{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:14:52Z","timestamp":1792790092393,"version":"4.5.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Exercise training increases muscle VO<jats:sub>2<\/jats:sub> by increasing O<jats:sub>2<\/jats:sub> transport and O<jats:sub>2<\/jats:sub> uptake while cardiac output increase might be limited by the conformation of the chest in subjects with pectus excavatum (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the present study was to investigate the influence of physical activity (PA) on functional parameters of cardiopulmonary performance and stroke volume obtained at Cardiopulmonary Exercise Test (CPET) in PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Procedures<\/jats:title><jats:p>A cohort of adolescents (15 with PE and 15 age- and sex-matched healthy controls, HC) underwent Cardiopulmonary Exercise Test (CPET) and administration of the International Physical Activity Questionnaire \u2013 Short Form (IPAQ-SF) with estimation of weekly PA (METs h<jats:sup>\u20131<\/jats:sup>\u22c5week<jats:sup>\u20131<\/jats:sup>). Determinants of CPET parameters were investigated with multivariable linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As expected, when compared to HC, PE had lower VO<jats:sub>2<\/jats:sub> max (37.2 \u00b1 6.6 vs. 45.4 \u00b1 6.4 mL\u22c5kg<jats:sup>\u20131<\/jats:sup>\u22c5min<jats:sup>\u20131<\/jats:sup>, <jats:italic>p<\/jats:italic> &amp;lt; 0.05), and VO<jats:sub>2<\/jats:sub>\/HR max (O<jats:sub>2<\/jats:sub> pulse, 12.1 \u00b1 2.4 vs. 16.2 \u00b1 3.6 mL\u22c5min<jats:sup>\u20131<\/jats:sup>\u22c5bpm<jats:sup>\u20131<\/jats:sup>, <jats:italic>p<\/jats:italic> &amp;lt; 0.05). Importantly, physical activity level was a predictor of VO<jats:sub>2<\/jats:sub> max (adjusted for sex, body mass index, FEV<jats:sub>1<\/jats:sub>%, and presence of PE, \u03b2 = 0.085; 95% Cl 0.010 to 0.160, <jats:italic>p<\/jats:italic> = 0.029) whereas O<jats:sub>2<\/jats:sub> pulse was independent from PA level (\u03b2 = 0.035; 95% Cl \u22120.004 to 0.074).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Physical activity is a determinant of VO<jats:sub>2<\/jats:sub> max (cardiopulmonary performance), whereas it appears not to affect O<jats:sub>2<\/jats:sub> pulse (a measure of stroke volume at peak exercise) related to constrained diastolic filling in PE.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphys.2022.831504","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T07:21:33Z","timestamp":1643872893000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Differential Influence of Physical Activity on Cardiopulmonary Performance and Stroke Volume Assessed at Cardiopulmonary Exercise Test in Pectus Excavatum: A Pilot Study"],"prefix":"10.3389","volume":"13","author":[{"given":"Lorenzo","family":"Casatori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Pellegrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Messineo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ghionzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Facchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Modesti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro Amedeo","family":"Modesti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.7556\/jaoa.2017.021","article-title":"Pectus excavatum: a review of diagnosis and current treatment options.","volume":"117","author":"Abid","year":"2017","journal-title":"J. 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