{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:59:57Z","timestamp":1788580797728,"version":"build-2803163510"},"reference-count":93,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Transient receptor potential vanilloid 1 (TRPV1), a non-selective ligand-gated cation channel with high permeability for Ca<jats:sup>2+<\/jats:sup>, has received considerable attention as potential therapeutic target for the treatment of several disorders including pain, inflammation, and hyperlipidemia. In particular, TRPV1 regulates lipid metabolism by mechanisms that are not completely understood. Interestingly, TRPV1 and lipids regulate each other in a reciprocal and complex manner. This review surveyed the recent literature dealing with the role of TRPV1 in the hyperlipidemia-associated metabolic syndrome. Besides TRPV1 structure, molecular mechanisms underlying the regulatory effect of TRPV1 on lipid metabolism such as the involvement of uncoupling proteins (UCPs), ATP-binding cassette (ABC) transporters, peroxisome proliferation-activated receptors (PPAR), sterol responsive element binding protein (SREBP), and hypoxia have been discussed. Additionally, this review extends our understanding of the lipid-dependent modulation of TRPV1 activity through affecting both the gating and the expression of TRPV1. The regulatory role of different classes of lipids such as phosphatidylinositol (PI), cholesterol, estrogen, and oleoylethanolamide (OEA), on TRPV1 has also been addressed.<\/jats:p>","DOI":"10.3389\/fphys.2022.1066023","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T05:37:16Z","timestamp":1671082636000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["The interaction of TRPV1 and lipids: Insights into lipid metabolism"],"prefix":"10.3389","volume":"13","author":[{"given":"Shtaywy S.","family":"Abdalla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani A.","family":"Harb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab M.","family":"Almasri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser K.","family":"Bustanji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102057","DOI":"10.1016\/j.ceca.2019.102057","article-title":"Deranged hepatocyte intracellular Ca2+ homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma","volume":"82","author":"Ali","year":"2019","journal-title":"Cell. Calcium"},{"key":"B2","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.lfs.2007.12.022","article-title":"Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo","volume":"82","author":"Alm\u00e1si","year":"2008","journal-title":"Life Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/s41467-021-20946-6","article-title":"Anti-inflammatory dopamine-and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel","volume":"12","author":"Arnold","year":"2021","journal-title":"Nat. Commun."},{"key":"B4","first-page":"77","article-title":"Chiral specificity of cholesterol orientation within cholesterol binding sites in inwardly rectifying K+ channels","volume-title":"The","author":"Barbera","year":"2019"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1111\/bph.13514","article-title":"Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel\u2010dependent mechanisms","volume":"173","author":"Baskaran","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1002\/1873-3468.14105","article-title":"Mice lacking endogenous TRPV1 express reduced levels of thermogenic proteins and are susceptible to diet\u2010induced obesity and metabolic dysfunction","volume":"595","author":"Baskaran","year":"2021","journal-title":"FEBS Lett."},{"key":"B7","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.bbrc.2007.10.062","article-title":"Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha\/retinoid X receptor","volume":"364","author":"Belanger","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.3390\/ijms21103421","article-title":"TRPV1: Structure, endogenous agonists, and mechanisms","volume":"21","author":"Ben\u00edtez-Angeles","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1152\/physiol.00026.2008","article-title":"Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control","volume":"23","author":"Bessac","year":"2008","journal-title":"Physiology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.3390\/ijms20071660","article-title":"Capsaicin targets lipogenesis in HepG2 cells through AMPK activation, AKT inhibition and PPARs regulation","volume":"20","author":"Bort","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plipres.2017.04.001","article-title":"Oleic acid-derived oleoylethanolamide: A nutritional science perspective","volume":"67","author":"Bowen","year":"2017","journal-title":"Prog. Lipid Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"H2489","DOI":"10.1152\/ajpheart.01191.2007","article-title":"Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome","volume":"294","author":"Bratz","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1523\/JNEUROSCI.0803-20.2020.0803-20.2020","article-title":"Deficiency of inositol monophosphatase activity decreases phosphoinositide lipids and enhances TRPV1 function in vivo","volume":"41","author":"Caires","year":"2021","journal-title":"J. