{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:00:16Z","timestamp":1769756416588,"version":"3.49.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Background and Purpose:<\/jats:bold> Delayed intraparenchymal hemorrhages (DIPHs) are one of the most serious complications of cerebral aneurysm treatment with flow diverters (FD), yet their causes are largely unknown. This study analyzes distal hemodynamic alterations induced by the treatment of intracranial aneurysms with FDs.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A realistic model of the brain arterial network was constructed from MRA images and extended with a constrained constructive optimization technique down to vessel diameters of approximately <jats:inline-formula><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"m1\"><mml:mrow><mml:mn>50<\/mml:mn><mml:mi>\u03bc<\/mml:mi><mml:mi>m<\/mml:mi><\/mml:mrow><\/mml:math><\/jats:inline-formula>. Different variants of the circle of Willis were created by alternatively occluding communicating arteries. Collateral vessels connecting different arterial trees were then added to the model, and a distributed lumped parameter approach was used to model the pulsatile blood flow in the arterial network. The treatment of an ICA aneurysm was modeled by changing the local resistance, flow inertia, and compliance of the aneurysmal segment.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The maximum relative change in distal pressure induced by the aneurysm treatment was below 1%. However, for certain combinations of the circle of Willis and distal collateralization, important flow reversals (with a wall shear stress larger than approximately <jats:inline-formula><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"m2\"><mml:mrow><mml:mn>1.0<\/mml:mn><mml:mo>\u00a0<\/mml:mo><mml:mi>d<\/mml:mi><mml:mi>y<\/mml:mi><mml:mi>n<\/mml:mi><mml:mi>e<\/mml:mi><mml:mo>\/<\/mml:mo><mml:mi>c<\/mml:mi><mml:msup><mml:mi>m<\/mml:mi><mml:mn>2<\/mml:mn><\/mml:msup><\/mml:mrow><\/mml:math><\/jats:inline-formula>) were observed in collateral vessels, both ipsilaterally and contralaterally to the treated aneurysm.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This study suggests the hypothesis that flow diverters treatment of intracranial aneurysms could cause important flow reversal in distal collaterals. Flow reversal has previously been shown to be pro-inflammatory and pro-atherogenic and could therefore have a detrimental effect on these collateral vessels, and thus could be a suitable explanation of DIPHs, while the small distal pressure increase is not.<\/jats:p>","DOI":"10.3389\/fphys.2022.881627","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T06:20:32Z","timestamp":1658125232000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Flow reversal in distal collaterals as a possible mechanism of delayed intraparenchymal hemorrhage after flow diversion treatment of cerebral aneurysms"],"prefix":"10.3389","volume":"13","author":[{"given":"Sara","family":"Hadad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aseem","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramanathan","family":"Kadirvel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kallmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan R.","family":"Cebral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Mut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0166569","DOI":"10.1371\/journal.pone.0166569","article-title":"Interaction between the stress phase Angle (SPA) and the oscillatory shear index (OSI) affects endothelial cell gene expression","volume":"11","author":"Amaya","year":"2016","journal-title":"PloS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1227\/01.neu.0000430297.17961.f1","article-title":"Flow-diverter devices for intracranial aneurysms: Systematic review and meta-analysis","volume":"73","author":"Arrese","year":"2013","journal-title":"Neurosurgery"},{"key":"B3","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1161\/STROKEAHA.112.678151","article-title":"Endovascular treatment of intracranial aneurysms with flow diverters: A meta-analysis","volume":"44","author":"Brinjikji","year":"2013","journal-title":"Stroke"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1161\/01.STR.0000095791.85737.65","article-title":"Anatomy and functionality of leptomeningeal anastomoses: A review","volume":"34","author":"Brozici","year":"2003","journal-title":"Stroke"},{"key":"B5","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s11517-009-0492-6","article-title":"Dynamics of pulsatile flow in fractal models of vascular branching networks","volume":"47","author":"Bui","year":"2009","journal-title":"Med. 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