{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:41:54Z","timestamp":1792564914400,"version":"4.5.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> This study aimed to investigate the application value of the renal region of interest (ROI) corrected by computed tomography (CT) in single-kidney glomerular filtration rate (GFR) in patients with hydronephrosis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 46 patients with hydronephrosis were divided into four groups based on their degree of unilateral hydronephrosis: a normal group (left kidney and right kidney) and three abnormal groups (mild, moderate, and severe hydronephrosis). GFR was measured using the two-sample method (tGFR). The single-kidney GFR of each patient was derived from differential renal function values in dynamic renal imaging multiplied by GFR. The single-kidney GFRs, including GFR from the Gates method (gGFR<jats:sub>single<\/jats:sub>) and CT area-corrected GFR (aGFR<jats:sub>single<\/jats:sub>), were compared with tGFR<jats:sub>single<\/jats:sub>. A paired-sample <jats:italic>t<\/jats:italic>-test and Pearson\u2019s test were used for data analysis. <jats:italic>p<\/jats:italic> &amp;lt; 0.05 was considered statistically significant.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There were no significant differences between aGFR<jats:sub>single<\/jats:sub> and tGFR<jats:sub>single<\/jats:sub> in patients in the normal, mild hydronephrosis, and moderate hydronephrosis groups (<jats:italic>t<\/jats:italic> = \u20130.604\u223c1.982, all <jats:italic>p<\/jats:italic> &amp;gt; 0.05), but there was a significant difference between them in the severe hydronephrosis group (<jats:italic>t<\/jats:italic> = 2.302, <jats:italic>p<\/jats:italic> &amp;lt; 0.05). There were no significant differences between gGFR<jats:sub>single<\/jats:sub> and tGFR<jats:sub>single<\/jats:sub> in the normal and mild hydronephrosis groups (<jats:italic>t<\/jats:italic> = 0.194\u223c0.962, all <jats:italic>p<\/jats:italic> &amp;gt; 0.05), but there was a significant difference between them in the moderate and severe hydronephrosis groups (<jats:italic>t<\/jats:italic> = 3.321, 3.494, <jats:italic>p<\/jats:italic> &amp;lt; 0.05). Both gGFR<jats:sub>single<\/jats:sub> and aGFR<jats:sub>single<\/jats:sub> were correlated with tGFR<jats:sub>single<\/jats:sub>, with aGFR<jats:sub>single<\/jats:sub> being more strongly correlated (<jats:italic>r<\/jats:italic> = 0.890, <jats:italic>p<\/jats:italic> &amp;lt; 0.001).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In patients with moderate hydronephrosis, aGFR<jats:sub>single<\/jats:sub> is more strongly correlated with tGFR<jats:sub>single<\/jats:sub> than gGFR<jats:sub>single<\/jats:sub>. However, in patients with severe hydronephrosis and accompanying renal morphological changes, the aGFR<jats:sub>single<\/jats:sub> measured by the renal ROI area-correction method using CT has higher accuracy and better clinical application value than the conventional gGFR<jats:sub>single<\/jats:sub>.<\/jats:p>","DOI":"10.3389\/fphys.2022.861895","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T07:21:46Z","timestamp":1652080906000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Application Value of the Renal Region of Interest Corrected by Computed Tomography in Single-Kidney Glomerular Filtration Rate for the Evaluation of Patients With Moderate or Severe Hydronephrosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Haixia","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deshan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2577","DOI":"10.1093\/ndt\/gfl227","article-title":"Differences in Decline in GFR with Age between Males and Females. 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