{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:50:12Z","timestamp":1781563812018,"version":"3.54.5"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Pancreatin secretion is dramatically decreased over time after weaning, thus affecting the utilization of nutrients in piglets. Therefore, exogenous pancreatin is expected to alleviate this situation. This experiment was conducted to investigate the effects of exogenous pancreatin on the growth performance, nutrient digestion and absorption, and intestinal microbiota of piglets. One hundred eighty piglets (Duroc \u00d7 Landrace \u00d7 Yorkshire, 40\u00a0days) were randomly allotted to three treatments (basal diets supplemented with 0, 250, or 500\u00a0mg\/kg pancreatin) with three replicate pens per treatment and 20 piglets per pen. Compared with the control diet, dietary 500\u00a0mg\/kg pancreatin significantly increased (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) the average daily gain (ADG) and the apparent digestibility of crude protein and crude fat of piglets. Regarding endogenous enzymes, pancrelipase activity in the pancreas, duodenal mucosa, and small intestinal digesta as well as trypsin activity in the jejunal digesta were increased in piglets fed a diet supplemented with 500\u00a0mg\/kg pancreatin (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Moreover, amylopsin activity was significantly strengthened in the pancreas, duodenal mucosa, and digesta in piglets fed a diet with 500\u00a0mg\/kg pancreatin (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). The mRNA expression of nutrient transporters, including oligopeptide transporter-1 (PepT1), excitatory amino acid transporter-1 (EAAC1), cationic amino acid transporter-1 (CAT1), sodium glucose cotransporter-1 (SGLT1), glucose transporter-2 (GLUT2), and fatty acid transporter-4 (FATP4), in the jejunum significantly increased after dietary supplementation with 500\u00a0mg\/kg pancreatin (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). An increased villus height-to-crypt depth ratio of the ileum was observed in the 500\u00a0mg\/kg pancreatin-treated group (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). The composition of the colonic microbiota modulated by the addition of 500\u00a0mg\/kg pancreatin was characterized by an increased relative abundance of <jats:italic>Lactobacillus<\/jats:italic> (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), and the predicted functions revealed that 500\u00a0mg\/kg pancreatin supplementation enhanced the functional abundance of genetic information processing in colonic microorganisms and environmental information processing. Our findings suggested that the addition of 500\u00a0mg\/kg pancreatin improved the growth performance of piglets, improved intestinal structure, and modulated the colon microbiota, thereby increasing nutrient digestibility.<\/jats:p>","DOI":"10.3389\/fphys.2022.906522","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T05:58:56Z","timestamp":1660024736000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["The Positive Effects of Exogenous Pancreatin on Growth Performance, Nutrient Digestion and Absorption, and Intestinal Microbiota in Piglets"],"prefix":"10.3389","volume":"13","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.2527\/jas.2015-9027","article-title":"Effect of Supplementing a Fibrous Diet with a Xylanase and \u03b2-glucanase Blend on Growth Performance, Intestinal Glucose Uptake, and Transport-Associated Gene Expression in Growing Pigs1","volume":"93","author":"Agyekum","year":"2015","journal-title":"J. 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