{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:45:33Z","timestamp":1781325933463,"version":"3.54.1"},"reference-count":119,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Pain is one of the most serious problems plaguing human health today. Pain is not an independent pathophysiological condition and is associated with a high impact on elevated disability and organ dysfunction. Several lines of evidence suggested the associations of pain with cardiovascular diseases, especially myocardial ischemia-reperfusion (I\/R) injury, while the role of pain in I\/R injury and related mechanisms are not yet comprehensively assessed. In this review, we attempted to explore the role of pain in myocardial I\/R injury, and we concluded that acute pain protects myocardial ischemia-reperfusion injury and chronic pain aggravates cardiac ischemia-reperfusion injury. In addition, the construction of different pain models and animal models commonly used to study the role of pain in myocardial I\/R injury were discussed in detail, and the potential mechanism of pain-related myocardial I\/R injury was summarized. Finally, the future research direction was prospected. That is, the remote regulation of pain to cardiac function requires peripheral pain signals to be transmitted from the peripheral to the cardiac autonomic nervous system, which then affects autonomic innervation during cardiac ischemia-reperfusion injury and finally affects the cardiac function.<\/jats:p>","DOI":"10.3389\/fphys.2022.900664","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T10:35:23Z","timestamp":1662114923000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Opportunities and challenges of pain-related myocardial ischemia-reperfusion injury"],"prefix":"10.3389","volume":"13","author":[{"given":"Wenhua","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"108997","DOI":"10.1016\/j.jneumeth.2020.108997","article-title":"Animal models of pain: Diversity and benefits","volume":"348","author":"Abboud","year":"2021","journal-title":"J. Neurosci. Methods"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.3109\/09638280902874154","article-title":"Increased mortality among individuals with chronic widespread pain relates to lifestyle factors: A prospective population-based study","volume":"31","author":"Andersson","year":"2009","journal-title":"Disabil. Rehabil."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1002\/cphy.c150046","article-title":"Neurocardiology: Structure-Based function","volume":"6","author":"Ardell","year":"2016","journal-title":"Compr. Physiol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002287","article-title":"Classification of chronic pain for the international classification of diseases (ICD-11): Results of the 2017 international WHO field testing","volume":"63","author":"Barke","year":"2021","journal-title":"PAIN"},{"key":"B5","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s00395-014-0452-7","article-title":"Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning","volume":"110","author":"Barsukevich","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1113\/expphysiol.2012.064923","article-title":"Remote ischaemic pre- and delayed postconditioning - similar degree of cardioprotection but distinct mechanisms","volume":"97","author":"Basalay","year":"2012","journal-title":"Exp. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00395-018-0684-z","article-title":"Neural mechanisms in remote ischaemic conditioning in the heart and brain: Mechanistic and translational aspects","volume":"113","author":"Basalay","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00395-020-00825-9","article-title":"Targeting myocardial ischaemic injury in the absence of reperfusion","volume":"115","author":"Basalay","year":"2020","journal-title":"Basic Res. Cardiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.1111\/bph.15021","article-title":"Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options","volume":"177","author":"Bencsik","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: A report from the American heart association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"B11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1161\/01.cir.96.5.1641","article-title":"Ischemic preconditioning at a distance: Reduction of myocardial infarct size by partial reduction of blood supply combined with rapid stimulation of the gastrocnemius muscle in the rabbit","volume":"96","author":"Birnbaum","year":"1997","journal-title":"Circulation"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1111\/jocn.15292","article-title":"Chronic pain, cardiovascular health and related medication use in ageing African Americans with osteoarthritis","volume":"29","author":"Booker","year":"2020","journal-title":"J. Clin. Nurs."},{"key":"B14","doi-asserted-by":"publisher","first-page":"102030","DOI":"10.1016\/j.pneurobio.2021.102030","article-title":"Neuropathic pain modeling: Focus on synaptic and ion channel mechanisms","volume":"201","author":"Bouali-Benazzouz","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.pain.2007.08.013","article-title":"Prevalence of chronic pain with neuropathic characteristics in the general population","volume":"136","author":"Bouhassira","year":"2008","journal-title":"Pain"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1172\/jci112160","article-title":"Myocardial reperfusion: A double-edged sword?","volume":"76","author":"Braunwald","year":"1985","journal-title":"J. Clin. Invest."