{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:33:42Z","timestamp":1780720422591,"version":"3.54.1"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Microgravity induces spinal elongation and Low Back Pain (LBP) but the pathophysiology is unknown. Changes in paraspinal muscle viscoelastic properties may play a role. Dry Immersion (DI) is a ground-based microgravity analogue that induces changes in m. <jats:italic>erector spinae<\/jats:italic> superficial myofascial tissue tone within 2\u00a0h. This study sought to determine whether bilateral m. <jats:italic>erector spinae<\/jats:italic> tone, creep, and stiffness persist beyond 2\u00a0h; and if such changes correlate with DI-induced spinal elongation and\/or LBP.<\/jats:p><jats:p>Ten healthy males lay in the DI bath at the Institute of Biomedical Problems (Moscow, Russia) for 6\u00a0h. Bilateral lumbar (L1, L4) and thoracic (T11, T9) trunk myofascial tone, stiffness and creep (MyotonPRO), and subjective LBP (0-10 NRS) were recorded before DI, after 1h, 6\u00a0h of DI, and 30min post. The non-standing spinal length was evaluated on the bath lifting platform using a bespoke stadiometer before and following DI.<\/jats:p><jats:p>DI significantly modulated m. <jats:italic>erector spinae<\/jats:italic> viscoelastic properties at L4, L1, T11, and T9 with no effect of laterality. Bilateral tissue tone was significantly reduced after 1 and 6\u00a0h DI at L4, L1, T11, and T9 to a similar extent. Stiffness was also reduced by DI at 1\u00a0h but partially recovered at 6\u00a0h for L4, L1, and T11. Creep was increased by DI at 1\u00a0h, with partial recovery at 6\u00a0h, although only T11 was significant. All properties returned to baseline 30\u00a0min following DI. Significant spinal elongation (1.17 \u00b1 0.20\u00a0cm) with mild (at 1\u00a0h) to moderate (at 6\u00a0h) LBP was induced, mainly in the upper lumbar and lower thoracic regions. Spinal length increases positively correlated (Rho = 0.847, <jats:italic>p<\/jats:italic> = 0.024) with middle thoracic (T9) tone reduction, but with no other stiffness or creep changes. Spinal length positively correlated (Rho = 0.557, <jats:italic>p<\/jats:italic> = 0.039) with Max LBP; LBP failed to correlate with any m. <jats:italic>erector spinae<\/jats:italic> measured parameters.<\/jats:p><jats:p>The DI-induced bilateral m. <jats:italic>erector spinae<\/jats:italic> tone, creep, and stiffness changes persist beyond 2\u00a0h. Evidence of spinal elongation and LBP allows suggesting that the trunk myofascial tissue changes could play a role in LBP pathogenesis observed in real and simulated microgravity. Further study is warranted with longer duration DI, assessment of IVD geometry, and vertebral column stability.<\/jats:p>","DOI":"10.3389\/fphys.2022.1039924","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T04:24:09Z","timestamp":1665635049000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Dry immersion induced acute low back pain and its relationship with trunk myofascial viscoelastic changes"],"prefix":"10.3389","volume":"13","author":[{"given":"Anastasija","family":"Plehuna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Andrew","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubov E.","family":"Amirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena S.","family":"Tomilovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya V.","family":"Rukavishnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inessa B.","family":"Kozlovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0149076","DOI":"10.1371\/journal.pone.0149076","article-title":"Muscle activity adaptations to spinal tissue creep in the presence of muscle fatigue","volume":"11","author":"Abboud","year":"2016","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"661922","DOI":"10.3389\/fphys.2021.661922","article-title":"Sharp changes in muscle tone in humans under simulated microgravity","volume":"12","author":"Amirova","year":"2021","journal-title":"Front. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.spinee.2017.08.261","article-title":"From the international space station to the clinic: How prolonged unloading may disrupt lumbar spine stability","volume":"18","author":"Bailey","year":"2018","journal-title":"Spine J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.spinee.2021.07.021","article-title":"Biomechanical changes in the lumbar spine following spaceflight and factors associated with postspaceflight disc herniation","volume":"22","author":"Bailey","year":"2022","journal-title":"Spine J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/S0140-6736(11)60610-7","article-title":"Non-specific low back pain","volume":"4","author":"Balagu\u00e9","year":"2012","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s00586-015-3917-y","article-title":"Disc herniations in astronauts: What causes them, and what does it tell us about herniation on Earth?","volume":"25","author":"Belav\u00fd","year":"2016","journal-title":"Eur. Spine J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/BRS.0b013e3181cc93e8","article-title":"Muscle atrophy and changes in spinal morphology: Is the lumbar spine vulnerable after prolonged bed-rest?","volume":"36","author":"Belav\u00fd","year":"2011","journal-title":"Spine"},{"key":"B8","volume-title":"Crew height measurements, the Apollo-Soyuz test project medical report","author":"Brown","year":"1977"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1097\/BRS.0000000000001873","article-title":"Lumbar spine paraspinal muscle and intervertebral disc height changes in astronauts after long-duration spaceflight on the international space station.","volume":"41","author":"Chang","year":"2016","journal-title":"Spine"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s005860000190","article-title":"CT imaging of trunk muscles in chronic low back pain patients and healthy control subjects","volume":"9","author":"Danneels","year":"2000","journal-title":"Eur. Spine J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3389\/fphys.2017.00799","article-title":"Multi-system deconditioning in 3-day dry immersion without daily raise","volume":"8","author":"de Abreu","year":"2017","journal-title":"Front. Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1002\/jum.14438","article-title":"Real-time ultrasound assessment of astronaut spinal anatomy and disorders on the international space station","volume":"37","author":"Garcia","year":"2018","journal-title":"J. Ultrasound Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.3389\/fphys.2017.01126","article-title":"Spinal health during unloading and reloading associated with spaceflight","volume":"8","author":"Green","year":"2018","journal-title":"Front. Physiol."},{"key":"B13","first-page":"508","article-title":"[The role of support afferents in organisation of the tonic muscle system]","volume":"90","author":"Grigor\u2019ev","year":"2004","journal-title":"Ross. Fiziol. Zh. Im. I. M. Sechenova"},{"key":"B14","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1136\/oem.59.10.680","article-title":"Working hours spent on repeated activities and prevalence of back pain","volume":"59","author":"Guo","year":"2002","journal-title":"Occup. Environ. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"537","DOI":"10.5604\/15093492.1230520","article-title":"Multiple impulse therapy in the assessment of paraspinal muscle tone in patients with low back pain","volume":"18","author":"Haladaj","year":"2016","journal-title":"Ortop. Traumatol. Rehabil."},{"key":"B16","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1152\/japplphysiol.00935.2015","article-title":"Long-duration bed rest as an analog to microgravity","volume":"120","author":"Hargens","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1016\/S0140-6736(18)30480-X","article-title":"What low back pain is and why we need to pay attention","volume":"391","author":"Hartvigsen","year":"2018","journal-title":"Lancet"},{"key":"B18","doi-asserted-by":"publisher","first-page":"S240","DOI":"10.1002\/acr.20543","article-title":"Measures of adult pain: Visual analog Scale for pain (VAS pain), numeric rating Scale for pain (NRS pain), McGill pain questionnaire (MPQ), short-form McGill pain questionnaire (SF-mpq), chronic pain grade Scale (CPGS), short form-36 bodily pain Scale (SF-36 BPS), and measure of intermittent and constant osteoarthritis pain (ICOAP)","volume":"63","author":"Hawker","year":"2011","journal-title":"Arthritis Care Res."},{"key":"B73","article-title":"How does creep of spinal tissues affect reflex activation of the back muscles? Orthopaedic Proceedings. 84","author":"Hayward","year":"2018"},{"key":"B19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.math.2006.07.017","article-title":"Multifidus size and symmetry among chronic LBP and healthy asymptomatic subjects","volume":"13","author":"Hides","year":"2008","journal-title":"Man. Ther."