{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:15:42Z","timestamp":1790381742210,"version":"4.1.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000893"],"award-info":[{"award-number":["82000893"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800821"],"award-info":[{"award-number":["81800821"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate choroidal vascularity (CV) and choriocapillaris blood perfusion before and after accommodation in myopia, emmetropia, and hyperopia groups among children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 39 myopic eyes from 22 subjects, 17 emmetropic eyes from 11 subjects, and 18 hyperopic eyes from 10 subjects. All subjects were children. Choroidal thickness (CT) and CV, including total choroidal area (TCA), luminal area (LA), and stromal area (SA) were measured using swept-source optical coherence tomography (SS-OCT). Choriocapillaris luminal area (CLA) was measured using SS-OCT-angiography before and after accommodation (near reading with an additional \u22123 diopter lens).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For baseline results, except horizontal CV (showing no significant differences between myopia and emmetropia groups), both horizontal and vertical CT and CV were significantly smaller in the myopia group than in the emmetropia or hyperopia groups. In terms of CLA, no significant differences were observed among the myopia, emmetropia, and hyperopia groups. In addition, only myopic eyes showed significant decreases in CT and CV, whereas most CT and CV of emmetropic and hyperopic eyes showed non-significant decreases after accommodation. Furthermore, accommodation induced no significant changes in CLA in the myopia, emmetropia, or hyperopia groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Myopia had thinner baseline choroid and lower baseline choroidal blood perfusion. Furthermore, myopic eyes were more prone to choroidal thinning and blood perfusion decreases after accommodation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2022.854240","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T05:51:06Z","timestamp":1647496266000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Assessment of Choroidal Vascularity and Choriocapillaris Blood Perfusion After Accommodation in Myopia, Emmetropia, and Hyperopia Groups Among Children"],"prefix":"10.3389","volume":"13","author":[{"given":"Xuejiao","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"21090","DOI":"10.1038\/srep21090","article-title":"Choroidal vascularity index as a measure of vascular status of the choroid: measurements in healthy eyes from a population-based study","volume":"6","author":"Agrawal","year":"2016","journal-title":"Sci. Rep."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"116027","DOI":"10.1117\/1.3652713","article-title":"Speckle reduction in optical coherence tomography imaging by affine-motion image registration","volume":"16","author":"Alonso-Caneiro","year":"2011","journal-title":"J. Biomed. Opt."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s40942-017-0081-z","article-title":"Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning","volume":"3","author":"Alshareef","year":"2017","journal-title":"Int. J. Retina Vitreous"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1167\/iovs.16-21289","article-title":"Quantitative OCT angiography of the retinal microvasculature and the choriocapillaris in myopic eyes","volume":"58","author":"Al-Sheikh","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4353","DOI":"10.1167\/iovs.08-2008","article-title":"Ciliary body thickness and refractive error in children","volume":"49","author":"Bailey","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"Baird","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1046\/j.1475-1313.2003.00135.x","article-title":"The autonomic control of accommodation and implications for human myopia development: a review","volume":"23","author":"Chen","year":"2003","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1136\/bjo.2006.102277","article-title":"Inferring myopia over the lifecourse from uncorrected distance visual acuity in childhood","volume":"91","author":"Cumberland","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1167\/iovs.04-0260","article-title":"The changing prevalence of myopia in young adults: a 13-year series of population-based prevalence surveys","volume":"46","author":"Dayan","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1167\/iovs.17-22748","article-title":"Distribution pattern of choroidal thickness at the posterior pole in Chinese children with myopia","volume":"59","author":"Deng","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1136\/bjophthalmol-2019-314769","article-title":"Optical coherence tomography angiography for the assessment of choroidal vasculature in high myopia","volume":"104","author":"Devarajan","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/519276a","article-title":"The myopia boom","volume":"519","author":"Dolgin","year":"2015","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e99690","DOI":"10.1371\/journal.pone.0099690","article-title":"Choroidal Haller\u2019s and Sattler\u2019s layer thickness measurement using 3-dimensional 1060-nm optical coherence tomography","volume":"9","author":"Esmaeelpour","year":"2014","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1159\/000310728","article-title":"Presence of a contractile cell network in the human choroid","volume":"210","author":"Fl\u00fcgel-Koch","year":"1996","journal-title":"Ophthalmologica"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"730","DOI":"10.5301\/ejo.5000965","article-title":"Choroidal thickness and ametropia in children: a longitudinal study","volume":"27","author":"Fontaine","year":"2017","journal-title":"Eur. J. Ophthalmol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/OPX.0000000000000166","article-title":"Axial elongation associated with biomechanical factors during near work","volume":"91","author":"Ghosh","year":"2014","journal-title":"Optom. Vis. Sci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e0219785","DOI":"10.1371\/journal.pone.0219785","article-title":"Optical coherence tomography angiography of superficial retinal vessel density and foveal avascular zone in myopic children","volume":"14","author":"Golebiewska","year":"2019","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1016\/S0140-6736(00)02864-6","article-title":"Nearwork and myopia","volume":"356","author":"Goss","year":"2000","journal-title":"Lancet"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ajo.2017.02.001","article-title":"Characterization of choroidal morphologic and vascular features in young men with high myopia using spectral-domain optical coherence tomography","volume":"177","author":"Gupta","year":"2017","journal-title":"Am J. Ophthalmol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.visres.2008.10.008","article-title":"Spectacle lens compensation in the pigmented Guinea pig","volume":"49","author":"Howlett","year":"2008","journal-title":"Vis. Res."