},{"key":"B17","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in europe: Prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur. J. Pain"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1002\/jnr.23768","article-title":"Animal models of chronic pain: Advances and challenges for clinical translation","volume":"95","author":"Burma","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/s0304-3959(01)00354-2","article-title":"A new model of sciatic inflammatory neuritis (SIN): Induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats","volume":"94","author":"Chacur","year":"2001","journal-title":"Pain"},{"key":"B20","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.tcm.2019.10.011","article-title":"Hype or hope: Vagus nerve stimulation against acute myocardial ischemia-reperfusion injury","volume":"30","author":"Chen","year":"2020","journal-title":"Trends cardiovasc. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/s41467-017-00891-z","article-title":"Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus","volume":"8","author":"Cheng","year":"2017","journal-title":"Nat. Commun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/978-981-13-1756-9_9","article-title":"Chronic neuropathic pain protects the heart from ischemia-reperfusion injury","volume":"1099","author":"Cheng","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1016\/j.jacc.2006.01.066","article-title":"Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: First clinical application in humans","volume":"47","author":"Cheung","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/s0140-6736(16)31460-x","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: A systematic analysis for the global burden of disease study 2015","volume":"388","author":"Collaborators","year":"2016","journal-title":"Lancet"},{"key":"B25","doi-asserted-by":"publisher","first-page":"S183","DOI":"10.1007\/s10072-006-0598-7","article-title":"Medications for neuropathic pain: Current trends","volume":"27","author":"Colombo","year":"2006","journal-title":"Neurol. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0304-3959(93)90059-x","article-title":"Streptozocin-induced diabetic rats: Behavioural evidence for a model of chronic pain","volume":"53","author":"Courteix","year":"1993","journal-title":"Pain"},{"key":"B27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s0304-3959(00)00276-1","article-title":"Spared nerve injury: An animal model of persistent peripheral neuropathic pain","volume":"87","author":"Decosterd","year":"2000","journal-title":"Pain"},{"key":"B28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0304-3959(94)90145-7","article-title":"Characterization of a neuropathic pain model: Sciatic cryoneurolysis in the rat","volume":"56","author":"DeLeo","year":"1994","journal-title":"Pain"},{"key":"B29","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.pain.2011.09.018","article-title":"Unpacking the burden: Understanding the relationships between chronic pain and comorbidity in the general population","volume":"153","author":"Dominick","year":"2012","journal-title":"Pain"},{"key":"B30","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.sjpain.2016.06.005","article-title":"Assessing the relationship between chronic pain and cardiovascular disease: A systematic review and meta-analysis","volume":"13","author":"Fayaz","year":"2016","journal-title":"Scand. J. Pain"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/s0140-6736(16)31460-x","article-title":"Global regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE)","volume":"388","author":"Forget","year":"","journal-title":"1990-2015 a Syst. analysis Glob. Burd. Dis. Study 2015 Lancet"},{"key":"B32","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/clc.4960220911","article-title":"Determinants of collateral development in patients with acute myocardial infarction","volume":"22","author":"Fujita","year":"1999","journal-title":"Clin. Cardiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"135966","DOI":"10.1016\/j.neulet.2021.135966","article-title":"Evaluating the impact of age and inflammatory duration on behavioral assessments of nociception","volume":"756","author":"Geltmeier","year":"2021","journal-title":"Neurosci. Lett."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1016\/j.pain.2013.04.043","article-title":"Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain: Results from a cross-sectional general population study","volume":"154","author":"Goodson","year":"2013","journal-title":"Pain"},{"key":"B35","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s10557-011-6321-9","article-title":"Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts","volume":"25","author":"Gross","year":"2011","journal-title":"Cardiovasc. Drugs Ther."