33","author":"Kirch","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"F1008","DOI":"10.1152\/ajprenal.00102.2016","article-title":"Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts","volume":"310","author":"Klein","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1001\/archpedi.1969.02100030438009","article-title":"Treatment of vasopressin-sensitive diabetes insipidus with chlorpropamide","volume":"117","author":"Kunstadter","year":"1969","journal-title":"Am. J. Dis. Child."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.krcp.2013.07.005","article-title":"Regulation of aquaporin-2 in the kidney: A molecular mechanism of body-water homeostasis","volume":"32","author":"Kwon","year":"2013","journal-title":"Kidney Res. Clin. Pract."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/0006-291x(87)90641-3","article-title":"The effect of cyclophosphamide on arginine vasopressin and the atrial natriuretic factor","volume":"143","author":"Larose","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1093\/ndt\/gfp657","article-title":"Hyponatraemia induced by low-dose intravenous pulse cyclophosphamide","volume":"25","author":"Lee","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1172\/jci39680","article-title":"A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus","volume":"119","author":"Li","year":"2009","journal-title":"J. Clin. Invest."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"F309","DOI":"10.1152\/ajprenal.00001.2011","article-title":"Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of rho GTPase","volume":"301","author":"Li","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"36","DOI":"10.2310\/6650.2007.06027","article-title":"Uric acid homeostasis in the evaluation of diuretic-induced hyponatremia","volume":"55","author":"Liamis","year":"2007","journal-title":"J. Investig. Med."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1053\/j.ajkd.2008.03.004","article-title":"A review of drug-induced hyponatremia","volume":"52","author":"Liamis","year":"2008","journal-title":"Am. J. Kidney Dis."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1210\/jcem-34-4-704","article-title":"Studies of the mode of action of the sulfonylureas and phenylacetamides in enhancing the effect of vasopressin","volume":"34","author":"Lozada","year":"1972","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1080\/14740338.2017.1248399","article-title":"Hyponatremia induced by antiepileptic drugs in patients with epilepsy","volume":"16","author":"Lu","year":"2017","journal-title":"Expert Opin. Drug Saf."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/j.1552-4604.1978.tb01602.x","article-title":"Chlorthalidone-induced syndrome of inappropriate secretion of antidiuretic hormone","volume":"18","author":"Luboshitzky","year":"1978","journal-title":"J. Clin. Pharmacol."},{"key":"ref69","first-page":"136","article-title":"Treatment of monosymptomatic nocturnal enuresis: sertraline for non-responders to desmopressin","volume":"39","author":"Mahdavi-Zafarghandi","year":"2014","journal-title":"Iran J. Med. Sci."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.maturitas.2013.08.010","article-title":"Characteristics, prevalence, risk factors, and underlying mechanism of hyponatremia in elderly patients treated with antidepressants: a cross-sectional study","volume":"76","author":"Mannesse","year":"2013","journal-title":"Maturitas"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1136\/bmj.311.7000.292","article-title":"Water intoxication after low dose cyclophosphamide","volume":"311","author":"Mccarron","year":"1995","journal-title":"BMJ"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1042\/cs0490283","article-title":"Paradoxical diuresis after vasopressin administration to patients with neurohypophyseal diabetes insipidus treated with chlorpropamide, carbamazepine or clofibrate","volume":"49","author":"Meinders","year":"1975","journal-title":"Clin. Sci. Mol. Med."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1210\/endo-84-2-411","article-title":"Effect of chlorpropamide on the permeability of the urinary bladder of the toad and the response to vasopressin, adenosine-3\u2032,5\u2032-monophosphate and theophylline","volume":"84","author":"Mendoza","year":"1969","journal-title":"Endocrinology"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1210\/jcem-38-5-883","article-title":"Effect of chlorpropamide on osmotic water flow across toad bladder and the response to vasopressin, theophylline and cyclic AMP","volume":"38","author":"Mendoza","year":"1974","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1210\/endo-86-5-1024","article-title":"Potentiation of vasopressin action by chlorpropamide in vivo","volume":"86","author":"Miller","year":"1970","journal-title":"Endocrinology"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1210\/er.2012-1044","article-title":"Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment","volume":"34","author":"Moeller","year":"2013","journal-title":"Endocr. 