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3390\/ijms23010256","article-title":"Emerging roles of calcium signaling in the development of non-alcoholic fatty liver disease","volume":"23","author":"Chen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"10839","DOI":"10.18632\/aging.102488","article-title":"HIF-2\u03b1 upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway","volume":"11","author":"Chen","year":"2019","journal-title":"Aging"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3816","DOI":"10.1096\/fj.201701303R","article-title":"Endogenously generated arachidonate\u2010derived ligands for TRPV1 induce cardiac protection in sepsis","volume":"32","author":"Chen","year":"2018","journal-title":"FASEB J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"E319","DOI":"10.1152\/ajpendo.00277.2018","article-title":"Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity","volume":"316","author":"Clemente-Postigo","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1007\/s00394-020-02459-y","article-title":"Tart cherry (Prunus cerasus L.) dietary supplement modulates visceral adipose tissue CB1 mRNA levels along with other adipogenesis-related genes in rat models of diet-induced obesity","volume":"60","author":"Cocci","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"403881","DOI":"10.1101\/403881","article-title":"Sex-specific protection against diet-induced non-alcoholic fatty liver disease in TRPV1 null mice","author":"Connell","year":"2018"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1016\/j.lfs.2005.05.021","article-title":"Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels","volume":"77","author":"De Petrocellis","year":"2005","journal-title":"Life Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1111\/bju.12876","article-title":"Transient receptor potential channel modulators as pharmacological treatments for lower urinary tract symptoms (LUTS): Myth or reality?","volume":"115","author":"Deruyver","year":"2015","journal-title":"BJU Int."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3389\/fphys.2019.01064","article-title":"The role of transient receptor potential vanilloid 1 in common diseases of the digestive tract and the cardiovascular and respiratory system","volume":"10","author":"Du","year":"2019","journal-title":"Front. Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"12775","DOI":"10.1038\/s41598-017-13054-3","article-title":"Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1","volume":"7","author":"Eberhardt","year":"2017","journal-title":"Sci. Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0021-9150(93)90224-I","article-title":"Lipopolysaccharide stimulation of RAW 264.7 macrophages induces lipid accumulation and foam cell formation","volume":"98","author":"Funk","year":"1993","journal-title":"Atherosclerosis"},{"key":"B25","doi-asserted-by":"publisher","first-page":"491963","DOI":"10.1155\/2014\/491963","article-title":"TRPV1 activation attenuates high-salt diet-induced cardiac hypertrophy and fibrosis through PPAR-\u03b4 upregulation","volume":"2014","author":"Gao","year":"2014","journal-title":"PPAR Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nature17964","article-title":"TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action","volume":"534","author":"Gao","year":"2016","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"publisher","first-page":"536a","DOI":"10.1016\/j.bpj.2018.11.2885","article-title":"Activation of TRPV1 by lipids: Can lipid tails bridge the gap between the vanilloid binding site and the peripheral cavities?","volume":"116","author":"Gianti","year":"2019","journal-title":"Biophys. J."},{"key":"B28","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.1096\/fj.10-159806","article-title":"Hypoxia\u2010inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia\u2010inducible factor\u20101","volume":"24","author":"Gimm","year":"2010","journal-title":"FASEB J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"8289","DOI":"10.29219\/fnr.v66.8289","article-title":"Capsaicin regulates lipid metabolism through modulation of bile acid\/gut microbiota metabolism in high-fat-fed SD rats","volume":"66","author":"Gong","year":"2022","journal-title":"Food Nutr. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1089\/gtmb.2019.0213","article-title":"The relationship of single nucleotide polymorphisms in the TRPV1 gene with lipid profile, glucose, and blood pressure in Mexican population","volume":"24","author":"Gonz\u00e1lez-Mercado","year":"2020","journal-title":"Genet. Test. Mol. Biomarkers"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.03.130864","article-title":"Multi-omic analysis reveals cannabidiol disruption of cholesterol homeostasis in human cell lines","author":"Guard","year":"2020"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1080\/09168451.2020.1789836","article-title":"Intragastric administration of AMG517, a TRPV1 antagonist, enhanced activity-dependent energy metabolism via capsaicin-sensitive sensory nerves in mice","volume":"84","author":"Hai","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1111\/bph.15726","article-title":"20\u2010hydroxyeicosatetraenoic acid (20\u2010HETE) is a pivotal endogenous ligand for TRPV1\u2010mediated neurogenic inflammation in the skin","volume":"179","author":"Hamers","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"14003","DOI":"10.1038\/s41598-019-50352-4","article-title":"Eugenol reduces LDL cholesterol and hepatic steatosis in hypercholesterolemic rats by modulating TRPV1 receptor","volume":"9","author":"Harb","year":"2019","journal-title":"Sci. Rep."