},{"key":"B36","doi-asserted-by":"publisher","first-page":"E614","DOI":"10.3390\/ijms18030614","article-title":"Myocardial ischemic postconditioning promotes autophagy against ischemia reperfusion injury via the activation of the nNOS\/AMPK\/mTOR pathway","volume":"18","author":"Hao","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1093\/geronj\/41.1.58","article-title":"Effects of age on pain perception: Thermonociception","volume":"41","author":"Harkins","year":"1986","journal-title":"J. Gerontol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s00395-016-0588-8","article-title":"Ischaemic conditioning and targeting reperfusion injury: A 30 year voyage of discovery","volume":"111","author":"Hausenloy","year":"2016","journal-title":"Basic Res. Cardiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1093\/eurheartj\/ehw145","article-title":"Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: Trials and tribulations","volume":"38","author":"Hausenloy","year":"2017","journal-title":"Eur. Heart J."},{"key":"B40","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/jci62874","article-title":"Myocardial ischemia-reperfusion injury: A neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B41","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/s0022-2828(03)00043-9","article-title":"The mitochondrial permeability transition pore: Its fundamental role in mediating cell death during ischaemia and reperfusion","volume":"35","author":"Hausenloy","year":"2003","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/s0749-0690(05)70078-1","article-title":"The epidemiology of pain in elderly people","volume":"17","author":"Helme","year":"2001","journal-title":"Clin. Geriatr. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1093\/eurheartj\/ehw224","article-title":"The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: A continual challenge","volume":"38","author":"Heusch","year":"2017","journal-title":"Eur. Heart J."},{"key":"B44","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/circresaha.116.305348","article-title":"Molecular basis of cardioprotection: Signal transduction in ischemic pre-post-and remote conditioning","volume":"116","author":"Heusch","year":"2015","journal-title":"Circ. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","article-title":"Myocardial ischaemia-reperfusion injury and cardioprotection in perspective","volume":"17","author":"Heusch","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.1161\/01.cir.103.24.2876","article-title":"Nitroglycerin and delayed preconditioning in humans: Yet another new mechanism for an old drug?","volume":"103","author":"Heusch","year":"2001","journal-title":"Circulation"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/j.jcin.2017.05.063","article-title":"Vagal cardioprotection in reperfused acute myocardial infarction","volume":"10","author":"Heusch","year":"2017","journal-title":"JACC. Cardiovasc. Interv."},{"key":"B48","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat","volume":"50","author":"Ho Kim","year":"1992","journal-title":"Pain"},{"key":"B49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/s0304-3959(98)00067-0","article-title":"An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat","volume":"77","author":"Hu","year":"1998","journal-title":"Pain"},{"key":"B50","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","article-title":"The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain","volume":"30","author":"Hunskaar","year":"1987","journal-title":"Pain"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1378\/chest.127.4.1116","article-title":"Preinfarction angina limits myocardial infarction size in nondiabetic patients treated with primary coronary angioplasty","volume":"127","author":"Iglesias-Garriz","year":"2005","journal-title":"Chest"},{"key":"B52","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1161\/CIRCULATIONAHA.108.843938","article-title":"Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling","volume":"120","author":"Jones","year":"2009","journal-title":"Circulation"},{"key":"B53","doi-asserted-by":"publisher","first-page":"i3857","DOI":"10.1136\/bmj.i3857","article-title":"Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: Systematic review and dose-response meta-analysis for the global burden of disease study 2013","volume":"354","author":"Kyu","year":"2016","journal-title":"BMJ"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.7150\/thno.22414","article-title":"Targeting ALDH2 for therapeutic interventions in chronic pain-related myocardial ischemic susceptibility","volume":"8","author":"Li","year":"2018","journal-title":"Theranostics"},{"key":"B55","doi-asserted-by":"publisher","first-page":"H29","DOI":"10.1152\/ajpheart.01031.2001","article-title":"Sites of action of adenosine in interorgan preconditioning of the heart","volume":"283","author":"Liem","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/s0140-6736(99)01311-2","article-title":"Pain: An overview","volume":"353","author":"Loeser","year":"1999","journal-title":"Lancet"},{"key":"B57","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/ner.12927","article-title":"Chronic electrical stimulation reduces hyperalgesia and associated spinal changes induced by peripheral nerve