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Scand."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/0026-0495(81)90222-5","article-title":"Chlorpropamide effect: measurement of neurophysin and vasopressin in humans and rats","volume":"30","author":"Pokracki","year":"1981","journal-title":"Metabolism"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00424-011-1007-5","article-title":"Fluvastatin modulates renal water reabsorption in vivo through increased AQP2 availability at the apical plasma membrane of collecting duct cells","volume":"462","author":"Procino","year":"2011","journal-title":"Pflugers Arch."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/0002-9343(86)90929-0","article-title":"Effect of prostaglandins on renal salt and water excretion","volume":"80","author":"Raymond","year":"1986","journal-title":"Am. J. Med."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1056\/nejm198908243210810","article-title":"Syndrome of inappropriate antidiuresis","volume":"321","author":"Robertson","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1001\/archinte.1973.03650110061013","article-title":"Vincristine neurotoxicity and abnormal secretion of antidiuretic hormone","volume":"132","author":"Robertson","year":"1973","journal-title":"Arch. Intern. Med."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1002\/ana.10190","article-title":"Effects of oxcarbazepine on sodium concentration and water handling","volume":"51","author":"Sachdeo","year":"2002","journal-title":"Ann. 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Disord."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s13730-017-0295-9","article-title":"A case of nephrogenic syndrome of inappropriate antidiuresis caused by carbamazepine","volume":"7","author":"Sekiya","year":"2018","journal-title":"CEN Case Rep."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"F525","DOI":"10.1152\/ajprenal.00617.2013","article-title":"Hydrochlorothiazide attenuates lithium-induced nephrogenic diabetes insipidus independently of the sodium-chloride cotransporter","volume":"306","author":"Sinke","year":"2014","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref97","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s00228-020-03006-8","article-title":"Association between lipid-lowering agents and severe hyponatremia: a population-based case-control study","volume":"77","author":"Skov","year":"2021","journal-title":"Eur. J. Clin. 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Nephrol."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"337","DOI":"10.14740\/jem319w","article-title":"Cyclophosphamide-induced hyponatremia in a patient with diabetes insipidus","volume":"5","author":"Steinman","year":"2015","journal-title":"J. Endocrinol. Metab."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1182\/blood.V45.3.315.315","article-title":"Syndrome of recurrent increased secretion of antidiuretic hormone following multiple doses of vincristine","volume":"45","author":"Stuart","year":"1975","journal-title":"Blood"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/s0022-3476(72)80381-0","article-title":"Syndrome of inappropriate secretion of antidiuretic hormone produced by vincristine toxicity (with bioassay of ADH level)","volume":"81","author":"Suskind","year":"1972","journal-title":"J. Pediatr."},{"key":"ref104","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1253\/jcj.34.595","article-title":"Effect of sulfonylureas on the permeability to water and electrical properties of the urinary bladder of the toad","volume":"34","author":"Urakabe","year":"1970","journal-title":"Jpn. Circ. J."},{"key":"ref105","first-page":"349","article-title":"Vincristine neurotoxicity in rodents","volume":"121","author":"Uy","year":"1967","journal-title":"Johns Hopkins Med. J."},{"key":"ref106","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/BF03258235","article-title":"Basic pharmacology of desmopressin","volume":"2","author":"Vilhardt","year":"1990","journal-title":"Drug Invest."},{"key":"ref107","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1681\/asn.2018060668","article-title":"Fluconazole increases osmotic water transport in renal collecting duct through effects on aquaporin-2 trafficking","volume":"30","author":"Vuki\u0107evi\u0107","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"F52","DOI":"10.1152\/ajprenal.2000.278.1.F52","article-title":"UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin","volume":"278","author":"Wade","year":"2000","journal-title":"Am. J. Physiol. 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