},{"key":"ref22","first-page":"1259","article-title":"Vision-dependent changes in the choroidal thickness of macaque monkeys","volume":"41","author":"Hung","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1167\/iovs.07-0804","article-title":"Role of near work in myopia: findings in a sample of Australian school children","volume":"49","author":"Ip","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1097\/IAE.0000000000002090","article-title":"Longitudinal changes in choroidal and retinal thicknesses in children with myopic shift","volume":"39","author":"Jin","year":"2019","journal-title":"Retina"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s00417-020-04620-z","article-title":"Analysis of choroidal thickness and vascularity in patients with unilateral polypoidal choroidal vasculopathy","volume":"258","author":"Lee","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.18240\/ijo.2017.08.08","article-title":"Diurnal macular choroidal area fluctuation in normal and primary open angle glaucoma groups","volume":"10","author":"Li","year":"","journal-title":"Int. J. Ophthalmol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1167\/iovs.14-15016","article-title":"Choroidal thickness in relation to birth parameters in 11- to 12-year-old children: the Copenhagen child cohort 2000 eye study","volume":"56","author":"Li","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e247","DOI":"10.1111\/aos.13564","article-title":"Influence of exercise on the structure of the anterior chamber of the eye","volume":"96","author":"Li","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e6293","DOI":"10.1097\/MD.0000000000006293","article-title":"Choroidal area assessment in various fundus sectors of patients at different stages of primary open-angle glaucoma by using enhanced depth imaging optical coherence tomography","volume":"96","author":"Li","year":"","journal-title":"Medicine (Baltimore)"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e1002674","DOI":"10.1371\/journal.pmed.1002674","article-title":"Prediction of myopia development among Chinese school-aged children using refraction data from electronic medical records: a retrospective, multicentre machine learning study","volume":"15","author":"Lin","year":"2018","journal-title":"PLoS Med."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.exer.2009.02.019","article-title":"Axial myopia induced by hyperopic defocus in Guinea pigs: a detailed assessment on susceptibility and recovery","volume":"89","author":"Lu","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/j.visres.2004.11.022","article-title":"Sympathetic innervation of ciliary muscle and oculomotor function in emmetropic and myopic young adults","volume":"45","author":"Mallen","year":"2005","journal-title":"Vis. Res."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"3827","DOI":"10.1523\/JNEUROSCI.07-12-03827.1987","article-title":"Cholinergic innervation of the smooth muscle cells in the choroid coat of the chick eye and its development","volume":"7","author":"Meriney","year":"1987","journal-title":"J. Neurosci."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e013571","DOI":"10.1136\/bmjopen-2016-013571","article-title":"Vascular flow density in pathological myopia: an optical coherence tomography angiography study","volume":"7","author":"Mo","year":"2017","journal-title":"BMJ Open"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1016\/S0140-6736(12)60272-4","article-title":"Myopia","volume":"379","author":"Morgan","year":"2012","journal-title":"Lancet"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/eye.2008.178","article-title":"Ciliary body thickness in unilateral high axial myopia","volume":"23","author":"Muftuoglu","year":"2009","journal-title":"Eye"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s00417-020-04616-9","article-title":"Evaluation of choroidal thickness and choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) using SD-OCT and Angio-OCT","volume":"258","author":"Noce","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"11","DOI":"10.18926\/AMO\/30704","article-title":"Electron microscopic studies on retinochoroidal atrophy in the human eye","volume":"36","author":"Okabe","year":"1982","journal-title":"Acta Med. Okayama"},{"key":"ref39","first-page":"1765","article-title":"Nonvascular contractile cells in sclera and choroid of humans and monkeys","volume":"39","author":"Poukens","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.1167\/iovs.13-11658","article-title":"Region-specific relationships between refractive error and ciliary muscle thickness in children","volume":"54","author":"Pucker","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/s0002-9394(14)70484-2","article-title":"Indocyanine green angiographic features of pathologic myopia","volume":"122","author":"Quaranta","year":"1996","journal-title":"Am. J. Ophthalmol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1167\/iovs.15-16446","article-title":"Longitudinal changes in choroidal thickness and eye growth in childhood","volume":"56","author":"Read","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"7578","DOI":"10.1167\/iovs.13-12772","article-title":"Choroidal thickness in myopic and nonmyopic children assessed with enhanced depth imaging optical coherence tomography","volume":"54","author":"Read","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s00417-019-04555-0","article-title":"Stopping the rise of myopia in Asia","volume":"258","author":"Spillmann","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s00417-020-04639-2","article-title":"Quantitative assessment of the retinal microvasculature and choriocapillaris in myopic patients