},{"key":"B35","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/978-3-319-05161-1_11","article-title":"High-resolution views of TRPV1 and their implications for the TRP channel superfamily","volume-title":"The mammalian transient receptor potential (TRP) cation channels","author":"Hellmich","year":"2014"},{"key":"B36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.5772\/51821","article-title":"Lipid metabolism, metabolic syndrome, and cancer","volume-title":"Lipid metabolism","author":"Hu","year":"2013"},{"key":"B37","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1271\/bbb.100850","article-title":"TRPV1 agonist monoacylglycerol increases UCP1 content in Brown adipose tissue and suppresses accumulation of visceral fat in mice fed a high-fat and high-sucrose diet","volume":"75","author":"Iwasaki","year":"2011","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1248\/bpb.b14-00281","article-title":"Eugenol ameliorates hepatic steatosis and fibrosis by down-regulating SREBP1 gene expression via AMPK-mTOR-p70S6K signaling pathway","volume":"37","author":"Jo","year":"2014","journal-title":"Biol. Pharm. Bull."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1124\/mol.106.023945","article-title":"Functional mapping of the transient receptor potential vanilloid 1 intracellular binding site","volume":"70","author":"Johnson","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s12576-011-0185-4","article-title":"Differential effects of acute hypoxia on the activation of TRPV1 by capsaicin and acidic pH","volume":"62","author":"Kim","year":"2012","journal-title":"J. Physiol. Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.bbadis.2018.11.004","article-title":"Troglitazone activates TRPV1 and causes deacetylation of PPAR\u03b3 in 3T3-L1 cells","volume":"1865","author":"Krishnan","year":"2019","journal-title":"Biochim. Biophys. Acta. Mol. Basis Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s00424-012-1078-y","article-title":"TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice","volume":"463","author":"Li","year":"2012","journal-title":"Pflugers Arch."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1097\/01.hjh.0000548049.33639.c8","article-title":"A9216 Deficiency of transient receptor potential vanilloid subtype 1 and uncoupling protein 1 in Brown fat causes obesity-associated hypertension","volume":"36","author":"Li","year":"2018","journal-title":"J. Hypertens. Los. Angel."},{"key":"B44","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/s41440-021-00842-8","article-title":"Lack of TRPV1 aggravates obesity-associated hypertension through the disturbance of mitochondrial Ca2+ homeostasis in Brown adipose tissue","volume":"45","author":"Li","year":"2022","journal-title":"Hypertens. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s00424-013-1274-4","article-title":"Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor \u03b4 activation","volume":"465","author":"Li","year":"2013","journal-title":"Pflugers Arch."},{"key":"B46","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nature12822","article-title":"Structure of the TRPV1 ion channel determined by electron cryo-microscopy","volume":"504","author":"Liao","year":"2013","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fphar.2017.00316","article-title":"The alkamide trans-pellitorine targets PPAR\u03b3 via TRPV1 and TRPA1 to reduce lipid accumulation in developing 3T3-L1 adipocytes","volume":"8","author":"Lieder","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/cr.2011.205","article-title":"TRPV1 activation improves exercise endurance and energy metabolism through PGC-1\u03b1 upregulation in mice","volume":"22","author":"Luo","year":"2012","journal-title":"Cell. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"611952","DOI":"10.3389\/fcell.2021.611952","article-title":"Activation of TRPV1 by capsaicin or heat drives changes in 2-acyl glycerols and n-acyl ethanolamines in a time, dose, and temperature dependent manner","volume":"9","author":"Manchanda","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1161\/hypertensionaha.112.201434","article-title":"A role for TRPV1 in influencing the onset of cardiovascular disease in obesity","volume":"61","author":"Marshall","year":"2013","journal-title":"Hypertension"},{"key":"B51","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jtbi.2018.02.004","article-title":"Thermal actuation in TRPV1: Role of embedded lipids and intracellular domains","volume":"444","author":"Melnick","year":"2018","journal-title":"J. Theor. Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.3390\/antiox10111746","article-title":"Mitochondrial uncoupling proteins (UCPs) as key modulators of ROS homeostasis: A crosstalk between diabesity and male infertility?","volume":"10","author":"Monteiro","year":"2021","journal-title":"Antioxidants"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1016\/j.febslet.2008.05.021","article-title":"TRPV1-null mice are protected from diet-induced obesity","volume":"582","author":"Motter","year":"2008","journal-title":"FEBS Lett."