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1097\/01.brs.0000248453.51165.0b","article-title":"Rapid atrophy of the lumbar multifidus follows experimental disc or nerve root injury","volume":"31","author":"Hodges","year":"2006","journal-title":"Spine"},{"key":"B21","doi-asserted-by":"publisher","first-page":"14343","DOI":"10.1038\/s41598-018-32418-x","article-title":"Quantifying paraspinal muscle tone and stiffness in young adults with chronic low back pain: A reliability study","volume":"8","author":"Hu","year":"2018","journal-title":"Sci. Rep."},{"key":"B22","first-page":"256","article-title":"Back pain during 6 degrees head-down tilt approximates that during actual microgravity.","volume":"66","author":"Hutchinson","year":"1995","journal-title":"Aviat. Space Environ. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jelekin.2017.11.001","article-title":"Characterization of tissue stiffness of the infraspinatus, erector spinae, and gastrocnemius muscle using ultrasound shear wave elastography and superficial mechanical deformation","volume":"38","author":"Kelly","year":"2018","journal-title":"J. Electromyogr. Kinesiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3357\/asem.2876.2012","article-title":"Space adaptation back pain: a retrospective study","volume":"83","author":"Kertsman","year":"2012","journal-title":"Aviat. Space Environ."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1097\/00007632-200112010-00014","article-title":"Lumbar spine disc height and curvature responses to an axial load generated by a compression device compatible with magnetic resonance imaging","volume":"26","author":"Kimura","year":"2001","journal-title":"Spine"},{"key":"B25","first-page":"8","article-title":"Dry immersion as a powerful tool in studies of sensory-motor effects of microgravity","volume-title":"5th international head-out water immersion symposium: Research simulations to model microgravity","author":"Kozlovskaya","year":"2002"},{"key":"B26","first-page":"3","article-title":"Fundamental and applied objectives of investigations in immersion","volume":"42","author":"Kozlovskaya","year":"2008","journal-title":"Aviakosm. Ekol. Med."},{"key":"B27","first-page":"115","article-title":"Gravitational mechanisms in the motor system","volume-title":"Contemporary course of classical physiology","author":"Kozlovskaya","year":"2007"},{"key":"B28","first-page":"22","article-title":"Comparative analysis of the effects of weightlessness and its ground models on the speed-strength properties and the tone of human skeletal muscle","volume":"18","author":"Kozlovskaya","year":"1984","journal-title":"Aviakosm. Ekol. Med."},{"key":"B29","first-page":"345","article-title":"Gravitational mechanisms in motor system","volume-title":"Studies in real and simulated weightlessness. New concepts of motor control","author":"Kozlovskaya","year":"1987"},{"key":"B30","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.actaastro.2006.09.038","article-title":"New approaches to counter measures of the negative effects of micro-gravity in long-term space flights","volume":"60","author":"Kozlovskaya","year":"2006","journal-title":"Acta Astronaut."},{"key":"B31","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.actaastro.2006.08.010","article-title":"Role of support afferentation in control of the tonic muscle activity","volume":"60","author":"Kozlovskaya","year":"2007","journal-title":"Acta Astronaut."},{"key":"B32","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1097\/00007632-199404000-00015","article-title":"Changes in intervertebral disc cross-sectional area with bed rest and space flight flight","volume":"19","author":"LeBlanc","year":"1994","journal-title":"Spine"},{"key":"B33","first-page":"1151","article-title":"Regional muscle loss after short duration spaceflight","volume":"66","author":"LeBlanc","year":"1995","journal-title":"Aviat. Space Environ. Med."},{"key":"B34","first-page":"512","article-title":"Lumbar spine disc heights and curvature: Upright posture vs. supine compression harness","volume":"74","author":"Lee","year":"2003","journal-title":"Aviat. Space Environ. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1097\/00007632-199906150-00011","article-title":"The association between static pelvic asymmetry and low back pain","volume":"24","author":"Levangie","year":"1999","journal-title":"Spine"},{"key":"B72","doi-asserted-by":"publisher","first-page":"4294028","DOI":"10.1155\/2017\/4294028","article-title":"Relative and Absolute Interrater Reliabilities of a Hand-Held Myotonometer to Quantify Mechanical Muscle Properties in Patients with Acute Stroke in an Inpatient Ward","author":"Lo","year":"2017","journal-title":"Biomed Res. Int"},{"key":"B36","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.math.2006.02.004","article-title":"The lumbar multifidus: Does the evidence support clinical beliefs?","volume":"11","author":"MacDonald","year":"2006","journal-title":"Man. Ther."