using swept-source optical coherence tomography angiography","volume":"258","author":"Su","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref46","first-page":"1678","article-title":"Posterior attachment of ciliary muscle in young, accommodating old, presbyopic monkeys","volume":"32","author":"Tamm","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.ajo.2015.04.039","article-title":"Luminal and stromal areas of choroid determined by Binarization method of optical coherence tomographic images","volume":"160","author":"Tan","year":"2015","journal-title":"Am J. Ophthalmol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"6452","DOI":"10.1167\/iovs.13-13771","article-title":"Macular choroidal thicknesses in healthy adults\u2013relationship with ocular and demographic factors","volume":"55","author":"Tan","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1167\/iovs.11-8782","article-title":"Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography","volume":"53","author":"Tan","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1167\/iovs.07-0197","article-title":"Additivity of near work-induced transient myopia and its decay characteristics in different refractive groups","volume":"49","author":"Vasudevan","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ophtha.2014.07.030","article-title":"Visual consequences of refractive errors in the general population","volume":"122","author":"Verhoeven","year":"2015","journal-title":"Ophthalmology"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0042-6989(94)e0049-q","article-title":"Moving the retina: choroidal modulation of refractive state","volume":"35","author":"Wallman","year":"1995","journal-title":"Vis. Res."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1001\/jamaophthalmol.2018.2658","article-title":"Incidence of and factors associated with myopia and high myopia in Chinese children, based on refraction without cycloplegia","volume":"136","author":"Wang","year":"2018","journal-title":"JAMA. Ophthalmol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ophtha.2012.07.048","article-title":"Subfoveal choroidal thickness: the Beijing eye study","volume":"120","author":"Wei","year":"2013","journal-title":"Ophthalmology"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/0042-6989(94)00233-c","article-title":"Choroidal and scleral mechanisms of compensation for spectacle lenses in chicks","volume":"35","author":"Wildsoet","year":"1995","journal-title":"Vis. Res."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s10654-015-0010-0","article-title":"Prevalence of refractive error in Europe: the European eye epidemiology (E(3)) consortium","volume":"30","author":"Williams","year":"2015","journal-title":"Eur. J. Epidemiol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.visres.2012.09.009","article-title":"Axial length and choroidal thickness changes accompanying prolonged accommodation in myopes and emmetropes","volume":"72","author":"Woodman","year":"2012","journal-title":"Vis. Res."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1136\/bjo.2010.180323","article-title":"Axial elongation following prolonged near work in myopes and emmetropes","volume":"95","author":"Woodman","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"6414","DOI":"10.1167\/iovs.15-17102","article-title":"Regional changes in choroidal thickness associated with accommodation","volume":"56","author":"Woodman-Pieterse","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1167\/iovs.62.9.40","article-title":"Differences in retinal and choroidal vasculature and perfusion related to axial length in pediatric anisomyopes","volume":"62","author":"Wu","year":"","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/iovs.62.1.8","article-title":"Assessment of choroidal vascularity and choriocapillaris blood perfusion in anisomyopic adults by SS-OCT\/OCTA","volume":"62","author":"Wu","year":"","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ajo.2020.01.003","article-title":"Changes in choroidal thickness varied by age and refraction in children and adolescents: a 1-year longitudinal study","volume":"213","author":"Xiong","year":"2020","journal-title":"Am J. Ophthalmol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1111\/opo.12875","article-title":"Wide-field choroidal thickness and vascularity index in myopes and emmetropes","volume":"41","author":"Yazdani","year":"2021","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"15382","DOI":"10.1038\/s41598-021-94680-w","article-title":"Effects of prolonged use of virtual reality smartphone-based head-mounted display on visual parameters: a randomised controlled trial","volume":"11","author":"Yoon","year":"2021","journal-title":"Sci. Rep."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"3074","DOI":"10.1167\/iovs.18-26397","article-title":"Changes in choroidal thickness and choroidal blood perfusion in Guinea pig myopia","volume":"60","author":"Zhang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1167\/iovs.17-22953","article-title":"A novel strategy for quantifying choriocapillaris flow voids using swept-source OCT angiography","volume":"59","author":"Zhang","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.1038\/s41598-018-22745-4","article-title":"Macular choroidal small-vessel layer, Sattler\u2019s layer and Haller\u2019s layer thicknesses: the Beijing Eye Study","volume":"8","author":"Zhao","year":"2018","journal-title":"Sci. Rep."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40662-020-00224-0","article-title":"Choroidal blood perfusion as a potential \u201crapid predictive index\u201d for myopia development and progression","volume":"8","author":"Zhou","year":"2021","journal-title":"Eye Vis."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1167\/iovs.04-0956","article-title":"In a matter of minutes, the eye can know which way to grow","volume":"46","author":"Zhu","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.854240\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T05:51:12Z","timestamp":1647496272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.854240\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,17]]},"references-count":69,"alternative-id":["10.3389\/fphys.2022.854240"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2022.854240","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,17]]},"article-number":"854240"}}