},{"key":"B54","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3389\/fmolb.2020.00144","article-title":"A closer look at anandamide interaction with TRPV1","volume":"7","author":"Muller","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3389\/fcimb.2019.00150","article-title":"Phosphatidylinositol kinases and phosphatases in Entamoeba histolytica","volume":"9","author":"Nakada-Tsukui","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1152\/physiolgenomics.00226.2007","article-title":"Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo","volume":"33","author":"Neschen","year":"2008","journal-title":"Physiol. Genomics"},{"key":"B57","doi-asserted-by":"publisher","first-page":"E1568","DOI":"10.1210\/jc.2011-1131","article-title":"Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-\u03b4 agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity","volume":"96","author":"Ooi","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B58","doi-asserted-by":"publisher","first-page":"4834","DOI":"10.1038\/ncomms5834","article-title":"Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers","volume":"5","author":"Park","year":"2014","journal-title":"Nat. Commun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"F1063","DOI":"10.1152\/ajprenal.00234.2016","article-title":"Sex-dependent expression of TRPV1 in bladder arterioles","volume":"311","author":"Phan","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"24966","DOI":"10.1074\/jbc.M111.237537","article-title":"Identification of a binding motif in the S5 helix that confers cholesterol sensitivity to the TRPV1 ion channel","volume":"286","author":"Picazo-Juarez","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"7348372","DOI":"10.1155\/2017\/7348372","article-title":"Uncoupling protein 2: A key player and a potential therapeutic target in vascular diseases","volume":"2017","author":"Pierelli","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B62","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1530\/JME-15-0184","article-title":"Estrogen-dependent up-regulation of TRPA1 and TRPV1 receptor proteins in the rat endometrium","volume":"56","author":"Poh\u00f3czky","year":"2016","journal-title":"J. Mol. Endocrinol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3390\/pharmaceutics12040339","article-title":"Lipid nanoparticle inclusion prevents capsaicin-induced TRPV1 defunctionalization","volume":"12","author":"Puglia","year":"2020","journal-title":"Pharmaceutics"},{"key":"B64","doi-asserted-by":"publisher","first-page":"6256","DOI":"10.3390\/ijms21176256","article-title":"Two-Player game in a complex landscape: 26S proteasome, PKA, and intracellular calcium concentration modulate mammalian sperm capacitation by creating an integrated dialogue-A computational analysis","volume":"22","author":"Ramal-Sanchez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.pain.2011.02.024","article-title":"Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC","volume":"152","author":"Ristoiu","year":"2011","journal-title":"PAIN"},{"key":"B66","doi-asserted-by":"publisher","first-page":"19462","DOI":"10.1074\/jbc.M111.289751","article-title":"Agonist-and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation","volume":"287","author":"Sanz-Salvador","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"107952","DOI":"10.1016\/j.neuropharm.2020.107952","article-title":"The omega-3 lipid 17, 18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP)","volume":"166","author":"Sch\u00e4fer","year":"2020","journal-title":"Neuropharmacology"},{"key":"B68","article-title":"TRPV1 activation counters vascular dysfunction by increasing PPARs, SiRT-1, PGC-1\u03b1 and UCP-1 expression in the thoracic aorta","author":"Schilling","year":"2017"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fncel.2020.00002","article-title":"Beyond neuronal heat sensing: Diversity of TRPV1 heat-capsaicin receptor-channel functions","volume":"14","author":"Shuba","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"117442","DOI":"10.1016\/j.lfs.2020.117442","article-title":"Berberine attenuated olanzapine-induced metabolic alterations in mice: Targeting transient receptor potential vanilloid type 1 and 3 channels","volume":"247","author":"Singh","year":"2020","journal-title":"Life Sci."},{"key":"B71","article-title":"PPAR delta: Its role in cholesterol metabolism","author":"Skogsberg","year":"2003"},{"key":"B72","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1107\/S2053230X20001533","article-title":"Structure determination of the human TRPV1 ankyrin-repeat domain under nonreducing conditions","volume":"76","author":"Tanaka","year":"2020","journal-title":"Acta Crystallogr. F. Struct. Biol. Commun."},{"key":"B73","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.33549\/physiolres.931478","article-title":"Calcium-dependent desensitization of vanilloid receptor TRPV1: A mechanism possibly involved in analgesia induced by topical application of capsaicin","volume":"57","author":"Vyklick\u00fd","year":"2008","journal-title":"Physiol. Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"101109","DOI":"10.1016\/j.bbrep.2021.101109","article-title":"Lipid-dependent sequential allosteric activation of heat-sensing TRPV1 channels by anchor-stereoselective \u201chot\u201d vanilloid compounds and analogs","volume":"28","author":"Wang","year":"2021","journal-title":"Biochem. Biophys. Rep."