},{"key":"B37","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/ncprheum0646","article-title":"Pain measurement in patients with low back pain","volume":"3","author":"Mannion","year":"2007","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1134\/s0362119712070146","article-title":"The effects of support deprivation and stimulation of the foot support zones on the lateral stiffness and electromyogram of the resting calf muscles","volume":"38","author":"Miller","year":"2012","journal-title":"Hum. Physiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"13654","DOI":"10.1038\/s41598-022-17507-2","article-title":"Protocol and reference values for minimal detectable change of MyotonPRO and ultrasound imaging measurements of muscle and subcutaneous tissue","volume":"12","author":"Muckelt","year":"2022","journal-title":"Sci. Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.jbmt.2015.12.005","article-title":"Stiffness of resting lumbar myofascia in healthy young subjects quantified using a handheld myotonometer and concurrently with surface electromyography monitoring","volume":"20","author":"Nair","year":"2016","journal-title":"J. Bodyw. Mov. Ther."},{"key":"B41","first-page":"p63","article-title":"Human Integration design book","volume":"1","year":"2014","journal-title":"(HIDH) Revis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s00421-010-1750-x","article-title":"Long-term dry immersion: Review and prospects","volume":"111","author":"Navasiolava","year":"2011","journal-title":"Eur. J. Appl. Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s00421-002-0603-7","article-title":"Effect of support stimulation on unloaded soleus in rat.","volume":"87","author":"Nemirovskaya","year":"2002","journal-title":"Eur. J. Appl. Physiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3357\/AMHP.4169.2015","article-title":"Low back pain in microgravity and bed rest studies","volume":"86","author":"Pool-Goudzwaard","year":"2015","journal-title":"Aerosp. Med. Hum. Perform."},{"key":"B45","volume-title":"JSC-17798: Complexity of sizing for space suit applications","author":"Rajulu","year":"2009"},{"key":"B46","doi-asserted-by":"publisher","first-page":"R310","DOI":"10.1152\/ajpregu.00055.2022","article-title":"Spinal changes after 5-day dry immersion as shown by magnetic resonance imaging (DI-5-CUFFS)","volume":"323","author":"Robin","year":"2022","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1134\/s0362119717030173","article-title":"Effects of gravitational unloading on back muscles tone","volume":"43","author":"Rukavishnikov","year":"2017","journal-title":"Hum. Physiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3357\/asem.1994.2008","article-title":"Pathophysiology of low back pain during exposure to microgravity.","volume":"79","author":"Sayson","year":"2008","journal-title":"Aviat. Space Environ. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.actaastro.2012.05.016","article-title":"Back pain in space and post-flight spine injury: Mechanisms and countermeasure development","volume":"86","author":"Sayson","year":"2013","journal-title":"Acta Astronaut."},{"key":"B50","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11517-014-1211-5","article-title":"Feasibility of monitoring muscle health in microgravity environments using Myoton technology","volume":"53","author":"Schneider","year":"2015","journal-title":"Med. Biol. Eng. Comput."},{"key":"B51","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3389\/fphys.2018.00810","article-title":"Bed rest, exercise countermeasure and reconditioning effects on the human resting muscle tone system","volume":"9","author":"Schoenrock","year":"2018","journal-title":"Front. Physiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.actaastro.2006.08.012","article-title":"Afferent control mechanisms involved in the development of soleus fiber alterations in simulated hypogravity","volume":"60","author":"Shenkman","year":"2007","journal-title":"Acta Astronaut."},{"key":"B53","doi-asserted-by":"publisher","first-page":"85","DOI":"10.32607\/actanaturae.10953","article-title":"Molecular mechanisms of muscle tone impairment under conditions of real and simulated space flight","volume":"13","author":"Shenkman","year":"2021","journal-title":"Acta Naturae"},{"key":"B54","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1134\/S036211971507021X","article-title":"Effect of support deprivation on the order of motor unit recruitment","volume":"41","author":"Shigueva","year":"2015","journal-title":"Hum. Physiol."