{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:09:34Z","timestamp":1791360574501,"version":"4.3.1"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>The kisspeptin receptor, crucial for hypothalamic control of puberty and reproduction, is also present in the pituitary gland. Its role in the pituitary gland is not defined. Kisspeptin signaling <jats:italic>via<\/jats:italic> the Kiss1r could potentially regulate reproductive function at the level of pituitary gonadotrope. Using Cre\/Lox technology, we deleted the <jats:italic>Kiss1r<\/jats:italic> gene in pituitary gonadotropes (PKiRKO). PKiRKO males have normal genital development (anogenital distance WT: 19.1 \u00b1 0.4 vs. PKiRKO: 18.5 \u00b1 0.4\u00a0mm), puberty onset, testes cell structure on gross histology, normal testes size, and fertility. PKiRKO males showed significantly decreased serum FSH levels compared to WT males (5.6 \u00b1 1.9 vs. 10.2 \u00b1 1.8\u00a0ng\/ml) with comparable LH (1.1 \u00b1 0.2 vs. 1.8 \u00b1 0.4\u00a0ng\/ml) and testosterone levels (351.8 \u00b1 213.0 vs. 342.2 \u00b1 183.0\u00a0ng\/dl). PKiRKO females have normal puberty onset, cyclicity, LH and FSH levels and fertility. Overall, these findings indicate that absence of pituitary Kiss1r reduces FSH levels in male mice without affecting testis function. PKiRKO mice have normal reproductive function in both males and females.<\/jats:p>","DOI":"10.3389\/fphys.2022.868593","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T15:45:59Z","timestamp":1650987959000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Lower FSH With Normal Fertility in Male Mice Lacking Gonadotroph Kisspeptin Receptor"],"prefix":"10.3389","volume":"13","author":[{"given":"Yaping","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olubusayo","family":"Awe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Radovick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Divall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5488","DOI":"10.1210\/en.2009-0604","article-title":"Melanocortins May Stimulate Reproduction by Activating Orexin Neurons in the Dorsomedial Hypothalamus and Kisspeptin Neurons in the Preoptic Area of the Ewe","volume":"150","author":"Backholer","year":"2009","journal-title":"Endocrinology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/00003081-198528030-00013","article-title":"Body Weight and the Initiation of Puberty","volume":"28","author":"Baker","year":"1985","journal-title":"Clin. 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