injury","volume":"22","author":"L\u00f3pez-\u00c1lvarez","year":"2019","journal-title":"Neuromodulation"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1136\/annrheumdis-2017-211476","article-title":"Persons with chronic widespread pain experience excess mortality: Longitudinal results from UK biobank and meta-analysis","volume":"76","author":"Macfarlane","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1097\/j.pain.0000000000000676","article-title":"The epidemiology of chronic pain","volume":"157","author":"Macfarlane","year":"2016","journal-title":"Pain"},{"key":"B60","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0304-3959(96)03036-9","article-title":"Calcitonin gene-related peptide content, basal outflow and electrically-evoked release from monoarthritic rat spinal cord in vitro","volume":"66","author":"Malcangio","year":"1996","journal-title":"Pain"},{"key":"B61","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/cvr\/cvs212","article-title":"Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones","volume":"95","author":"Mastitskaya","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"Mathers","year":"2006","journal-title":"PLoS Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1093\/rheumatology\/ken424","article-title":"Musculoskeletal pain is associated with a long-term increased risk of cancer and cardiovascular-related mortality","volume":"48","author":"McBeth","year":"2009","journal-title":"Rheumatol. Oxf."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1016\/j.jacc.2019.10.009","article-title":"The global burden of cardiovascular diseases and risk factors: 2020 and beyond","volume":"74","author":"Mensah","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s00395-014-0406-0","article-title":"Transcutaneous electrical nerve stimulation as a novel method of remote preconditioning: In vitro validation in an animal model and first human observations","volume":"109","author":"Merlocco","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1253\/circj.cj-13-0385","article-title":"Postconditioning the heart of ST-elevation myocardial infarction patients","volume":"77","author":"Mewton","year":"2013","journal-title":"Circ. J."},{"key":"B67","first-page":"413","article-title":"The cardioprotective role of preinfarction angina as shown in outcomes of patients after first myocardial infarction","volume":"35","author":"Mladenovic","year":"2008","journal-title":"Tex. Heart Inst. J."},{"key":"B68","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrn2606","article-title":"Animal models of pain: Progress and challenges","volume":"10","author":"Mogil","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nrn3360","article-title":"Sex differences in pain and pain inhibition: Multiple explanations of a controversial phenomenon","volume":"13","author":"Mogil","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/s0002-8703(05)80008-0","article-title":"Relationship between antecedent angina pectoris and short-term prognosis after thrombolytic therapy for acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group","volume":"119","author":"Muller","year":"1990","journal-title":"Am. Heart J."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/0735-1097(94)00542-x","article-title":"Effect of angina pectoris on myocardial protection in patients with reperfused anterior wall myocardial infarction: Retrospective clinical evidence of \"preconditioning","volume":"25","author":"Nakagawa","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1089\/ars.2007.1679","article-title":"Ischemic preconditioning: From molecular mechanisms to therapeutic opportunities","volume":"10","author":"Otani","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"B73","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1161\/01.cir.91.2.291","article-title":"Prodromal angina limits infarct size. A role for ischemic preconditioning","volume":"91","author":"Ottani","year":"1995","journal-title":"Circulation"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1006\/jmcc.2002.2072","article-title":"Cardioprotection at a distance: Mesenteric artery occlusion protects the myocardium via an opioid sensitive mechanism","volume":"34","author":"Patel","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"H1542","DOI":"10.1152\/ajpheart.1998.275.5.H1542","article-title":"Renal ischemia preconditions myocardium: Role of adenosine receptors and ATP-sensitive potassium channels","volume":"275","author":"Pell","year":"1998","journal-title":"Am. J. Physiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/s0735-1097(97)00521-4","article-title":"Influence of collateral circulation on in-hospital death from anterior acute myocardial infarction","volume":"31","author":"P\u00e9rez-Castellano","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1177\/204946370900300102","article-title":"The cost and burden of chronic pain","volume":"3","author":"Phillips","year":"2009","journal-title":"Rev. Pain"},{"key":"B78","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/ng.3570","article-title":"Detection and interpretation of shared genetic influences on 42 human traits","volume":"48","author":"Pickrell","year":"2016","journal-title":"Nat. Genet."