{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:25:19Z","timestamp":1789575919789,"version":"build-2803163510"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    In this observational cross-sectional study, we investigated predictors of orthostatic intolerance (OI) in adults reporting long COVID symptoms. Participants underwent a 3-min active stand (AS) with Finapres\n                    <jats:sup>\u00ae<\/jats:sup>\n                    NOVA, followed by a 10-min unmedicated 70\u00b0 head-up tilt test. Eighty-five participants were included (mean age 46 years, range 25\u201378; 74% women), of which 56 (66%) reported OI during AS (OI\n                    <jats:sub>AS<\/jats:sub>\n                    ). OI\n                    <jats:sub>AS<\/jats:sub>\n                    seemed associated with female sex, more fatigue and depressive symptoms, and greater inability to perform activities of daily living (ADL), as well as a higher heart rate (HR) at the lowest systolic blood pressure (SBP) point before the first minute post-stand (mean HR\n                    <jats:sub>nadir<\/jats:sub>\n                    : 88 vs. 75 bpm,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.004). In a regression model also including age, sex, fatigue, depression, ADL inability, and peak HR after the nadir SBP, HR\n                    <jats:sub>nadir<\/jats:sub>\n                    was the only OI\n                    <jats:sub>AS<\/jats:sub>\n                    predictor (OR = 1.09, 95% CI: 1.01\u20131.18,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.027). Twenty-two (26%) participants had initial (iOH) and 5 (6%) classical (cOH\n                    <jats:sub>AS<\/jats:sub>\n                    ) orthostatic hypotension, but neither correlated with OI\n                    <jats:sub>AS<\/jats:sub>\n                    . Seventy-one participants proceeded to tilt, of which 28 (39%) had OI during tilt (OI\n                    <jats:sub>tilt<\/jats:sub>\n                    ). Of the 53 who had a 10-min tilt, 7 (13%) had an HR increase &amp;gt;30 bpm without cOH\n                    <jats:sub>tilt<\/jats:sub>\n                    (2 to HR &amp;gt; 120 bpm), but six did not report OI\n                    <jats:sub>tilt<\/jats:sub>\n                    . In conclusion, OI\n                    <jats:sub>AS<\/jats:sub>\n                    was associated with a higher initial HR on AS, which after 1 min equalised with the non-OI\n                    <jats:sub>AS<\/jats:sub>\n                    group. Despite these initial orthostatic HR differences, POTS was infrequent (2%).\n                    <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>\n                    Identifier: NCT05027724 (retrospectively registered on August 30, 2021).\n                  <\/jats:p>","DOI":"10.3389\/fphys.2022.833650","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T04:26:42Z","timestamp":1646368002000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Orthostatic Intolerance in Adults Reporting Long COVID Symptoms Was Not Associated With Postural Orthostatic Tachycardia Syndrome"],"prefix":"10.3389","volume":"13","author":[{"given":"Ann","family":"Monaghan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin","family":"Duggan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Romero-Ortuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1007\/s15010-021-01666-x","article-title":"Long COVID, a comprehensive systematic scoping review.","volume":"49","author":"Akbarialiabad","year":"2021","journal-title":"Infection"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1038\/s41591-021-01402-w","article-title":"Causation or confounding: why controls are critical for characterizing long COVID.","volume":"27","author":"Amin-Chowdhury","year":"2021","journal-title":"Nat. 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