},{"key":"B55","first-page":"39","volume-title":"Simulation of the human body deconditioning with the method of \u2018\u2018dry\u2019\u2019 immersion","author":"Shulzhenko","year":"1975"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0304-3959(97)00102-4","article-title":"Understanding and measurement of muscle tone as related to clinical muscle pain","volume":"75","author":"Simons","year":"1998","journal-title":"Pain"},{"key":"B57","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/s0268-0033(03)00024-x","article-title":"Flexion-relaxation response to static lumbar flexion in males and females","volume":"18","author":"Solomonow","year":"2003","journal-title":"Clin. Biomech. (Bristol, Avon)"},{"key":"B58","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jelekin.2011.11.008","article-title":"Neuromuscular manifestations of viscoelastic tissue degradation following high and low risk repetitive lumbar flexion","volume":"22","author":"Solomonow","year":"2012","journal-title":"J. Electromyogr. Kinesiol."},{"key":"B59","first-page":"24","article-title":"Height increase, neuromuscular function, and back pain during 6 degrees head-down tilt with traction.","volume":"68","author":"Styf","year":"1997","journal-title":"Aviat. Space Environ. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.spinee.2007.11.011","article-title":"Different parts of erector spinae muscle fatigability in subjects with and without low back pain","volume":"9","author":"Sung","year":"2009","journal-title":"Spine J."},{"key":"B61","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3389\/fphys.2019.00284","article-title":"Dry immersion as a ground-based model of microgravity physiological effects","volume":"10","author":"Tomilovskaya","year":"2019","journal-title":"Front. Physiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"5","DOI":"10.21687\/0233-528X-2020-54-4-5-14","article-title":"21-day dry immersion: Design and primary results","volume":"54","author":"Tomilovskaya","year":"2020","journal-title":"Aviakosmicheskaya i Ekol. Meditsina Russ."},{"key":"B63","article-title":"Functional sensory-motor performance following long term space flight: The first results of \"field test\" experiment","volume-title":"65th international astronautical congress","author":"Tomilovskaya","year":"2014"},{"key":"B64","doi-asserted-by":"publisher","first-page":"9602131","DOI":"10.1155\/2017\/9602131","article-title":"Pain and vertebral dysfunction in dry immersion: A model of microgravity simulation different from bed rest studies","volume":"2017","author":"Treffel","year":"2017","journal-title":"Pain Res. Manag."},{"key":"B65","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3389\/fphys.2016.00605","article-title":"Intervertebral disc swelling demonstrated by 3D and water content magnetic resonance analyses after a 3-day dry immersion simulating microgravity","volume":"7","author":"Treffel","year":"2016","journal-title":"Front. Physiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3748","DOI":"10.3390\/ijms21113748","article-title":"DI-5-Cuffs: Lumbar intervertebral disc proteoglycan and water content changes in humans after five days of dry immersion to simulate microgravity","volume":"21","author":"Treffel","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/nrrheum.2018.37","article-title":"Skeletal changes during and after spaceflight","volume":"14","author":"Vico","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/s0030-5898(20)31651-5","article-title":"Back pain and spinal changes in microgravity","volume":"22","author":"Wing","year":"1991","journal-title":"Orthop. Clin. North Am."},{"key":"B69","doi-asserted-by":"publisher","first-page":"102995","DOI":"10.1016\/j.apergo.2019.102995","article-title":"Changes in seated height in microgravity","volume":"83","author":"Young","year":"2020","journal-title":"Appl. Ergon."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.1039924\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T04:24:29Z","timestamp":1665635069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.1039924\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":73,"alternative-id":["10.3389\/fphys.2022.1039924"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2022.1039924","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,13]]},"article-number":"1039924"}}