},{"key":"B79","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1161\/01.cir.87.3.893","article-title":"Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion","volume":"87","author":"Przyklenk","year":"1993","journal-title":"Circulation"},{"key":"B80","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s12576-013-0259-6","article-title":"Electroacupuncture reduces myocardial infarct size and improves post-ischemic recovery by invoking release of humoral, dialyzable, cardioprotective factors","volume":"63","author":"Redington","year":"2013","journal-title":"J. Physiol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00395-011-0241-5","article-title":"Remote cardioprotection by direct peripheral nerve stimulation and topical capsaicin is mediated by circulating humoral factors","volume":"107","author":"Redington","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"key":"B83","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/ncpcardio0047","article-title":"Ischemic preconditioning and preinfarction angina in the clinical arena","volume":"1","author":"Rezkalla","year":"2004","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jpain.2013.10.015","article-title":"Age and race effects on pain sensitivity and modulation among middle-aged and older adults","volume":"15","author":"Riley","year":"2014","journal-title":"J. Pain"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1093\/gerona\/glz186","article-title":"Age and sex differences in acute and osteoarthritis-like pain responses in rats","volume":"75","author":"Ro","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.trsl.2013.02.003","article-title":"Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease","volume":"161","author":"Robbins","year":"2013","journal-title":"Transl. Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"zwac127","DOI":"10.1093\/eurjpc\/zwac127","article-title":"The association between short-term, chronic localized and chronic widespread pain and risk for cardiovascular disease in the UK Biobank","author":"R\u00f6nneg\u00e5rd","year":"2022","journal-title":"Eur. J. Prev. Cardiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: Update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/s0140-6736(97)11144-8","article-title":"Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction","volume":"351","author":"Rovere","year":"1998","journal-title":"Lancet"},{"key":"B90","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","article-title":"The IASP classification of chronic pain for ICD-11: Chronic neuropathic pain","volume":"160","author":"Scholz","year":"2019","journal-title":"Pain"},{"key":"B91","doi-asserted-by":"publisher","first-page":"10886","DOI":"10.1523\/jneurosci.19-24-10886.1999","article-title":"Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain","volume":"19","author":"Schwei","year":"1999","journal-title":"J. Neurosci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1517\/14656566.2012.685163","article-title":"Targeting reperfusion injury in acute myocardial infarction: A review of reperfusion injury pharmacotherapy","volume":"13","author":"Sharma","year":"2012","journal-title":"Expert Opin. Pharmacother."},{"key":"B93","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1113\/JP272580","article-title":"Cardiac autonomic control in health and disease","volume":"594","author":"Shivkumar","year":"2016","journal-title":"J. Physiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1161\/CIRCULATIONAHA.105.558122","article-title":"Postconditioning the human heart","volume":"112","author":"Staat","year":"2005","journal-title":"Circulation"},{"key":"B95","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/s0735-1097(98)00559-2","article-title":"Renal ischemia\/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: Effects of \u201cremote preconditioning\u201d","volume":"33","author":"Takaoka","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.jss.2007.12.747","article-title":"Remote ischemic preconditioning: A novel protective method from ischemia reperfusion injury--a review","volume":"150","author":"Tapuria","year":"2008","journal-title":"J. Surg. Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1093\/eurheartj\/ehz111","article-title":"Widespread pain is a risk factor for cardiovascular mortality: Results from the Framingham heart study","volume":"40","author":"Tesarz","year":"2019","journal-title":"Eur. Heart J."},{"key":"B98","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.biopsycho.2005.11.013","article-title":"The role of vagal function in the risk for cardiovascular disease and mortality","volume":"74","author":"Thayer","year":"2007","journal-title":"Biol. Psychol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1093\/eurheartj\/ehx628","article-title":"European society of cardiology: Cardiovascular disease statistics 2017","volume":"39","author":"Timmis","year":"2018","journal-title":"Eur. Heart J."