},{"key":"B75","doi-asserted-by":"publisher","first-page":"37","DOI":"10.5646\/jksh.2011.17.2.37","article-title":"Transient receptor potential vanilloid type-1 channel in cardiometabolic protection","volume":"17","author":"Wang","year":"2011","journal-title":"J. Korean Soc. Hypertens."},{"key":"B76","doi-asserted-by":"publisher","first-page":"e13548","DOI":"10.1111\/jfbc.13548","article-title":"Effect of Zanthoxylum alkylamides on lipid metabolism and its mechanism in rats fed with a high\u2010fat diet","volume":"45","author":"Wang","year":"2020","journal-title":"J. Food Biochem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1039\/C3MD00177F","article-title":"Small-molecule inhibitors of SREBP activation\u2013potential for new treatment of metabolic disorders","volume":"4","author":"Watanabe","year":"2013","journal-title":"Med. Chem. Commun."},{"key":"B78","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/apha.12005","article-title":"Essential role of transient receptor potential vanilloid type 1 in evodiamine\u2010mediated protection against atherosclerosis","volume":"207","author":"Wei","year":"2013","journal-title":"Acta Physiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"C1018","DOI":"10.1152\/ajpcell.00161.2019","article-title":"TRPV1 activation mitigates hypoxic injury in mouse cardiomyocytes by inducing autophagy through the AMPK signaling pathway","volume":"318","author":"Wei","year":"2020","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/cdd.2008.12","article-title":"Biology of HIF-1\u03b1","volume":"15","author":"Weidemann","year":"2008","journal-title":"Cell. Death Differ."},{"key":"B81","doi-asserted-by":"publisher","first-page":"4706410","DOI":"10.1155\/2021\/4706410","article-title":"Total sesquiterpene glycosides from loquat leaves ameliorate HFD-induced insulin resistance by modulating IRS-1\/GLUT4, TRPV1, and SIRT6\/Nrf2 signaling pathways","volume":"2021","author":"Wu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-1719825\/v1","article-title":"Non-targeted metabolomics analysis reveals changes in plasma and skin metabolic profiles after capsaicin gavage in mice","author":"Xiao","year":"2022","journal-title":"Res. Square"},{"key":"B83","doi-asserted-by":"publisher","first-page":"18392","DOI":"10.1002\/jcp.28474","article-title":"Immunomodulatory effect of oleoylethanolamide in dendritic cells via TRPV1\/AMPK activation","volume":"234","author":"Yao","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1210\/me.2009-0352","article-title":"PPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1","volume":"24","author":"Yazawa","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"100573","DOI":"10.1016\/j.jbc.2021.100573","article-title":"Dual regulation of TRPV1 channels by phosphatidylinositol via functionally distinct binding sites","volume":"296","author":"Yazici","year":"2021","journal-title":"J. Biol. Chem."},{"key":"B86","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12986-020-00478-4","article-title":"The impact of ATP-binding cassette transporters on metabolic diseases","volume":"17","author":"Ye","year":"2020","journal-title":"Nutr. Metab."},{"key":"B87","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.3390\/ijms21114177","article-title":"Calcium entry through TRPV1: A potential target for the regulation of proliferation and apoptosis in cancerous and healthy cells","volume":"21","author":"Zhai","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/19336950.2020.1747803","article-title":"The role of TRPV1 channels in atherosclerosis","volume":"14","author":"Zhang","year":"2020","journal-title":"Channels"},{"key":"B89","doi-asserted-by":"publisher","first-page":"5138","DOI":"10.1016\/j.cell.2021.08.012","article-title":"Structural snapshots of TRPV1 reveal mechanism of polymodal functionality","volume":"184","author":"Zhang","year":"2021","journal-title":"Cell."},{"key":"B90","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1186\/s12876-020-01515-5","article-title":"HFD and HFD-provoked hepatic hypoxia act as reciprocal causation for NAFLD via HIF-independent signaling","volume":"20","author":"Zhang","year":"","journal-title":"BMC Gastroenterol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"925171","DOI":"10.1155\/2013\/925171","article-title":"Activation of TRPV1 prevents ox-LDL-induced lipid accumulation and TNF-\u03b1-induced inflammation in macrophages: Role of liver X receptor \u03b1","volume":"2013","author":"Zhao","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"B92","doi-asserted-by":"publisher","first-page":"18","DOI":"10.7150\/ijbs.13549","article-title":"Excess nitric oxide activates TRPV1-Ca2+-calpain signaling and promotes PEST-dependent degradation of liver X receptor \u03b1","volume":"12","author":"Zhao","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1002\/jcp.25704","article-title":"Versatile roles of intracellularly located TRPV1 channel","volume":"232","author":"Zhao","year":"2017","journal-title":"J. Cell. Physiol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.1066023\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T05:37:23Z","timestamp":1671082643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.1066023\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,15]]},"references-count":93,"alternative-id":["10.3389\/fphys.2022.1066023"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2022.1066023","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,15]]},"article-number":"1066023"}}