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3390\/biom11081256","article-title":"Chronic pain in the elderly: Mechanisms and distinctive features","volume":"11","author":"Tinnirello","year":"2021","journal-title":"Biomolecules"},{"key":"B101","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.ejpain.2009.07.006","article-title":"Severe chronic pain is associated with increased 10 year mortality. A cohort record linkage study","volume":"14","author":"Torrance","year":"2010","journal-title":"Eur. J. Pain"},{"key":"B102","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jpain.2005.11.008","article-title":"The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey","volume":"7","author":"Torrance","year":"2006","journal-title":"J. Pain"},{"key":"B103","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.acvd.2014.08.004","article-title":"Ischaemic postconditioning reduces infarct size: Systematic review and meta-analysis of randomized controlled trials","volume":"108","author":"Touboul","year":"2015","journal-title":"Arch. Cardiovasc. Dis."},{"key":"B104","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.jpain.2008.05.005","article-title":"Common chronic pain conditions in developed and developing countries: Gender and age differences and comorbidity with depression-anxiety disorders","volume":"9","author":"Tsang","year":"2008","journal-title":"J. Pain"},{"key":"B105","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s00395-013-0392-7","article-title":"Redox balance and cardioprotection","volume":"108","author":"Tullio","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"e0170653","DOI":"10.1371\/journal.pone.0170653","article-title":"Chronic pain, depression and cardiovascular disease linked through a shared genetic predisposition: Analysis of a family-based cohort and twin study","volume":"12","author":"van Hecke","year":"2017","journal-title":"PLoS One"},{"key":"B107","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1155\/2011\/727094","article-title":"Diet, lifestyle and chronic widespread pain: Results from the 1958 British birth cohort study","volume":"16","author":"Vandenkerkhof","year":"2011","journal-title":"Pain Res. Manag."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.3389\/fphar.2019.01253","article-title":"The TRPA1 channel in the cardiovascular system: Promising features and challenges","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"e0185663","DOI":"10.1371\/journal.pone.0185663","article-title":"Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants","volume":"12","author":"Winsvold","year":"","journal-title":"PLoS One"},{"key":"B110","doi-asserted-by":"publisher","first-page":"e0185663","DOI":"10.1371\/journal.pone.0185663","article-title":"Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants","volume":"12","author":"Winsvold","year":"","journal-title":"PLoS One"},{"key":"B111","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1212\/nxg.0000000000000010","article-title":"Genetic analysis for a shared biological basis between migraine and coronary artery disease","volume":"1","author":"Winsvold","year":"","journal-title":"Neurol. Genet."},{"key":"B112","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1212\/NXG.0000000000000010","article-title":"Genetic analysis for a shared biological basis between migraine and coronary artery disease","volume":"1","author":"Winsvold","year":"","journal-title":"Neurol. Genet."},{"key":"B113","doi-asserted-by":"publisher","first-page":"3742","DOI":"10.1172\/JCI45178","article-title":"What is this thing called pain?","volume":"120","author":"Woolf","year":"2010","journal-title":"J. Clin. Invest."},{"key":"B114","first-page":"830","article-title":"Effects of preinfarction angina on myocardial injury in patients with acute myocardial infarction: A study with resting 123I-bmipp and 201T1 myocardial SPECT","volume":"41","author":"Yamagishi","year":"2000","journal-title":"J. Nucl. Med."},{"key":"B115","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.yjmcc.2018.10.018","article-title":"Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL\/CaMKII dependent necroptosis","volume":"125","author":"Yang","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.joca.2014.11.014","article-title":"Electrical stimulation for pain relief in knee osteoarthritis: Systematic review and network meta-analysis","volume":"23","author":"Zeng","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"B117","doi-asserted-by":"publisher","first-page":"H579","DOI":"10.1152\/ajpheart.01064.2002","article-title":"Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning","volume":"285","author":"Zhao","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.tins.2016.01.006","article-title":"Neural mechanisms underlying anxiety-chronic pain interactions","volume":"39","author":"Zhuo","year":"2016","journal-title":"Trends Neurosci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/978-3-642-54215-2_23","article-title":"Trpa1","volume":"222","author":"Zygmunt","year":"2014","journal-title":"Handb. Exp. Pharmacol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.900664\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T10:35:32Z","timestamp":1662114932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.900664\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,2]]},"references-count":119,"alternative-id":["10.3389\/fphys.2022.900664"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2022.900664","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,2]]},"article-number":"900664"}}